{"id":"https://openalex.org/W2134774909","doi":null,"title":"New ways to test beta cell functionality in health and diabetes","display_name":"New ways to test beta cell functionality in health and diabetes","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2134774909","mag":"2134774909"},"language":"en","primary_location":{"id":"mag:2134774909","doi":null,"is_oa":false,"landing_page_url":"http://orbit.dtu.dk/services/downloadRegister/12516652/PhDThesis_Thomas_Korsgaard.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021317945","display_name":"Thomas Vagn Korsgaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Thomas Vagn Korsgaard","raw_affiliation_strings":["Department of Physics","Technical University of Denmark, Department of Physics, DK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics","institution_ids":[]},{"raw_affiliation_string":"Technical University of Denmark, Department of Physics, DK","institution_ids":["https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021317945"],"corresponding_institution_ids":["https://openalex.org/I96673099"],"apc_list":null,"apc_paid":null,"fwci":0.2054,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61903277,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.9470000267028809},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8169999718666077},{"id":"https://openalex.org/keywords/glucokinase","display_name":"glucokinase","score":0.847000002861023},{"id":"https://openalex.org/keywords/glucose-detection","display_name":"glucose detection","score":0.9259999990463257},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/meal-tolerance-test","display_name":"meal tolerance test","score":0.949999988079071},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8519999980926514},{"id":"https://openalex.org/keywords/insulin-action","display_name":"insulin action","score":0.4180000126361847},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.6480000019073486},{"id":"https://openalex.org/keywords/glucose-profile","display_name":"glucose profile","score":0.41499999165534973},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.4860000014305115},{"id":"https://openalex.org/keywords/beta-cell-heterogeneity","display_name":"beta-cell heterogeneity","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5907552242279053},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5575171113014221},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5150830149650574},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.5047777891159058},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35712164640426636},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3346185088157654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28206098079681396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2002144753932953},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.11344319581985474},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11326691508293152},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.06053519248962402},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2134774909","doi":null,"is_oa":false,"landing_page_url":"http://orbit.dtu.dk/services/downloadRegister/12516652/PhDThesis_Thomas_Korsgaard.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W631732704","https://openalex.org/W1482297831","https://openalex.org/W1484556304","https://openalex.org/W1489454661","https://openalex.org/W1505083320","https://openalex.org/W1510217511","https://openalex.org/W1526357026","https://openalex.org/W1526477057","https://openalex.org/W1536188564","https://openalex.org/W1577720842","https://openalex.org/W1588747660","https://openalex.org/W1594379317","https://openalex.org/W1602802197","https://openalex.org/W1757044574","https://openalex.org/W1894212043","https://openalex.org/W1918502072","https://openalex.org/W1941926305","https://openalex.org/W1969897154","https://openalex.org/W1970617837","https://openalex.org/W1973259490","https://openalex.org/W1975007709","https://openalex.org/W1976955725","https://openalex.org/W1979180498","https://openalex.org/W1980164069","https://openalex.org/W1981456793","https://openalex.org/W1981581852","https://openalex.org/W1986183203","https://openalex.org/W1987560885","https://openalex.org/W1990607115","https://openalex.org/W1991251155","https://openalex.org/W1992505070","https://openalex.org/W1994576689","https://openalex.org/W1995259122","https://openalex.org/W1995288989","https://openalex.org/W1995678701","https://openalex.org/W1997008557","https://openalex.org/W1997022650","https://openalex.org/W1998802885","https://openalex.org/W2000569688","https://openalex.org/W2003380115","https://openalex.org/W2008157469","https://openalex.org/W2011632526","https://openalex.org/W2017394631","https://openalex.org/W2018459966","https://openalex.org/W2021925516","https://openalex.org/W2022842991","https://openalex.org/W2026118624","https://openalex.org/W2027219674","https://openalex.org/W2032566775","https://openalex