{"id":"https://openalex.org/W2135077779","doi":"https://doi.org/10.1007/s10439-006-9178-5","title":"Proteoglycan Breakdown of Meniscal Explants Following Dynamic Compression Using a Novel Bioreactor","display_name":"Proteoglycan Breakdown of Meniscal Explants Following Dynamic Compression Using a Novel Bioreactor","publication_year":2006,"publication_date":"2006-10-09","ids":{"openalex":"https://openalex.org/W2135077779","doi":"https://doi.org/10.1007/s10439-006-9178-5","mag":"2135077779","pmid":"https://pubmed.ncbi.nlm.nih.gov/17031596","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1705544"},"language":"en","primary_location":{"id":"doi:10.1007/s10439-006-9178-5","doi":"https://doi.org/10.1007/s10439-006-9178-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-006-9178-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-006-9178-5.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10439-006-9178-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006721252","display_name":"Jeffrey A. Mchenry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. McHenry","raw_affiliation_strings":["Department of Mechanical Engineering, Michigan Technological University, Houghton, MI 49931, USA",", Michigan Technological University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Michigan Technological University, Houghton, MI 49931, USA","institution_ids":["https://openalex.org/I11957088"]},{"raw_affiliation_string":", Michigan Technological University","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040391438","display_name":"Barbara Zielinska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Zielinska","raw_affiliation_strings":["Department of Mechanical Engineering, Michigan Technological University, Houghton, MI, 49931, USA",", Michigan Technological University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Michigan Technological University, Houghton, MI, 49931, USA","institution_ids":["https://openalex.org/I11957088"]},{"raw_affiliation_string":", Michigan Technological University","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039534172","display_name":"Tammy L. Haut Donahue","orcid":"https://orcid.org/0000-0001-7129-9503","observed_orcids":["https://orcid.org/0000-0001-7129-9503"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"T. L. Haut Donahue","raw_affiliation_strings":["Department of Mechanical Engineering, Michigan Technological University, Houghton, MI, 49931, USA",", Michigan Technological University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Michigan Technological University, Houghton, MI, 49931, USA","institution_ids":["https://openalex.org/I11957088"]},{"raw_affiliation_string":", Michigan Technological University","institution_ids":["https://openalex.org/I11957088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039534172"],"corresponding_institution_ids":["https://openalex.org/I11957088"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":1.355,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.83010536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"34","issue":"11","first_page":"1758","last_page":"1766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.07859999686479568,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meniscus","display_name":"meniscus","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tissue-engineering-bioreactors","display_name":"tissue engineering bioreactors","score":0.828000009059906},{"id":"https://openalex.org/keywords/cyclic-compression","display_name":"cyclic compression","score":0.9190000295639038},{"id":"https://openalex.org/keywords/compressive-strain","display_name":"compressive strain","score":0.8510000109672546},{"id":"https://openalex.org/keywords/partial-meniscectomy","display_name":"partial meniscectomy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/linear-actuator","display_name":"linear actuator","score":0.5870000123977661},{"id":"https://openalex.org/keywords/load-cell","display_name":"load cell","score":0.6850000023841858},{"id":"https://openalex.org/keywords/meniscus-tissue-engineering","display_name":"meniscus tissue engineering","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7133036851882935},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.7095544338226318},{"id":"https://openalex.org/C2779797317","wikidata":"https://www.wikidata.org/wiki/Q906997","display_name":"Plunger","level":2,"score":0.6191668510437012},{"id":"https://openalex.org/C180016635","wikidata":"https://www.wikidata.org/wiki/Q2712821","display_name":"Compression (physics)","level":2,"score":0.5857594013214111},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5467173457145691},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5453476905822754},{"id":"https://openalex.org/C157890192","wikidata":"https://www.wikidata.org/wiki/Q2561978","display_name":"Explant culture","level":3,"score":0.5065773725509644},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4764443039894104},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.43264806270599365},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.3760402798652649},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3639599084854126},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25437766313552856},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1529015302658081},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15152981877326965},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10466593503952026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08546259999275208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0833294689655304},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07580128312110901},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008592","descriptor_name":"Menisci, Tibial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016474","descriptor_name":"Weight-Bearing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019245","descriptor_name":"Compressive Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s10439-006-9178-5","doi":"https://doi.org/10.1007/s10439-006-9178-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-006-9178-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-006-9178-5.