{"id":"https://openalex.org/W2135022152","doi":"https://doi.org/10.1371/journal.pone.0005803","title":"Heme Oxygenase-1 Accelerates Cutaneous Wound Healing in Mice","display_name":"Heme Oxygenase-1 Accelerates Cutaneous Wound Healing in Mice","publication_year":2009,"publication_date":"2009-06-03","ids":{"openalex":"https://openalex.org/W2135022152","doi":"https://doi.org/10.1371/journal.pone.0005803","mag":"2135022152","pmid":"https://pubmed.ncbi.nlm.nih.gov/19495412","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2686151"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0005803","doi":"https://doi.org/10.1371/journal.pone.0005803","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005803","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005803&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005803&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043992991","display_name":"Anna Grochot\u2010Przeczek","orcid":"https://orcid.org/0000-0003-0533-7254","observed_orcids":["https://orcid.org/0000-0003-0533-7254"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Grochot-Przeczek","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061148694","display_name":"Rados\u0142aw Lach","orcid":"https://orcid.org/0000-0001-8513-6780","observed_orcids":["https://orcid.org/0000-0001-8513-6780"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Radoslaw Lach","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060772678","display_name":"Jacek Mis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jacek Mis","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057446036","display_name":"Klaudia Skrzypek","orcid":"https://orcid.org/0000-0002-3997-924X","observed_orcids":["https://orcid.org/0000-0002-3997-924X"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Klaudia Skrzypek","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009475425","display_name":"Malgorzata Gozdecka","orcid":"https://orcid.org/0000-0002-3134-1276","observed_orcids":["https://orcid.org/0000-0002-3134-1276"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Malgorzata Gozdecka","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016021594","display_name":"Patrycja Sroczy\u0144ska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Patrycja Sroczynska","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015142890","display_name":"Milena Dubiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Milena Dubiel","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrzej Rutkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Rutkowski","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073185149","display_name":"Magdalena Kozakowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Kozakowska","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003845987","display_name":"Anna Zag\u00f3rska","orcid":"https://orcid.org/0000-0003-3703-1364","observed_orcids":["https://orcid.org/0000-0003-3703-1364"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Zagorska","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048686580","display_name":"Jacek Walczynski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jacek Walczynski","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041415326","display_name":"Halina Wa\u015b","orcid":"https://orcid.org/0000-0003-2743-0337","observed_orcids":["https://orcid.org/0000-0003-2743-0337"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Halina Was","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075203866","display_name":"Jerzy Kotlinowski","orcid":"https://orcid.org/0000-0002-3133-3364","observed_orcids":["https://orcid.org/0000-0002-3133-3364"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jerzy Kotlinowski","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044052126","display_name":"Justyna Druka\u0142a","orcid":"https://orcid.org/0000-0001-5573-2979","observed_orcids":["https://orcid.org/0000-0001-5573-2979"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Justyna Drukala","raw_affiliation_strings":["Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","Department of Cell Biology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krak\u00f3w, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Department of Cell Biology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krak\u00f3w, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110106561","display_name":"Krzysztof Kurowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109771","display_name":"Adamed (Poland)","ror":"https://ror.org/01pgeyv96","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210109771"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Krzysztof Kurowski","raw_affiliation_strings":["R&D Division, Adamed Ltd., Pienkow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Division, Adamed Ltd., Pienkow, Poland","institution_ids":["https://openalex.org/I4210109771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058317825","display_name":"Claudine Ki\u00e9da","orcid":"https://orcid.org/0000-0002-7573-029X","observed_orcids":["https://orcid.org/0000-0002-7573-029X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210118525","display_name":"Centre de Biophysique Mol\u00e9culaire","ror":"https://ror.org/02dpqcy73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I110017253","https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118525","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claudine