{"id":"https://openalex.org/W2135236355","doi":null,"title":"Analysis of kidney glomerular and microvascular transcriptomes","display_name":"Analysis of kidney glomerular and microvascular transcriptomes","publication_year":2007,"publication_date":"2007-09-21","ids":{"openalex":"https://openalex.org/W2135236355","mag":"2135236355"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26922868","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Analysis_of_kidney_glomerular_and_microvascular_transcriptomes/26922868","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/37824","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010803737","display_name":"Liqun He","orcid":"https://orcid.org/0000-0003-2127-7597","observed_orcids":["https://orcid.org/0000-0003-2127-7597"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liqun He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2127-7597","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010803737"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerulus","display_name":"glomeruli","score":0.9679999947547913},{"id":"https://openalex.org/keywords/glomerular-transcriptome","display_name":"glomerular transcriptome","score":0.9490000009536743},{"id":"https://openalex.org/keywords/microvascular-pericytes","display_name":"microvascular pericytes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pericyte-markers","display_name":"pericyte markers","score":0.7839999794960022},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.640999972820282},{"id":"https://openalex.org/keywords/cdna-microarray","display_name":"cDNA microarray","score":0.628000020980835},{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2778305430","wikidata":"https://www.wikidata.org/wiki/Q26261754","display_name":"Glomerulus","level":3,"score":0.8879987001419067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7575523853302002},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.6169074177742004},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6150562167167664},{"id":"https://openalex.org/C149034497","wikidata":"https://www.wikidata.org/wiki/Q1384835","display_name":"Expressed sequence tag","level":4,"score":0.5630945563316345},{"id":"https://openalex.org/C2910856063","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Kidney Glomerulus","level":4,"score":0.5377618670463562},{"id":"https://openalex.org/C2780427682","wikidata":"https://www.wikidata.org/wiki/Q500446","display_name":"Pericyte","level":4,"score":0.5105053186416626},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.4797000586986542},{"id":"https://openalex.org/C3018920779","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Renal glomerulus","level":4,"score":0.4707896113395691},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4462597370147705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42085155844688416},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34097278118133545},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3305925726890564},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2997053265571594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29533788561820984},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.1671607494354248},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.1027350127696991},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26922868","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Analysis_of_kidney_glomerular_and_microvascular_transcriptomes/26922868","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/37824","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/37824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2135236355","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/bitstream/handle/10616/37824/thesis.