{"id":"https://openalex.org/W2135341978","doi":"https://doi.org/10.1093/nar/gku360","title":"Unraveling the regulatory connections between two controllers of breast cancer cell fate","display_name":"Unraveling the regulatory connections between two controllers of breast cancer cell fate","publication_year":2014,"publication_date":"2014-05-03","ids":{"openalex":"https://openalex.org/W2135341978","doi":"https://doi.org/10.1093/nar/gku360","mag":"2135341978","pmid":"https://pubmed.ncbi.nlm.nih.gov/24792166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4066784"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gku360","doi":"https://doi.org/10.1093/nar/gku360","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku360","pdf_url":"https://academic.oup.com/nar/article-pdf/42/11/6839/4248774/gku360.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/42/11/6839/4248774/gku360.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100447622","display_name":"Jin\u2010Ho Lee","orcid":"https://orcid.org/0000-0002-5877-0222","observed_orcids":["https://orcid.org/0000-0002-5877-0222"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Lee","raw_affiliation_strings":["Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA Department of Bioengineering, Rice University, Houston, TX 77005, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA Department of Bioengineering, Rice University, Houston, TX 77005, USA","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Tiwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Tiwari","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX 77005, USA","Department of Bioengineering, Rice University, Houston, TX 77005,#N#USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX 77005, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX 77005,#N#USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105858619","display_name":"Victor Shum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Shum","raw_affiliation_strings":["Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA Department of Physics, University of Houston, Houston, TX 77004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA Department of Physics, University of Houston, Houston, TX 77004, USA","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129560433","display_name":"Gordon B. Mills","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. B. Mills","raw_affiliation_strings":["Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103147933","display_name":"Michael A. Mancini","orcid":"https://orcid.org/0000-0002-4862-1944","observed_orcids":["https://orcid.org/0000-0002-4862-1944"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. Mancini","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016582420","display_name":"Oleg A. Igoshin","orcid":"https://orcid.org/0000-0002-1449-4772","observed_orcids":["https://orcid.org/0000-0002-1449-4772"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O. A. Igoshin","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX 77005, USA igoshin@rice.edu","**Rice University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX 77005, USA igoshin@rice.edu","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"**Rice University;","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050076723","display_name":"G\u00e1bor Bal\u00e1zsi","orcid":"https://orcid.org/0000-0002-6865-5818","observed_orcids":["https://orcid.org/0000-0002-6865-5818"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G. Balazsi","raw_affiliation_strings":["Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA gbalazsi@mdanderson.org gabor@laufercenter.org","Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA gbalazsi@mdanderson.org gabor@laufercenter.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Systems Biology - Unit 950, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050076723"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":0.8197,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71111235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"42","issue":"11","first_page":"6839","last_page":"6849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.19519999623298645,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gata3","display_name":"GATA3","score":0.9369999766349792},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"negative feedback","score":0.7020000219345093},{"id":"https://openalex.org/keywords/stochastic-gene-expression","display_name":"stochastic gene expression","score":0.6150000095367432},{"id":"https://openalex.org/keywords/transcriptional-autoregulation","display_name":"transcriptional autoregulation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/single-cell-gene-expression","display_name":"single-cell gene expression","score":0.593999981880188},{"id":"https://openalex.org/keywords/single-nucleus-rna-sequencing","display_name":"single-nucleus RNA sequencing","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mathematical-modeling-of-gene-regulation","display_name":"mathematical modeling of gene