{"id":"https://openalex.org/W2134401593","doi":"https://doi.org/10.1073/pnas.0405665101","title":"Synergistic interactions of lipids and myelin basic protein","display_name":"Synergistic interactions of lipids and myelin basic protein","publication_year":2004,"publication_date":"2004-09-07","ids":{"openalex":"https://openalex.org/W2134401593","doi":"https://doi.org/10.1073/pnas.0405665101","mag":"2134401593","pmid":"https://pubmed.ncbi.nlm.nih.gov/15353595","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/518780"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0405665101","doi":"https://doi.org/10.1073/pnas.0405665101","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0405665101","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/518780","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048589953","display_name":"Yufang Hu","orcid":"https://orcid.org/0000-0002-5973-2527","observed_orcids":["https://orcid.org/0000-0002-5973-2527"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Yufang Hu","raw_affiliation_strings":["Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa","institution_ids":["https://openalex.org/I154570441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012807149","display_name":"Ivo Doudevski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Ivo Doudevski","raw_affiliation_strings":["Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa","institution_ids":["https://openalex.org/I154570441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110094947","display_name":"Denise D. Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Denise Wood","raw_affiliation_strings":["Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa","institution_ids":["https://openalex.org/I154570441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111798985","display_name":"Mario A. Moscarello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Mario Moscarello","raw_affiliation_strings":["Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa","institution_ids":["https://openalex.org/I154570441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038128149","display_name":"Cynthia A. Husted","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Cynthia Husted","raw_affiliation_strings":["Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa","institution_ids":["https://openalex.org/I154570441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112159830","display_name":"Claude P. Genain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Claude Genain","raw_affiliation_strings":["Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa","institution_ids":["https://openalex.org/I154570441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029251110","display_name":"Joseph A. Zasadzinski","orcid":"https://orcid.org/0000-0001-5663-6989","observed_orcids":["https://orcid.org/0000-0001-5663-6989"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Joseph A. Zasadzinski","raw_affiliation_strings":["Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa","institution_ids":["https://openalex.org/I154570441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065342198","display_name":"Jacob Nissim Israelachvili","orcid":"https://orcid.org/0000-0001-8915-8741","observed_orcids":["https://orcid.org/0000-0001-8915-8741"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Jacob Israelachvili","raw_affiliation_strings":["Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering and Biology and Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106; Department of Structural Biology and Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8; Center for the Study of Neurodegenerative Disorders, Neuroscience Research Institute, University of California, Santa","institution_ids":["https://openalex.org/I154570441","https://openalex.org/I185261750","https://openalex.org/I2801317318"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3664,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.78313125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"101","issue":"37","first_page":"13466","last_page":"13471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-lipid-interactions","display_name":"protein-lipid interactions","score":0.9750000238418579},{"id":"https://openalex.org/keywords/myelin-sheath","display_name":"myelin sheath","score":0.8610000014305115},{"id":"https://openalex.org/keywords/membrane-adhesion","display_name":"membrane adhesion","score":0.8220000267028809},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.9959999918937683},{"id":"https://openalex.org/keywords/membrane-stability","display_name":"membrane stability","score":0.628000020980835},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/membrane-defects","display_name":"membrane defects","score":0.39500001072883606},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.7870000004768372},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/model-membranes","display_name":"model membranes","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.7865850329399109},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.7163676023483276},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.6402932405471802},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6308006048202515},{"id":"https://openalex.org/C7821365","wikidata":"https://www.wikidata.org/wiki/Q14912011","display_name":"Proteolipid protein 1","level":5,"score":0.5801859498023987},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5762224793434143},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5434998273849487},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.49085527658462524},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.4593522846698761},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4572851061820984},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3959306478500366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23789721727371216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18420162796974182},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10791116952896118},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0736033022403717},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.0405665101","doi":"https://doi.org/10.1073/pnas.0405665101","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0405665101","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1993038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/518780","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:518780","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/518780","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:15353595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15353595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8zs9712s","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8zs9712s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences, vol 