{"id":"https://openalex.org/W2135166643","doi":null,"title":"Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats.","display_name":"Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats.","publication_year":2005,"publication_date":"2005-08-22","ids":{"openalex":"https://openalex.org/W2135166643","mag":"2135166643","pmid":"https://pubmed.ncbi.nlm.nih.gov/16401388"},"language":"en","primary_location":{"id":"pmid:16401388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16401388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015123190","display_name":"Hossein Hosseinzadeh","orcid":"https://orcid.org/0000-0002-3483-851X","observed_orcids":["https://orcid.org/0000-0002-3483-851X","https://orcid.org/0000-0002-7755-2204"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Hosseinzadeh","raw_affiliation_strings":["Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran. hosseinzadehh@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran. hosseinzadehh@yahoo.com","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078645015","display_name":"Hamid Reza Sadeghnia","orcid":"https://orcid.org/0000-0002-3228-6897","observed_orcids":["https://orcid.org/0000-0002-3228-6897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamid R Sadeghnia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027858312","display_name":"Toktam Ziaee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toktam Ziaee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025771342","display_name":"Aghdas Danaee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aghdas Danaee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7164,"has_fulltext":false,"cited_by_count":239,"citation_normalized_percentile":{"value":0.82439863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"8","issue":"3","first_page":"387","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12742","display_name":"Sunflower and Safflower Cultivation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saffron-extract","display_name":"saffron extract","score":0.9490000009536743},{"id":"https://openalex.org/keywords/saffron","display_name":"saffron","score":0.9919999837875366},{"id":"https://openalex.org/keywords/crocin","display_name":"crocin","score":1.0},{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.984000027179718},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.6079999804496765},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.4180000126361847},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7110000252723694},{"id":"https://openalex.org/keywords/warm-ischemia","display_name":"warm ischemia","score":0.6819999814033508},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.3199999928474426},{"id":"https://openalex.org/keywords/total-thiol","display_name":"total thiol","score":0.4749999940395355},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.8510000109672546},{"id":"https://openalex.org/keywords/frap-assay","display_name":"FRAP","score":0.7129999995231628},{"id":"https://openalex.org/keywords/total-antioxidant-capacity","display_name":"total antioxidant capacity","score":0.46799999475479126},{"id":"https://openalex.org/keywords/total-antioxidant-status","display_name":"total antioxidant status","score":0.3140000104904175},{"id":"https://openalex.org/keywords/total-oxidant-status","display_name":"total oxidant status","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C2777637054","wikidata":"https://www.wikidata.org/wiki/Q424767","display_name":"Crocin","level":2,"score":0.9476180672645569},{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.893190860748291},{"id":"https://openalex.org/C2779571273","wikidata":"https://www.wikidata.org/wiki/Q15041677","display_name":"Crocus sativus","level":2,"score":0.8533560633659363},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.749732494354248},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.680113673210144},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.6597495079040527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5894467830657959},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.5411623120307922},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5362668633460999},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5362099409103394},{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.4876655340194702},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4601477086544037},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4597063660621643},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36037471890449524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3493092358112335},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.33929938077926636},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3122960925102234},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16548138856887817},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13336899876594543}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D027622","descriptor_name":"Crocus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16401388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16401388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques","raw_type":"Comparative