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/37824","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/37824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1258891317","https://openalex.org/W1485771066","https://openalex.org/W1534220125","https://openalex.org/W1548843388","https://openalex.org/W1550732922","https://openalex.org/W1967142676","https://openalex.org/W1969976209","https://openalex.org/W1970156673","https://openalex.org/W1973614663","https://openalex.org/W1974171881","https://openalex.org/W1985841182","https://openalex.org/W1992190771","https://openalex.org/W1995861596","https://openalex.org/W2004365533","https://openalex.org/W2005713680","https://openalex.org/W2007414747","https://openalex.org/W2010888033","https://openalex.org/W2017096105","https://openalex.org/W2024599421","https://openalex.org/W2025139150","https://openalex.org/W2029863361","https://openalex.org/W2033660490","https://openalex.org/W2033848557","https://openalex.org/W2038508315","https://openalex.org/W2039537505","https://openalex.org/W2043856222","https://openalex.org/W2046540619","https://openalex.org/W2047873003","https://openalex.org/W2053484736","https://openalex.org/W2054212910","https://openalex.org/W2055043387","https://openalex.org/W2081098333","https://openalex.org/W2081163339","https://openalex.org/W2082360972","https://openalex.org/W2086096310","https://openalex.org/W2102211328","https://openalex.org/W2103907281","https://openalex.org/W2105388550","https://openalex.org/W2106876831","https://openalex.org/W2109619915","https://openalex.org/W2109972881","https://openalex.org/W2110065044","https://openalex.org/W2110153861","https://openalex.org/W2110230080","https://openalex.org/W2112219075","https://openalex.org/W2112965812","https://openalex.org/W2119939122","https://openalex.org/W2120176508","https://openalex.org/W2120833234","https://openalex.org/W2125190708","https://openalex.org/W2127923616","https://openalex.org/W2129416468","https://openalex.org/W2133691034","https://openalex.org/W2135187880","https://openalex.org/W2139703939","https://openalex.org/W2141545875","https://openalex.org/W2146098038","https://openalex.org/W2148115950","https://openalex.org/W2148171171","https://openalex.org/W2150926065","https://openalex.org/W2157795344","https://openalex.org/W2159203162","https://openalex.org/W2166131221","https://openalex.org/W2167679198","https://openalex.org/W2169199162","https://openalex.org/W2170346765","https://openalex.org/W2331030820","https://openalex.org/W7098496635"],"related_works":["https://openalex.org/W1607153294","https://openalex.org/W2492400493","https://openalex.org/W2033848557","https://openalex.org/W2117795615","https://openalex.org/W7099891353","https://openalex.org/W1819008786","https://openalex.org/W2087611712","https://openalex.org/W2120431179","https://openalex.org/W2132401778","https://openalex.org/W2167168726"],"abstract_inverted_index":{"Kidney":[0,392],"glomeruli":[1,75],"play":[2],"a":[3,236,244,253,525],"crucial":[4],"role":[5],"in":[6,45,131,147,170,213,257,280,298,446],"the":[7,15,23,27,30,59,71,127,132,148,189,193,218,241,258,268,271,277,318,322,326,348],"maintenance":[8],"of":[9,29,52,73,103,116,155,179,208,246,270,321,347,352,443,481,539],"body":[10],"homeostasis.":[11],"Many":[12],"diseases":[13],"attack":[14],"kidney":[16,74,117,139,197,323,349,386,447],"function":[17,28],"by":[18,159,184,216],"primarily":[19],"affecting":[20],"glomeruli.":[21,108],"However,":[22],"transcriptome":[24,72,319,523],"profiles":[25,115,130,279,320],"and":[26,40,65,76,81,89,105,119,206,226,229,239,285,325,329,337,382,450,486,524],"glomerulus":[31,118,133,194,259,324,448],"is":[32],"poorly":[33],"understood.":[34],"Microvascular":[35],"pericytes":[36],"are":[37,42],"multifunctional":[38],"cells":[39],"they":[41],"actively":[43],"involved":[44],"angiogenesis":[46],"at":[47],"different":[48],"aspects.":[49],"But":[50],"shortage":[51],"molecular":[53],"markers":[54,492],"for":[55,61,493],"pericyte":[56,273,306],"has":[57],"hampered":[58],"studies":[60],"its":[62],"identification,":[63],"origin":[64],"function.":[66,451],"In":[67],"order":[68,171],"to":[69,172,187,267],"explore":[70],"microvascular":[77,272,281,327],"pericytes,":[78,328],"several":[79],"genomics":[80],"bioinformatics":[82],"approaches":[83],"were":[84,157,165,210,296],"applied.":[85],"First,":[86],"we":[87,141,199,234,290,312],"constructed":[88],"large":[90],"scale":[91],"sequenced":[92],"four":[93],"Express":[94],"Sequence":[95],"Tag":[96],"(EST)":[97],"libraries":[98,135],"generated":[99,314],"from":[100,192,220,283,484],"pure":[101],"preparations":[102],"