{"id":"https://openalex.org/W2135403791","doi":null,"title":"Expression of the SIL gene is correlated with growth induction and cellular proliferation.","display_name":"Expression of the SIL gene is correlated with growth induction and cellular proliferation.","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W2135403791","mag":"2135403791","pmid":"https://pubmed.ncbi.nlm.nih.gov/9372240"},"language":"en","primary_location":{"id":"pmid:9372240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9372240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026358643","display_name":"Shai Izraeli","orcid":"https://orcid.org/0000-0002-6938-2540","observed_orcids":["https://orcid.org/0000-0002-6938-2540","https://orcid.org/0009-0001-2131-8638"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Izraeli","raw_affiliation_strings":["Genetics Department, National Cancer Institute, Bethesda, Maryland 20889-5101, USA","Cancer Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Department, National Cancer Institute, Bethesda, Maryland 20889-5101, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Cancer Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031790135","display_name":"Tina Colaizzo\u2010Anas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Colaizzo-Anas","raw_affiliation_strings":["Roswell Park Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058327176","display_name":"Virginia L. Bertness","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V L Bertness","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K Mani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Mani","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049170518","display_name":"Peter D. Aplan","orcid":"https://orcid.org/0000-0001-5686-9969","observed_orcids":["https://orcid.org/0000-0001-5686-9969"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P D Aplan","raw_affiliation_strings":["Roswell Park Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021146139","display_name":"Ilan Richard Kirsch","orcid":"https://orcid.org/0000-0001-5592-5201","observed_orcids":["https://orcid.org/0000-0001-5592-5201"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I R Kirsch","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3481,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.80771885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"11","first_page":"1171","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immediate-early-genes","display_name":"immediate early genes","score":0.7519999742507935},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.781000018119812},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.6380000114440918},{"id":"https://openalex.org/keywords/serum-induced-gene-expression","display_name":"serum-induced gene expression","score":0.6549999713897705},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/contact-inhibition","display_name":"contact inhibition","score":0.722000002861023},{"id":"https://openalex.org/keywords/terminal-differentiation","display_name":"terminal differentiation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.7059999704360962},{"id":"https://openalex.org/keywords/3t3-cells","display_name":"3T3 fibroblasts","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.5910000205039978},{"id":"https://openalex.org/keywords/g2-phase","display_name":"G2 phase","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8265643119812012},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6679719686508179},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6358555555343628},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6181726455688477},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.594646692276001},{"id":"https://openalex.org/C64979461","wikidata":"https://www.wikidata.org/wiki/Q3151077","display_name":"Contact inhibition","level":3,"score":0.5243057012557983},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5241070985794067},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5204158425331116},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5180644989013672},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5117318630218506},{"id":"https://openalex.org/C2776746612","wikidata":"https://www.wikidata.org/wiki/Q68153243","display_name":"3T3 