{"id":"https://openalex.org/W2135141908","doi":"https://doi.org/10.3899/jrheum.120506","title":"Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis","display_name":"Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2135141908","doi":"https://doi.org/10.3899/jrheum.120506","mag":"2135141908","pmid":"https://pubmed.ncbi.nlm.nih.gov/23027890"},"language":"en","primary_location":{"id":"doi:10.3899/jrheum.120506","doi":"https://doi.org/10.3899/jrheum.120506","is_oa":false,"landing_page_url":"https://doi.org/10.3899/jrheum.120506","pdf_url":null,"source":{"id":"https://openalex.org/S50602745","display_name":"The Journal of Rheumatology","issn_l":"0315-162X","issn":["0315-162X","1499-2752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320417","host_organization_name":"The Journal of Rheumatology Publishing Company Limited","host_organization_lineage":["https://openalex.org/P4310320417"],"host_organization_lineage_names":["The Journal of Rheumatology Publishing Company Limited"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.jrheum.org/content/jrheum/39/12/2294.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100683876","display_name":"Mar\u00eda Carmen C\u00e9nit","orcid":"https://orcid.org/0000-0001-8667-5313","observed_orcids":["https://orcid.org/0000-0001-8667-5313"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210153588","display_name":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez - Neyra\"","ror":"https://ror.org/05ncvzk72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"MARIA CARMEN C\u00c9NIT","raw_affiliation_strings":["Instituto de Parasitolog\u00eda y Biomedicina L\u00f3pez-Neyra,IPBLN-CSIC, Granada, The Netherlands. mccenit@ipb.csic.es","From the Instituto de Parasitolog\u00eda y Biomedicina L\u00f3pez-Neyra,IPBLN-CSIC, Granada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Parasitolog\u00eda y Biomedicina L\u00f3pez-Neyra,IPBLN-CSIC, Granada, The Netherlands. mccenit@ipb.csic.es","institution_ids":["https://openalex.org/I4210153588"]},{"raw_affiliation_string":"From the Instituto de Parasitolog\u00eda y Biomedicina L\u00f3pez-Neyra,IPBLN-CSIC, Granada","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089828020","display_name":"Carmen Pilar Sime\u00f3n\u2010Aznar","orcid":"https://orcid.org/0000-0003-3390-9029","observed_orcids":["https://orcid.org/0000-0003-3390-9029"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"CARMEN P. SIME\u00d3N","raw_affiliation_strings":["Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, #N#Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, #N#Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100518800","display_name":"MADELON C. VONK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"MADELON C. VONK","raw_affiliation_strings":["Department of Rheumatology Radboud University Nijmegen Medical Center Nijmegen the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology Radboud University Nijmegen Medical Center Nijmegen the Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014834437","display_name":"Jos\u00e9 Lu\u00eds Callejas-Rubio","orcid":"https://orcid.org/0000-0002-1653-0087","observed_orcids":["https://orcid.org/0000-0002-1653-0087"]},"institutions":[{"id":"https://openalex.org/I4210121788","display_name":"Complejo Hospitalario Universitario de Granada","ror":"https://ror.org/02pnm9721","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210121788"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JOSE L. CALLEJAS-RUBIO","raw_affiliation_strings":["Department of Internal Medicine, Hospital Cl\u00ednico Universitario, Granada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital Cl\u00ednico Universitario, Granada","institution_ids":["https://openalex.org/I4210121788"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044648562","display_name":"Gerard Espinosa","orcid":"https://orcid.org/0000-0003-1336-0163","observed_orcids":["https://orcid.org/0000-0003-1336-0163"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"GERARD ESPINOSA","raw_affiliation_strings":["Department of Internal Medicine, Hospital Cl\u00ednico de Barcelona, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital Cl\u00ednico de Barcelona, Barcelona","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061815657","display_name":"Patricia Esmeralda Carreira","orcid":"https://orcid.org/0000-0001-8279-3806","observed_orcids":["https://orcid.org/0000-0001-8279-3806"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"PATRICIA CARREIRA","raw_affiliation_strings":["Department of Rheumatology, Hospital 12 de Octubre, Madrid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hospital 12 de Octubre, Madrid","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019811024","display_name":"Francisco