{"id":"https://openalex.org/W2134944707","doi":null,"title":"Reduction in the radiation-induced late S phase and G2 blocks in HL-60 cell populations by amiloride, an efficient inhibitor of the Na+/H+ transporter.","display_name":"Reduction in the radiation-induced late S phase and G2 blocks in HL-60 cell populations by amiloride, an efficient inhibitor of the Na+/H+ transporter.","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2134944707","mag":"2134944707","pmid":"https://pubmed.ncbi.nlm.nih.gov/9458082"},"language":"en","primary_location":{"id":"pmid:9458082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9458082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044722311","display_name":"Brian L. Sailer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B L Sailer","raw_affiliation_strings":["Los Alamos National Laboratory, Life Sciences Division, New Mexico 87545, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory, Life Sciences Division, New Mexico 87545, USA","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061421156","display_name":"Anna M. Barrasso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Barrasso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109990853","display_name":"Joseph G. Valdez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J G Valdez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108931678","display_name":"J. Cobo","orcid":"https://orcid.org/0000-0001-8580-8743","observed_orcids":["https://orcid.org/0000-0001-8580-8743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Cobo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091484920","display_name":"Joseph A. D'Anna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A D'Anna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049132559","display_name":"Harry A. Crissman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H A Crissman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0432,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74298211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"58","issue":"3","first_page":"413","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.06949999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":1.0},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/radiation-induced-cell-cycle-arrest","display_name":"radiation-induced cell cycle arrest","score":0.7450000047683716},{"id":"https://openalex.org/keywords/late-s-phase","display_name":"late S phase","score":0.6850000023841858},{"id":"https://openalex.org/keywords/g2-checkpoint","display_name":"G2 checkpoint","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/na-h-exchanger-inhibition","display_name":"Na+/H+ exchanger inhibition","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/p34cdc2-kinase","display_name":"p34cdc2 kinase","score":0.878000020980835},{"id":"https://openalex.org/keywords/mitotic-progression","display_name":"mitotic progression","score":0.6299999952316284},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.6570000052452087},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.9286993741989136},{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.6202384829521179},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5419344305992126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41281330585479736},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.354965478181839},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35226619243621826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33584100008010864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3219623863697052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20318502187728882},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.19443351030349731},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.13156649470329285},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.09404075145721436},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056744","descriptor_name":"Cyclin B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9458082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9458082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"mag:2134944707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9458082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2629217951","display_name":"FLOW CYTOMETER FOR QUANTIFYING FLUORESCENCE LIFETIME","funder_award_id":"R01RR007855","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2707414799","display_name":"National Flow Cytometry and Sorting Research Resource","funder_award_id":"P41RR001315","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7945052784","display_name":"FLOW CYTOMETRIC ANALYSIS OF MULTIPLE DNA FLUOROCHROMES","funder_award_id":"R01RR006758","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1576659748","https://openalex.org/W1646316897","https://openalex.org/W1986155069","https://openalex.org/W2017994880","https://openalex.org/W2022128427","https://openalex.org/W2023454748","https://openalex.org/W2045717142","https://openalex.org/W2054412884","https://openalex.org/W2057739013","https://openalex.org/W2318996479"],"related_works":["https://openalex.org/W2026007262","https://openalex.org/W1989283929","https://openalex.org/W2074981528","https://openalex.org/W1559639669","https://openalex.org/W2041444090","https://openalex.org/W562587258","https://openalex.org/W2326596666","https://openalex.org/W2358321254","https://openalex.org/W2029529561","https://openalex.org/W2327078524"],"abstract_inverted_index":{"Recent":[0],"investigations":[1],"that":[2,4,122,154,188],"showed":[3],"amiloride":[5,37,46,123,155,189,219],"delayed":[6],"or":[7,113],"inhibited":[8],"apoptosis":[9,112],"indicated":[10],"it":[11],"might":[12],"also":[13],"attenuate":[14,48],"cell":[15,39,108,131,233],"cycle":[16,40,234],"checkpoints":[17],"activated":[18],"by":[19,57,177,218],"ionizing":[20],"radiation.":[21,65],"In":[22],"this":[23],"report,":[24],"single-":[25],"and":[26,42,51,60,76,103,138,147,228],"dual-parameter":[27],"flow":[28],"cytometry":[29],"were":[30,89],"used":[31],"to":[32,47,139,195,222],"investigate":[33],"the":[34,43,49,98,125,191,197,207,231],"effects":[35],"of":[36,45,63,97,149,171,200],"on":[38],"progression,":[41,205],"effectiveness":[44],"S":[50,101],"G2":[52,79,104,127,174],"phase":[53,102],"checkpoint":[54],"responses":[55],"induced":[56,217],"2.5,":[58],"5.0,":[59],"7.5":[61],"Gy":[62],"gamma":[64],"The":[66,185],"late":[67,100],"S-phase":[68],"delay,":[69,175],"noted":[70],"at":[71,84],"8":[72],"h":[73,86],"following":[74,162],"irradiation,":[75,88],"a":[77,116,140,168,172,178],"radiation-induced":[78,99,126],"block,":[80],"which":[81],"was":[82,167],"maximum":[83],"16":[85],"after":[87],"both":[90],"significantly":[91,157],"reduced":[92,158],"in":[93,107,129,182,213,224],"amiloride-treated":[94],"samples.":[95],"Attenuation":[96],"blocks":[105],"resulted":[106],"division":[109],"without":[110],"apparent":[111],"necrosis":[114],"over":[115],"24-h":[117],"period.":[118],"Results":[119],"presented":[120],"indicate":[121],"reduces":[124],"block":[128],"HL-60":[130],"populations":[132],"almost":[133],"equally":[134],"well":[135],"as":[136],"caffeine":[137],"greater":[141],"extent":[142],"than":[143],"staurosporine.":[144],"Immunofluorescent":[145],"detection":[146],"quantitation":[148],"cyclin":[150,159,208],"B1":[151,160],"expression":[152,161],"demonstrated":[153],"only":[156],"5.0":[163],"Gy,":[164],"when":[165],"there":[166],"notable":[169],"induction":[170],"significant":[173],"followed":[176],"relatively":[179],"rapid":[180],"recovery":[181],"cycling":[183],"potential.":[184],"results":[186],"suggest":[187],"affects":[190],"radiation-triggered":[192],"signaling":[193,226],"cascades":[194,227],"alter":[196],"kinase":[198],"activity":[199],"proteins":[201],"associated":[202],"with":[203],"mitotic":[204],"particularly":[206],"B1-p34cdc2":[209],"complex.":[210],"Alternatively,":[211],"alterations":[212],"intracellular":[214],"ion":[215],"concentrations":[216],"may":[220],"lead":[221],"changes":[223],"Ca2+-dependent":[225],"thereby":[229],"decrease":[230],"radiation-mediated":[232],"perturbations.":[235]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
