{"id":"https://openalex.org/W2134326480","doi":"https://doi.org/10.1093/gbe/evt044","title":"The Evolution of Genomic Instability in the Obligate Endosymbionts of Whiteflies","display_name":"The Evolution of Genomic Instability in the Obligate Endosymbionts of Whiteflies","publication_year":2013,"publication_date":"2013-03-29","ids":{"openalex":"https://openalex.org/W2134326480","doi":"https://doi.org/10.1093/gbe/evt044","mag":"2134326480","pmid":"https://pubmed.ncbi.nlm.nih.gov/23542079","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3673631"},"language":"en","primary_location":{"id":"doi:10.1093/gbe/evt044","doi":"https://doi.org/10.1093/gbe/evt044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gbe/evt044","pdf_url":"https://academic.oup.com/gbe/article-pdf/5/5/783/17920009/evt044.pdf","source":{"id":"https://openalex.org/S10195028","display_name":"Genome Biology and Evolution","issn_l":"1759-6653","issn":["1759-6653"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/gbe/article-pdf/5/5/783/17920009/evt044.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087267927","display_name":"Daniel B. Sloan","orcid":"https://orcid.org/0000-0002-3618-0897","observed_orcids":["https://orcid.org/0000-0002-3618-0897"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel B. Sloan","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Yale University, USA. daniel.sloan@yale.edu","Dept. of Ecology & Evolutionary Biology, Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Yale University, USA. daniel.sloan@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Dept. of Ecology & Evolutionary Biology, Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013005155","display_name":"Nancy A. Moran","orcid":"https://orcid.org/0000-0003-2983-9769","observed_orcids":["https://orcid.org/0000-0003-2983-9769"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy A. Moran","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Yale University","Dept. of Ecology & Evolutionary Biology, Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Yale University","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Dept. of Ecology & Evolutionary Biology, Yale University","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087267927"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":2850,"currency":"USD","value_usd":2850},"apc_paid":{"value":2850,"currency":"USD","value_usd":2850},"fwci":10.2438,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.98751017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"5","issue":"5","first_page":"783","last_page":"793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7009999752044678},{"id":"https://openalex.org/keywords/genomic-rearrangements","display_name":"genome rearrangement","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gene-conversion","display_name":"gene conversion","score":0.5960000157356262},{"id":"https://openalex.org/keywords/recombination","display_name":"recombination","score":0.5759999752044678},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.7950000166893005},{"id":"https://openalex.org/keywords/gene-loss","display_name":"gene loss","score":0.5740000009536743},{"id":"https://openalex.org/keywords/bemisia-tabaci","display_name":"Bemisia tabaci","score":0.824999988079071},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9440059065818787},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7660200595855713},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6655619144439697},{"id":"https://openalex.org/C24990904","wikidata":"https://www.wikidata.org/wiki/Q7075144","display_name":"Obligate","level":2,"score":0.6600061058998108},{"id":"https://openalex.org/C195139083","wikidata":"https://www.wikidata.org/wiki/Q3463539","display_name":"Intergenic region","level":4,"score":0.6181814074516296},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.617178738117218},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.5279380679130554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48248887062072754},{"id":"https://openalex.org/C61271108","wikidata":"https://www.wikidata.org/wiki/Q3180866","display_name":"Genome size","level":4,"score":0.479465126991272},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.46638917922973633},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.44733744859695435},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.07674810290336609}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006430","descriptor_name":"Hemiptera","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006430","descriptor_name":"Hemiptera","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006430","descriptor_name":"Hemiptera","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044129","descriptor_name":"Halomonadaceae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/gbe/evt044","doi":"https://doi.org/10.1093/gbe/evt044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gbe/evt044","pdf_url":"https://academic.oup.com/gbe/article-pdf/5/5/783/17920009/evt044.pdf","source":{"id":"https://openalex.org/S10195028","display_name":"Genome Biology and Evolution","issn_l":"1759-6653","issn":["1759-6653"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology and Evolution","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2672000","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3673631","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3673631","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3673631","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol Evol","raw_type":"Text"},{"id":"pmid:23542079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23542079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology and evolution","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.800.9579","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.800.9579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/77/b4/evt044.PMC3673631.