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1705544","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1705544","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Biomed Eng","raw_type":"Text"},{"id":"pmid:17031596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17031596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of biomedical engineering","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.3","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9d/8d/Ann_Biomed_Eng_2006_Nov_10_34(11)_1758-1766.tar.gz","raw_type":"text"},{"id":"pmh:oai:digitalcommons.mtu.edu:michigantech-p-24133","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.mtu.edu/michigantech-p/4831","pdf_url":null,"source":{"id":"https://openalex.org/S4377196391","display_name":"Digital Commons - Michigan Tech (Michigan Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11957088","host_organization_name":"Michigan Technological University","host_organization_lineage":["https://openalex.org/I11957088"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Michigan Tech Publications, Part 1","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1007/s10439-006-9178-5","doi":"https://doi.org/10.1007/s10439-006-9178-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-006-9178-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-006-9178-5.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.47999998927116394}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2135077779.pdf","grobid_xml":"https://content.openalex.org/works/W2135077779.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1971407952","https://openalex.org/W1972766239","https://openalex.org/W1987004514","https://openalex.org/W2009350275","https://openalex.org/W2022086692","https://openalex.org/W2024217515","https://openalex.org/W2024533065","https://openalex.org/W2032255522","https://openalex.org/W2056001843","https://openalex.org/W2057635936","https://openalex.org/W2070267630","https://openalex.org/W2079356591","https://openalex.org/W2115685969","https://openalex.org/W2135377744","https://openalex.org/W2143170071","https://openalex.org/W2155873300","https://openalex.org/W2245165785","https://openalex.org/W2337019382"],"related_works":["https://openalex.org/W1988649956","https://openalex.org/W2030784278","https://openalex.org/W4288748923","https://openalex.org/W1995039059","https://openalex.org/W2360177211","https://openalex.org/W2064149612","https://openalex.org/W2596384870","https://openalex.org/W4200602668","https://openalex.org/W7042244882","https://openalex.org/W2085283520"],"abstract_inverted_index":{"Motivated":[0],"by":[1,53],"our":[2],"interest":[3],"in":[4,76,127,175],"examining":[5],"meniscal":[6,37,129,171,179],"mechanotransduction":[7],"processes,":[8],"we":[9],"report":[10],"on":[11],"the":[12,23,42,104,176],"validation":[13],"of":[14,28,36,170,178],"a":[15,29,45,68,77],"new":[16],"tissue":[17,30,46,110,172,180],"engineering":[18,31],"bioreactor.":[19],"This":[20],"paper":[21],"describes":[22],"design":[24],"and":[25,56,63,71,85,90,113,152],"performance":[26],"capabilities":[27],"bioreactor":[32,118],"for":[33,87],"cyclic":[34],"compression":[35,99],"explants.":[38],"We":[39],"showed":[40],"that":[41,51,57,79,167],"system":[43,66,119],"maintains":[44],"culture":[47],"environment":[48],"equivalent":[49],"to":[50,103,108,122,158,160],"provided":[52],"conventional":[54],"incubators":[55],"its":[58],"strain":[59,151],"output":[60],"was":[61,120,144],"uniform":[62],"reproducible.":[64],"The":[65,117,140],"incorporates":[67],"linear":[69],"actuator":[70,105],"load":[72],"cell":[73],"aligned":[74],"together":[75],"frame":[78],"is":[80,101],"contained":[81],"within":[82],"an":[83],"incubator":[84],"allows":[86],"large":[88],"loads":[89],"small":[91],"displacements.":[92],"A":[93],"plunger":[94],"with":[95,114],"six":[96,109],"Teflon-filled":[97],"Delrin":[98],"rods":[100],"attached":[102],"compressing":[106],"up":[107],"explants":[111,130],"simultaneously":[112],"even":[115],"pressure.":[116],"used":[121],"study":[123],"proteoglycan":[124],"(PG)":[125],"breakdown":[126,143,177],"porcine":[128],"following":[131,146],"various":[132],"input":[133],"loading":[134],"tests":[135],"(0-20%":[136],"strain,":[137],"0-0.1":[138],"MPa).":[139],"greatest":[141],"PG":[142],"measured":[145],"20%":[147],"compressive":[148],"strain.":[149],"These":[150],"stress":[153],"levels":[154],"have":[155],"been":[156],"shown":[157],"correspond":[159],"partial":[161],"meniscectomy.":[162],"Thus,":[163],"these":[164],"data":[165],"suggest":[166],"removing":[168],"30-60%":[169],"will":[173],"result":[174],"proteoglycans.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}