{"id":"https://openalex.org/W2135347448","doi":"https://doi.org/10.3892/mmr.2014.2302","title":"Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF-1\u03b1 expression in vivo","display_name":"Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF-1\u03b1 expression in vivo","publication_year":2014,"publication_date":"2014-06-05","ids":{"openalex":"https://openalex.org/W2135347448","doi":"https://doi.org/10.3892/mmr.2014.2302","mag":"2135347448","pmid":"https://pubmed.ncbi.nlm.nih.gov/24912495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094770"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2014.2302","doi":"https://doi.org/10.3892/mmr.2014.2302","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2014.2302","pdf_url":"http://www.spandidos-publications.com/mmr/10/2/585/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/mmr/10/2/585/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100837915","display_name":"Huaqi Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HUAQI ZHU","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103107263","display_name":"Qi\u2010Man Sun","orcid":"https://orcid.org/0000-0002-7638-9089","observed_orcids":["https://orcid.org/0000-0002-7638-9089"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"QIMAN SUN","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102137700","display_name":"Chang\u2010Jun Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHANGJUN TAN","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102004782","display_name":"Min Xu","orcid":"https://orcid.org/0000-0001-9455-9494","observed_orcids":["https://orcid.org/0000-0001-9455-9494","https://orcid.org/0000-0001-7670-6155","https://orcid.org/0000-0002-0567-7323"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MIN XU","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108391566","display_name":"Zhi Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZHI DAI","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100659416","display_name":"Zheng Wang","orcid":"https://orcid.org/0000-0003-4838-0965","observed_orcids":["https://orcid.org/0000-0003-4838-0965"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZHENG WANG","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100659621","display_name":"Jia Fan","orcid":"https://orcid.org/0000-0001-5158-629X","observed_orcids":["https://orcid.org/0000-0001-5158-629X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIA FAN","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070334439","display_name":"Jian Zhou","orcid":"https://orcid.org/0000-0002-7650-7540","observed_orcids":["https://orcid.org/0000-0002-7650-7540"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"JIAN ZHOU","raw_affiliation_strings":["Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070334439"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"],"apc_list":null,"apc_paid":null,"fwci":0.4821,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.68077617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"2","first_page":"585","last_page":"592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.12319999933242798,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sdf-1alpha","display_name":"SDF-1\u03b1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/amd3100","display_name":"AMD3100","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.953000009059906},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.968999981880188},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.5720000267028809},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/rat-tumor-model","display_name":"rat tumor model","score":0.6159999966621399},{"id":"https://openalex.org/keywords/hepatoma-cell-lines","display_name":"hepatoma cell lines","score":0.36500000953674316},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.30300000309944153},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5988094806671143},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5308409929275513},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.520160436630249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5085970163345337},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4812707304954529},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.47063419222831726},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.4395657479763031},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4293926954269409},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4125465750694275},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28363236784935},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26876354217529297},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.23343881964683533},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22978511452674866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000080027","descriptor_name":"Cyclams","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001596","descriptor_name":"Benzylamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3892/mmr.2014.2302","doi":"https://doi.org/10.3892/mmr.2014.2302","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2014.2302","pdf_url":"http://www.spandidos-publications.com/mmr/10/2/585/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4094770","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4094770","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med