regulation","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8348040580749512},{"id":"https://openalex.org/C102037460","wikidata":"https://www.wikidata.org/wiki/Q18025464","display_name":"GATA3","level":4,"score":0.7841018438339233},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5884986519813538},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5761025547981262},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5546247363090515},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5028347373008728},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.487428218126297},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4456416964530945},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.435133695602417},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.40766406059265137},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4028970003128052},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37804484367370605},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3636530637741089},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31244850158691406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23439401388168335},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16976124048233032},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050990","descriptor_name":"GATA3 Transcription Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050990","descriptor_name":"GATA3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050990","descriptor_name":"GATA3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gku360","doi":"https://doi.org/10.1093/nar/gku360","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku360","pdf_url":"https://academic.oup.com/nar/article-pdf/42/11/6839/4248774/gku360.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4066784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4066784","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:24792166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24792166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.715.6861","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.715.6861","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://igoshin.rice.edu/papers/Lee%282014%29NAR.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.3661","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.3661","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1c/58/gku360.PMC4066784.pdf","raw_type":"text"},{"id":"pmh:oai:repository.rice.edu:1911/76330","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1093/nar/gku360.","pdf_url":null,"source":{"id":"https://openalex.org/S4306401268","display_name":"Rice Research Repository (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:oai:scholarship.rice.edu:1911/76330","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1911/76330","pdf_url":null,"source":{"id":"https://openalex.org/S4306401268","display_name":"Rice Research Repository (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1093/nar/gku360","doi":"https://doi.org/10.1093/nar/gku360","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku360","pdf_url":"https://academic.oup.com/nar/article-pdf/42/11/6839/4248774/gku360.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1081826082","display_name":null,"funder_award_id":"DK56338","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1248842723","display_name":null,"funder_award_id":"GM096189","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G128840436","display_name":null,"funder_award_id":"GM096189-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1690115124","display_name":null,"funder_award_id":"CA-112970","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2183314662","display_name":"Research Training Award","funder_award_id":"RP101489","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G2408464258","display_name":null,"funder_award_id":"R01-GM096189-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2557638927","display_name":null,"funder_award_id":"HD007495","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G274084553","display_name":null,"funder_award_id":"DK56338","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G3070052981","display_name":"Feedback regulation and transcirptional coupling in bacterial stress-response","funder_award_id":"R01GM096189","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3470012156","display_name":null,"funder_award_id":"CA125123","funder_id":"https://openalex.org/F4320309422","funder_display_name":"John S. Dunn Foundation"},{"id":"https://openalex.org/G3643660333","display_name":null,"funder_award_id":"DK56338","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5465708471","display_name":null,"funder_award_id":"CA125123","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G579812685","display_name":null,"funder_award_id":"HD007495","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G586652818","display_name":"Spatially-delineated System-level Analyses and Control of Cytoskeletal Regulation","funder_award_id":"R01GM106027","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7523309225","display_name":null,"funder_award_id":"CA125123","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7837447426","display_name":null,"funder_award_id":"CA125123","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G9000893404","display_name":"Texas Medical Center Digestive Diseases Center","funder_award_id":"P30DK056338","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000902408","display_name":"Baylor College of Medicine Cancer Center - Cancer Center Support Grant","funder_award_id":"P30CA125123","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G945509937","display_name":"Model-based predictions of responses RTK Pathway therapies","funder_award_id":"U54CA112970","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320309422","display_name":"John S. Dunn Foundation","ror":"https://ror.org/03yhprz62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2135341978.pdf","grobid_xml":"https://content.openalex.org/works/W2135341978.