{"id":"https://openalex.org/W2134592992","doi":"https://doi.org/10.2337/diabetes.53.6.1445","title":"Role of Adipocyte-Derived Factors in Enhancing Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Mice Lacking Acyl CoA:Diacylglycerol Acyltransferase 1","display_name":"Role of Adipocyte-Derived Factors in Enhancing Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Mice Lacking Acyl CoA:Diacylglycerol Acyltransferase 1","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2134592992","doi":"https://doi.org/10.2337/diabetes.53.6.1445","mag":"2134592992","pmid":"https://pubmed.ncbi.nlm.nih.gov/15161747"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.53.6.1445","doi":"https://doi.org/10.2337/diabetes.53.6.1445","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.53.6.1445","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/53/6/1445/376720/zdb00604001445.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/53/6/1445/376720/zdb00604001445.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043239657","display_name":"Hubert C. Chen","orcid":"https://orcid.org/0000-0002-7599-7218","observed_orcids":["https://orcid.org/0000-0002-7599-7218"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hubert C. Chen","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, California","Department of Medicine, University of California, San Francisco, California","Gladstone Institute of Cardiovascular Disease, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, San Francisco, California","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110904643","display_name":"Meghana Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghana Rao","raw_affiliation_strings":["Gladstone Institute of Cardiovascular Disease, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, San Francisco, California","institution_ids":["https://openalex.org/I1321430492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062938574","display_name":"Mini P. Sajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mini P. Sajan","raw_affiliation_strings":["Department of Medicine, University of South Florida, Tampa, Florida","James A. Haley Veterans Hospital, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"James A. Haley Veterans Hospital, Tampa, Florida","institution_ids":["https://openalex.org/I4210088910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036492033","display_name":"Mary L. Standaert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Standaert","raw_affiliation_strings":["Department of Medicine, University of South Florida, Tampa, Florida","James A. Haley Veterans Hospital, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"James A. Haley Veterans Hospital, Tampa, Florida","institution_ids":["https://openalex.org/I4210088910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036738100","display_name":"Yoshinori Kanoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshinori Kanoh","raw_affiliation_strings":["Department of Medicine, University of South Florida, Tampa, Florida","James A. Haley Veterans Hospital, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"James A. Haley Veterans Hospital, Tampa, Florida","institution_ids":["https://openalex.org/I4210088910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113007234","display_name":"Atsushi Miura","orcid":"https://orcid.org/0000-0002-4273-1026","observed_orcids":["https://orcid.org/0000-0002-4273-1026"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atsushi Miura","raw_affiliation_strings":["Department of Medicine, University of South Florida, Tampa, Florida","James A. Haley Veterans Hospital, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"James A. Haley Veterans Hospital, Tampa, Florida","institution_ids":["https://openalex.org/I4210088910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083674919","display_name":"Robert V. Farese","orcid":"https://orcid.org/0000-0001-8103-2239","observed_orcids":["https://orcid.org/0000-0001-8103-2239"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert V. Farese","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, California","Department of Medicine, University of California, San Francisco, California","Department of Medicine, University of South Florida, Tampa, Florida","Gladstone Institute of Cardiovascular Disease, San Francisco, California","James A. Haley Veterans Hospital, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, San Francisco, California","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"James A. Haley Veterans Hospital, Tampa, Florida","institution_ids":["https://openalex.org/I4210088910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083674919","display_name":"Robert V. Farese","orcid":"https://orcid.org/0000-0001-8103-2239","observed_orcids":["https://orcid.org/0000-0001-8103-2239"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert V. Farese","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, California","Department of Medicine, University of California, San Francisco, California","Department of Medicine, University of South Florida, Tampa, Florida","Gladstone Institute of Cardiovascular Disease, San Francisco, California","James A. Haley Veterans Hospital, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Gladstone Institute of Cardiovascular Disease, San Francisco, California","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"James A. Haley Veterans Hospital, Tampa, Florida","institution_ids":["https://openalex.org/I4210088910"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0977,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.87928136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"6","first_page":"1445","last_page":"1451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.4560999870300293,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.4560999870300293,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.44209998846054077,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dgat1","display_name":"DGAT1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7609999775886536},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.6060000061988831},{"id":"https://openalex.org/keywords/glucose-transport","display_name":"glucose transport","score":0.7770000100135803},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9110000133514404},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.9990000128746033},{"id":"https://openalex.org/keywords/triacylglycerol-biosynthesis","display_name":"triglyceride synthesis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/irs-1-serine-phosphorylation","display_name":"IRS-1 serine phosphorylation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/pkc-lambda","display_name":"PKC lambda","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/adipose-tissue-transplantation","display_name":"adipose tissue