Javier Blanco","orcid":"https://orcid.org/0000-0001-9821-7635","observed_orcids":["https://orcid.org/0000-0001-9821-7635","https://orcid.org/0000-0003-2545-4319"]},"institutions":[{"id":"https://openalex.org/I4210140856","display_name":"Complexo Hospitalario Universitario A Coru\u00f1a","ror":"https://ror.org/044knj408","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210140856"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"FRANCISCO J. BLANCO","raw_affiliation_strings":["Complejo Hospitalario Universitario a Coru\u00f1a, La Coru\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complejo Hospitalario Universitario a Coru\u00f1a, La Coru\u00f1a","institution_ids":["https://openalex.org/I4210140856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008485597","display_name":"Javier Narv\u00e1ez","orcid":"https://orcid.org/0000-0002-1614-8064","observed_orcids":["https://orcid.org/0000-0002-1614-8064"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JAVIER NARVAEZ","raw_affiliation_strings":["Department of Rheumatology, Hospital de Bellvitge, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hospital de Bellvitge, Barcelona","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091384425","display_name":"Carles Tolosa","orcid":"https://orcid.org/0000-0003-0706-9046","observed_orcids":["https://orcid.org/0000-0003-0706-9046"]},"institutions":[{"id":"https://openalex.org/I4210115578","display_name":"Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed","ror":"https://ror.org/02pg81z63","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210115578"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"CARLOS TOLOSA","raw_affiliation_strings":["Department of Internal Medicine, Hospital Parc Tauli, Sabadell"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital Parc Tauli, Sabadell","institution_ids":["https://openalex.org/I4210115578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100518785","display_name":"JOS\u00c9 A. ROM\u00c1N-IVORRA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"JOS\u00c9 A. ROM\u00c1N-IVORRA","raw_affiliation_strings":["Department of Rheumatology, Hospital La Fe, Valencia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hospital La Fe, Valencia","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057550413","display_name":"I G\u00f3mez-Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"INMACULADA G\u00d3MEZ-GARC\u00cdA","raw_affiliation_strings":["Department of Rheumatology, Hospital Reina Sof\u00eda, C\u00f3rdoba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hospital Reina Sof\u00eda, C\u00f3rdoba","institution_ids":["https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075566642","display_name":"Francisco Jos\u00e9 Garc\u00eda Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-2600-0485","observed_orcids":["https://orcid.org/0000-0002-2600-0485"]},"institutions":[{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"FRANCISCO J. GARC\u00cdA-HERN\u00c1NDEZ","raw_affiliation_strings":["Department of Internal Medicine, Hospital Virgen del Roc\u00edo, Sevilla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital Virgen del Roc\u00edo, Sevilla","institution_ids":["https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100518787","display_name":"MAR\u00cdA GALLEGO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133994","display_name":"Hospital Universitario Central de Asturias","ror":"https://ror.org/03v85ar63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210133994","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"MAR\u00cdA GALLEGO","raw_affiliation_strings":["Department of Internal Medicine, Hospital Central de Asturias, Oviedo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital Central de Asturias, Oviedo","institution_ids":["https://openalex.org/I4210133994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108097706","display_name":"Rosa Garc\u00eda-Portales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157481","display_name":"Hospital Cl\u00ednico Universitario Virgen de la Victoria","ror":"https://ror.org/05xxs2z38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210157481"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"ROSA GARC\u00cdA-PORTALES","raw_affiliation_strings":["Department of Rheumatology, Hospital Virgen de la Victoria, M\u00e1laga"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hospital Virgen de la Victoria, M\u00e1laga","institution_ids":["https://openalex.org/I4210157481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111898740","display_name":"Mar\u00eda Victoria Egurbide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"MAR\u00cdA VICTORIA EGURBIDE","raw_affiliation_strings":["Department