{"id":"https://openalex.org/W2134802402","doi":"https://doi.org/10.3109/10799893.2012.695798","title":"PTEN regulation of ERK1/2 signaling in cancer","display_name":"PTEN regulation of ERK1/2 signaling in cancer","publication_year":2012,"publication_date":"2012-06-28","ids":{"openalex":"https://openalex.org/W2134802402","doi":"https://doi.org/10.3109/10799893.2012.695798","mag":"2134802402","pmid":"https://pubmed.ncbi.nlm.nih.gov/22737980","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3503241"},"language":"en","primary_location":{"id":"doi:10.3109/10799893.2012.695798","doi":"https://doi.org/10.3109/10799893.2012.695798","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10799893.2012.695798","pdf_url":null,"source":{"id":"https://openalex.org/S116485566","display_name":"Journal of Receptors and Signal Transduction","issn_l":"1079-9893","issn":["1079-9893","1532-4281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Receptors and Signal Transduction","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3503241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018472630","display_name":"Mahandranauth A. Chetram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahandranauth A. Chetram","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013946172","display_name":"Cimona V. Hinton","orcid":"https://orcid.org/0000-0002-5724-1804","observed_orcids":["https://orcid.org/0000-0002-5724-1804"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cimona V. Hinton","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I52064589"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013946172"],"corresponding_institution_ids":["https://openalex.org/I52064589"],"apc_list":null,"apc_paid":null,"fwci":1.0499,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.73191361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"32","issue":"4","first_page":"190","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.4812000095844269,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.4812000095844269,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.25589999556541443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.23669999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":1.0},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/shc","display_name":"Shc","score":0.47699999809265137},{"id":"https://openalex.org/keywords/signaling-crosstalk","display_name":"signaling crosstalk","score":0.597000002861023},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8937363624572754},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.570812463760376},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5577712059020996},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4913386404514313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4136168658733368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3291265666484833},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27677643299102783},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2308010458946228},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22246402502059937}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048053","descriptor_name":"Mitogen-Activated Protein Kinase 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048053","descriptor_name":"Mitogen-Activated Protein Kinase 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048053","descriptor_name":"Mitogen-Activated Protein Kinase 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3109/10799893.2012.695798","doi":"https://doi.org/10.3109/10799893.2012.695798","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10799893.2012.695798","pdf_url":null,"source":{"id":"https://openalex.org/S116485566","display_name":"Journal of Receptors and Signal Transduction","issn_l":"1079-9893","issn":["1079-9893","1532-4281"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Receptors and Signal Transduction","raw_type":"journal-article"},{"id":"pmid:22737980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22737980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of receptor and signal transduction research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2723191","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3503241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3503241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3503241","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Recept Signal Transduct Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2723191","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3503241","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6918336860","display_name":"The Regulatory Role of PTEN on CXCR4-mediated Metastasis in Prostate Cancer Cells","funder_award_id":"F31CA153908","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7546212254","display_name":"CNTR OF EXCELLENCE FOR PROSTATE CANCER RESEARCH EDUCATION AND COMM SERVICE","funder_award_id":"P20MD002285","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G8029105834","display_name":"Clark Atlanta University Biomedical Science