{"id":"https://openalex.org/W2135472971","doi":"https://doi.org/10.1002/1615-9861(200203)2:3<262::aid-prot262>3.0.co;2-w","title":"A model of random mass-matching and its use for automated significance testing in mass spectrometric proteome analysis","display_name":"A model of random mass-matching and its use for automated significance testing in mass spectrometric proteome analysis","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2135472971","doi":"https://doi.org/10.1002/1615-9861(200203)2:3<262::aid-prot262>3.0.co;2-w","mag":"2135472971","pmid":"https://pubmed.ncbi.nlm.nih.gov/11921442"},"language":"en","primary_location":{"id":"doi:10.1002/1615-9861(200203)2:3<262::aid-prot262>3.0.co;2-w","doi":"https://doi.org/10.1002/1615-9861(200203)2:3<262::aid-prot262>3.0.co;2-w","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1615-9861(200203)2:3<262::aid-prot262>3.0.co;2-w","pdf_url":null,"source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jan Eriksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Eriksson","raw_affiliation_strings":["Department of Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065792746","display_name":"David Feny\u00f6","orcid":"https://orcid.org/0000-0001-5049-3825","observed_orcids":["https://orcid.org/0000-0001-5049-3825"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David Feny\u00f6","raw_affiliation_strings":["Proteometrics LLC, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteometrics LLC, New York, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065792746"],"corresponding_institution_ids":[],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":2.9438,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.92782843,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"2","issue":"3","first_page":"262","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/significance-testing","display_name":"significance testing","score":0.6460000276565552},{"id":"https://openalex.org/keywords/protein-identification","display_name":"protein identification","score":0.8220000267028809},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"false discovery rate","score":0.5879999995231628},{"id":"https://openalex.org/keywords/score-distribution","display_name":"score distribution","score":0.4699999988079071},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C48000682","wikidata":"https://www.wikidata.org/wiki/Q5227411","display_name":"Database search engine","level":3,"score":0.6531543731689453},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6035014986991882},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5501424670219421},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5124269127845764},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.5081548690795898},{"id":"https://openalex.org/C112979427","wikidata":"https://www.wikidata.org/wiki/Q4949102","display_name":"Bottom-up proteomics","level":5,"score":0.4868006408214569},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4531469941139221},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.43018779158592224},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.3966187536716461},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.310842901468277},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3088974952697754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27094000577926636},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.23289796710014343},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2101142406463623},{"id":"https://openalex.org/C97854310","wikidata":"https://www.wikidata.org/wiki/Q19541","display_name":"Search engine","level":2,"score":0.20631909370422363},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.156229168176651},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15202412009239197},{"id":"https://openalex.org/C202157981","wikidata":"https://www.wikidata.org/wiki/Q7251488","display_name":"Protein mass spectrometry","level":4,"score":0.12681838870048523},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.09466943144798279},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1615-9861(200203)2:3<262::aid-prot262>3.0.co;2-w","doi":"https://doi.org/10.1002/1615-9861(200203)2:3<262::aid-prot262>3.0.co;2-w","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1615-9861(200203)2:3<262::aid-prot262>3.0.co;2-w","pdf_url":null,"source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},{"id":"pmid:11921442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11921442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2322066099"],"related_works":["https://openalex.org/W7100210709","https://openalex.org/W2058590378","https://openalex.org/W2135427956","https://openalex.org/W7101229871","https://openalex.org/W7095236830","https://openalex.org/W1996600592","https://openalex.org/W2124606291","https://openalex.org/W2030460975","https://openalex.org/W2144129208","https://openalex.org/W2097058336"],"abstract_inverted_index":{"A":[0,99,120],"rapid":[1],"and":[2,20,43,77,92,149,175],"accurate":[3],"method":[4,27],"for":[5,128,202,205],"testing":[6,145,187,201],"the":[7,38,53,65,70,78,105,108,113,123,139,196,224],"significance":[8,144,186,200],"of":[9,17,37,41,55,67,83,90,122,126,138,198],"protein":[10,18,157,225],"identities":[11],"determined":[12],"by":[13,73,215],"mass":[14,74,169,218],"spectrometric":[15],"analysis":[16,76,214],"digests":[19],"genome":[21,57],"database":[22,58,85,150,180],"searching":[23],"is":[24,28,101,132],"presented.":[25],"The":[26,87],"based":[29,63,188],"on":[30,64,189],"direct":[31,190,199],"computation":[32],"using":[33],"a":[34,56,61,84,117,179],"statistical":[35],"model":[36,137],"random":[39,88,129,140],"matching":[40,89],"measured":[42],"theoretical":[44,79,93],"proteolytic":[45,80,167],"peptide":[46,81,168,212],"masses.":[47],"Protein":[48],"identification":[49,158],"algorithms":[50],"typically":[51],"rank":[52],"proteins":[54],"according":[59],"to":[60,155,178,184,211,222],"score":[62,106,114,124],"number":[66],"matches":[68],"between":[69],"masses":[71,82,94],"obtained":[72],"spectrometry":[75,219],"protein.":[86],"experimental":[91,148],"can":[95],"cause":[96],"false":[97,118],"results.":[98],"result":[100,109],"significant":[102],"only":[103],"if":[104],"characterizing":[107],"deviates":[110],"significantly":[111],"from":[112,116,135],"expected":[115],"result.":[119],"distribution":[121],"(number":[125],"matches)":[127],"(false)":[130],"results":[131],"computed":[133],"directly":[134],"our":[136],"matching,":[141],"which":[142],"allows":[143],"under":[146],"any":[147],"search":[151,181],"constraints.":[152],"In":[153],"order":[154,221],"mimic":[156],"data":[159,170],"quality":[160,166],"in":[161,173,220],"large-scale":[162],"proteome":[163],"projects,":[164],"low-to-high":[165],"were":[171],"generated":[172],"silico":[174],"subsequently":[176],"submitted":[177],"program":[182],"designed":[183],"include":[185],"computation.":[191],"This":[192],"simulation":[193],"procedure":[194],"demonstrates":[195],"usefulness":[197],"automatically":[203],"screening":[204],"samples":[206],"that":[207],"must":[208],"be":[209],"subjected":[210],"sequence":[213],"e.g.":[216],"tandem":[217],"determine":[223],"identity.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}