of Internal Medicine, Hospital de Cruces, Barakaldo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital de Cruces, Barakaldo","institution_ids":["https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054812221","display_name":"Vicent Fonollosa\u2010Pla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VICENTE FONOLLOSA","raw_affiliation_strings":["Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103541392","display_name":"Paloma Garc\u00eda de la Pe\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"PALOMA GARC\u00cdA de la PE\u00d1A","raw_affiliation_strings":["Department of Rheumatology, Hospital General Universitario Gregorio Mara\u00f1\u00f2n"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hospital General Universitario Gregorio Mara\u00f1\u00f2n","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100518792","display_name":"FRANCISCO J. L\u00d3PEZ-LONGO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"FRANCISCO J. L\u00d3PEZ-LONGO","raw_affiliation_strings":["Department of Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla, IFIMAV, Santander, #N#Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla, IFIMAV, Santander, #N#Spain","institution_ids":["https://openalex.org/I4210099858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016922988","display_name":"Miguel \u00c1ngel Gonz\u00e1lez-Gay","orcid":"https://orcid.org/0000-0002-7924-7406","observed_orcids":["https://orcid.org/0000-0002-7924-7406"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"MIGUEL A. GONZ\u00c1LEZ-GAY","raw_affiliation_strings":["Department of Rheumatology, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"The Spanish Scleroderma Group","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"The Spanish Scleroderma Group","raw_affiliation_strings":["Clinic for Immunology and Rheumatology Medical School, Hannover, #N#Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Immunology and Rheumatology Medical School, Hannover, #N#Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026915556","display_name":"Roger Hesselstrand","orcid":"https://orcid.org/0000-0001-6794-2201","observed_orcids":["https://orcid.org/0000-0001-6794-2201"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"ROGER HESSELSTRAND","raw_affiliation_strings":["Department of Rheumatology, VU University Medical Center, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, VU University Medical Center, Amsterdam","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100518795","display_name":"GABRIELA RIEMEKASTEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"GABRIELA RIEMEKASTEN","raw_affiliation_strings":["Department of Rheumatology; Leiden\u00a0University Medical Center; Leiden The\u00a0Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology; Leiden\u00a0University Medical Center; Leiden The\u00a0Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100518796","display_name":"TORSTEN WITTE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"TORSTEN WITTE","raw_affiliation_strings":["Centre for Rheumatic Disease University of Glasgow, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Rheumatic Disease University of Glasgow, Glasgow","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027096828","display_name":"Alexandre E. Voskuyl","orcid":"https://orcid.org/0000-0002-9699-1827","observed_orcids":["https://orcid.org/0000-0002-9699-1827"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"ALEXANDRE E. VOSKUYL","raw_affiliation_strings":["Centre for Rheumatology, Royal Free and University College Medical                         School, London, UK,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Rheumatology, Royal Free and University College Medical                         School, London, UK,","institution_ids":["https://openalex.org/I2801138448","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003652734","display_name":"Annemie J. Schuerwegh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"ANNEMIE J. SCHUERWEGH","raw_affiliation_strings":["Center for Molecular Medicine, Karolinska Institute, Stockholm, #N#Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine, Karolinska Institute, Stockholm, #N#Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"RAJAN MADHOK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"RAJAN MADHOK","raw_affiliation_strings":["Dept. of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103106743","display_name":"Carmen Fonseca","orcid":"https://orcid.org/0009-0005-7267-9619","observed_orcids":["https://orcid.org/0009-0005-7267-9619"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"CARMEN FONSECA","raw_affiliation_strings":["Institute of Cellular Medicine Newcastle University  Newcastle UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Medicine Newcastle University  Newcastle UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105923117","display_name":"Christopher Paul Denton","orcid":"https://orcid.org/0000-0003-3975-8938","observed_orcids":["https://orcid.org/0000-0003-3975-8938","https://orcid.org/0000-0003-3070-1775"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"CHRISTOPHER DENTON","raw_affiliation_strings":["*Department of Dermatology, University of Cologne, Cologne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Dermatology, University of Cologne, Cologne","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007878256","display_name":"Annica Nordin","orcid":"https://orcid.org/0000-0003-1976-4679","observed_orcids":["https://orcid.org/0000-0003-1976-4679"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"ANNIKA NORDIN","raw_affiliation_strings":["Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020224846","display_name":"\u00d8yvind Palm","orcid":"https://orcid.org/0000-0001-5395-0665","observed_orcids":["https://orcid.org/0000-0001-5395-0665"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"\u00d8YVIND PALM","raw_affiliation_strings":["Klinik f\u00fcr Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, #N#Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Dermatologie, Venerologie und Allergologie, Ruhr University of Bochum, Bochum, #N#Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044386973","display_name":"Jacob M. van Laar","orcid":"https://orcid.org/0000-0001-5544-5785","observed_orcids":["https://orcid.org/0000-0001-5544-5785","https://orcid.org/0000-0001-8221-1669"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JACOB M. van LAAR","raw_affiliation_strings":["Arthritis Research #N#UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, #N#UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthritis Research #N#UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, #N#UK","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046636617","display_name":"Nicolas Hunzelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"NICOLAS HUNZELMANN","raw_affiliation_strings":["Department of Medical Genetics, University Medical Center Utrecht, Utrecht,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, University Medical Center Utrecht, Utrecht,","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100518803","display_name":"J\u00d6RG H.W. DISTLER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J\u00d6RG H.W. DISTLER","raw_affiliation_strings":["and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The #N#Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and Department of Rheumatology and Clinical Immunology, Utrecht Medical Center, Utrecht, The #N#Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083044979","display_name":"Alexander Kreuter","orcid":"https://orcid.org/0000-0003-2275-499X","observed_orcids":["https://orcid.org/0000-0003-2275-499X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALEXANDER KREUTER","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056447660","display_name":"Ariane L. Herrick","orcid":"https://orcid.org/0000-0003-4941-7926","observed_orcids":["https://orcid.org/0000-0003-4941-7926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ARIANE HERRICK","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104580999","display_name":"Jane Worthington","orcid":"https://orcid.org/0000-0003-0544-042X","observed_orcids":["https://orcid.org/0000-0003-0544-042X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JANE WORTHINGTON","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104491024","display_name":"Bobby P.C. Koeleman","orcid":"https://orcid.org/0000-0001-7749-182X","observed_orcids":["https://orcid.org/0000-0001-7749-182X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BOBBY P. KOELEMAN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046171667","display_name":"Timothy R. D. J. Radstake","orcid":"https://orcid.org/0000-0003-1241-6911","observed_orcids":["https://orcid.org/0000-0003-1241-6911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TIMOTHY R.D.J. RADSTAKE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069412319","display_name":"Javier J. Martin","orcid":"https://orcid.org/0000-0002-2202-0622","observed_orcids":["https://orcid.org/0000-0002-2202-0622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JAVIER MART\u00cdN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":35,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3208,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91787683,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"39","issue":"12","first_page":"2294","last_page":"2302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9089999794960022},{"id":"https://openalex.org/keywords/il-6-gene","display_name":"IL-6 