Rep","raw_type":"Text"},{"id":"pmid:24912495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24912495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/mmr.2014.2302","doi":"https://doi.org/10.3892/mmr.2014.2302","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2014.2302","pdf_url":"http://www.spandidos-publications.com/mmr/10/2/585/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2980541578","display_name":null,"funder_award_id":"81172277","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5331362926","display_name":"\u591a\u5149\u5b50\u201c\u5149\u5b66\u6d3b\u68c0\u201d\u7ed3\u5408\u5faa\u73af\u8840\u80bf\u7624\u7ec6\u80de\u5728\u809d\u764c\u4e2a\u4f53\u5316\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u57fa\u7840\u7814\u7a76","funder_award_id":"81272574","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2135347448.pdf","grobid_xml":"https://content.openalex.org/works/W2135347448.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W141770798","https://openalex.org/W1971704183","https://openalex.org/W1988371410","https://openalex.org/W1994193851","https://openalex.org/W2004411083","https://openalex.org/W2005975965","https://openalex.org/W2006217850","https://openalex.org/W2015521617","https://openalex.org/W2021299297","https://openalex.org/W2036995683","https://openalex.org/W2043103956","https://openalex.org/W2043908624","https://openalex.org/W2044038155","https://openalex.org/W2047114489","https://openalex.org/W2072413179","https://openalex.org/W2086016550","https://openalex.org/W2087683535","https://openalex.org/W2089265692","https://openalex.org/W2089697275","https://openalex.org/W2094115571","https://openalex.org/W2094573329","https://openalex.org/W2106787323","https://openalex.org/W2113343417","https://openalex.org/W2122656254","https://openalex.org/W2132294567","https://openalex.org/W2137052325","https://openalex.org/W2141314162","https://openalex.org/W2149780959","https://openalex.org/W2152932484","https://openalex.org/W2154288516","https://openalex.org/W2156323704","https://openalex.org/W2162667703","https://openalex.org/W2169385554","https://openalex.org/W2170113248"],"related_works":["https://openalex.org/W1973923070","https://openalex.org/W2274662762","https://openalex.org/W1971704183","https://openalex.org/W2361618528","https://openalex.org/W2166382518","https://openalex.org/W2624400082","https://openalex.org/W2140740501","https://openalex.org/W2188972139","https://openalex.org/W2366170351","https://openalex.org/W2050681550"],"abstract_inverted_index":{"The":[0,189],"aim":[1],"of":[2,10,14,36,45,54,69,82,116,122,130,151,159,178,186,191,226,232,240,264,270,280,290],"our":[3],"study":[4],"was":[5,61,71,194],"to":[6,26,109,136],"elucidate":[7],"the":[8,27,52,64,67,76,80,111,120,128,133,137,149,157,176,184,224,230,250,253,262,268,278,281,287],"effect":[9,174,289],"tacrolimus":[11],"(FK506)":[12],"and":[13,34,75,79,90,114,127,155,238,252,267,272],"C-X-C":[15],"chemokine":[16],"receptor":[17,24],"type":[18],"4":[19],"(CXCR4),":[20],"which":[21],"is":[22],"a":[23,87,92],"specific":[25],"stromal":[28],"cell-derived":[29],"factor-1\u03b1":[30],"(SDF\u20111\u03b1),":[31],"on":[32,175,292],"growth":[33],"metastasis":[35,222],"hepatocellular":[37],"carcinoma":[38],"(HCC).":[39],"Following":[40],"treatment":[41,199],"with":[42,73,86,105,165,200],"different":[43,248],"concentrations":[44],"FK506,":[46,201],"AMD3100":[47,171,212],"or":[48,209],"normal":[49],"saline":[50],"(NS),":[51],"proliferation":[53,150,177,263],"Morris":[55],"rat":[56,102],"hepatoma":[57],"3924A":[58],"(MH3924A)":[59],"cells":[60,83,153,193,266],"measured":[62],"by":[63],"MTT":[65],"assay,":[66],"expression":[68,121,129,158,185,231,269],"CXCR4":[70,123,160,187,233,271],"analyzed":[72],"immunohistochemistry,":[74],"morphological":[77],"changes":[78,113],"invasiveness":[81,115,190],"were":[84,107,246],"studied":[85],"transwell":[88],"assay":[89],"under":[91],"scanning":[93],"electron":[94],"microscope,":[95],"respectively.":[96],"In":[97,142,215],"addition,":[98],"August":[99],"Copenhagen":[100],"Irish":[101],"models":[103],"implanted":[104],"tumor":[106,117,125,217,235],"used":[108],"examine":[110],"pathological":[112],"in":[118,124,132,161,234,242,274],"vivo,":[119,216],"tissues":[126,135,236,244],"SDF\u20111\u03b1":[131,208,241,273],"adjacent":[134,243],"HCC":[138],"ones,":[139],"using":[140],"immunohistochemistry.":[141],"vitro,":[143],"FK506":[144,203,206,210,260,291],"(100\u20111,000":[145],"\u00b5g/l)":[146],"significantly":[147,182,195,247],"promoted":[148],"MH3924A":[152,162,179,192,265],"(P<0.01),":[154],"increased":[156],"cells,":[163,180],"albeit":[164],"no":[166,173],"significance":[167],"(P>0.05).":[168],"By":[169],"contrast,":[170],"had":[172],"but":[181],"reduced":[183],"(P<0.05).":[188],"(P<0.01)":[196],"enhanced":[197],"following":[198],"SDF\u20111\u03b1,":[202],"+":[204,207,211,213],"AMD3100,":[205],"SDF\u20111\u03b1.":[214],"weight":[218],"(P=0.041),":[219],"lymph":[220],"node":[221],"(P=0.002),":[223],"number":[225],"pulmonary":[227],"nodules":[228],"(P=0.012),":[229],"(P=0.048)":[237],"that":[239,259],"(P=0.026)":[245],"between":[249],"FK506-treated":[251],"NS":[254],"group.":[255],"Our":[256],"results":[257],"suggest":[258],"promotes":[261],"vivo.":[275],"Therefore,":[276],"inhibiting":[277],"formation":[279],"CXCR4/SDF\u20111\u03b1":[282],"complex":[283],"may":[284],"partly":[285],"reduce":[286],"promoting":[288],"HCC.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