newborn":[104,149],"adult":[106,151],"mouse":[107,145,152,202],"EST":[109,134],"sequence":[110,388],"analysis":[111,238,269,480],"produced":[112],"direct":[113],"expression":[114,122,278],"revealed":[120],"glomerulus-specific":[121],"patterns":[123],"(GlomBase).":[124],"By":[125,275],"comparing":[126,276],"transcript":[128,309],"abundance":[129],"with":[136,176,195],"public":[137],"whole":[138,222],"libraries,":[140],"identified":[142,200,291,384],"497":[143],"glomerulus-enriched":[144,205,248],"transcripts":[146,294,381],"and/or":[150],"glomerulus,":[153],"eight":[154],"which":[156,301],"confirmed":[158],"individual":[160],"experiments.":[161],"The":[162,308,521],"glomerular":[163,522],"ESTs":[164],"printed":[166],"on":[167,251],"glass":[168],"slides":[169],"generate":[173],"cDNA":[174,231],"microarrays":[175],"broad":[177],"representation":[178],"glomerulus-expressed":[180],"genes":[181,203,444],"(GlomChip).":[182],"Subsequently,":[183],"using":[185],"GlomChip":[186,263],"compare":[188],"RNA":[190],"samples":[191],"non-glomerulus":[196],"tissues,":[198],"357":[201],"as":[204],"some":[207],"them":[209],"individually":[211],"studied":[212],"detail.":[214],"Further,":[215],"combing":[217],"result":[219],"Affymetrix":[221],"genome":[223],"array":[224,232],"study":[225],"published":[227],"SAGE":[228],"Stanford":[230],"results,":[233],"did":[235],"meta":[237],"merged":[240],"data":[242],"into":[243],"catalogue":[245],"1407":[247],"genes.":[249],"Based":[250],"this,":[252],"protein-protein":[254],"interaction":[255,529],"network":[256],"(GlomNet)":[260],"was":[261,264],"constructed.":[262],"also":[265],"applied":[266],"transcriptome.":[274],"fragments":[282],"wild-type":[284],"pericyte-deficient":[286],"Pdgfb/Pdgfrb":[287],"knockout":[288],"mice,":[289],"142":[292],"gene":[293],"that":[295,311],"down-regulated":[297],"both":[299],"mutants,":[300],"could":[302],"be":[303],"potential":[304],"new":[305,331],"markers.":[307],"catalogues":[310],"have":[313],"provide":[315],"information":[316,332],"about":[317,333],"contribute":[330,342],"their":[334],"function,":[335],"physiology":[336],"disease.":[338],"Also,":[339],"GlomNet":[340],"will":[341],"an":[343],"integrated":[344],"systematic":[345],"understanding":[346],"glomerulus.":[350],"List":[351],"scientific":[353],"papers":[354],"I.":[355],"He":[356,404,464,506],"L,":[357,405,465,507],"Sun":[358,420,508],"Y,":[359,421,431,509],"Patrakka":[360,408],"J,":[361,365,369,407,409,417,469,513],"Mostad":[362,424],"P,":[363,425,475],"Norlin":[364,406,468,512],"Xiao":[366,410],"Z,":[367,411],"Andrae":[368],"Tryggvason":[370,436,514],"K,":[371,433,437,515],"Samuelsson":[372,422,516],"T,":[373,413,423,517],"Betsholtz":[374,438,476,518],"C,":[375,415,463],"Takemoto":[376,402,466,510],"M":[377],"(2007).":[378,520],"Glomerulus-specific":[379],"mRNA":[380],"proteins":[383],"through":[385],"expressed":[387],"tag":[389],"database":[390],"analysis.":[391],"Int.":[393],"71(9):":[394],"889-900.":[395],"Epub":[396,456,500,537],"2007":[397],"Feb":[398,458],"28":[399,503],"https://pubmed.ncbi.nlm.nih.gov/17332733":[400],"II.":[401],"M,":[403,467,473,511],"Petrova":[412],"Bondjers":[414,462],"Asp":[416],"Wallgard":[418],"E,":[419],"Lundin":[426],"S,":[427],"Miura":[428],"N,":[429,471],"Sado":[430],"Alitalo":[432],"Quaggin":[434],"SE,":[435],"C":[439,477,519],"(2006).":[440,478],"Large-scale":[441],"identification":[442],"implicated":[445],"development":[449],"EMBO":[452],"J.":[453,497],"25(5):":[454],"1160-74.":[455],"2006":[457,501],"23":[459],"https://pubmed.ncbi.nlm.nih.gov/16498405":[460],"III.":[461],"Asker":[470],"Hellstr\u00f6m":[472],"Lindahl":[474],"Microarray":[479],"blood":[482],"microvessels":[483],"PDGF-B":[485],"PDGF-Rbeta":[487],"mutant":[488],"mice":[489],"identifies":[490],"novel":[491],"brain":[494],"pericytes.":[495],"FASEB":[496],"20(10):":[498],"1703-5.":[499],"Jun":[502],"https://pubmed.ncbi.nlm.nih.gov/16807374":[504],"IV.":[505],"predicted":[526],"protein":[527,528],"network.":[530],"J":[531],"Am":[532],"Soc":[533],"Nephrol.":[534],"Nov":[535],"21:":[536],"ahead":[538],"print":[540],"https://pubmed.ncbi.nlm.nih.gov/18032794":[541]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