gene","score":0.8669999837875366},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9350000023841858},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rs1800795","display_name":"rs1800795","score":0.9929999709129333},{"id":"https://openalex.org/keywords/limited-cutaneous-systemic-sclerosis","display_name":"limited cutaneous systemic sclerosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/diffuse-cutaneous-systemic-sclerosis","display_name":"diffuse cutaneous systemic sclerosis","score":1.0},{"id":"https://openalex.org/keywords/disease-phenotype","display_name":"disease phenotypes","score":0.7360000014305115},{"id":"https://openalex.org/keywords/allelic-combinations","display_name":"allelic combinations","score":0.7120000123977661},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6269999742507935},{"id":"https://openalex.org/keywords/autoimmune-disease-genetics","display_name":"autoimmune disease genetics","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.842063844203949},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.6118402481079102},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5192137360572815},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4157883822917938},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.3200433850288391},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3073176145553589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.061533182859420776}],"mesh":[{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.3899/jrheum.120506","doi":"https://doi.org/10.3899/jrheum.120506","is_oa":false,"landing_page_url":"https://doi.org/10.3899/jrheum.120506","pdf_url":null,"source":{"id":"https://openalex.org/S50602745","display_name":"The Journal of Rheumatology","issn_l":"0315-162X","issn":["0315-162X","1499-2752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320417","host_organization_name":"The Journal of Rheumatology Publishing Company Limited","host_organization_lineage":["https://openalex.org/P4310320417"],"host_organization_lineage_names":["The Journal of Rheumatology Publishing Company Limited"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Rheumatology","raw_type":"journal-article"},{"id":"pmid:23027890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23027890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/5cb73d49-7a4b-4fc6-8edb-f21d4d89dadb","doi":null,"is_oa":true,"landing_page_url":"http://www.jrheum.org/content/39/12/2294.full.pdf+html","pdf_url":"https://www.jrheum.org/content/jrheum/39/12/2294.full.pdf","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dnet:runa________::c0f9bf0b549d33887196ae85fbeee401","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11940/7508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lup.lub.lu.se:a065cf22-3974-434e-876f-9395a6cb1eaf","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/3161301","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0315-162X","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/7a5adf3f-a9af-4ab9-af0e-1115c98e87dd","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/7a5adf3f-a9af-4ab9-af0e-1115c98e87dd","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/108354","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/108354","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:runa.sergas.gal:20.500.11940/7508","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11940/7508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402506","display_name":"RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210158352","host_organization_name":"Servicio Gallego de Salud","host_organization_lineage":["https://openalex.org/I4210158352"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/108354","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/108354","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Rheumatology, 39, 2294 - 2302","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/14dbd44c-9566-4512-8a8e-b127dbc18322","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/14dbd44c-9566-4512-8a8e-b127dbc18322","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Rheumatology, 39(12), 2294 - 2302. Journal of Rheumatology","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.25405/ncl.34196229","doi":"https://doi.org/10.25405/ncl.34196229","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34196229","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34196229.v1","doi":"https://doi.org/10.25405/ncl.34196229.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34196229.