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W33672729","https://openalex.org/W1585692887","https://openalex.org/W1769240683","https://openalex.org/W1924229597","https://openalex.org/W1924240366","https://openalex.org/W1964525918","https://openalex.org/W1965425724","https://openalex.org/W1968667083","https://openalex.org/W1972890383","https://openalex.org/W1976739900","https://openalex.org/W1977934858","https://openalex.org/W1979112610","https://openalex.org/W1979445518","https://openalex.org/W1987012261","https://openalex.org/W1987522464","https://openalex.org/W1988779765","https://openalex.org/W1994032485","https://openalex.org/W1995152101","https://openalex.org/W1998398174","https://openalex.org/W2004801113","https://openalex.org/W2007800670","https://openalex.org/W2008651555","https://openalex.org/W2009980816","https://openalex.org/W2015523481","https://openalex.org/W2029821696","https://openalex.org/W2038208040","https://openalex.org/W2040889971","https://openalex.org/W2044909461","https://openalex.org/W2055505762","https://openalex.org/W2056879222","https://openalex.org/W2062233672","https://openalex.org/W2063921800","https://openalex.org/W2067233094","https://openalex.org/W2070102480","https://openalex.org/W2073266209","https://openalex.org/W2073552107","https://openalex.org/W2076372398","https://openalex.org/W2077046573","https://openalex.org/W2077986050","https://openalex.org/W2080174206","https://openalex.org/W2081684816","https://openalex.org/W2087004443","https://openalex.org/W2091198609","https://openalex.org/W2097851712","https://openalex.org/W2100218575","https://openalex.org/W2101647844","https://openalex.org/W2103989098","https://openalex.org/W2106391833","https://openalex.org/W2122534935","https://openalex.org/W2123880844","https://openalex.org/W2123973944","https://openalex.org/W2124245667","https://openalex.org/W2124980889","https://openalex.org/W2127013070","https://openalex.org/W2129036353","https://openalex.org/W2129383700","https://openalex.org/W2130344395","https://openalex.org/W2131994307","https://openalex.org/W2135783707","https://openalex.org/W2138258825","https://openalex.org/W2140347764","https://openalex.org/W2142806844","https://openalex.org/W2143704915","https://openalex.org/W2147673480","https://openalex.org/W2155399095","https://openalex.org/W2155826575","https://openalex.org/W2158485828","https://openalex.org/W2160803964","https://openalex.org/W2168267005","https://openalex.org/W2171280873","https://openalex.org/W2361838659","https://openalex.org/W4231356616","https://openalex.org/W4232254206"],"related_works":["https://openalex.org/W2103989098","https://openalex.org/W7098201013","https://openalex.org/W2329834153","https://openalex.org/W3013192308","https://openalex.org/W2004851542","https://openalex.org/W2062233672","https://openalex.org/W2121390329","https://openalex.org/W6996251735","https://openalex.org/W2138258825","https://openalex.org/W2041575663"],"abstract_inverted_index":{"Estrogen":[0],"receptor":[1],"alpha":[2],"(ER\u03b1)":[3],"expression":[4,13,97],"is":[5,102],"critical":[6],"for":[7],"breast":[8],"cancer":[9,159],"classification,":[10],"high":[11],"ER\u03b1":[12,19,35,79,100,124],"being":[14],"associated":[15],"with":[16,23,52],"better":[17],"prognosis.":[18],"levels":[20],"strongly":[21],"correlate":[22],"that":[24,75,91,99,109],"of":[25,34,41,59,138,155],"GATA":[26],"binding":[27],"protein":[28],"3":[29],"(GATA3),":[30],"a":[31],"major":[32],"regulator":[33],"expression.":[36,127],"However,":[37],"the":[38,57,63,76,110,115,121,136,153],"mechanistic":[39],"details":[40],"ER\u03b1-GATA3":[42,64,116],"regulation":[43],"remain":[44],"incompletely":[45],"understood.":[46],"Here":[47],"we":[48,73,107],"combine":[49],"mathematical":[50,88],"modeling":[51,89],"perturbation":[53],"experiments":[54],"to":[55,83,144,152],"unravel":[56],"nature":[58],"regulatory":[60],"connections":[61,113],"in":[62,114,123,135,147],"network.":[65],"Through":[66],"cell":[67,132],"population-average,":[68],"single-cell":[69],"and":[70,80,98,140],"single-nucleus":[71],"measurements,":[72],"show":[74,108],"cross-regulation":[77],"between":[78],"GATA3":[81,92,126],"amounts":[82],"overall":[84],"negative":[85,117],"feedback.":[86],"Further,":[87],"reveals":[90],"positively":[93],"regulates":[94],"its":[95],"own":[96],"autoregulation":[101],"most":[103],"likely":[104],"absent.":[105],"Lastly,":[106],"two":[111],"cross-regulatory":[112],"feedback":[118],"network":[119],"decrease":[120],"noise":[122],"or":[125],"This":[128],"may":[129],"ensure":[130],"robust":[131],"fate":[133],"maintenance":[134,154],"face":[137],"intracellular":[139],"environmental":[141],"fluctuations,":[142],"contributing":[143],"tissue":[145],"homeostasis":[146],"normal":[148],"conditions,":[149],"but":[150],"also":[151],"pathogenic":[156],"states":[157],"during":[158],"progression.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}