{"id":"https://openalex.org/W21351444","doi":null,"title":"Preparation and in vitro evaluation of a pluronic lecithin organogel containing ricinoleic acid for transdermal delivery.","display_name":"Preparation and in vitro evaluation of a pluronic lecithin organogel containing ricinoleic acid for transdermal delivery.","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W21351444","mag":"21351444","pmid":"https://pubmed.ncbi.nlm.nih.gov/25306775"},"language":"en","primary_location":{"id":"pmid:25306775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25306775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutical compounding","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080251199","display_name":"Sai H. S. Boddu","orcid":"https://orcid.org/0000-0003-2513-5879","observed_orcids":["https://orcid.org/0000-0003-2513-5879"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sai Hs Boddu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009049561","display_name":"Sindhu Prabha Bonam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sindhu Prabha Bonam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046776157","display_name":"Yangjie Wei","orcid":"https://orcid.org/0000-0002-4268-1065","observed_orcids":["https://orcid.org/0000-0002-4268-1065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yangjie Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020849093","display_name":"Kenneth Alexander","orcid":"https://orcid.org/0000-0003-3921-5722","observed_orcids":["https://orcid.org/0000-0003-3921-5722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth Alexander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0625,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.69977053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"3","first_page":"256","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pluronic-lecithin-organogel","display_name":"pluronic lecithin organogel","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ricinoleic-acid","display_name":"ricinoleic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ketoprofen","display_name":"ketoprofen","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/thixotropy","display_name":"thixotropy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/gel-stability","display_name":"gel stability","score":0.5659999847412109},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/isopropyl-palmitate","display_name":"isopropyl palmitate","score":0.8980000019073486},{"id":"https://openalex.org/keywords/topical-gel-formulation","display_name":"topical gel formulation","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2779072430","wikidata":"https://www.wikidata.org/wiki/Q424484","display_name":"Ricinoleic acid","level":3,"score":0.922444224357605},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.8806799650192261},{"id":"https://openalex.org/C2779564620","wikidata":"https://www.wikidata.org/wiki/Q241595","display_name":"Lecithin","level":2,"score":0.7503332495689392},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6711119413375854},{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.6113767623901367},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5833514928817749},{"id":"https://openalex.org/C2780744026","wikidata":"https://www.wikidata.org/wiki/Q409192","display_name":"Ketoprofen","level":2,"score":0.5022468566894531},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.36914652585983276},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.32136037945747375},{"id":"https://openalex.org/C2778229996","wikidata":"https://www.wikidata.org/wiki/Q337492","display_name":"Castor oil","level":2,"score":0.30115950107574463},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.2332339584827423},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08242547512054443},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0656830370426178},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007660","descriptor_name":"Ketoprofen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007660","descriptor_name":"Ketoprofen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007660","descriptor_name":"Ketoprofen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012277","descriptor_name":"Ricinoleic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020442","descriptor_name":"Poloxamer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054709","descriptor_name":"Lecithins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25306775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25306775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutical compounding","raw_type":"Comparative Study"},{"id":"mag:21351444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25306775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1761955360","https://openalex.org/W7096814798","https://openalex.org/W2026441489","https://openalex.org/W2072511784","https://openalex.org/W2155752924","https://openalex.org/W2383325607","https://openalex.org/W2505735841","https://openalex.org/W2408869013","https://openalex.org/W2783310747","https://openalex.org/W2112189580"],"abstract_inverted_index":{"The":[0,47,66,97,121,173],"present":[1],"study":[2],"deals":[3],"with":[4,80,90,108,113],"the":[5,34,81,94,114,137,182,188,210],"preparation":[6],"and":[7,37,44,60,68,74,78,99,149,164],"in":[8,69,145],"vitro":[9,70],"evaluation":[10],"of":[11,72,101,124,176],"a":[12,146],"Pluronic":[13,24,49,103,117,127,140,183,193],"lecithin":[14,25,50,86,104,118,128,141,184,194],"organogel":[15,26,51,87,105,119,129,142,185,195],"gel":[16,52,88,106,130,196],"containing":[17,197],"ricinoleic":[18,31,109,125,198],"acid":[19,32,110,126,199],"for":[20,39,168,190],"transdermal":[21],"delivery.":[22],"Blank":[23],"gels":[27,143],"were":[28,152],"prepared":[29,107],"using":[30,57],"as":[33,63,93,207],"oil":[35,95],"phase":[36],"characterized":[38],"pH,":[40],"viscosity,":[41],"gelation":[42],"temperature,":[43],"microscopic":[45],"structure.":[46],"optimized":[48],"formulation":[53,84],"was":[54,76,111,131,178,200],"further":[55],"evaluated":[56,77],"ketoprofen":[58,73,191],"(10%)":[59],"dexamethasone":[61,75,177],"(0.5%)":[62],"model":[64],"drugs.":[65],"stability":[67],"permeability":[71,189],"compared":[79,208],"corresponding":[82],"control":[83,211],"(Pluronic":[85],"made":[89],"isopropyl":[91,115],"palmitate":[92,116],"phase).":[96],"pH":[98],"viscosity":[100],"blank":[102],"comparable":[112],"gel.":[120],"thixotropic":[122],"property":[123],"found":[132,153,201],"to":[133,154,170,202,209],"be":[134,155,203],"better":[135],"than":[136],"control.":[138],"Drug-loaded":[139],"behaved":[144],"similar":[147,179],"manner":[148],"all":[150],"formulations":[151],"stable":[156],"at":[157],"25":[158],"degrees":[159,162,166],"C,":[160,163],"35":[161,171],"40":[165],"C":[167],"up":[169],"days.":[172],"penetration":[174],"profile":[175],"from":[180,192],"both":[181],"gels,":[186],"while":[187],"three":[204],"times":[205],"higher":[206],"formulation.":[212]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}