.org/W2035871389","https://openalex.org/W2035967698","https://openalex.org/W2036393318","https://openalex.org/W2039211694","https://openalex.org/W2041272729","https://openalex.org/W2042381753","https://openalex.org/W2050724341","https://openalex.org/W2054212116","https://openalex.org/W2056093631","https://openalex.org/W2059325517","https://openalex.org/W2060392241","https://openalex.org/W2060732854","https://openalex.org/W2062476437","https://openalex.org/W2066898102","https://openalex.org/W2068803404","https://openalex.org/W2069335580","https://openalex.org/W2070862761","https://openalex.org/W2078317071","https://openalex.org/W2081189796","https://openalex.org/W2082695535","https://openalex.org/W2083360466","https://openalex.org/W2085820623","https://openalex.org/W2087008389","https://openalex.org/W2087036494","https://openalex.org/W2088160164","https://openalex.org/W2092510134","https://openalex.org/W2093499847","https://openalex.org/W2093720031","https://openalex.org/W2102783853","https://openalex.org/W2103358437","https://openalex.org/W2105912552","https://openalex.org/W2105955034","https://openalex.org/W2106036385","https://openalex.org/W2106881342","https://openalex.org/W2112397727","https://openalex.org/W2113274746","https://openalex.org/W2113396686","https://openalex.org/W2113594895","https://openalex.org/W2113637996","https://openalex.org/W2113657076","https://openalex.org/W2116990096","https://openalex.org/W2118446334","https://openalex.org/W2120282127","https://openalex.org/W2120525555","https://openalex.org/W2120711739","https://openalex.org/W2124620553","https://openalex.org/W2125272907","https://openalex.org/W2125624587","https://openalex.org/W2126547041","https://openalex.org/W2126592113","https://openalex.org/W2127375515","https://openalex.org/W2129179898","https://openalex.org/W2130132916","https://openalex.org/W2132549450","https://openalex.org/W2133137653","https://openalex.org/W2135217219","https://openalex.org/W2137028096","https://openalex.org/W2139834641","https://openalex.org/W2140192657","https://openalex.org/W2140777158","https://openalex.org/W2141363931","https://openalex.org/W2142452255","https://openalex.org/W2144525814","https://openalex.org/W2145265693","https://openalex.org/W2145498419","https://openalex.org/W2147329254","https://openalex.org/W2147868795","https://openalex.org/W2149409837","https://openalex.org/W2150709240","https://openalex.org/W2153117421","https://openalex.org/W2155126124","https://openalex.org/W2156353972","https://openalex.org/W2157337717","https://openalex.org/W2157739430","https://openalex.org/W2158158671","https://openalex.org/W2159047663","https://openalex.org/W2159570963","https://openalex.org/W2160234571","https://openalex.org/W2161641259","https://openalex.org/W2162028789","https://openalex.org/W2164418602","https://openalex.org/W2165252181","https://openalex.org/W2168149788","https://openalex.org/W2168505877","https://openalex.org/W2169171744","https://openalex.org/W2170772645","https://openalex.org/W2179274119","https://openalex.org/W2211873152","https://openalex.org/W2398746253","https://openalex.org/W4244503335","https://openalex.org/W4245974900"],"related_works":["https://openalex.org/W1998802885","https://openalex.org/W2032566775","https://openalex.org/W1997022650","https://openalex.org/W2162028789","https://openalex.org/W7126006009","https://openalex.org/W2057659922","https://openalex.org/W6940865342","https://openalex.org/W1997008557","https://openalex.org/W2035871389","https://openalex.org/W2008157469"],"abstract_inverted_index":{"Beta":[0],"cell":[1,39,49,121,228,261,697],"functionality":[2,50,698],"is":[3,51,139,153,188,207,254,392,452,463,506,571,623,636,655],"often":[4],"characterised":[5],"by":[6,648],"indices":[7,262,266],"describing":[8,122],"different":[9,64,75,129,421,552],"phases":[10,65],"of":[11,37,44,56,66,82,104,113,162,170,185,193,195,211,287,301,315,348,369,372,382,388,429,477,517,532,582,588,604,621,658,666,671],"insulin":[12,17,67,83,130,176,186,268,364,462,478,490,553,559,577,622],"secretion.":[13],"The":[14,133,427,539,586],"typical":[15],"biphasic":[16],"secretion":[18,68,84,131,177,187,476],"pattern":[19],"observed":[20],"with":[21,78,242,293,318,384,410,445,535,545,606,642],"a":[22,57,106,111,198,238,271,284,298,436,510,593,613,629,656,705],"square":[23],"wave":[24],"glucose":[25,115,146,155,196,222,304,343,376,390,433,469,481,504,518,540,563,569,667,672,702],"stimulation":[26],"has":[27,470,482],"laid":[28],"the":[29,42,47,63,74,79,88,93,98,114,119,123,128,140,145,163,168,174,182,191,204,221,226,246,255,309,312,316,329,338,340,349,360,367,370,373,379,389,402,405,408,430,440,453,457,460,488,503,515,521,529,533,543,562,580,583,589,598,659,663],"foundation":[30],"for":[31,258,267,337,456,542],"most":[32],"modelling":[33],"work":[34],"regarding":[35],"quantification":[36],"beta":[38,48,120,227,260,696],"function.":[40],"Within":[41],"context":[43,277],"control":[45,76,90,100,665],"theory,":[46],"usually":[