{"id":"https://openalex.org/W2135447632","doi":"https://doi.org/10.1093/cercor/bhg128","title":"Co-expression and In Vivo Interaction of Serotonin1A and Serotonin2A Receptors in Pyramidal Neurons of Prefrontal Cortex","display_name":"Co-expression and In Vivo Interaction of Serotonin1A and Serotonin2A Receptors in Pyramidal Neurons of Prefrontal Cortex","publication_year":2004,"publication_date":"2004-01-30","ids":{"openalex":"https://openalex.org/W2135447632","doi":"https://doi.org/10.1093/cercor/bhg128","mag":"2135447632","pmid":"https://pubmed.ncbi.nlm.nih.gov/14754868"},"language":"en","primary_location":{"id":"doi:10.1093/cercor/bhg128","doi":"https://doi.org/10.1093/cercor/bhg128","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cercor/bhg128","pdf_url":null,"source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013778683","display_name":"Merc\u00e8 Amarg\u00f3s\u2010Bosch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M. Amargos-Bosch","raw_affiliation_strings":["Department of Neurochemistry, Institut d'Investigacions Biom\u00e8diques de Barcelona (CSIC), IDIBAPs, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Institut d'Investigacions Biom\u00e8diques de Barcelona (CSIC), IDIBAPs, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013778683"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"],"apc_list":{"value":5038,"currency":"USD","value_usd":5038},"apc_paid":null,"fwci":6.1929,"has_fulltext":false,"cited_by_count":377,"citation_normalized_percentile":{"value":0.97962164,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"14","issue":"3","first_page":"281","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.8769999742507935},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/receptor-colocalization","display_name":"receptor colocalization","score":0.8360000252723694},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.9480000138282776},{"id":"https://openalex.org/keywords/raphe-nuclei","display_name":"raphe nuclei","score":0.8999999761581421},{"id":"https://openalex.org/keywords/serotonin-release","display_name":"serotonin release","score":0.7319999933242798},{"id":"https://openalex.org/keywords/digital-object-identifiers","display_name":"digital object identifiers","score":0.42899999022483826},{"id":"https://openalex.org/keywords/way-100635","display_name":"WAY-100635","score":0.9850000143051147},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.8299999833106995},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/receptor-interaction","display_name":"receptor interaction","score":0.492000013589859},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.744587242603302},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7376137971878052},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4853028655052185},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4732283353805542},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4538425803184509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31194061040878296},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.15125301480293274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07681536674499512}],"mesh":[{"descriptor_ui":"D000662","descriptor_name":"Amphetamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044282","descriptor_name":"Receptor, Serotonin, 5-HT1A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D044282","descriptor_name":"Receptor, Serotonin, 5-HT1A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/cercor/bhg128","doi":"https://doi.org/10.1093/cercor/bhg128","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cercor/bhg128","pdf_url":null,"source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},{"id":"pmid:14754868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14754868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral cortex (New York, N.Y. : 1991)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.558.5452","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.558.5452","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cercor.oxfordjournals.org/content/14/3/281.full.pdf","raw_type":"text"},{"id":"pmh:oai:digital.csic.es:10261/34683","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/34683","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W1473482462","https://openalex.org/W1495834546","https://openalex.org/W1503601165","https://openalex.org/W1522048223","https://openalex.org/W1522335173","https://openalex.org/W1543276710","https://openalex.org/W1552042987","https://openalex.org/W1566743778","https://openalex.org/W1579518684","https://openalex.org/W1627822089","https://openalex.org/W1635746382","https://openalex.org/W1759458675","https://openalex.org/W1828538530","https://openalex.org/W1956954604","https://openalex.org/W1964176367","https://openalex.org/W1967218109","https://openalex.org/W1969591746","https://openalex.org/W1969768785","https://openalex.org/W1969852349","https://openalex.org/W1969855549","https://openalex.org/W1972075343","https://openalex.org/W1975130619","https://openalex.org/W1977832150","https://openalex.org/W1978605718","https://openalex.org/W1978846422","https://openalex.org/W1981271637","https://openalex.org/