{"id":"https://openalex.org/W2134880341","doi":"https://doi.org/10.1242/dev.007138","title":"BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration","display_name":"BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration","publication_year":2007,"publication_date":"2007-10-18","ids":{"openalex":"https://openalex.org/W2134880341","doi":"https://doi.org/10.1242/dev.007138","mag":"2134880341","pmid":"https://pubmed.ncbi.nlm.nih.gov/17942485"},"language":"en","primary_location":{"id":"doi:10.1242/dev.007138","doi":"https://doi.org/10.1242/dev.007138","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.007138","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011162507","display_name":"Peter W. Reddien","orcid":"https://orcid.org/0000-0002-5569-333X","observed_orcids":["https://orcid.org/0000-0002-5569-333X"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W. Reddien","raw_affiliation_strings":["MIT Biology, Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02138,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIT Biology, Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02138,USA","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013632673","display_name":"Adam L. Bermange","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam L. Bermange","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Neurobiology and Anatomy,University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Neurobiology and Anatomy,University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063111446","display_name":"Adrienne M. Kicza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne M. Kicza","raw_affiliation_strings":["MIT Biology, Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02138,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIT Biology, Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02138,USA","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061204199","display_name":"Alejandro S\u00e1nchez Alvarado","orcid":"https://orcid.org/0000-0002-1966-6959","observed_orcids":["https://orcid.org/0000-0002-1966-6959"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Sa\u0301nchez Alvarado","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Neurobiology and Anatomy,University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Neurobiology and Anatomy,University of Utah School of Medicine, 401 MREB, 20N 1900E, Salt Lake City, UT 84132, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4817,"has_fulltext":false,"cited_by_count":176,"citation_normalized_percentile":{"value":0.94291655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"134","issue":"22","first_page":"4043","last_page":"4051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/planarian-regeneration","display_name":"planarian regeneration","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dorsal-midline","display_name":"dorsal midline","score":0.8930000066757202},{"id":"https://openalex.org/keywords/bilateral-symmetry","display_name":"bilateral symmetry","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dorsoventral-patterning","display_name":"dorsoventral patterning","score":0.9490000009536743},{"id":"https://openalex.org/keywords/blastema-formation","display_name":"blastema formation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/left-right-symmetry","display_name":"left-right symmetry","score":0.6830000281333923},{"id":"https://openalex.org/keywords/tissue-homeostasis","display_name":"tissue homeostasis","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C2775935104","wikidata":"https://www.wikidata.org/wiki/Q6502673","display_name":"Planarian","level":3,"score":0.9516693353652954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9046728610992432},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.8113647699356079},{"id":"https://openalex.org/C78214289","wikidata":"https://www.wikidata.org/wiki/Q882043","display_name":"Blastema","level":3,"score":0.7729111909866333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6607512831687927},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.523435115814209},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.46222057938575745},{"id":"https://openalex.org/C2781355164","wikidata":"https://www.wikidata.org/wiki/Q124900","display_name":"Flatworm","level":2,"score":0.45733198523521423},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42526721954345703},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010932","descriptor_name":"Planarians","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D010932","descriptor_name":"Planarians","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010932","descriptor_name":"Planarians","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1242/dev.007138","doi":"https://doi.org/10.1242/dev.007138","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.007138","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:17942485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17942485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:develop:134/22/4043","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/134/22/4043","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G97969120","display_name":"The molecular basis of planarian regeneration","funder_award_id":"R01GM057260","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1496387202","https://openalex.org/W1519592199","https://openalex.org/W1905290144","https://openalex.org/W1971481058","https://openalex.org/W1972752128","https://openalex.org/W1974119570","https://openalex.org/W1978146894","https://openalex.org/W1986260964","https://openalex.org/W1986469118","https://openalex.org/W1995483818","https://openalex.org/W1997389247","https://openalex.org/W1998342476","https://openalex.org/W2011175428","https://openalex.org/W2011193034","https://openalex.org/W2023719014","https://openalex.org/W2026641296","https://openalex.org/W2028213428","https://openalex.org/W2029177926","https://openalex.org/W2037614897","https://openalex.org/W2037961284","https://openalex.org/W2040723453","https://openalex.org/W2044615295","https://openalex.org/W2072572526","https://openalex.org/W2073514647","https://openalex.org/W2074658822","https://openalex.org/W2077346948","https://openalex.org/W2081689397","https://openalex.org/W2084098307","https://openalex.org/W2097923096","https://openalex.org/W2100522747","https://openalex.org/W2102258780","https://openalex.org/W2117006120","https://openalex.org/W2162160001","https://openalex.org/W2293403752","https://openalex.org/W2344627353","https://openalex.org/W2346925206","https://openalex.org/W2492914305","https://openalex.org/W4245499445"],"related_works":["https://openalex.org/W2002653689","https://openalex.org/W1981231762","https://openalex.org/W2072515756","https://openalex.org/W4294243575","https://openalex.org/W4386883454","https://openalex.org/W2472487356","https://openalex.org/W4408458766","https://openalex.org/W2759596130","https://openalex.org/W3008608887","https://openalex.org/W2056965916"],"abstract_inverted_index":{"Planarians":[0],"can":[1],"be":[2],"cut":[3],"into":[4],"irregularly":[5],"shaped":[6],"fragments":[7,35,115,132],"capable":[8],"of":[9,46,55,79,85,90,96,100,126,156],"regenerating":[10],"new":[11,80,91,120],"and":[12,67,93,162],"complete":[13],"organisms.":[14],"Such":[15],"regenerative":[16,128],"capacities":[17],"involve":[18],"a":[19,47,59,63,68,117,127],"robust":[20],"ability":[21],"to":[22,36,124],"restore":[23],"bilateral":[24],"symmetry.":[25],"We":[26,143],"have":[27],"identified":[28],"three":[29],"genes":[30,42],"needed":[31],"for":[32],"bilaterally":[33],"asymmetric":[34],"regenerate":[37],"missing":[38],"body":[39],"parts.":[40],"These":[41],"are":[43],"candidate":[44],"components":[45],"signaling":[48,73],"pathway":[49],"that":[50,147],"controls":[51],"the":[52,77,83,87,94,97,111,134,141],"dorsal-ventral":[53,88,98],"patterning":[54,89],"many":[56],"animal":[57],"embryos:":[58],"BMP1/Tolloid-like":[60],"gene":[61,65,70],"(smedolloid-1),":[62],"SMAD4-like":[64],"(smedsmad4-1),":[66],"BMP2/4/DPP-like":[69],"(smedbmp4-1).":[71],"BMP":[72,157],"was":[74,107],"involved":[75],"in":[76,104,165],"formation":[78,125],"tissues":[81],"at":[82,110],"midline":[84,118,135,153],"regeneration,":[86],"tissues,":[92],"maintenance":[95],"pattern":[99],"existing":[101],"adult":[102],"tissue":[103],"homeostasis.":[105],"smedbmp4-1":[106,121,138],"normally":[108],"expressed":[109],"dorsal":[112],"midline.":[113],"Asymmetric":[114,131],"lacking":[116],"displayed":[119,136],"expression":[122,139],"prior":[123],"outgrowth":[129],"(blastema).":[130],"containing":[133],"expanded":[137],"towards":[140],"wound.":[142],"suggest":[144],"injured":[145],"animals":[146],"lack":[148],"left-right":[149],"symmetry":[150],"reset":[151],"their":[152],"through":[154],"modulation":[155],"activity":[158],"as":[159],"an":[160],"early":[161],"necessary":[163],"event":[164],"regeneration.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}