cells","level":4,"score":0.4781419038772583},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.455811470746994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1685914397239685},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09219467639923096},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.08551633358001709}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9372240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9372240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.534.7263","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.534.7263","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cgd.aacrjournals.org/cgi/reprint/8/11/1171.pdf","raw_type":"text"},{"id":"mag:2135403791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9372240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W89272259","https://openalex.org/W122007457","https://openalex.org/W266334352","https://openalex.org/W1486057264","https://openalex.org/W1488748940","https://openalex.org/W1543438262","https://openalex.org/W1606900722","https://openalex.org/W1608909968","https://openalex.org/W1801254229","https://openalex.org/W1811606715","https://openalex.org/W1869555064","https://openalex.org/W1884284628","https://openalex.org/W1919210158","https://openalex.org/W1925481732","https://openalex.org/W1932210510","https://openalex.org/W1958160711","https://openalex.org/W1971194885","https://openalex.org/W1974391793","https://openalex.org/W1989043810","https://openalex.org/W1989998960","https://openalex.org/W1997805342","https://openalex.org/W1999689481","https://openalex.org/W2003209070","https://openalex.org/W2021752473","https://openalex.org/W2023920753","https://openalex.org/W2039839254","https://openalex.org/W2043645942","https://openalex.org/W2045798063","https://openalex.org/W2051740914","https://openalex.org/W2053006912","https://openalex.org/W2068446924","https://openalex.org/W2072810131","https://openalex.org/W2088692721","https://openalex.org/W2107359522","https://openalex.org/W2115701574","https://openalex.org/W2119121495","https://openalex.org/W2124241283","https://openalex.org/W2144042281","https://openalex.org/W2160913805","https://openalex.org/W2164515753","https://openalex.org/W2165383990","https://openalex.org/W2183391261","https://openalex.org/W2193330140","https://openalex.org/W2198974858","https://openalex.org/W2394517472","https://openalex.org/W2405336827","https://openalex.org/W2412681093","https://openalex.org/W2417227387"],"related_works":["https://openalex.org/W7096623480","https://openalex.org/W2156650182","https://openalex.org/W1988991132","https://openalex.org/W1793987231","https://openalex.org/W2077492124","https://openalex.org/W2397657266","https://openalex.org/W7098025442","https://openalex.org/W2005850222","https://openalex.org/W2133056037","https://openalex.org/W2402020574"],"abstract_inverted_index":{"The":[0,25],"SIL":[1,27,46,70,106,119,140,149,174],"gene":[2,28],"was":[3],"discovered":[4],"at":[5,159],"the":[6,18,44,97,100,129,145,160,163],"site":[7],"of":[8,20,60,67,76,89,99,116,162,168],"a":[9,21,30,125],"cancer-associated":[10],"interstitial":[11],"deletion":[12],"in":[13,43,49,81,96,135,180],"which":[14],"its":[15],"promoter":[16],"assumed":[17],"regulation":[19],"second":[22],"gene,":[23],"SCL.":[24],"human":[26],"encodes":[29],"1287-amino":[31],"acid":[32],"cytosolic":[33],"protein":[34,90,101,122,150],"that":[35,173],"has":[36],"been":[37],"found":[38],"to":[39],"be":[40],"highly":[41],"conserved":[42],"mouse.":[45],"is":[47,53,71,87,94,107,142],"expressed":[48],"proliferating":[50],"cells":[51],"and":[52,121,155,183],"down-regulated":[54],"when":[55],"cellular":[56,181],"proliferation":[57],"ceases":[58],"because":[59,92],"serum":[61,80,114],"starvation,":[62],"contact":[63],"inhibition,":[64],"or":[65],"induction":[66,86],"terminal":[68],"differentiation.":[69],"induced":[72],"within":[73],"1":[74],"h":[75],"stimulation":[77],"by":[78],"20%":[79],"growth-arrested":[82],"3T3":[83,117],"cells.":[84],"This":[85,166],"independent":[88],"synthesis":[91,102],"\"superinduction\"":[93],"observed":[95],"presence":[98],"inhibitor":[103],"cyclohexamide.":[104],"Thus,":[105],"an":[108,177],"immediate-early":[109],"gene.":[110],"Upon":[111],"release":[112],"from":[113],"starvation":[115],"fibroblasts,":[118],"mRNA":[120,141],"levels":[123],"display":[124],"biphasic":[126],"pattern":[127,167],"during":[128],"first":[130],"cell":[131,146,164,169],"cycle.":[132,165],"In":[133],"contrast,":[134],"exponentially":[136],"growing":[137],"EL4":[138],"lymphoblasts,":[139],"stable":[143],"throughout":[144],"cycle,":[147],"whereas":[148],"accumulates":[151],"into":[152],"G2":[153],"phase":[154],"then":[156],"falls":[157],"precipitously":[158],"completion":[161],"cycle":[170],"expression":[171],"suggests":[172],"may":[175],"play":[176],"important":[178],"role":[179],"growth":[182],"proliferation.":[184]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