transplantation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9309999942779541},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8745085597038269},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8633854389190674},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.8026584386825562},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6739641427993774},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.5944558382034302},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.590814471244812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5416117310523987},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5225212574005127},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.5144405961036682},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4839501678943634},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.4824581742286682},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.482316255569458},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4528138041496277},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.4521957337856293},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4389514923095703},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4252226948738098},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.39147183299064636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15727826952934265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11818590760231018}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051048","descriptor_name":"Diacylglycerol O-Acyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diabetes.53.6.1445","doi":"https://doi.org/10.2337/diabetes.53.6.1445","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.53.6.1445","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/53/6/1445/376720/zdb00604001445.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:15161747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15161747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1025.5147","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1025.5147","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/diabetes/53/6/1445.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/diabetes.53.6.1445","doi":"https://doi.org/10.2337/diabetes.53.6.1445","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.53.6.1445","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/53/6/1445/376720/zdb00604001445.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2003719314","display_name":"LIPID REGULATED KINASES IN INSULIN ACTION","funder_award_id":"R01DK038079","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2575194627","display_name":"Mediators of Pulmonary Vasodilatation in Liver Disease","funder_award_id":"R01DK056804","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4692166286","display_name":"Role of DGAT in Triacyglycerol Metabolism","funder_award_id":"R01DK056084","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4836743404","display_name":"Activation of Atypical PKC by Insulin and Other Agonists","funder_award_id":"R01DK065969","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8194967104","display_name":"Increased leptin sensitivity in Dgat -/- mice","funder_award_id":"K08DK061363","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2134592992.pdf","grobid_xml":"https://content.openalex.org/works/W2134592992.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1580646470","https://openalex.org/W1587875569","https://openalex.org/W1596759199","https://openalex.org/W1649021695","https://openalex.org/W1773423156","https://openalex.org/W1973186908","https://openalex.org/W1977795081","https://openalex.org/W2010895424","https://openalex.org/W2022047218","https://openalex.org/W2035187068","https://openalex.org/W2038018821","https://openalex.org/W2038715027","https://openalex.org/W2039481955","https://openalex.org/W2043106623","https://openalex.org/W2046766433","https://openalex.org/W2053073281","https://openalex.org/W2065620282","https://openalex.org/W2067096633","https://openalex.org/W2069623607","https://openalex.org/W2102683312","https://openalex.org/W2126317966","https://openalex.org/W2142831736","https://openalex.org/W2157843109","https://openalex.org/W2168224573","https://openalex.org/W2169731368","https://openalex.org/W2171968999","https://openalex.org/W2320835784","https://openalex.org/W2323664431","https://openalex.org/W2327640792"],"related_works":["https://openalex.org/W7097091374","https://openalex.org/W2169731368","https://openalex.org/W2168793854","https://openalex.org/W2157843109","https://openalex.org/W2142416266","https://openalex.org/W2090893930","https://openalex.org/W2013083923","https://openalex.org/W2113795181","https://openalex.org/W2033396762","https://openalex.org/W4244906287"],"abstract_inverted_index":{"Mice":[0],"that":[1,25,134,149,169],"lack":[2],"acyl":[3],"CoA:diacylglycerol":[4],"acyltransferase":[5],"1":[6,85],"(DGAT1),":[7],"a":[8,87,105],"key":[9,68],"enzyme":[10],"in":[11,31,46,70,90,95,101,121,142,155,161,173],"mammalian":[12],"triglyceride":[13],"synthesis,":[14],"have":[15],"decreased":[16,78,114],"adiposity":[17],"and":[18,35,62,74,113,159],"increased":[19,30,110],"insulin":[20,82,91,96,153,171],"sensitivity.":[21],"Here":[22],"we":[23],"show":[24],"insulin-stimulated":[26,52],"glucose":[27,47,140],"transport":[28,48],"is":[29],"the":[32,71,109,156],"skeletal":[33,157],"muscle":[34,158],"white":[36],"adipose":[37],"tissue":[38],"(WAT)":[39],"of":[40,54,80,117,136,166],"chow-fed":[41,122],"DGAT1-deficient":[42,102,127,137],"mice.":[43,145],"This":[44],"increase":[45],"correlated":[49],"with":[50,77,126,130],"enhanced":[51],"activities":[53],"phosphatidylinositol":[55],"3-kinase,":[56],"protein":[57,63],"kinase":[58,64],"B":[59],"(or":[60],"Akt),":[61],"Clambda":[65],"(PKC-lambda),":[66],"three":[67],"molecules":[69],"insulin-signaling":[72],"pathway,":[73],"was":[75],"associated":[76],"levels":[79],"serine-phosphorylated":[81],"receptor":[83],"substrate":[84],"(IRS-1),":[86],"molecule":[88],"implicated":[89],"resistance.":[92],"Similar":[93],"findings":[94,147],"signaling":[97,154,172],"were":[98,119],"also":[99],"observed":[100,120],"mice":[103,124],"fed":[104],"high-fat":[106],"diet.":[107],"Interestingly,":[108],"PKC-lambda":[111],"activity":[112],"serine":[115],"phosphorylation":[116],"IRS-1":[118],"wild-type":[123,143],"transplanted":[125],"WAT,":[128,160],"consistent":[129],"our":[131],"previous":[132],"finding":[133],"transplantation":[135],"WAT":[138],"enhances":[139,152],"disposal":[141],"recipient":[144],"Our":[146],"demonstrate":[148],"DGAT1":[150],"deficiency":[151],"part":[162],"through":[163],"altered":[164],"expression":[165],"adipocyte-derived":[167],"factors":[168],"modulate":[170],"peripheral":[174],"tissues.":[175]},"counts_by_year":[{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}