101","raw_type":"article"},{"id":"pmh:qt8zs9712s","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/8zs9712s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hu, Yufang; Doudevski, Ivo; Wood, Denise; Moscarello, Mario; Husted, Cynthia A. Ph.D.; Genain, Claude; \u00c2\u00a0et al.(2004). Synergistic interactions of lipids and myelin basic protein. Proceedings of the National Academy of Sciences, 101, 13466 - 13471. UC Santa Barbara: Center for the Study of Neurodegenerative Disorders. Retrieved from: http://www.escholarship.org/uc/item/8zs9712s","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1993038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/518780","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000885997","display_name":"Lipid and Protein Effects on Monolayer Stability","funder_award_id":"R01HL051177","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W19543129","https://openalex.org/W1966132361","https://openalex.org/W1974596355","https://openalex.org/W1975473423","https://openalex.org/W1979179748","https://openalex.org/W1981831781","https://openalex.org/W1982335417","https://openalex.org/W1991287825","https://openalex.org/W1999299844","https://openalex.org/W2007096583","https://openalex.org/W2008589862","https://openalex.org/W2008722942","https://openalex.org/W2008908542","https://openalex.org/W2023534523","https://openalex.org/W2028354588","https://openalex.org/W2031290591","https://openalex.org/W2031707158","https://openalex.org/W2033144355","https://openalex.org/W2033721385","https://openalex.org/W2043709291","https://openalex.org/W2045915778","https://openalex.org/W2049263103","https://openalex.org/W2053398492","https://openalex.org/W2056451248","https://openalex.org/W2062103399","https://openalex.org/W2065580960","https://openalex.org/W2072231537","https://openalex.org/W2080484385","https://openalex.org/W2083969639","https://openalex.org/W2090828881","https://openalex.org/W2098710325","https://openalex.org/W2124614417","https://openalex.org/W2127721851","https://openalex.org/W2132788929","https://openalex.org/W2133445717","https://openalex.org/W2171925564","https://openalex.org/W2298213915","https://openalex.org/W4238159754","https://openalex.org/W4240683483","https://openalex.org/W4256175533"],"related_works":["https://openalex.org/W2058671359","https://openalex.org/W2016473952","https://openalex.org/W1979946656","https://openalex.org/W2056928910","https://openalex.org/W2065409727","https://openalex.org/W2801169348","https://openalex.org/W2147630559","https://openalex.org/W4316500145","https://openalex.org/W2080484385","https://openalex.org/W7167922114"],"abstract_inverted_index":{"This":[0],"report":[1],"describes":[2],"force":[3,7],"measurements":[4],"and":[5,35,44,63,77,96,108,115,134,149,209,229,234],"atomic":[6],"microscope":[8],"imaging":[9],"of":[10,17,46,92,98,103,155,185,215,218,227],"lipid-protein":[11],"interactions":[12,37],"that":[13,22,31,50,86,111,150,181],"determine":[14],"the":[15,25,41,93,119,124,127,131,142,160,170,182,189,192,195,207,216],"structure":[16,43],"a":[18,56,65,82,88,224],"model":[19,85,109],"membrane":[20,147,187,232],"system":[21],"closely":[23],"mimics":[24],"myelin":[26,51,113,135,231],"sheath.":[27],"Our":[28,177],"results":[29,107,178],"suggest":[30],"noncovalent,":[32],"mainly":[33],"electrostatic":[34],"hydrophobic,":[36],"are":[38,194],"responsible":[39],"for":[40,223,240],"multilamellar":[42],"stability":[45,116],"myelin.":[47],"We":[48],"find":[49],"basic":[52,136],"protein":[53],"acts":[54],"as":[55,64,138,140,244],"lipid":[57,66,132],"coupler":[58],"between":[59],"two":[60],"apposed":[61],"bilayers":[62,133],"\"hole-filler,\"":[67],"effectively":[68],"preventing":[69],"defect":[70],"holes":[71],"from":[72,159],"developing.":[73],"From":[74],"our":[75],"protein-mediated-adhesion":[76],"force-distance":[78],"measurements,":[79],"we":[80],"develop":[81],"simple":[83],"quantitative":[84],"gives":[87],"reasonably":[89],"accurate":[90],"picture":[91],"molecular":[94],"mechanism":[95,217],"adhesion":[97,114,171,208],"bilayer-bridging":[99],"proteins":[100],"by":[101],"means":[102],"noncovalent":[104],"interactions.":[105],"The":[106],"indicate":[110],"optimum":[112,162],"depend":[117],"on":[118,130,141],"difference":[120],"between,":[121],"rather":[122],"than":[123],"product":[125],"of,":[126],"opposite":[128],"charges":[129],"protein,":[137],"well":[139],"repulsive":[143],"forces":[144],"associated":[145],"with":[146],"fluidity,":[148],"small":[151],"changes":[152,168],"in":[153,169],"any":[154],"these":[156],"parameters":[157],"away":[158],"synergistically":[161,204],"values":[163],"can":[164],"lead":[165,236],"to":[166,205,237],"large":[167],"or":[172,191],"even":[173],"its":[174],"total":[175],"elimination.":[176],"also":[179],"show":[180],"often-asked":[183],"question":[184],"which":[186],"species,":[188],"lipids":[190],"proteins,":[193],"\"important":[196],"ones\"":[197],"may":[198,221,235],"be":[199],"misplaced.":[200],"Both":[201],"components":[202],"work":[203],"provide":[206],"overall":[210],"structure.":[211],"A":[212],"better":[213,225,238],"appreciation":[214],"this":[219],"synergy":[220],"allow":[222],"understanding":[226],"stacked":[228],"especially":[230],"structures":[233],"treatments":[239],"demyelinating":[241],"diseases":[242],"such":[243],"multiple":[245],"sclerosis.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
