{"id":"https://openalex.org/W2135456661","doi":"https://doi.org/10.1158/1078-0432.ccr-12-0319","title":"Suppression of Human Glioma Xenografts with Second-Generation IL13R-Specific Chimeric Antigen Receptor\u2013Modified T Cells","display_name":"Suppression of Human Glioma Xenografts with Second-Generation IL13R-Specific Chimeric Antigen Receptor\u2013Modified T Cells","publication_year":2012,"publication_date":"2012-09-11","ids":{"openalex":"https://openalex.org/W2135456661","doi":"https://doi.org/10.1158/1078-0432.ccr-12-0319","mag":"2135456661","pmid":"https://pubmed.ncbi.nlm.nih.gov/22966020","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4337849"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-12-0319","doi":"https://doi.org/10.1158/1078-0432.ccr-12-0319","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-12-0319","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4337849","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043305508","display_name":"Seogkyoung Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seogkyoung Kong","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056288861","display_name":"Sadhak Sengupta","orcid":"https://orcid.org/0000-0002-5933-4430","observed_orcids":["https://orcid.org/0000-0002-5933-4430"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sadhak Sengupta","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010219978","display_name":"Betty Tyler","orcid":"https://orcid.org/0000-0001-9800-6969","observed_orcids":["https://orcid.org/0000-0001-9800-6969"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty Tyler","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040682667","display_name":"Anthony J. Bais","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J. Bais","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967103","display_name":"Qiangzhong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiangzhong Ma","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054124689","display_name":"Saryn Doucette","orcid":"https://orcid.org/0000-0002-9417-8744","observed_orcids":["https://orcid.org/0000-0002-9417-8744"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saryn Doucette","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049356393","display_name":"Jinyuan Zhou","orcid":"https://orcid.org/0000-0002-6684-7920","observed_orcids":["https://orcid.org/0000-0002-6684-7920"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinyuan Zhou","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103150664","display_name":"Ayguen Sahin","orcid":"https://orcid.org/0000-0001-9247-8383","observed_orcids":["https://orcid.org/0000-0001-9247-8383"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayguen Sahin","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005526815","display_name":"Bob S. Carter","orcid":"https://orcid.org/0000-0002-3586-1324","observed_orcids":["https://orcid.org/0000-0002-3586-1324"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bob S. Carter","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049334243","display_name":"Henry Brem","orcid":"https://orcid.org/0000-0001-7539-4786","observed_orcids":["https://orcid.org/0000-0001-7539-4786"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Brem","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113527586","display_name":"Richard Paul Junghans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard P. Junghans","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102749027","display_name":"Prakash Sampath","orcid":"https://orcid.org/0000-0001-5994-6819","observed_orcids":["https://orcid.org/0000-0001-5994-6819"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prakash Sampath","raw_affiliation_strings":["Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Brain Tumor Lab, Department of Neurosurgery, 2Biotherapeutics Development Lab, Department of Medicine, 3Department of Pathology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island; 4Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and 6Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113527586"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":7.1254,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.98117296,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"18","issue":"21","first_page":"5949","last_page":"5960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.6629999876022339},{"id":"https://openalex.org/keywords/il-13-receptor-alpha-2","display_name":"IL-13 receptor alpha 2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/il13ralpha2","display_name":"IL13R\u03b12","score":0.8100000023841858},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cd28-costimulation","display_name":"CD28 costimulation","score":0.871999979019165},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.5149999856948853},{"id":"https://openalex.org/keywords/intracranial-injection","display_name":"intracranial injection","score":0.6660000085830688},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6000000238418579},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6593948602676392},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5898658633232117},{"id":"https://openalex.org/C32046619","wikidata":"https://www.wikidata.org/wiki/Q14878303","display_name":"Interleukin 13","level":4,"score":0.53374183177948},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5274608135223389},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47360897064208984},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.444536030292511},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.425054669380188},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3817526698112488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3735896646976471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35289880633354187},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.2649368643760681}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023061","descriptor_name":"Gene Order","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053663","descriptor_name":"Interleukin-13 