{"id":"https://openalex.org/W2134609303","doi":"https://doi.org/10.1002/anie.200703367","title":"Interactions with Hydrophobic Clusters in the Urea\u2010Unfolded Membrane Protein OmpX","display_name":"Interactions with Hydrophobic Clusters in the Urea\u2010Unfolded Membrane Protein OmpX","publication_year":2007,"publication_date":"2007-12-27","ids":{"openalex":"https://openalex.org/W2134609303","doi":"https://doi.org/10.1002/anie.200703367","mag":"2134609303","pmid":"https://pubmed.ncbi.nlm.nih.gov/18161715"},"language":"en","primary_location":{"id":"doi:10.1002/anie.200703367","doi":"https://doi.org/10.1002/anie.200703367","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200703367","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060213327","display_name":"Sebastian Hiller","orcid":"https://orcid.org/0000-0002-6709-4684","observed_orcids":["https://orcid.org/0000-0002-6709-4684"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sebastian Hiller","raw_affiliation_strings":["Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland","Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland, Fax: (+41)\u2009446-331-151"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]},{"raw_affiliation_string":"Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland, Fax: (+41)\u2009446-331-151","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036728793","display_name":"Gerhard Wider","orcid":"https://orcid.org/0000-0001-9366-7645","observed_orcids":["https://orcid.org/0000-0001-9366-7645"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gerhard Wider","raw_affiliation_strings":["Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland, Fax: (+41)\u2009446-331-151"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland, Fax: (+41)\u2009446-331-151","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029745888","display_name":"Lukas Imbach","orcid":"https://orcid.org/0000-0002-6135-8642","observed_orcids":["https://orcid.org/0000-0002-6135-8642"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas\u2005L. Imbach","raw_affiliation_strings":["Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland,","Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland, Fax: (+41)\u2009446-331-151"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland,","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]},{"raw_affiliation_string":"Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland, Fax: (+41)\u2009446-331-151","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000254356","display_name":"Kurt W\u00fcthrich A","orcid":"https://orcid.org/0000-0001-8739-6965","observed_orcids":["https://orcid.org/0000-0001-8739-6965","https://orcid.org/0000-0003-2612-6616"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Kurt W\u00fcthrich","raw_affiliation_strings":["Further address: Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland, Fax: (+41)\u2009446\u2010331\u2010151"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Further address: Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland, Fax: (+41)\u2009446\u2010331\u2010151","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":0.6618,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.670398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"47","issue":"5","first_page":"977","last_page":"981"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.30790001153945923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ompx","display_name":"OmpX","score":0.9789999723434448},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.7889999747276306},{"id":"https://openalex.org/keywords/urea-induced-unfolding","display_name":"urea-induced unfolding","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hydrophobic-clusters","display_name":"hydrophobic clusters","score":0.8029999732971191},{"id":"https://openalex.org/keywords/protein-denaturation","display_name":"protein denaturation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/protein-folding-mechanism","display_name":"protein folding mechanism","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.6522647738456726},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.643397331237793},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.6113402843475342},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5294577479362488},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5234541296958923},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.43271148204803467},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.42422887682914734},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.40008193254470825},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35925304889678955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3511374592781067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18783041834831238},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15156415104866028},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08549520373344421},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006867","descriptor_name":"Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D010742","descriptor_name":"Phospholipid Ethers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012015","descriptor_name":"Reference Standards","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/anie.200703367","doi":"https://doi.org/10.1002/anie.200703367","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200703367","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:18161715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18161715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1491642680","https://openalex.org/W1580614613","https://openalex.org/W1966309781","https://openalex.org/W1970351230","https://openalex.org/W1977215032","https://openalex.org/W1982006129","https://openalex.org/W1992819425","https://openalex.org/W1995291690","https://openalex.org/W1996222219","https://openalex.org/W1996518756","https://openalex.org/W2003119577","https://openalex.org/W2005859698","https://openalex.org/W2015737242","https://openalex.org/W2017505620","https://openalex.org/W2021288400","https://openalex.org/W2021807096","https://openalex.org/W2040001997","https://openalex.org/W2050728065","https://openalex.org/W2052933818","https://openalex.org/W2054715902","https://openalex.org/W2062999231","https://openalex.org/W2070653598","https://openalex.org/W2071934645","https://openalex.org/W2078394309","https://openalex.org/W2082148481","https://openalex.org/W2088706964","https://openalex.org/W2092071120","https://openalex.org/W2092818861","https://openalex.org/W2128744164","https://openalex.org/W2155147384","https://openalex.org/W2949250147","https://openalex.org/W4243410897"],"related_works":["https://openalex.org/W2167053991","https://openalex.org/W2024981703","https://openalex.org/W2050728065","https://openalex.org/W2008302036","https://openalex.org/W1580614613","https://openalex.org/W2116512250","https://openalex.org/W1964778879","https://openalex.org/W2160472383","https://openalex.org/W2333694243","https://openalex.org/W2019352367"],"abstract_inverted_index":{"A":[0],"denatured":[1],"membrane":[2],"protein":[3,47],"in":[4,18],"8":[5],"M":[6],"urea":[7],"was":[8],"characterized.":[9],"Two":[10],"hydrophobic":[11],"clusters,":[12],"separated":[13],"by":[14],"50":[15],"amino":[16],"acids":[17],"the":[19,35],"polypeptide":[20],"chain,":[21],"are":[22,38],"shown":[23],"to":[24,27],"bind":[25],"independently":[26],"detergent":[28],"micelles":[29],"(see":[30],"picture).":[31],"Long-range":[32],"interactions":[33],"between":[34],"two":[36],"clusters":[37],"not":[39],"observed.":[40],"These":[41],"observations":[42],"provide":[43],"new":[44],"insights":[45],"into":[46],"folding":[48],"mechanisms.":[49]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}