Study"},{"id":"mag:2135166643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16401388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W30459625","https://openalex.org/W71395891","https://openalex.org/W1532672888","https://openalex.org/W1535110134","https://openalex.org/W1810387001","https://openalex.org/W1967935927","https://openalex.org/W1968417790","https://openalex.org/W1985177107","https://openalex.org/W1999317538","https://openalex.org/W2006370393","https://openalex.org/W2019493126","https://openalex.org/W2032508343","https://openalex.org/W2038804100","https://openalex.org/W2046650238","https://openalex.org/W2053054955","https://openalex.org/W2055494241","https://openalex.org/W2057111681","https://openalex.org/W2057295464","https://openalex.org/W2062377851","https://openalex.org/W2076417034","https://openalex.org/W2076919082","https://openalex.org/W2078074393","https://openalex.org/W2085478716","https://openalex.org/W2089249652","https://openalex.org/W2099845327","https://openalex.org/W2114640031","https://openalex.org/W2134685430","https://openalex.org/W2165292984","https://openalex.org/W2413066202","https://openalex.org/W2467826850","https://openalex.org/W2509022126","https://openalex.org/W2589770645"],"related_works":["https://openalex.org/W2734192772","https://openalex.org/W1515044191","https://openalex.org/W2472767512","https://openalex.org/W2795051773","https://openalex.org/W7096038021","https://openalex.org/W2117535762","https://openalex.org/W2767900078","https://openalex.org/W2293266331","https://openalex.org/W3005845300","https://openalex.org/W2302034839"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,32,66,94,111,257],"generation":[2],"of":[3,21,28,34,43,115,119,130,142,325],"reactive":[4,72],"oxygen":[5],"species":[6,73],"and":[7,50,75,79,91,122,126,133,154,174,183,214,234,278,313],"lipid":[8,262],"peroxidation":[9,263],"are":[10],"associated":[11],"with":[12,252],"tissue":[13],"injury":[14,61,330],"following":[15,58],"ischemic":[16,92],"insult;":[17],"therefore,":[18],"the":[19,26,35,41,306,323],"use":[20],"antioxidants":[22],"appears":[23],"rational":[24],"in":[25,63,89,170,176,188,198,216,295,331],"improvement":[27],"kidney":[29,96,189],"diseases":[30],"therapy.":[31],"aim":[33],"present":[36],"study":[37,302],"was":[38,97,149],"to":[39,99,140,151,205,225,242,269,286],"assess":[40],"effect":[42],"aqueous":[44,113,258,307],"saffron":[45,116,308],"extract":[46,114,259,309],"(Crocus":[47,310],"sativus":[48,311],"L.)":[49,312],"its":[51,314],"active":[52,315],"constituent,":[53,316],"crocin,":[54,317],"on":[55],"oxidative":[56,329],"stress":[57],"renal":[59,326],"ischemia-reperfusion":[60,296,327],"(IRI)":[62],"rats.":[64,332],"METHODS:":[65],"cellular":[67],"redox":[68],"status":[69],"(thiobarbituric":[70],"acid":[71],"(TBARS)":[74],"total":[76,184,235],"thiol":[77,185,236],"levels)":[78],"antioxidant":[80,178,217,280],"power":[81,85,179,218,281],"(using":[82],"ferric":[83],"reducing/antioxidant":[84],"test)":[86],"were":[87,137,255],"assessed":[88],"control":[90,152,253],"groups.":[93],"left":[95],"exposed":[98],"warm":[100],"ischemia":[101],"for":[102,108,322],"60":[103],"min":[104],"followed":[105],"by":[106],"reperfusion":[107],"90":[109],"min.":[110],"macerated":[112],"(with":[117,128],"doses":[118,129],"5,":[120],"20":[121],"80":[123,276,293],"mg/kg,":[124,135],"i.p.)":[125,136,148],"crocin":[127,193],"50,":[131],"200":[132,248],"400":[134,212,232],"administrated":[138],"prior":[139],"induction":[141],"ischemia.":[143],"Normal":[144],"saline":[145],"(10":[146],"ml/kg,":[147],"injected":[150],"group":[153,157],"a":[155,167,196],"sham":[156],"that":[158,305],"did":[159],"not":[160],"have":[161],"ischemia-reperfusion.":[162],"RESULTS:":[163],"Ischemia-reperfusion":[164],"(IR)":[165],"caused":[166],"significant":[168],"increase":[169],"TBARS":[171,199],"levels":[172,200],"(p<0.001)":[173,187],"decrement":[175],"both":[177],"(FRAP":[180,219],"value)":[181,220],"(p<0.05)":[182],"concentration":[186],"homogenate":[190],"samples.":[191],"In":[192],"pretreated":[194],"groups,":[195],"reduction":[197],"(from":[201,221,238,265,282],"85.8":[202,266],"+/-":[203,207,223,227,240,244,267,271,284,288],"5.4":[204,268],"20.9":[206],"1.5":[208],"nmol/g":[209,273],"tissue,":[210,230,274,291],"p<0.001;":[211,231,247,275,292],"mg/kg)":[213,233,277,294],"elevation":[215],"3.05":[222],"0.16":[224,228],"4.15":[226],"micromol/g":[229,290],"concentrations":[237],"0.38":[239],"0.03":[241,245],"0.62":[243],"mM,":[246],"mg/kg),":[249],"as":[250],"compared":[251],"group,":[254],"observed.":[256],"also":[260],"reduced":[261],"products":[264],"15.9":[270],"2.6":[272],"increased":[279],"2.98":[283],"0.11":[285],"5.97":[287],"0.56":[289],"injured":[297],"rat":[298],"kidneys.":[299],"CONCLUSION:":[300],"This":[301],"therefore":[303],"suggests":[304],"may":[318],"be":[319],"useful":[320],"agents":[321],"prevention":[324],"(IR)-induced":[328]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