52],"modelled":[53],"as":[54,235,237,263,265,512,699,701],"versions":[55],"classic":[58,239],"Proportional-Integral-Differential":[59],"(PID)":[60],"controller,":[61,241],"and":[62,92,172,202,290,327,419,487,555,631,669],"are":[69,352,398,424,691],"described":[70],"in":[71,118,144,197,225,230,245,270,311,359,497,508,625,640,662,704],"relation":[72],"to":[73,87,97,190,209,216,308,324,472,484,494,513,575,596,650,678,685,688,694],"component,":[77,91],"first":[80,183],"phase":[81,96,184,206],"being":[85],"related":[86,189],"differential":[89],"second":[94,205],"(late)":[95],"integral":[99],"component.":[101],"This":[102],"is,":[103],"course,":[105],"phenomenological":[107],"description.":[108],"We":[109,149,179,646],"propose":[110],"model":[112,134],"sensing":[116,147,223,247],"mechanisms":[117,224],"timedependent":[124],"physiological":[125,706],"processes":[126],"underlying":[127],"phases.":[132],"results":[135,397],"show":[136,180],"that":[137,151,166,181,203,276,455,502,558,612,615,632,652,683,690],"glucokinase":[138,212],"key":[141],"regulatory":[142],"step":[143],"mechanisms.":[148],"argue":[150],"it":[152,500,556],"not":[154,492],"per":[156],"se,":[157],"but":[158],"some":[159,231],"signal(s)":[160],"downstream":[161],"glycolytic":[164],"pathway":[165],"controls":[167],"activity":[169],"glucokinase,":[171],"hence":[173,475],"final":[175],"pattern.":[178],"rate":[192,516],"change":[194],"non-linear":[199],"saturable":[200],"fashion,":[201],"due":[208,574],"translocation":[210],"from":[213,283,291,346,404,439,443,520,528,602],"an":[214,217,680],"inactive":[215],"active":[218],"state.":[219],"Hence,":[220,674],"can,":[229],"sense,":[232],"be":[233,526,679,686],"regarded":[234],"working":[236],"PID":[240],"intrinsic":[243],"non-linearities":[244],"machinery.":[248],"A":[249],"meal":[250,530,584,630],"tolerance":[251],"test":[252,257],"(MTT)":[253],"best":[256],"assessing":[259],"well":[264,700],"action":[269],"physioloigcal":[272],"relevant":[273,707],"setting.":[274,708],"In":[275],"we":[278,320],"have":[279,414],"analysed":[280],"MTT":[281,590],"data":[282,403,591],"large":[285,357],"population":[286],"healthy":[288,432,458,498,599,626],"subjects":[289,292,317,330,383,409,444,499,534,544],"type":[294,411,446,536,546,643],"2":[295,412,447,537,547,644],"diabetes":[296,413,548],"displaying":[297],"wide":[299],"range":[300],"fasting":[302,473,485],"plasma":[303,342,363,461,468],"(FPG)":[305],"concentrations.":[306],"Due":[307],"heterogeneity":[310],"FPG":[313,326],"values":[314],"diabetes,":[319,385],"stratified":[321],"them":[322],"according":[323],"their":[325],"divided":[328],"into":[331],"five":[332,350],"groups.":[333],"Interestingly,":[334],"when":[335,400],"correcting":[336],"FPG,":[339],"mean":[341,362,431],"concentration":[344,578,668],"profiles":[345,377,391,531,541],"each":[347],"groups":[351,381],"strikingly":[353],"similar,":[354],"despite":[355,480,551],"quite":[356],"differences":[358],"corresponding":[361,441],"profiles.":[365],"From":[366],"graphs":[368,442],"means":[371],"differentiated":[374],"individual":[375],"within":[378],"respective":[380],"this":[386,633,653],"similarity":[387],"even":[393,466],"more":[394,617],"evident.":[395],"Same":[396],"obtained":[399],"analysing":[401],"database,":[406],"where":[407,420],"been":[415],"followed":[416],"throughout":[417],"years,":[418],"standard":[422],"treatments":[423],"also":[425],"present.":[426],"graph":[428],"profile":[434,564],"shows":[435],"clear":[437],"distinction":[438],"diabetes.":[448,538,607,645],"Of":[449],"special":[450],"interest":[451],"observation":[454],"persons":[459,627,641],"still":[464],"high":[465],"though":[467],"returned":[471,483],"values,":[474,486],"continues":[479],"increased":[489],"does":[491],"lead":[493],"hypoglycaemia.":[495],"Hence":[496],"appears":[501,557],"uptake":[505,703],"controlled":[507],"such":[509],"way":[511],"follow":[514],"appearance":[519],"meal.":[522],"Similar":[523],"conclusions":[524],"cannot":[525],"drawn":[527],"seem":[549,677],"similar":[550],"profiles,":[554],"merely":[560],"follows":[561],"without":[565],"controlling":[566],"it.":[567],"However":[568],"undershoot":[570],"observed,":[572],"probably":[573],"elevated":[576],"at":[579],"end":[581],"test.":[585],"analysis":[587,610],"provides":[592],"new":[594],"tool":[595],"distinguish":[597],"after-meal":[600],"responses":[601,603],"people":[605],"Furthermore":[608],"our":[609],"indicates":[611],"mechanism":[614,634,654],"works":[616],"or":[618],"less":[619],"independent":[620],"activated":[624],"after":[628],"apparently":[635],"damaged":[637],"and/or":[638],"diminished":[639],"argue,":[647],"referring":[649],"literature,":[651],"result":[657],"brain":[660],"participating":[661],"overall":[664],"fluxes":[670],"equivalents.":[673],"neural":[675],"effects":[676],"important":[681],"component":[682],"needs":[684],"added":[687],"models":[689],"set":[692],"up":[693],"describe":[695]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}