{"id":"https://openalex.org/W2134591303","doi":null,"title":"Time to castration resistance is an independent predictor of castration-resistant prostate cancer survival.","display_name":"Time to castration resistance is an independent predictor of castration-resistant prostate cancer survival.","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2134591303","mag":"2134591303","pmid":"https://pubmed.ncbi.nlm.nih.gov/21508406"},"language":"en","primary_location":{"id":"pmid:21508406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21508406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029860089","display_name":"Evangelos Bournakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelos Bournakis","raw_affiliation_strings":["Department of Clinical Therapeutics, The University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Therapeutics, The University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078910130","display_name":"Eleni Efstathiou","orcid":"https://orcid.org/0000-0002-3868-1396","observed_orcids":["https://orcid.org/0000-0002-3868-1396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleni Efstathiou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039296588","display_name":"Andreas S. Varkaris","orcid":"https://orcid.org/0000-0001-5776-8844","observed_orcids":["https://orcid.org/0000-0001-5776-8844"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Varkaris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040146877","display_name":"Sijin Wen","orcid":"https://orcid.org/0000-0002-6955-2917","observed_orcids":["https://orcid.org/0000-0002-6955-2917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sijin Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043010453","display_name":"Michael Chrisofos","orcid":"https://orcid.org/0000-0003-1688-005X","observed_orcids":["https://orcid.org/0000-0003-1688-005X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Chrisofos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053732212","display_name":"Charalambos Deliveliotis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charalambos Deliveliotis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113490883","display_name":"Christos Alamanis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christos Alamanis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110698679","display_name":"Ioannis P. Anastasiou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioannis Anastasiou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112150481","display_name":"Constantine A. Constantinides","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Constantine Constantinides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045869380","display_name":"Aristotelis Bamias","orcid":"https://orcid.org/0000-0002-5996-7262","observed_orcids":["https://orcid.org/0000-0002-5996-7262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aristotelis Bamias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033573338","display_name":"Meletios Athanasios Dimopoulos","orcid":"https://orcid.org/0000-0001-8990-3254","observed_orcids":["https://orcid.org/0000-0001-8990-3254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meletios A Dimopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5438,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.74595329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"31","issue":"4","first_page":"1475","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/time-to-castration-resistance","display_name":"time to castration resistance","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7749999761581421},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7979999780654907},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.7459999918937683},{"id":"https://openalex.org/keywords/psa-response","display_name":"PSA response","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.8765366077423096},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8615713119506836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8043057918548584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6939409971237183},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6488638520240784},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5028528571128845},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4908183515071869},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.42859864234924316},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3436783254146576}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21508406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21508406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2134591303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21508406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1680048361","https://openalex.org/W1705165894","https://openalex.org/W1990949011","https://openalex.org/W1993251988","https://openalex.org/W2038820904","https://openalex.org/W2058825665","https://openalex.org/W2080439368","https://openalex.org/W2112304044","https://openalex.org/W2116458141","https://openalex.org/W2117783793","https://openalex.org/W2120292596","https://openalex.org/W2142200772","https://openalex.org/W2144223323","https://openalex.org/W2145608595","https://openalex.org/W2227075123","https://openalex.org/W2285208736","https://openalex.org/W3011925872"],"related_works":["https://openalex.org/W4297494422","https://openalex.org/W2917793811","https://openalex.org/W1967055099","https://openalex.org/W3006793607","https://openalex.org/W243544667","https://openalex.org/W2284590989","https://openalex.org/W2921130169","https://openalex.org/W7154997700","https://openalex.org/W2344669089","https://openalex.org/W2603550842"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"Easily":[1],"assessable":[2],"clinical":[3,41],"predictors":[4,31,176],"of":[5,19,32,40,43,85,105,135,177,191,206],"response":[6],"to":[7,24,133,140,167,184],"chemotherapy":[8,202,207],"in":[9,47,88,193],"advanced":[10],"castration-resistant":[11],"prostate":[12,52],"cancer":[13,53],"(CRPC)":[14],"are":[15],"few.":[16],"The":[17],"objective":[18],"this":[20],"retrospective":[21,38],"study":[22],"was":[23,57,143,158],"search":[25],"for":[26,63,203],"and":[27,60,66,74,128,131,150,171,179],"identify":[28],"such":[29],"candidate":[30],"outcome.":[33],"PATIENTS":[34],"AND":[35],"METHODS:":[36],"A":[37],"analysis":[39,164],"data":[42],"CRPC":[44,134,204],"patients":[45,70,87],"entered":[46],"the":[48],"Clinical":[49],"Therapeutics'":[50],"departmental":[51],"database":[54,90],"from":[55],"1996-2009":[56],"performed.":[58],"Univariate":[59],"multivariate":[61],"analyses":[62],"progression-free":[64,152,180],"survival":[65,68,103,149,153,199],"overall":[67,148,178],"included":[69],"receiving":[71],"both":[72],"docetaxel-":[73],"non-docetaxel-containing":[75],"regimens.":[76],"RESULTS:":[77],"From":[78],"1996":[79],"until":[80],"June":[81],"2009,":[82],"286":[83],"out":[84],"313":[86],"our":[89],"were":[91],"treated":[92],"with":[93,101,145,160],"chemotherapy.":[94],"Prostate-specific":[95],"antigen":[96],"(PSA)":[97],"reduction":[98,196],">30%":[99,197],"correlated":[100],"improved":[102],"irrespective":[104],"treatment.":[106],"Beyond":[107],"previously":[108],"reported":[109],"predictors,":[110],"i.e.":[111],"baseline":[112],"PSA":[113,195],">30":[114],"ng/dl,":[115],"hemoglobin":[116],"below":[117],"10":[118],"mg/dl,":[119],"weight":[120],"loss,":[121],"poor":[122,147],"performance":[123],"status,":[124],"elevated":[125],"lactic":[126],"dehydrogenase":[127,170],"alkaline":[129,172],"phosphatase,":[130],"time":[132,166],"less":[136],"than":[137],"or":[138],"equal":[139],"two":[141],"years":[142],"associated":[144,159],"a":[146],"shorter":[151,161],"upon":[154],"univariate":[155],"analysis.":[156],"Pain":[157],"survival.":[162,181],"Multivariate":[163],"confirmed":[165],"CRPC,":[168],"lactate":[169],"phosphatase":[173],"as":[174],"independent":[175],"CONCLUSION:":[182],"Time":[183],"castration":[185],"resistance":[186],"is":[187],"an":[188],"important":[189],"predictor":[190],"outcome":[192],"CRPC.":[194],"predicts":[198],"improvement":[200],"following":[201],"regardless":[205],"applied.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}