{"id":"https://openalex.org/W2134672249","doi":"https://doi.org/10.4172/2169-0111.1000e108","title":"Genome Editing with ZFN, TALEN and CRISPR/Cas Systems:The Applications and Future Prospects","display_name":"Genome Editing with ZFN, TALEN and CRISPR/Cas Systems:The Applications and Future Prospects","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2134672249","doi":"https://doi.org/10.4172/2169-0111.1000e108","mag":"2134672249"},"language":"en","primary_location":{"id":"doi:10.4172/2169-0111.1000e108","doi":"https://doi.org/10.4172/2169-0111.1000e108","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2169-0111.1000e108","pdf_url":null,"source":{"id":"https://openalex.org/S2764887458","display_name":"Advancements in Genetic Engineering","issn_l":"2169-0111","issn":["2169-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advancements in Genetic Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101444238","display_name":"Youming Zhang","orcid":"https://orcid.org/0000-0001-5403-4044","observed_orcids":["https://orcid.org/0000-0001-5403-4044"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Youming Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101444238"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1366,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51288479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"03","issue":"01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.9990000128746033},{"id":"https://openalex.org/keywords/zinc-finger-nucleases","display_name":"zinc finger nucleases","score":0.9480000138282776},{"id":"https://openalex.org/keywords/transcription-activator-like-effector-nucleases","display_name":"TALEN","score":0.949999988079071},{"id":"https://openalex.org/keywords/crispr-cas-systems","display_name":"CRISPR-Cas","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.9138836860656738},{"id":"https://openalex.org/C31909778","wikidata":"https://www.wikidata.org/wiki/Q7833921","display_name":"Transcription activator-like effector nuclease","level":5,"score":0.9138220548629761},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.9092768430709839},{"id":"https://openalex.org/C35802184","wikidata":"https://www.wikidata.org/wiki/Q204773","display_name":"Zinc finger nuclease","level":5,"score":0.8066110014915466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6685128211975098},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.560172975063324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5459529161453247},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.43038415908813477},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3436475694179535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32865631580352783}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4172/2169-0111.1000e108","doi":"https://doi.org/10.4172/2169-0111.1000e108","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2169-0111.1000e108","pdf_url":null,"source":{"id":"https://openalex.org/S2764887458","display_name":"Advancements in Genetic Engineering","issn_l":"2169-0111","issn":["2169-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advancements in Genetic Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1978359174","https://openalex.org/W1982969769","https://openalex.org/W1984582197","https://openalex.org/W2009626008","https://openalex.org/W2019670881","https://openalex.org/W2020701293","https://openalex.org/W2028369290","https://openalex.org/W2036632122","https://openalex.org/W2060346254","https://openalex.org/W2072705248","https://openalex.org/W2099106733","https://openalex.org/W2102573752","https://openalex.org/W2112444085","https://openalex.org/W2112961046","https://openalex.org/W2121950548","https://openalex.org/W2138231299","https://openalex.org/W2151214732","https://openalex.org/W2160051211","https://openalex.org/W2167861050","https://openalex.org/W2168357216","https://openalex.org/W2170039745"],"related_works":["https://openalex.org/W2326883628","https://openalex.org/W627210887","https://openalex.org/W3217788105","https://openalex.org/W2984587971","https://openalex.org/W2256899836","https://openalex.org/W2016392433","https://openalex.org/W4408003856","https://openalex.org/W2315465482","https://openalex.org/W2988848400","https://openalex.org/W2371638901"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}