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/5cb73d49-7a4b-4fc6-8edb-f21d4d89dadb","doi":null,"is_oa":true,"landing_page_url":"http://www.jrheum.org/content/39/12/2294.full.pdf+html","pdf_url":"https://www.jrheum.org/content/jrheum/39/12/2294.full.pdf","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions","score":0.5600000023841858}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325330","display_name":"European League Against Rheumatism","ror":"https://ror.org/03f7j3221"},{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"},{"id":"https://openalex.org/F4320327899","display_name":"Sociedad Espa\u00f1ola de Reumatolog\u00eda","ror":"https://ror.org/01fm69p79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2135141908.pdf","grobid_xml":"https://content.openalex.org/works/W2135141908.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W182440400","https://openalex.org/W1971221338","https://openalex.org/W1975033483","https://openalex.org/W1976591271","https://openalex.org/W1981072142","https://openalex.org/W1983512827","https://openalex.org/W2000672660","https://openalex.org/W2003165120","https://openalex.org/W2028921539","https://openalex.org/W2046492421","https://openalex.org/W2063407488","https://openalex.org/W2078237175","https://openalex.org/W2080030870","https://openalex.org/W2088529501","https://openalex.org/W2089022749","https://openalex.org/W2098914621","https://openalex.org/W2116107710","https://openalex.org/W2118448966","https://openalex.org/W2137734744","https://openalex.org/W2151107265","https://openalex.org/W2151963525","https://openalex.org/W2156419690","https://openalex.org/W2164425676","https://openalex.org/W2299513640","https://openalex.org/W2342077805","https://openalex.org/W4233799263","https://openalex.org/W4247269513","https://openalex.org/W4252346179","https://openalex.org/W4285719527","https://openalex.org/W6607410464","https://openalex.org/W6697637764","https://openalex.org/W6704032274"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2081622023","https://openalex.org/W2112154467","https://openalex.org/W1982520318","https://openalex.org/W2133771865","https://openalex.org/W4285045497","https://openalex.org/W4306666454","https://openalex.org/W2050374169","https://openalex.org/W2023245937","https://openalex.org/W2013171748"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Systemic":[1],"sclerosis":[2],"(SSc)":[3],"is":[4],"a":[5,22,52,56,120],"genetically":[6],"complex":[7],"autoimmune":[8],"disease;":[9],"the":[10,36,42,108,114,124,130,150,154,157,176,181,206,211],"genetic":[11,111],"component":[12],"has":[13],"not":[14],"been":[15],"fully":[16],"defined.":[17],"Interleukin":[18],"6":[19,65],"(IL-6)":[20],"plays":[21],"crucial":[23],"role":[24],"in":[25,41],"immunity":[26],"and":[27,44,61,74,84,91,129,156,215],"fibrosis,":[28],"both":[29],"key":[30],"aspects":[31],"of":[32,38,47,58,105,107,127,147,153,213],"SSc.":[33,48],"We":[34,50],"investigated":[35],"influence":[37,210],"IL6":[39,78,110,177,207],"gene":[40,208],"susceptibility":[43],"phenotype":[45],"expression":[46],"METHODS:":[49],"performed":[51],"large":[53],"metaanalysis":[54,101],"including":[55],"total":[57],"2749":[59],"cases":[60],"3189":[62],"controls":[63],"from":[64],"white":[66],"populations":[67],"(Germany,":[68],"The":[69],"Netherlands,":[70],"Norway,":[71],"Spain,":[72],"Sweden,":[73],"United":[75],"Kingdom).":[76],"Three":[77],"single-nucleotide":[79],"polymorphisms":[80],"(SNP;":[81],"rs2069827,":[82],"rs1800795,":[83],"rs2069840)":[85],"were":[86],"selected":[87],"by":[88],"SNP":[89,100],"tagging":[90],"genotyped":[92],"using":[93],"TaqMan(\u00ae)":[94],"allele":[95,126,152],"discrimination":[96],"technology.":[97],"RESULTS:":[98],"Individual":[99],"showed":[102,186],"no":[103],"evidence":[104],"association":[106,122,148,188],"3":[109],"variants":[112],"with":[113,189],"global":[115],"disease.":[116],"Phenotype":[117],"analyses":[118],"revealed":[119],"significant":[121],"between":[123,149],"minor":[125,151],"rs2069840":[128],"limited":[131],"cutaneous":[132,159],"SSc":[133,160,191,214],"clinical":[134,161],"form":[135,162],"(Bonferroni":[136,166,192],"p":[137,167,193],"=":[138,168,194],"0.036,":[139],"OR":[140,170,196],"1.14,":[141],"95%":[142,172,198],"CI":[143,173,199],"1.04-1.25).":[144],"A":[145],"trend":[146],"rs1800795":[155],"diffuse":[158],"was":[163],"also":[164],"evident":[165],"0.072,":[169],"0.86,":[171],"0.77-0.96).":[174],"In":[175],"allelic":[178,183],"combination":[179,184],"analyses,":[180],"GGC":[182],"rs2069827-rs1800795-rs2069840":[185],"an":[187],"overall":[190],"0.016,":[195],"1.13,":[197],"1.04-1.23).":[200],"CONCLUSION:":[201],"Our":[202],"results":[203],"suggest":[204],"that":[205],"may":[209],"development":[212],"its":[216],"progression.":[217]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}