{"id":"https://openalex.org/W2135258241","doi":"https://doi.org/10.1136/gut.27.3.267","title":"Substance P-induced intestinal secretion of water and electrolytes.","display_name":"Substance P-induced intestinal secretion of water and electrolytes.","publication_year":1986,"publication_date":"1986-03-01","ids":{"openalex":"https://openalex.org/W2135258241","doi":"https://doi.org/10.1136/gut.27.3.267","mag":"2135258241","pmid":"https://pubmed.ncbi.nlm.nih.gov/2422093","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1433418"},"language":"en","primary_location":{"id":"doi:10.1136/gut.27.3.267","doi":"https://doi.org/10.1136/gut.27.3.267","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.27.3.267","pdf_url":"https://gut.bmj.com/content/gutjnl/27/3/267.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/27/3/267.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108325573","display_name":"D. McFadden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D McFadden","raw_affiliation_strings":["Department ofSurgery , State University of New York Downstate Medical Center , Brooklyn , New York , USA","SUNY Downstate Health Sciences University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofSurgery , State University of New York Downstate Medical Center , Brooklyn , New York , USA","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084502636","display_name":"Michael J. Zinner","orcid":"https://orcid.org/0009-0006-9833-6750","observed_orcids":["https://orcid.org/0009-0006-9833-6750"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Zinner","raw_affiliation_strings":["Department of Surgery, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA","From the Department ofSurgery, State University of New York Downstate Medical Center, Brooklyn, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"From the Department ofSurgery, State University of New York Downstate Medical Center, Brooklyn, New York, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023332339","display_name":"Bernard M. Jaffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B M Jaffe","raw_affiliation_strings":["Department of Surgery , Downstate Medical Center , 450 Clarkson Avenue , Brooklyn , New York 11203 , USA","SUNY Downstate Health Sciences University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery , Downstate Medical Center , 450 Clarkson Avenue , Brooklyn , New York 11203 , USA","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181697535"],"apc_list":null,"apc_paid":null,"fwci":0.9569,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.70629513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"3","first_page":"267","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":1.0},{"id":"https://openalex.org/keywords/carcinoid-syndrome","display_name":"carcinoid syndrome","score":0.9369999766349792},{"id":"https://openalex.org/keywords/electrolyte-secretion","display_name":"electrolyte secretion","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sodium","display_name":"sodium","score":0.7490000128746033},{"id":"https://openalex.org/keywords/chloride","display_name":"chloride","score":0.9950000047683716},{"id":"https://openalex.org/keywords/potassium","display_name":"potassium","score":0.9319999814033508},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6525623798370361},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.6051299571990967},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5958770513534546},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.555649995803833},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5468518137931824},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.46763089299201965},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.45441684126853943},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43626081943511963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39654138684272766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22145918011665344},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.16542136669158936},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/gut.27.3.267","doi":"https://doi.org/10.1136/gut.27.3.267","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.27.3.267","pdf_url":"https://gut.bmj.com/content/gutjnl/27/3/267.