{"id":"https://openalex.org/W2134533679","doi":"https://doi.org/10.1111/j.1460-9568.2008.06209.x","title":"Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia","display_name":"Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia","publication_year":2008,"publication_date":"2008-04-25","ids":{"openalex":"https://openalex.org/W2134533679","doi":"https://doi.org/10.1111/j.1460-9568.2008.06209.x","mag":"2134533679","pmid":"https://pubmed.ncbi.nlm.nih.gov/18445231","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738830"},"language":"en","primary_location":{"id":"doi:10.1111/j.1460-9568.2008.06209.x","doi":"https://doi.org/10.1111/j.1460-9568.2008.06209.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2008.06209.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738830","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037456393","display_name":"Steven P. Braithwaite","orcid":"https://orcid.org/0000-0003-0520-8823","observed_orcids":["https://orcid.org/0000-0003-0520-8823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven P. Braithwaite","raw_affiliation_strings":["AGY Therapeutics Inc, South San Francisco, CA 94080, USA. braiths@wyeth.com","AGY Therapeutics Inc, South San Francisco, CA 94080, USA","Wyeth Research, Princeton, NJ 08543, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGY Therapeutics Inc, South San Francisco, CA 94080, USA. braiths@wyeth.com","institution_ids":[]},{"raw_affiliation_string":"AGY Therapeutics Inc, South San Francisco, CA 94080, USA","institution_ids":[]},{"raw_affiliation_string":"Wyeth Research, Princeton, NJ 08543, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Xu","raw_affiliation_strings":["Child Study Center, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Study Center, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Leung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Leung","raw_affiliation_strings":["AGY Therapeutics Inc, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGY Therapeutics Inc, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047325624","display_name":"Roman Urfer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman Urfer","raw_affiliation_strings":["AGY Therapeutics Inc, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGY Therapeutics Inc, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075691839","display_name":"Karoly Nikolich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karoly Nikolich","raw_affiliation_strings":["AGY Therapeutics Inc, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGY Therapeutics Inc, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055599886","display_name":"Donna Oksenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donna Oksenberg","raw_affiliation_strings":["AGY Therapeutics Inc, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGY Therapeutics Inc, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080915093","display_name":"Paul J. Lombroso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Lombroso","raw_affiliation_strings":["Child Study Center, Yale University, New Haven, CT 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Study Center, Yale University, New Haven, CT 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079652069","display_name":"Mehrdad Shamloo","orcid":"https://orcid.org/0000-0003-4404-1755","observed_orcids":["https://orcid.org/0000-0003-4404-1755"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehrdad Shamloo","raw_affiliation_strings":["AGY Therapeutics Inc, South San Francisco, CA 94080, USA","Behavioral and Functional Neuroscience Laboratory, Neuroscience Institute, Stanford University, Palo Alto, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AGY Therapeutics Inc, South San Francisco, CA 94080, USA","institution_ids":[]},{"raw_affiliation_string":"Behavioral and Functional Neuroscience Laboratory, Neuroscience Institute, Stanford University, Palo Alto, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":1.096,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.75819998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"9","first_page":"2444","last_page":"2452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/striatal-enriched-protein-tyrosine-phosphatase","display_name":"striatal-enriched protein tyrosine phosphatase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/step","display_name":"STEP","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.984000027179718},{"id":"https://openalex.org/keywords/transient-middle-cerebral-artery-occlusion","display_name":"transient middle cerebral artery occlusion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/global-cerebral-ischemia","display_name":"global cerebral ischemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7350000143051147},{"id":"https://openalex.org/keywords/preconditioning","display_name":"preconditioning","score":0.8460000157356262},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.7680000066757202},{"id":"https://openalex.org/keywords/protein-dephosphorylation","display_name":"protein dephosphorylation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/synaptic-function","display_name":"synaptic function","score":0.4740000069141388},{"id":"https://openalex.org/keywords/ischemic-brain-injury","display_name":"ischemic brain injury","score":0.6439999938011169},{"id":"https://openalex.org/keywords/mrna-down-regulation","display_name":"mRNA down-regulation","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6913549304008484},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.606228232383728},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.603248655796051},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5650889873504639},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.5647791028022766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49974536895751953},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.47638481855392456},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4688509404659271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4323526620864868},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3955119252204895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37911370396614075},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34757840633392334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34644952416419983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3011627197265625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24481621384620667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12573912739753723}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054558","descriptor_name":"Protein Tyrosine Phosphatases, Non-Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1460-9568.2008.06209.x","doi":"https://doi.org/10.1111/j.1460-9568.2008.06209.