Kieda","raw_affiliation_strings":["Centre for Molecular Biophysics, CNRS, Orleans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Biophysics, CNRS, Orleans, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210118525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077455761","display_name":"Yann H\u00e9rault","orcid":"https://orcid.org/0000-0001-7049-6900","observed_orcids":["https://orcid.org/0000-0001-7049-6900"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yann Herault","raw_affiliation_strings":["Centre for Transgenic Animals, CNRS, Orleans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Transgenic Animals, CNRS, Orleans, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082864592","display_name":"J\u00f3zef Dulak","orcid":"https://orcid.org/0000-0001-5687-0839","observed_orcids":["https://orcid.org/0000-0001-5687-0839"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Jozef Dulak","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075717051","display_name":"Alicja J\u00f3zkowicz","orcid":"https://orcid.org/0000-0002-7317-260X","observed_orcids":["https://orcid.org/0000-0002-7317-260X"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Alicja Jozkowicz","raw_affiliation_strings":["Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075717051","https://openalex.org/A5082864592"],"corresponding_institution_ids":["https://openalex.org/I126596746"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.8568,"has_fulltext":true,"cited_by_count":130,"citation_normalized_percentile":{"value":0.91952693,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"4","issue":"6","first_page":"e5803","last_page":"e5803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.40230000019073486,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":1.0},{"id":"https://openalex.org/keywords/cutaneous-wound-healing","display_name":"skin wound healing","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8830000162124634},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tin-protoporphyrin-ix","display_name":"tin protoporphyrin IX","score":0.8650000095367432},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.7670000195503235},{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.8069999814033508},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.8316426277160645},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.823486328125},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.7672504186630249},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6742960214614868},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5261670351028442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5248632431030273},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5185883045196533},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4919740855693817},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.47926828265190125},{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.45851704478263855},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3485524654388428},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31211239099502563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3053426146507263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28602510690689087},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24781066179275513},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.07891371846199036},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0690409243106842},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06686699390411377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06006088852882385},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0005803","doi":"https://doi.org/10.1371/journal.pone.0005803","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005803","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005803&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2686151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2686151","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19495412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19495412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:ruj.uj.edu.pl:item/63070","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/63070","pdf_url":"http://ruj.uj.edu.pl/bitstreams/782915d0-4871-440a-899a-8b7bb5faddb2/download","source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.818.7042","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.818.7042","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/27/5c/pone.0005803.PMC2686151.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-00408274v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00408274","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 2009, 4 (6), pp.e5803. ⟨10.1371/journal.pone.0005803⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:b7f0081d2695492ca1ea3095b0fdff39","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b7f0081d2695492ca1ea3095b0fdff39","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 6, p e5803 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0005803","doi":"https://doi.org/10.1371/journal.pone.0005803","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0005803","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0005803&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321042","display_name":"Fundacja na rzecz Nauki Polskiej","ror":"https://ror.org/048zd9m77"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2135022152.pdf","grobid_xml":"https://content.openalex.org/works/W2135022152.