{"id":"https://openalex.org/W2134470076","doi":"https://doi.org/10.1677/jme.0.0220019","title":"Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets","display_name":"Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2134470076","doi":"https://doi.org/10.1677/jme.0.0220019","mag":"2134470076","pmid":"https://pubmed.ncbi.nlm.nih.gov/9924176"},"language":"en","primary_location":{"id":"doi:10.1677/jme.0.0220019","doi":"https://doi.org/10.1677/jme.0.0220019","is_oa":true,"landing_page_url":"https://doi.org/10.1677/jme.0.0220019","pdf_url":"https://jme.bioscientifica.com/downloadpdf/journals/jme/22/1/19.pdf","source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jme.bioscientifica.com/downloadpdf/journals/jme/22/1/19.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074801875","display_name":"Shanta Jean Persaud","orcid":"https://orcid.org/0000-0002-4933-5958","observed_orcids":["https://orcid.org/0000-0002-4933-5958"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SJ Persaud","raw_affiliation_strings":["Cellular and Molecular Endocrinology Group, Biomedical Sciences Division, King's College London, Campden Hill Road, London W8 7AH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Endocrinology Group, Biomedical Sciences Division, King's College London, Campden Hill Road, London W8 7AH, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113679323","display_name":"TE Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"TE Harris","raw_affiliation_strings":["Cellular and Molecular Endocrinology Group, Biomedical Sciences Division, King's College London, Campden Hill Road, London W8 7AH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Endocrinology Group, Biomedical Sciences Division, King's College London, Campden Hill Road, London W8 7AH, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":null,"display_name":"CJ Burns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"CJ Burns","raw_affiliation_strings":["King \u2018s College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King \u2018s College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107387136","display_name":"Peter M. Jones","orcid":"https://orcid.org/0000-0003-1201-2335","observed_orcids":["https://orcid.org/0000-0003-1201-2335"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"PM Jones","raw_affiliation_strings":["Cellular and Molecular Endocrinology Group , Biomedical Sciences Division , King's College London , Campden Hill Road , London W8 7AH , UK","Diabetes"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Endocrinology Group , Biomedical Sciences Division , King's College London , Campden Hill Road , London W8 7AH , UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Diabetes","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":null,"apc_paid":null,"fwci":3.1562,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.91619792,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"19","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/glucose-stimulation","display_name":"glucose stimulation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.8849999904632568},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sulfonylureas","display_name":"sulfonylureas","score":0.7979999780654907},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.8330000042915344},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.8989999890327454},{"id":"https://openalex.org/keywords/islets","display_name":"islets","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6892361640930176},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.6725577116012573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6586613059043884},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6123653650283813},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5503833889961243},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5444877743721008},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5196620225906372},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5091587901115417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4708658754825592},{"id":"https://openalex.org/C2780161494","wikidata":"https://www.wikidata.org/wiki/Q3510429","display_name":"Secretagogue","level":3,"score":0.4651077389717102},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.45090407133102417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35161757469177246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2979337275028229},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20404541492462158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08624890446662903}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010664","descriptor_name":"Phenylmethylsulfonyl