{"id":"https://openalex.org/W2134592697","doi":null,"title":"Radiation related prognostic factors in radiation oncology.","display_name":"Radiation related prognostic factors in radiation oncology.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2134592697","mag":"2134592697","pmid":"https://pubmed.ncbi.nlm.nih.gov/10726610"},"language":"en","primary_location":{"id":"pmid:10726610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10726610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gynaecological oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113609776","display_name":"Berend J. Smit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]},{"id":"https://openalex.org/I2802694459","display_name":"Tygerberg Hospital","ror":"https://ror.org/01hs8x754","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802694459"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"B J Smit","raw_affiliation_strings":["University of Stellenbosch and Tygerberg Hospital, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Stellenbosch and Tygerberg Hospital, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322","https://openalex.org/I2802694459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113609776"],"corresponding_institution_ids":["https://openalex.org/I26092322","https://openalex.org/I2802694459"],"apc_list":null,"apc_paid":null,"fwci":0.375,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64130612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"1","first_page":"7","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dose-fractionation","display_name":"dose fractionation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/biologically-effective-dose","display_name":"biologically effective dose","score":0.8259999752044678},{"id":"https://openalex.org/keywords/alpha-beta-ratio","display_name":"alpha/beta ratio","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-repopulation","display_name":"tumor repopulation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.5479999780654907},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"therapeutic index","score":0.5339999794960022},{"id":"https://openalex.org/keywords/dose-per-fraction","display_name":"dose per fraction","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8118176460266113},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5718377828598022},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.534545361995697},{"id":"https://openalex.org/C2908786992","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Hyperfractionation","level":4,"score":0.5136205554008484},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.5031542181968689},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.49079665541648865},{"id":"https://openalex.org/C97428945","wikidata":"https://www.wikidata.org/wiki/Q15305109","display_name":"Fractionation","level":2,"score":0.4818064570426941},{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.44457584619522095},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3263961672782898},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.3050730526447296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27390867471694946},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018787","descriptor_name":"Radiation Oncology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:10726610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10726610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gynaecological oncology","raw_type":"Journal Article"},{"id":"pmh:oai:scholar.sun.ac.za:10019.1/13734","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/13734","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Note"},{"id":"pmh:oai:scholar.sun.ac.za:10019.1/72299","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/72299","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Articles (subsidised)"},{"id":"mag:2134592697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10726610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2148117492","https://openalex.org/W2050145840","https://openalex.org/W2160552840","https://openalex.org/W2027501539","https://openalex.org/W2208096546","https://openalex.org/W2005911101","https://openalex.org/W4383993625","https://openalex.org/W2004764331","https://openalex.org/W2042330759","https://openalex.org/W2129299671"],"abstract_inverted_index":{"1.":[0],"The":[1,16,100,116,176],"outcome":[2],"of":[3,6,30,56,78,114,149,163,178,244,306],"a":[4,23,46,52,69,106,144,261],"course":[5],"radiotherapy":[7],"is":[8,40,105,123,128,266],"very":[9,199],"dependent":[10],"on":[11],"the":[12,18,26,28,31,54,76,112,121,124,179,190,204,231,241,252,269,273,278,307],"dose":[13,19,193],"per":[14,20,59,86,93],"fraction.":[15],"smaller":[17,288],"fraction,":[21],"as":[22,66,68,268],"general":[24],"rule,":[25],"better":[27],"sparing":[29],"late":[32,63,166],"reacting":[33,64],"normal":[34,169],"tissues.":[35],"2.":[36],"Overall":[37],"treatment":[38,72],"time":[39,73],"important,":[41],"especially":[42],"for":[43,133,151,156,165,183,187,272],"tumours":[44,135],"with":[45,213],"rapid":[47],"doubling":[48],"time.":[49],"In":[50],"such":[51],"case,":[53],"ideal":[55],"small":[57,84,247],"doses":[58,85],"fraction":[60,87,285],"(to":[61,74],"save":[62],"tissues)":[65],"well":[67],"short":[70],"overall":[71],"offset":[75],"effect":[77],"repopulating)":[79],"can":[80,139,172],"be":[81,140,173,219],"achieved":[82],"by":[83,211],"applied":[88],"two":[89],"to":[90,108,195,218,222,311],"three":[91],"times":[92],"day,":[94],"including":[95],"Saturdays":[96],"or":[97],"weekends.":[98],"3.":[99],"BED":[101,180],"(biologically":[102],"effective":[103],"dose)":[104],"simple":[107],"use":[109],"formula":[110,122],"indicating":[111],"effects":[113,167],"fractionation.":[115],"most":[117],"important":[118],"term":[119],"in":[120,260,304],"alpha/beta":[125,147,161],"ratio":[126,148,162,309],"which":[127,298],"available":[129],"from":[130],"experimental":[131],"work":[132],"many":[134],"and":[136,138,155,159,227,238,277,313],"tissues":[137],"looked":[141],"up.":[142],"As":[143],"guide,":[145],"an":[146,160,300],"10":[150],"early":[152],"(acute)":[153],"reaction":[154],"tumour":[157],"effects,":[158],"2":[164],"plus":[168],"tissue":[170],"complications":[171],"used.":[174],"4.":[175],"application":[177],"demonstrates":[181],"that":[182],"HDR":[184],"intracavitary":[185],"therapy":[186],"cervical":[188],"carcinoma,":[189],"biologically":[191],"relevant":[192],"lateral":[194],"point":[196,293],"M(A)":[197],"falls":[198],"much":[200],"more":[201,232],"rapidly":[202],"than":[203,289],"nominal":[205],"dose.":[206],"Line":[207],"sources":[208],"are":[209],"shown":[210],"comparison":[212],"other":[214],"published":[215],"reports,":[216],"not":[217,236],"intrinsically":[220],"inferior":[221],"tandem":[223],"ring/tandem":[224],"ovoid":[225],"systems":[226,234],"may":[228,239],"have":[229,240],"advantages":[230],"cumbersome":[233],"do":[235],"have,":[237],"large":[242],"advantage":[243],"allowing":[245],"multiple":[246],"fractions":[248],"without":[249],"anaesthesia.":[250],"For":[251],"particular":[253,282],"line":[254],"source":[255],"system":[256,283],"under":[257],"discussion,":[258],"water":[259],"40":[262],"cm3":[263],"Foleys":[264],"bulb":[265],"used":[267],"protecting":[270],"medium":[271],"posterior":[274],"bladder":[275],"wall":[276],"anterior":[279],"rectum.":[280],"This":[281],"allows":[284],"sizes":[286],"far":[287],"9.1":[290],"Gy":[291],"at":[292],"(M)A,":[294],"e.g.":[295],"3":[296],"Gy,":[297],"bestows":[299],"even":[301],"greater":[302],"benefit":[303],"terms":[305],"therapeutic":[308],"according":[310],"BED10":[312],"BED2":[314],"calculations.":[315]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}