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/gbe/evt044","doi":"https://doi.org/10.1093/gbe/evt044","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gbe/evt044","pdf_url":"https://academic.oup.com/gbe/article-pdf/5/5/783/17920009/evt044.pdf","source":{"id":"https://openalex.org/S10195028","display_name":"Genome Biology and Evolution","issn_l":"1759-6653","issn":["1759-6653"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4355922149","display_name":"Genomic Interactions between Psyllids and Their Obligately Intracellular Bacteria","funder_award_id":"F32GM099334","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320316170","display_name":"Joint Genome Institute","ror":"https://ror.org/04xm1d337"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2134326480.pdf","grobid_xml":"https://content.openalex.org/works/W2134326480.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W45443282","https://openalex.org/W1525248952","https://openalex.org/W1558087734","https://openalex.org/W1642698206","https://openalex.org/W1910370106","https://openalex.org/W1936630560","https://openalex.org/W1970034377","https://openalex.org/W1971496713","https://openalex.org/W1977499766","https://openalex.org/W1989245611","https://openalex.org/W2009360690","https://openalex.org/W2013749849","https://openalex.org/W2016588572","https://openalex.org/W2018643684","https://openalex.org/W2026197201","https://openalex.org/W2034229618","https://openalex.org/W2035576673","https://openalex.org/W2048883964","https://openalex.org/W2049436823","https://openalex.org/W2056732862","https://openalex.org/W2057804750","https://openalex.org/W2059699049","https://openalex.org/W2064306419","https://openalex.org/W2067436137","https://openalex.org/W2074916452","https://openalex.org/W2075942688","https://openalex.org/W2080229897","https://openalex.org/W2082195055","https://openalex.org/W2083350250","https://openalex.org/W2086341363","https://openalex.org/W2086521335","https://openalex.org/W2092437348","https://openalex.org/W2092604303","https://openalex.org/W2097341408","https://openalex.org/W2102131597","https://openalex.org/W2103628055","https://openalex.org/W2112688415","https://openalex.org/W2113035810","https://openalex.org/W2119585200","https://openalex.org/W2122387236","https://openalex.org/W2130788016","https://openalex.org/W2132545338","https://openalex.org/W2132926880","https://openalex.org/W2133090982","https://openalex.org/W2133104753","https://openalex.org/W2135441043","https://openalex.org/W2136231029","https://openalex.org/W2137119840","https://openalex.org/W2141617889","https://openalex.org/W2146003375","https://openalex.org/W2147838321","https://openalex.org/W2148904859","https://openalex.org/W2150570211","https://openalex.org/W2150934173","https://openalex.org/W2151614109","https://openalex.org/W2154369878","https://openalex.org/W2155374708","https://openalex.org/W2160969485","https://openalex.org/W2163666618","https://openalex.org/W2612651926","https://openalex.org/W2944768395"],"related_works":["https://openalex.org/W4388760320","https://openalex.org/W2117075053","https://openalex.org/W7167924372","https://openalex.org/W1769276649","https://openalex.org/W599641561","https://openalex.org/W2967405269","https://openalex.org/W7125366404","https://openalex.org/W7201991739","https://openalex.org/W2009360690","https://openalex.org/W2073037954"],"abstract_inverted_index":{"Many":[0],"insects":[1],"depend":[2],"on":[3],"ancient":[4,57,148],"associations":[5],"with":[6,169],"intracellular":[7],"bacteria":[8],"to":[9,214],"perform":[10],"essential":[11],"metabolic":[12],"functions.":[13],"These":[14,203],"endosymbionts":[15],"exhibit":[16],"striking":[17],"examples":[18],"of":[19,28,35,44,69,79,142,159,175,180,191,209,218],"convergence":[20],"in":[21,100,146,163,172,185,197,227],"genome":[22,43,81,103,129,144],"architecture,":[23],"including":[24],"a":[25,62,132,140,178],"high":[26],"degree":[27],"structural":[29,98,221],"stability":[30],"that":[31,52,104,120,156,206,223,232],"is":[32,112,212,224],"not":[33],"typical":[34],"their":[36],"free-living":[37],"counterparts.":[38],"However,":[39],"the":[40,45,67,76,101,157,164,173,189,207,216,219],"recently":[41],"sequenced":[42],"obligate":[46,228],"whitefly":[47,91,135],"endosymbiont":[48,229],"Portiera":[49,80,102,128],"revealed":[50],"features":[51],"distinguish":[53],"it":[54],"from":[55,131],"other":[56],"insect":[58],"associates,":[59],"such":[60],"as":[61],"low":[63],"gene":[64,124],"density":[65],"and":[66,85,188,201,231],"presence":[68],"perfectly":[70],"duplicated":[71],"sequences.":[72],"Here,":[73],"we":[74,95,154],"report":[75],"comparative":[77],"analysis":[78],"sequences":[82],"both":[83],"within":[84,107],"between":[86],"host":[87,136],"species.":[88],"In":[89],"one":[90],"lineage":[92],"(Bemisia":[93],"tabaci),":[94],"identify":[96],"large-scale":[97],"polymorphisms":[99],"exist":[105],"even":[106],"individual":[108],"insects.":[109],"This":[110],"variation":[111],"likely":[113],"mediated":[114],"by":[115,123],"recombination":[116],"across":[117],"identical":[118],"repeats":[119,183],"are":[121,237],"maintained":[122],"conversion.":[125],"The":[126],"complete":[127],"sequence":[130],"distantly":[133],"related":[134],"(Trialeurodes":[137],"vaporarium)":[138],"confirms":[139],"history":[141],"extensive":[143],"rearrangement":[145],"this":[147],"endosymbiont.":[149],"Using":[150],"gene-order-based":[151],"phylogenetic":[152],"analysis,":[153],"show":[155],"majority":[158],"rearrangements":[160],"have":[161],"occurred":[162],"B.":[165],"tabaci":[166],"lineage,":[167],"coinciding":[168],"an":[170,238],"increase":[171],"rate":[174],"nucleotide":[176],"substitutions,":[177],"proliferation":[179],"short":[181],"tandem":[182],"(microsatellites)":[184],"intergenic":[186,235],"regions,":[187],"loss":[190,208],"many":[192],"widely":[193],"conserved":[194],"genes":[195],"involved":[196],"DNA":[198],"replication,":[199],"recombination,":[200],"repair.":[202],"results":[204],"indicate":[205],"recombinational":[210],"machinery":[211],"unlikely":[213],"be":[215],"cause":[217],"extreme":[220],"conservation":[222],"generally":[225],"observed":[226],"genomes":[230],"large,":[233],"repetitive":[234],"regions":[236],"important":[239],"substrate":[240],"for":[241],"genomic":[242],"rearrangements.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}