W1981485683","https://openalex.org/W1981875451","https://openalex.org/W1982408943","https://openalex.org/W1982846286","https://openalex.org/W1985405824","https://openalex.org/W1990652280","https://openalex.org/W1993560189","https://openalex.org/W1994153884","https://openalex.org/W1994483494","https://openalex.org/W1994901510","https://openalex.org/W1995194777","https://openalex.org/W1996327177","https://openalex.org/W1996345484","https://openalex.org/W1998811784","https://openalex.org/W2004172377","https://openalex.org/W2007652683","https://openalex.org/W2008374290","https://openalex.org/W2012359231","https://openalex.org/W2015221148","https://openalex.org/W2016983964","https://openalex.org/W2019400297","https://openalex.org/W2022367168","https://openalex.org/W2026035034","https://openalex.org/W2028524283","https://openalex.org/W2028681152","https://openalex.org/W2029267570","https://openalex.org/W2031882709","https://openalex.org/W2034951640","https://openalex.org/W2035632600","https://openalex.org/W2037056616","https://openalex.org/W2041907941","https://openalex.org/W2043353451","https://openalex.org/W2048824332","https://openalex.org/W2049238120","https://openalex.org/W2050877266","https://openalex.org/W2052233674","https://openalex.org/W2052833744","https://openalex.org/W2053766371","https://openalex.org/W2060177975","https://openalex.org/W2062177692","https://openalex.org/W2064967783","https://openalex.org/W2068216349","https://openalex.org/W2071614008","https://openalex.org/W2074483296","https://openalex.org/W2079266000","https://openalex.org/W2082597159","https://openalex.org/W2084007108","https://openalex.org/W2086009204","https://openalex.org/W2089649622","https://openalex.org/W2091752086","https://openalex.org/W2093072166","https://openalex.org/W2094526136","https://openalex.org/W2095858175","https://openalex.org/W2098163527","https://openalex.org/W2101948750","https://openalex.org/W2111990860","https://openalex.org/W2115182798","https://openalex.org/W2123354702","https://openalex.org/W2125707003","https://openalex.org/W2131761257","https://openalex.org/W2139882380","https://openalex.org/W2143649581","https://openalex.org/W2147732387","https://openalex.org/W2151137320","https://openalex.org/W2155924534","https://openalex.org/W2158271326","https://openalex.org/W2159399023","https://openalex.org/W2159612818","https://openalex.org/W2159742364","https://openalex.org/W2163815564","https://openalex.org/W2264455884","https://openalex.org/W2413669493"],"related_works":["https://openalex.org/W7096820594","https://openalex.org/W2156868152","https://openalex.org/W2149734448","https://openalex.org/W7097769152","https://openalex.org/W2131937487","https://openalex.org/W7099887937","https://openalex.org/W1546809142","https://openalex.org/W2020016243","https://openalex.org/W2168545629","https://openalex.org/W2141403390"],"abstract_inverted_index":{"The":[0,51],"prefrontal":[1,37,76],"cortex":[2,38,77],"plays":[3],"a":[4,98],"key":[5,183],"role":[6],"in":[7,17,33,67,73,81,110,119,130,158,163,185],"the":[8,18,31,55,82,91,117,125,152,173,176,179,193],"control":[9],"of":[10,22,30,54,127,141,155,192,195],"higher":[11],"brain":[12],"functions":[13],"and":[14,20,35,57,64,105,107,151,160,178,188],"is":[15],"involved":[16],"pathophysiology":[19],"treatment":[21],"schizophrenia.":[23],"Here":[24],"we":[25],"report":[26],"that":[27,116],"approximately":[28],"60%":[29],"neurons":[32,70],"rat":[34,74],"mouse":[36],"express":[39],"5-HT(1A)":[40],"and/or":[41],"5-HT2A":[42,108,128],"receptor":[43,135],"mRNAs,":[44],"which":[45],"are":[46],"highly":[47],"co-localized":[48],"(approximately":[49],"80%).":[50],"electrical":[52],"stimulation":[53],"dorsal":[56],"median":[58],"raphe":[59,92,180],"nuclei":[60,93],"elicited":[61],"5-HT1A-mediated":[62],"inhibitions":[63],"5-HT2A-mediated":[65],"excitations":[66],"identified":[68],"pyramidal":[69,84,111],"recorded":[71],"extracellularly":[72],"medial":[75],"(mPFC).":[78],"Opposite":[79],"responses":[80],"same":[83],"neuron":[85],"could":[86],"be":[87],"evoked":[88,123],"by":[89,124,132,139,149],"stimulating":[90],"at":[94],"different":[95],"coordinates,":[96],"suggesting":[97],"precise":[99],"connectivity":[100],"between":[101,175],"5-HT":[102,121,201],"neuronal":[103],"subgroups":[104],"5-HT1A":[106,142,156,166],"receptors":[109,129,157],"neurons.":[112],"Microdialysis":[113],"experiments":[114],"showed":[115],"increase":[118],"local":[120],"release":[122],"activation":[126],"mPFC":[131,177],"DOI":[133],"(5-HT2A/2C":[134],"agonist)":[136],"was":[137,147,161],"reversed":[138],"co-perfusion":[140],"agonists.":[143],"This":[144],"inhibitory":[145],"effect":[146],"antagonized":[148],"WAY-100635":[150],"prior":[153],"inactivation":[154],"rats":[159],"absent":[162],"mice":[164],"lacking":[165],"receptors.":[167,202],"These":[168],"observations":[169],"help":[170],"to":[171],"clarify":[172],"interactions":[174],"nuclei,":[181],"two":[182],"areas":[184],"psychiatric":[186],"illnesses":[187],"improve":[189],"our":[190],"understanding":[191],"action":[194],"atypical":[196],"antipsychotics,":[197],"acting":[198],"through":[199],"these":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}