{"id":"https://openalex.org/W2134816331","doi":"https://doi.org/10.4172/2167-7719.1000e109","title":"Epithelial Sodium Channels Play a Role in Air & Water Borne Diseases","display_name":"Epithelial Sodium Channels Play a Role in Air & Water Borne Diseases","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2134816331","doi":"https://doi.org/10.4172/2167-7719.1000e109","mag":"2134816331"},"language":"en","primary_location":{"id":"doi:10.4172/2167-7719.1000e109","doi":"https://doi.org/10.4172/2167-7719.1000e109","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2167-7719.1000e109","pdf_url":null,"source":{"id":"https://openalex.org/S4210220393","display_name":"Air & Water Borne Diseases","issn_l":"2167-7719","issn":["2167-7719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Air &amp; Water Borne Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041635920","display_name":"Charles A. Downs","orcid":"https://orcid.org/0000-0003-4859-7929","observed_orcids":["https://orcid.org/0000-0003-4859-7929"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Charles A. Downs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041635920"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12845808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"01","issue":"03","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.3806000053882599,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enac","display_name":"epithelial sodium channel","score":0.9520000219345093},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.6629999876022339},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":1.0},{"id":"https://openalex.org/keywords/cation-selectivity","display_name":"cation selectivity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7979999780654907},{"id":"https://openalex.org/keywords/reactive-oxygen-and-nitrogen-species","display_name":"reactive oxygen and nitrogen species","score":0.8980000019073486},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9869999885559082},{"id":"https://openalex.org/keywords/waterborne-diseases","display_name":"waterborne diseases","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.6071212291717529},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4212183952331543},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.4104585647583008},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.373518705368042},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34004804491996765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3325025737285614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22722205519676208},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4172/2167-7719.1000e109","doi":"https://doi.org/10.4172/2167-7719.1000e109","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2167-7719.1000e109","pdf_url":null,"source":{"id":"https://openalex.org/S4210220393","display_name":"Air & Water Borne Diseases","issn_l":"2167-7719","issn":["2167-7719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Air &amp; Water Borne Diseases","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1964505390","https://openalex.org/W1977663423","https://openalex.org/W1980080388","https://openalex.org/W2052571887","https://openalex.org/W2065044742","https://openalex.org/W2125325789","https://openalex.org/W2156876013","https://openalex.org/W2172201608","https://openalex.org/W2185381295","https://openalex.org/W2400395945"],"related_works":["https://openalex.org/W68731548","https://openalex.org/W2156876013","https://openalex.org/W2095636862","https://openalex.org/W133291183","https://openalex.org/W4210554114","https://openalex.org/W2080619896","https://openalex.org/W2208098683","https://openalex.org/W2739046048","https://openalex.org/W4389027631","https://openalex.org/W1976830450"],"abstract_inverted_index":{"+,":[0],"Cl":[1],"and":[2,54,76,93,128,169,177],"water":[3],"from":[4,114],"the":[5,9,15,20,27,37,60,102,107],"airway":[6],"lumen":[7],"into":[8],"vascular":[10],"space.":[11,29],"ENaC":[12,34,58,105,134,148],"is":[13,62],"considered":[14],"rate":[16],"limiting":[17],"step":[18],"in":[19,43,59,106,164,173,188],"net":[21],"movement":[22],"of":[23,26,41,67,98,104,123],"fluid":[24],"out":[25],"alveolar":[28],"Thus,":[30],"strategies":[31],"to":[32,45,162],"enhance":[33],"activity":[35],"at":[36],"apical":[38],"membrane":[39],"are":[40,120,150],"interest":[42],"order":[44],"improve":[46],"outcomes":[47],"associated":[48],"with":[49],"diseases":[50],"such":[51],"as":[52],"pneumonia":[53],"acute":[55],"lung":[56,108,115],"injury.":[57],"airways":[61],"regulated":[63],"by":[64],"a":[65],"variety":[66],"agents":[68],"including":[69],"G-coupled":[70],"protein":[71],"receptors":[72],"(e.g.":[73],"adrenergic,":[74],"purinergic":[75],"dopaminergic),":[77],"chemokines":[78],"(TGF-\u03b2,":[79],"TNF-\u03b1),":[80],"reactive":[81],"oxygen/nitrogen":[82],"species":[83],"(H":[84],"2":[85,87,90],"O":[86,89],",":[88],".,":[91],"NO)":[92],"hormones":[94],"(glucocorticoids).":[95],"The":[96],"multitude":[97],"regulatory":[99],"pathways":[100],"highlights":[101],"importance":[103],"[3-6].":[109],"Single":[110],"channel":[111],"electrophysiology":[112],"measurements":[113],"tissue":[116],"demonstrate":[117],"that":[118],"there":[119],"two":[121],"types":[122],"ENaC\u2014highly":[124],"selective":[125],"cation":[126,130,165],"(HSC)":[127],"non-selective":[129],"(NSC)":[131],"channels.":[132],"HSC":[133,167],"channels":[135,149,168,171],"preferentially":[136],"transport":[137],"Na":[138,190],"+":[139,141,143,154,156,191],"(Na":[140,153],"/K":[142,155],"selectivity":[144,157],">40)":[145],"while":[146],"NSC":[147,170],"less":[151],"discriminant":[152],"1.4)":[158],"[7].":[159],"In":[160],"addition":[161],"differences":[163],"selectivity,":[166],"differ":[172],"their":[174],"unitary":[175],"conductance":[176],"other":[178],"biophysical":[179],"properties.":[180],"However,":[181],"they":[182],"both":[183],"play":[184],"an":[185],"important":[186],"role":[187],"epithelial":[189],"reabsorption.":[192]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