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:475015","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1433418","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1433418","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1433418","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmid:2422093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2422093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/gut.27.3.267","doi":"https://doi.org/10.1136/gut.27.3.267","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.27.3.267","pdf_url":"https://gut.bmj.com/content/gutjnl/27/3/267.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2135258241.pdf","grobid_xml":"https://content.openalex.org/works/W2135258241.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1576495154","https://openalex.org/W1607651866","https://openalex.org/W1792540601","https://openalex.org/W1861866660","https://openalex.org/W1970015981","https://openalex.org/W1978121364","https://openalex.org/W1981082319","https://openalex.org/W1985942603","https://openalex.org/W2002101681","https://openalex.org/W2008112394","https://openalex.org/W2008257197","https://openalex.org/W2011032430","https://openalex.org/W2025754377","https://openalex.org/W2027001430","https://openalex.org/W2031085889","https://openalex.org/W2055039397","https://openalex.org/W2068128398","https://openalex.org/W2068130158","https://openalex.org/W2069306418","https://openalex.org/W2110455787","https://openalex.org/W2244394634","https://openalex.org/W2303417058","https://openalex.org/W2342470507","https://openalex.org/W2402197040","https://openalex.org/W2402343784","https://openalex.org/W2413837100","https://openalex.org/W2414275943","https://openalex.org/W2415836368","https://openalex.org/W2416145340","https://openalex.org/W2418510894","https://openalex.org/W2427652685","https://openalex.org/W4406969521"],"related_works":["https://openalex.org/W2034692445","https://openalex.org/W29926206","https://openalex.org/W1848477923","https://openalex.org/W2407669470","https://openalex.org/W2055039397","https://openalex.org/W2126886011","https://openalex.org/W2342470507","https://openalex.org/W3045055988","https://openalex.org/W1673935185","https://openalex.org/W1985450414"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,43,54,142,156],"initiated":[3],"to":[4,80,110,121,132,158,185],"determine":[5],"if":[6],"raised":[7],"(carcinoid)":[8],"plasma":[9,71],"concentrations":[10,73,166,179],"of":[11,17,85,98,145,167,207],"substance":[12,52,194],"P":[13,53,195],"induced":[14],"jejunal":[15,29,205],"secretion":[16,97,144,160,206],"water":[18,208],"and":[19,25,48,101,169,209],"electrolytes.":[20],"Five":[21],"dogs":[22],"had":[23],"isolated":[24],"cannulated":[26],"25":[27],"cm":[28],"segments":[30],"perfused":[31],"at":[32,57,196],"2":[33],"ml/min":[34],"with":[35],"a":[36,81],"neutral,":[37],"isotonic":[38],"perfusate.":[39],"Saline,":[40],"1.0":[41],"ml,":[42],"infused":[44],"intravenously":[45,56],"during":[46,62,151,173],"basal":[47,75,106,117,128,139],"recovery":[49],"periods,":[50],"while":[51],"administered":[55],"75":[58],"ng/kg/min":[59],"(55":[60],"pmol/kg/min)":[61],"the":[63,200,212],"four":[64],"15":[65],"minute":[66],"experimental":[67],"periods.":[68],"Infusion":[69],"increased":[70],"SP":[72,94,111,122,133,152,174],"from":[74,181],"(5.8":[76],"+/-":[77,87,91,108,113,119,124,130,135,148,162,183,187],"1.3":[78],"pg/ml)":[79],"mean":[82],"plateau":[83],"level":[84],"121.2":[86],"25.2":[88],"pg/ml":[89],"(mean":[90],"SEM).":[92],"During":[93],"infusion,":[95,153,175],"intestinal":[96],"water,":[99],"Na+,":[100],"Cl-":[102,127],"were":[103,171],"documented":[104],"(H2O":[105],"+102":[107],"60":[109],"-275":[112],"60;":[114],"microliter/min;":[115],"Na+":[116],"+19.8":[118],"7.2":[120],"-23.2":[123],"7.5":[125,131],"microEq/min;":[126],"21.7":[129],"-16.5":[134],"5.6":[136],"microEq/min).":[137,164],"Under":[138],"conditions,":[140],"there":[141],"minimal":[143],"potassium":[146,178],"(-0.264":[147],"0.282":[149],"microEq/min);":[150],"K+":[154],"flux":[155],"altered":[157],"significant":[159,204],"(-1.784":[161],"0.271":[163],"Serum":[165],"Na":[168],"Cl":[170],"unchanged":[172],"but":[176],"serum":[177],"fell":[180],"4.64":[182],"0.12":[184],"3.85":[186],"0.40":[188],"mEq/l.":[189],"The":[190],"data":[191],"demonstrate":[192],"that":[193],"levels":[197],"noted":[198],"in":[199,211],"carcinoid":[201],"syndrome":[202],"induces":[203],"electrolytes":[210],"dog.":[213]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}