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2008.06209.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:18445231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18445231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1503472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738830","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2738830","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738830","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Eur J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1503472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738830","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1617545833","display_name":null,"funder_award_id":"MH 52711","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5797098481","display_name":"Molecular and Cellular Analysis of Brain Enriched PTP's","funder_award_id":"R01MH052711","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G702483932","display_name":null,"funder_award_id":"MH01527","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7324967781","display_name":"Structural and Functional Analyses of Neuronal PTPs","funder_award_id":"K02MH001527","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W65530805","https://openalex.org/W127856909","https://openalex.org/W1499907682","https://openalex.org/W1616343296","https://openalex.org/W1896569873","https://openalex.org/W1974135000","https://openalex.org/W1976678881","https://openalex.org/W1980750700","https://openalex.org/W1981919501","https://openalex.org/W1982624291","https://openalex.org/W1982892406","https://openalex.org/W1996886208","https://openalex.org/W2010872706","https://openalex.org/W2012772303","https://openalex.org/W2016284077","https://openalex.org/W2016826128","https://openalex.org/W2019344077","https://openalex.org/W2020275569","https://openalex.org/W2020622209","https://openalex.org/W2033108407","https://openalex.org/W2044704316","https://openalex.org/W2045929030","https://openalex.org/W2047604907","https://openalex.org/W2055078523","https://openalex.org/W2059640915","https://openalex.org/W2066168019","https://openalex.org/W2068704377","https://openalex.org/W2072585950","https://openalex.org/W2076034559","https://openalex.org/W2079862834","https://openalex.org/W2080941377","https://openalex.org/W2081976133","https://openalex.org/W2083875726","https://openalex.org/W2086207218","https://openalex.org/W2091174273","https://openalex.org/W2110402980","https://openalex.org/W2125683177","https://openalex.org/W2149709906","https://openalex.org/W2151790869","https://openalex.org/W2154343843","https://openalex.org/W2155654709","https://openalex.org/W2159891593","https://openalex.org/W2165312126","https://openalex.org/W2174668858"],"related_works":["https://openalex.org/W2000597812","https://openalex.org/W127856909","https://openalex.org/W3118476157","https://openalex.org/W2108841749","https://openalex.org/W2772397283","https://openalex.org/W2040599194","https://openalex.org/W4403645007","https://openalex.org/W1972909510","https://openalex.org/W2086207218","https://openalex.org/W7034481504"],"abstract_inverted_index":{"Striatal":[0],"enriched":[1],"protein":[2],"tyrosine":[3],"phosphatase":[4],"(STEP)":[5],"acts":[6],"in":[7,20,36,61,75,91,98,106,118,152,174,207,216,241,248],"the":[8,55,58,76,92,121,164,175,183,218,221,230,249],"central":[9],"nervous":[10],"system":[11],"to":[12,34,109,127,145,159,188,200,209],"dephosphorylate":[13],"a":[14,41,73,113,138,147,153,189,245],"number":[15],"of":[16,44,64,78,94,120,141,155,166,169,178,185,223,232,234,251],"important":[17],"proteins":[18,30],"involved":[19],"synaptic":[21],"function":[22],"including":[23],"ERK":[24],"and":[25,57,67,117,201,220],"NMDA":[26],"receptor":[27],"subunits.":[28],"These":[29,239],"are":[31,88,124,133,172,213],"also":[32],"linked":[33],"stroke,":[35],"which":[37],"cerebral":[38,65,84],"ischemia":[39,66,100,144],"triggers":[40],"complex":[42],"cascade":[43],"events.":[45],"Here":[46],"we":[47],"demonstrate":[48],"that":[49,68,123,182],"STEP":[50,95,101,130,142,156,186,242],"is":[51,103,137],"regulated":[52],"at":[53],"both":[54,217],"transcriptional":[56],"post-transcriptional":[59],"levels":[60,93,132],"rat":[62],"models":[63],"its":[69,203,225,235],"regulation":[70],"may":[71,243],"play":[72],"role":[74,247],"outcome":[77],"ischemic":[79,110,128,210,252],"insults.":[80],"After":[81],"transient":[82],"middle":[83],"artery":[85],"occlusion,":[86],"there":[87,136,171,212],"profound":[89,214],"decreases":[90],"mRNA,":[96],"whilst":[97],"global":[99],"mRNA":[102,131],"selectively":[104],"down-regulated":[105],"areas":[107],"susceptible":[108],"damage.":[111],"In":[112],"neuroprotective":[114],"preconditioning":[115],"paradigm,":[116],"regions":[119],"brain":[122,253],"relatively":[125],"resistant":[126],"damage,":[129],"increased.":[134],"Furthermore,":[135],"significant":[139],"processing":[140],"after":[143],"generate":[146],"novel":[148],"species,":[149],"STEP(33),":[150],"resulting":[151],"redistribution":[154],"from":[157],"membrane-bound":[158],"soluble":[160],"compartments.":[161],"Concomitant":[162],"with":[163],"cleavage":[165,184],"mature":[167],"forms":[168],"STEP,":[170,224],"changes":[173,240],"phosphorylation":[176],"state":[177],"ERK.":[179],"We":[180],"show":[181],"leads":[187],"catalytically":[190],"active":[191],"form,":[192],"but":[193],"this":[194],"cleaved":[195],"form":[196],"no":[197],"longer":[198],"binds":[199],"dephosphorylates":[202],"substrate":[204],"pERK.":[205,238],"Therefore,":[206],"response":[208],"insults,":[211],"reductions":[215],"amount":[219],"activity":[222,231],"localization,":[226],"as":[227,229],"well":[228],"one":[233],"key":[236],"substrates,":[237],"reflect":[244],"critical":[246],"outcomes":[250],"injury.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}