Receptor alpha2 Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053663","descriptor_name":"Interleukin-13 Receptor alpha2 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-12-0319","doi":"https://doi.org/10.1158/1078-0432.ccr-12-0319","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-12-0319","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:22966020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22966020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3301630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4337849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4337849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4337849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3301630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4337849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000911005","display_name":"Regional Oncology Research Center","funder_award_id":"P30CA006973","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W5786864","https://openalex.org/W137108379","https://openalex.org/W620612307","https://openalex.org/W1518708260","https://openalex.org/W1519526369","https://openalex.org/W1574443686","https://openalex.org/W1594689884","https://openalex.org/W1897024726","https://openalex.org/W1965642226","https://openalex.org/W1966747978","https://openalex.org/W1972232097","https://openalex.org/W1972497890","https://openalex.org/W1986474919","https://openalex.org/W2012738581","https://openalex.org/W2017596953","https://openalex.org/W2017851655","https://openalex.org/W2024473337","https://openalex.org/W2033883454","https://openalex.org/W2034780740","https://openalex.org/W2039721940","https://openalex.org/W2040108818","https://openalex.org/W2040866755","https://openalex.org/W2043046650","https://openalex.org/W2044673785","https://openalex.org/W2056011525","https://openalex.org/W2062619192","https://openalex.org/W2072122733","https://openalex.org/W2093654081","https://openalex.org/W2094652659","https://openalex.org/W2113989224","https://openalex.org/W2122465970","https://openalex.org/W2125437229","https://openalex.org/W2130848313","https://openalex.org/W2140621853","https://openalex.org/W2140788444","https://openalex.org/W2146702849","https://openalex.org/W2151461066","https://openalex.org/W2156327992","https://openalex.org/W2165917993","https://openalex.org/W2370823328","https://openalex.org/W4255289481","https://openalex.org/W6631032314","https://openalex.org/W6684386963"],"related_works":["https://openalex.org/W2766649683","https://openalex.org/W2567459696","https://openalex.org/W2225524101","https://openalex.org/W2219167334","https://openalex.org/W2608184359","https://openalex.org/W2555124772","https://openalex.org/W4400517754","https://openalex.org/W1828443506","https://openalex.org/W2064341586","https://openalex.org/W2039721940"],"abstract_inverted_index":{"PURPOSE:":[0],"Glioblastoma":[1],"multiforme":[2],"(GBM)":[3],"remains":[4],"highly":[5],"incurable,":[6],"with":[7,115,148,174],"frequent":[8],"recurrences":[9],"after":[10],"standard":[11],"therapies":[12],"of":[13,62,73,82,90,97,118,151,183,202,205,226,236],"maximal":[14],"surgical":[15],"resection,":[16],"radiation,":[17],"and":[18,78,95,120,154,156],"chemotherapy.":[19],"To":[20],"address":[21],"the":[22,74,83,91,105,131,200],"need":[23],"for":[24,93],"new":[25],"treatments,":[26],"we":[27],"have":[28],"undertaken":[29],"a":[30,49,56,63,175],"chimeric":[31],"antigen":[32],"receptor":[33,45],"(CAR)":[34],"\"designer":[35],"T":[36,165],"cell\"":[37],"(dTc)":[38],"immunotherapeutic":[39],"strategy":[40],"by":[41,130,243],"exploiting":[42],"interleukin":[43],"(IL)13":[44],"\u03b1-2":[46],"(IL13R\u03b12)":[47],"as":[48],"GBM-selective":[50],"target.":[51],"EXPERIMENTAL":[52],"DESIGN:":[53],"We":[54,134],"tested":[55],"second-generation":[57],"IL13":[58,65,138,184,238],"\"zetakine\"":[59],"CAR":[60,92],"composed":[61],"mutated":[64],"extracellular":[66],"domain":[67],"linked":[68],"to":[69,87,217,228],"intracellular":[70],"signaling":[71],"elements":[72],"CD28":[75],"costimulatory":[76],"molecule":[77],"CD3\u03b6.":[79],"The":[80],"aim":[81,111],"mutation":[84],"(IL13.E13K.R109K)":[85],"was":[86,112],"enhance":[88],"selectivity":[89],"recognition":[94,117],"killing":[96,143],"IL13R\u03b12(+)":[98,144],"GBMs":[99],"while":[100],"sparing":[101],"normal":[102,126,246],"cells":[103,129,166,209],"bearing":[104],"composite":[106],"IL13R\u03b11/IL4R\u03b1":[107],"receptor.":[108],"RESULTS:":[109],"Our":[110],"partially":[113],"realized":[114],"improved":[116],"tumor":[119,187],"reduced":[121],"but":[122],"persisting":[123],"activity":[124],"against":[125,245],"tissue":[127],"IL13R\u03b11(+)":[128],"IL13.E13K.R109K":[132],"CAR.":[133],"show":[135],"that":[136],"these":[137,237],"dTcs":[139,227],"were":[140],"efficient":[141],"in":[142,167,171,190,193],"glioma":[145,177],"cell":[146],"targets":[147],"abundant":[149],"secretion":[150],"cytokines":[152],"IL2":[153],"IFN\u03b3,":[155],"they":[157],"displayed":[158],"enhanced":[159],"tumor-induced":[160],"expansion":[161],"versus":[162],"control":[163],"unmodified":[164],"vitro.":[168],"In":[169],"an":[170],"vivo":[172],"test":[173],"human":[176],"xenograft":[178],"model,":[179],"single":[180],"intracranial":[181],"injections":[182],"dTc":[185,212,239],"into":[186,214],"sites":[188],"resulted":[189],"marked":[191],"increases":[192],"animal":[194],"survivals.":[195],"CONCLUSIONS:":[196],"These":[197],"data":[198],"raise":[199],"possibility":[201],"immune":[203],"targeting":[204],"diffusely":[206],"invasive":[207],"GBM":[208,219],"either":[210],"via":[211,222],"infusion":[213],"resection":[215],"cavities":[216],"prevent":[218],"recurrence":[220],"or":[221,231],"direct":[223],"stereotactic":[224],"injection":[225],"suppress":[229],"inoperable":[230],"recurrent":[232],"tumors.":[233],"Systemic":[234],"administration":[235],"could":[240],"be":[241],"complicated":[242],"reaction":[244],"tissues":[247],"expressing":[248],"IL13Ra1.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}