Fluoride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014638","descriptor_name":"Vanadates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020032","descriptor_name":"Tyrphostins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1677/jme.0.0220019","doi":"https://doi.org/10.1677/jme.0.0220019","is_oa":true,"landing_page_url":"https://doi.org/10.1677/jme.0.0220019","pdf_url":"https://jme.bioscientifica.com/downloadpdf/journals/jme/22/1/19.pdf","source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:9924176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9924176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/fcbdb909-feff-4f43-af30-f1adcbae26b4","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/fcbdb909-feff-4f43-af30-f1adcbae26b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Persaud, S J, Harris, T E, Burns, C J & Jones, P M 1999, 'Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets', Journal of Molecular Endocrinology, vol. 22, no. 1, pp. 19 - 28. https://doi.org/10.1677/jme.0.0220019","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1677/jme.0.0220019","doi":"https://doi.org/10.1677/jme.0.0220019","is_oa":true,"landing_page_url":"https://doi.org/10.1677/jme.0.0220019","pdf_url":"https://jme.bioscientifica.com/downloadpdf/journals/jme/22/1/19.pdf","source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2134470076.pdf","grobid_xml":"https://content.openalex.org/works/W2134470076.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W181566666","https://openalex.org/W590561559","https://openalex.org/W1728162925","https://openalex.org/W1731971168","https://openalex.org/W1964045795","https://openalex.org/W1973386513","https://openalex.org/W1979967204","https://openalex.org/W1980020986","https://openalex.org/W1984675604","https://openalex.org/W1987908541","https://openalex.org/W1988426164","https://openalex.org/W1992968276","https://openalex.org/W2009592438","https://openalex.org/W2011506953","https://openalex.org/W2018734675","https://openalex.org/W2020455451","https://openalex.org/W2031404762","https://openalex.org/W2033824454","https://openalex.org/W2045677943","https://openalex.org/W2049133393","https://openalex.org/W2051028721","https://openalex.org/W2065165296","https://openalex.org/W2065863044","https://openalex.org/W2069342390","https://openalex.org/W2077077391","https://openalex.org/W2082299946","https://openalex.org/W2093218432","https://openalex.org/W2112156772","https://openalex.org/W2340586018","https://openalex.org/W2594939815"],"related_works":["https://openalex.org/W2066816978","https://openalex.org/W1821581156","https://openalex.org/W2093218432","https://openalex.org/W1994481196","https://openalex.org/W2065165296","https://openalex.org/W2416222640","https://openalex.org/W1988426164","https://openalex.org/W4235182032","https://openalex.org/W2077077391","https://openalex.org/W2095679817"],"abstract_inverted_index":{"The":[0,108],"role(s)":[1],"played":[2],"by":[3],"protein":[4,89,141],"tyrosine":[5,35,63,79,90,102,119],"kinases":[6],"(PTKs)":[7],"in":[8,48,81],"the":[9,24,28,34,49,76,83,88,193,196],"regulation":[10],"of":[11,26,38,51,78,87,104,195],"insulin":[12,31,45,130,162,179],"secretion":[13,163,180],"from":[14,164],"pancreatic":[15],"beta":[16,43,205],"cells":[17,206],"is":[18,187],"not":[19],"clear.":[20],"We":[21],"have":[22],"examined":[23],"effects":[25,177],"glucose,":[27],"major":[29],"physiological":[30],"secretagogue,":[32],"on":[33,62,75,153,178],"phosphorylation":[36,103],"state":[37],"islet":[39,106,118],"proteins,":[40],"and":[41,65,113,122,128,137,185,209],"assessed":[42],"cell":[44],"secretory":[46],"responses":[47],"presence":[50,86],"PTK":[52,109,172],"inhibitors.":[53],"Under":[54],"basal":[55],"conditions":[56],"islets":[57],"contained":[58],"many":[59],"proteins":[60],"phosphorylated":[61],"residues,":[64],"glucose":[66,134],"(20":[67],"mM;":[68],"5-15":[69],"min)":[70],"was":[71],"without":[72,132],"demonstrable":[73],"effect":[74,152],"pattern":[77],"phosphorylation,":[80],"either":[82],"absence":[84],"or":[85,157],"phosphatase":[91],"(PTP)":[92],"inhibitor,":[93],"sodium":[94],"pervanadate":[95],"(PV).":[96],"PV":[97],"alone":[98],"(100":[99],"microM)":[100],"increased":[101],"several":[105],"proteins.":[107],"inhibitors":[110,173],"genistein":[111],"(GS)":[112],"tyrphostin":[114],"A47":[115],"(TA47)":[116],"inhibited":[117,140],"kinase":[120,143],"activities":[121,144],"glucose-,":[123],"4alpha":[124],"ketoisocaproic":[125],"acid":[126],"(KIC)-":[127],"sulphonylurea-stimulated":[129],"release,":[131],"affecting":[133],"metabolism.":[135],"GS":[136],"TA47":[138],"also":[139],"serine/threonine":[142],"to":[145,182],"a":[146],"limited":[147],"extent,":[148],"but":[149],"had":[150],"no":[151],"Ca2+,":[154],"cyclic":[155],"AMP-":[156],"phorbol":[158],"myristate":[159],"acetate":[160],"(PMA)-induced":[161],"electrically":[165],"permeabilised":[166],"islets.":[167],"These":[168],"results":[169],"suggest":[170],"that":[171,189],"exert":[174],"their":[175],"inhibitory":[176],"proximal":[181],"Ca2+":[183,198,202],"entry":[184],"it":[186],"proposed":[188],"they":[190],"act":[191],"at":[192],"site":[194],"voltage-dependent":[197],"channel":[199],"which":[200],"regulates":[201],"influx":[203],"into":[204],"following":[207],"nutrient-":[208],"sulphonylurea-induced":[210],"depolarisation.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