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W64267049","https://openalex.org/W133023973","https://openalex.org/W1496965652","https://openalex.org/W1543367477","https://openalex.org/W1577847062","https://openalex.org/W1592939002","https://openalex.org/W1764777687","https://openalex.org/W1966999008","https://openalex.org/W1968985115","https://openalex.org/W1969173372","https://openalex.org/W1972491801","https://openalex.org/W1973185752","https://openalex.org/W1973271446","https://openalex.org/W1978642360","https://openalex.org/W1980904750","https://openalex.org/W1989483643","https://openalex.org/W1990549067","https://openalex.org/W1990858299","https://openalex.org/W1995674175","https://openalex.org/W1996527898","https://openalex.org/W1997441608","https://openalex.org/W2001019228","https://openalex.org/W2004777773","https://openalex.org/W2008030530","https://openalex.org/W2009046724","https://openalex.org/W2011788727","https://openalex.org/W2013538303","https://openalex.org/W2015070155","https://openalex.org/W2018204790","https://openalex.org/W2021186614","https://openalex.org/W2021669660","https://openalex.org/W2021939552","https://openalex.org/W2022496784","https://openalex.org/W2023272006","https://openalex.org/W2025706759","https://openalex.org/W2027788850","https://openalex.org/W2037686094","https://openalex.org/W2038610259","https://openalex.org/W2040107798","https://openalex.org/W2045189214","https://openalex.org/W2046598834","https://openalex.org/W2049300493","https://openalex.org/W2049474811","https://openalex.org/W2050754416","https://openalex.org/W2066303502","https://openalex.org/W2067714284","https://openalex.org/W2071102787","https://openalex.org/W2075331317","https://openalex.org/W2077807400","https://openalex.org/W2083383675","https://openalex.org/W2083495321","https://openalex.org/W2085293124","https://openalex.org/W2087466296","https://openalex.org/W2090393228","https://openalex.org/W2094555338","https://openalex.org/W2098923926","https://openalex.org/W2101580341","https://openalex.org/W2107114596","https://openalex.org/W2112548745","https://openalex.org/W2112937322","https://openalex.org/W2117422863","https://openalex.org/W2118260179","https://openalex.org/W2119330771","https://openalex.org/W2120472250","https://openalex.org/W2124433916","https://openalex.org/W2124920102","https://openalex.org/W2125206586","https://openalex.org/W2128120260","https://openalex.org/W2135920231","https://openalex.org/W2136988580","https://openalex.org/W2145530136","https://openalex.org/W2154162798","https://openalex.org/W2155514122","https://openalex.org/W2158563216","https://openalex.org/W2159940061","https://openalex.org/W2164930319","https://openalex.org/W2180781245","https://openalex.org/W4241123725"],"related_works":["https://openalex.org/W7100247466","https://openalex.org/W2118589241","https://openalex.org/W7100381693","https://openalex.org/W2103685975","https://openalex.org/W2023272006","https://openalex.org/W7097520489","https://openalex.org/W1764777687","https://openalex.org/W4304136172","https://openalex.org/W2037686094","https://openalex.org/W7062734237"],"abstract_inverted_index":{"Heme":[0],"oxygenase-1":[1],"(HO-1),":[2],"a":[3],"cytoprotective,":[4],"pro-angiogenic":[5],"and":[6,42,78,116,132,142,162,177,192],"anti-inflammatory":[7],"enzyme,":[8],"is":[9,110,171],"strongly":[10],"induced":[11],"in":[12,22,34,54,63,91,108,126,134,138,182],"injured":[13],"tissues.":[14],"Our":[15],"aim":[16],"was":[17,37,60,129],"to":[18,73,79,112],"clarify":[19],"its":[20],"role":[21],"cutaneous":[23],"wound":[24,57,143,160,175,180],"healing.":[25],"In":[26,147,166],"wild":[27],"type":[28],"mice,":[29,66,137],"maximal":[30],"expression":[31],"of":[32,48,56,69,76,81,98,106,120,124,152,169],"HO-1":[33,49,64,70,95,107,125,153,170,190,197],"the":[35,40,114,118,159,164],"skin":[36,83,128],"observed":[38],"on":[39],"2(nd)":[41],"3(rd)":[43],"days":[44],"after":[45],"wounding.":[46],"Inhibition":[47],"by":[50,86,196],"tin":[51],"protoporphyrin-IX":[52],"resulted":[53],"retardation":[55],"closure.":[58],"Healing":[59],"also":[61,140],"delayed":[62,133,189],"deficient":[65],"where":[67],"lack":[68],"could":[71],"lead":[72],"complete":[74],"suppression":[75],"reepithelialization":[77],"formation":[80],"extensive":[82],"lesions,":[84],"accompanied":[85],"impaired":[87],"neovascularization.":[88,178],"Experiments":[89],"performed":[90],"transgenic":[92],"mice":[93,184],"bearing":[94],"under":[96],"control":[97],"keratin":[99],"14":[100],"promoter":[101],"showed":[102],"that":[103],"increased":[104,163],"level":[105],"keratinocytes":[109],"enough":[111],"improve":[113],"neovascularization":[115],"hasten":[117],"closure":[119,144,176],"wounds.":[121],"Importantly,":[122],"induction":[123,168],"wounded":[127],"relatively":[130],"weak":[131],"diabetic":[135,183],"(db/db)":[136],"which":[139],"angiogenesis":[141],"were":[145],"impaired.":[146],"such":[148],"animals":[149],"local":[150],"delivery":[151],"transgene":[154],"using":[155],"adenoviral":[156],"vectors":[157],"accelerated":[158],"healing":[161,181],"vascularization.":[165],"summary,":[167],"necessary":[172],"for":[173],"efficient":[174],"Impaired":[179],"may":[185],"be":[186,194],"associated":[187],"with":[188],"upregulation":[191],"can":[193],"improved":[195],"gene":[198],"transfer.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}