Development","funder_award_id":"G12RR003062","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W161453622","https://openalex.org/W1525136518","https://openalex.org/W1596038553","https://openalex.org/W1643628872","https://openalex.org/W1964410726","https://openalex.org/W1964769336","https://openalex.org/W1969820174","https://openalex.org/W1976137605","https://openalex.org/W1977416006","https://openalex.org/W1980889252","https://openalex.org/W1988769784","https://openalex.org/W1997503905","https://openalex.org/W1997656209","https://openalex.org/W2000269495","https://openalex.org/W2000624133","https://openalex.org/W2003511221","https://openalex.org/W2012447867","https://openalex.org/W2018896819","https://openalex.org/W2021346058","https://openalex.org/W2048075898","https://openalex.org/W2054388774","https://openalex.org/W2063292448","https://openalex.org/W2067751798","https://openalex.org/W2068345721","https://openalex.org/W2068427129","https://openalex.org/W2068635845","https://openalex.org/W2075514051","https://openalex.org/W2076457965","https://openalex.org/W2076627331","https://openalex.org/W2077673188","https://openalex.org/W2078590818","https://openalex.org/W2082017108","https://openalex.org/W2085679570","https://openalex.org/W2087846936","https://openalex.org/W2091699981","https://openalex.org/W2092014913","https://openalex.org/W2096008575","https://openalex.org/W2099658407","https://openalex.org/W2105333044","https://openalex.org/W2108640797","https://openalex.org/W2109283410","https://openalex.org/W2111062014","https://openalex.org/W2116403673","https://openalex.org/W2130263407","https://openalex.org/W2135838271","https://openalex.org/W2146989813","https://openalex.org/W2147690515","https://openalex.org/W2151308486","https://openalex.org/W2155730420","https://openalex.org/W2158204812","https://openalex.org/W2160102037","https://openalex.org/W2161810908","https://openalex.org/W2165014096","https://openalex.org/W2167985694","https://openalex.org/W4233973967"],"related_works":["https://openalex.org/W2110452000","https://openalex.org/W2795174081","https://openalex.org/W2360392060","https://openalex.org/W2773474457","https://openalex.org/W2164013013","https://openalex.org/W64642140","https://openalex.org/W1537003936","https://openalex.org/W2151258296","https://openalex.org/W2374272643","https://openalex.org/W2161975859"],"abstract_inverted_index":{"Mahandranauth":[0],"A.":[1],"Chetrama":[2],"&":[3],"Cimona":[4,22],"V.":[5,23],"Hinton*aa":[6],"Center":[7,26],"for":[8,20,27,162],"Cancer":[9,28],"Research":[10,29],"and":[11,30,60,113,122,139,177,210,213],"Therapeutic":[12,31],"Development,":[13,32],"Clark":[14,33],"Atlanta":[15,34],"University,":[16,35],"Atlanta,":[17,42],"GA,":[18],"USAAddress":[19],"Correspondence:":[21],"Hinton,":[24],"Ph.D.,":[25],"223":[36],"James":[37],"P.":[38],"Brawley":[39],"Drive,":[40],"S.W,":[41],"GA":[43],"30314,":[44],"USA.":[45],"Tel:":[46],"(404)":[47,50],"880-8134.":[48],"Fax:":[49],"880-8065.":[51],"E-mail:":[52],"chinton@cau.eduSince":[53],"its":[54,79],"discovery,":[55],"the":[56,148,163,183,199,218],"tumor":[57],"suppressor":[58],"phosphatase":[59,81],"tensin":[61],"homolog":[62],"(PTEN)":[63],"has":[64,169],"become":[65],"a":[66,69,88,214],"molecule":[67],"with":[68],"wide":[70],"spectrum":[71],"of":[72,115,131,145,152,201],"functions,":[73],"which":[74,187],"is":[75,92,155,191],"typically":[76,134],"meditated":[77],"through":[78],"lipid":[80],"activity;":[82],"however,":[83],"PTEN":[84,96,175,188,202],"also":[85],"functions":[86],"in":[87,179,203],"phosphatase-independent":[89],"manner.":[90],"It":[91],"well":[93,156],"established":[94],"that":[95],"regulates":[97,189],"several":[98,180],"signaling":[99],"pathways,":[100,147],"such":[101],"as":[102],"phosphoinositide":[103],"3-kinase":[104],"(PI3K)/protein":[105],"kinase":[106,110,120,127],"B":[107],"(AKT),":[108],"janus":[109],"(JAK)/signal":[111],"transducers":[112],"activators":[114],"transcription":[116],"(STAT),":[117],"focal":[118],"adhesion":[119],"(FAK),":[121],"more":[123],"recent,":[124],"extracellular":[125],"signal-regulated":[126],"(ERK)1/2,":[128],"where":[129],"activation":[130],"these":[132,146],"pathways":[133],"leads":[135],"to":[136,143],"cancer":[137],"development":[138],"progression.":[140],"In":[141,194],"regard":[142],"most":[144],"underlining":[149],"molecular":[150],"mechanism":[151,185],"PTEN-mediated":[153],"regulation":[154],"established,":[157],"but":[158],"not":[159],"so":[160],"much":[161],"ERK1/2":[164,178,190,205],"pathway.":[165],"Indeed,":[166],"accumulating":[167],"evidence":[168],"shown":[170],"an":[171],"inverse":[172],"correlation":[173],"between":[174,217],"expression":[176],"malignancies.":[181],"However,":[182],"detailed":[184],"by":[186,206],"poorly":[192],"understood.":[193],"this":[195],"review,":[196],"we":[197],"discuss":[198],"role":[200],"regulating":[204],"directly":[207],"targeting":[208],"shc/Raf/MEK":[209],"PI3K/AKT":[211],"cascades,":[212],"putative":[215],"cross-talk":[216],"two.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
