{"id":"https://openalex.org/W2134305294","doi":null,"title":"Consideraciones gen\u00e9ticas sobre las dislipidemias y la aterosclerosis","display_name":"Consideraciones gen\u00e9ticas sobre las dislipidemias y la aterosclerosis","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2134305294","mag":"2134305294"},"language":"es","primary_location":{"id":"pmh:oai:revista.cnic.cu:article/684","doi":null,"is_oa":true,"landing_page_url":"https://revista.cnic.edu.cu/index.php/RevBiol/article/view/684","pdf_url":null,"source":{"id":"https://openalex.org/S4306526263","display_name":"Revista CENIC. Ciencias biol\u00f3gicas","issn_l":"0253-5688","issn":["0253-5688","2221-2450"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","scielo"],"host_organization":"https://openalex.org/I4210132269","host_organization_name":"Centro Nacional de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I4210132269"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-5688","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://revista.cnic.edu.cu/index.php/RevBiol/article/view/684","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034376120","display_name":"Fern\u00e1ndez Travieso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132269","display_name":"Centro Nacional de Investigaciones Cient\u00edficas","ror":"https://ror.org/03zxtdc90","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210132269"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Fern\u00e1ndez Travieso","raw_affiliation_strings":["Centro Nacional de Investigaciones Cient\u00edficas, Centro de Productos Naturales, La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cient\u00edficas, Centro de Productos Naturales, La Habana, Cuba","institution_ids":["https://openalex.org/I4210132269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040074695","display_name":"J\u00falio C\u00e9sar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00falio C\u00e9sar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"3","first_page":"161","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8220000267028809},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.7450000047683716},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.8859999775886536},{"id":"https://openalex.org/keywords/apolipoprotein-genes","display_name":"apolipoprotein genes","score":0.6840000152587891},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.5809999704360962},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.7749999761581421},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lpa","display_name":"LPA","score":0.7049999833106995},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cholesteryl-ester-transfer-protein","display_name":"cholesteryl ester transfer protein","score":0.9539999961853027},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.8159999847412109},{"id":"https://openalex.org/keywords/apolipoprotein-a-ii","display_name":"apolipoprotein A-II","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lcat","display_name":"lecithin:cholesterol acyltransferase","score":0.796999990940094},{"id":"https://openalex.org/keywords/genetic-risk-markers","display_name":"genetic risk markers","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6408312320709229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.586253821849823},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.5789427161216736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5606144666671753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5423605442047119},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5313340425491333},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5086677670478821},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.47939372062683105},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.45140278339385986},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3460818827152252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32313311100006104},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.30407577753067017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14461171627044678}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:revista.cnic.cu:article/684","doi":null,"is_oa":true,"landing_page_url":"https://revista.cnic.edu.cu/index.php/RevBiol/article/view/684","pdf_url":null,"source":{"id":"https://openalex.org/S4306526263","display_name":"Revista CENIC. Ciencias biol\u00f3gicas","issn_l":"0253-5688","issn":["0253-5688","2221-2450"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","scielo"],"host_organization":"https://openalex.org/I4210132269","host_organization_name":"Centro Nacional de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I4210132269"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-5688","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e483eaf16ab44742bf4b8df1b945d6a4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e483eaf16ab44742bf4b8df1b945d6a4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista CENIC. Ciencias Biol\u00f3gicas, Vol 39, Iss 3, Pp 161-172 (2008)","raw_type":"article"},{"id":"pmh:oai:redalyc.org:181223609004","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=181223609004","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista CENIC. Ciencias Biol\u00f3gicas (Cuba) Num.3 Vol.39","raw_type":"art\u00edculo cient\u00edfico"},{"id":"mag:2134305294","doi":null,"is_oa":true,"landing_page_url":"http://www.redalyc.org/pdf/1812/181223609004.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306526263","display_name":"Revista CENIC. Ciencias biol\u00f3gicas","issn_l":"0253-5688","issn":["0253-5688","2221-2450"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","scielo"],"host_organization":"https://openalex.org/I4210132269","host_organization_name":"Centro Nacional de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I4210132269"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista CENIC Ciencias Biol\u00f3gicas","raw_type":null}],"best_oa_location":{"id":"pmh:oai:revista.cnic.cu:article/684","doi":null,"is_oa":true,"landing_page_url":"https://revista.cnic.edu.cu/index.php/RevBiol/article/view/684","pdf_url":null,"source":{"id":"https://openalex.org/S4306526263","display_name":"Revista CENIC. Ciencias biol\u00f3gicas","issn_l":"0253-5688","issn":["0253-5688","2221-2450"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["latindex","scielo"],"host_organization":"https://openalex.org/I4210132269","host_organization_name":"Centro Nacional de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I4210132269"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0253-5688","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W147823787","https://openalex.org/W171505232","https://openalex.org/W592424158","https://openalex.org/W651627589","https://openalex.org/W1546107817","https://openalex.org/W1893696402","https://openalex.org/W1965644421","https://openalex.org/W1966101029","https://openalex.org/W1967439374","https://openalex.org/W1972581489","https://openalex.org/W1978052360","https://openalex.org/W1988090824","https://openalex.org/W1991165792","https://openalex.org/W1991251155","https://openalex.org/W1993966022","https://openalex.org/W1994424340","https://openalex.org/W1995345926","https://openalex.org/W1997801947","https://openalex.org/W2002345850","https://openalex.org/W2008363902","https://openalex.org/W2010503586","https://openalex.org/W2011468836","https://openalex.org/W2012929041","https://openalex.org/W2013105798","https://openalex.org/W2014534729","https://openalex.org/W2015600361","https://openalex.org/W2017305693","https://openalex.org/W2024330142","https://openalex.org/W2029561034","https://openalex.org/W2030060743","https://openalex.org/W2030751874","https://openalex.org/W2033994925","https://openalex.org/W2039813201","https://openalex.org/W2040492546","https://openalex.org/W2047276638","https://openalex.org/W2051679035","https://openalex.org/W2058034919","https://openalex.org/W2070445328","https://openalex.org/W2070580285","https://openalex.org/W2072150135","https://openalex.org/W2083506674","https://openalex.org/W2091851974","https://openalex.org/W2097883007","https://openalex.org/W2104211766","https://openalex.org/W2107601712","https://openalex.org/W2108816386","https://openalex.org/W2113727840","https://openalex.org/W2115220026","https://openalex.org/W2117580286","https://openalex.org/W2117965977","https://openalex.org/W2120259334","https://openalex.org/W2123656702","https://openalex.org/W2125171397","https://openalex.org/W2129624996","https://openalex.org/W2129883875","https://openalex.org/W2135307086","https://openalex.org/W2140872110","https://openalex.org/W2143966005","https://openalex.org/W2144422677","https://openalex.org/W2144942835","https://openalex.org/W2145297297","https://openalex.org/W2146281408","https://openalex.org/W2156674697","https://openalex.org/W2158256445","https://openalex.org/W2163802092","https://openalex.org/W2169504251","https://openalex.org/W2183912980","https://openalex.org/W2317113633","https://openalex.org/W2335129974","https://openalex.org/W2339428433","https://openalex.org/W2409921744","https://openalex.org/W2438254240","https://openalex.org/W2461814001","https://openalex.org/W2885697355","https://openalex.org/W4365786727"],"related_works":["https://openalex.org/W2592798270","https://openalex.org/W2276053012","https://openalex.org/W2313926632","https://openalex.org/W2081052916","https://openalex.org/W2184361356","https://openalex.org/W2353425152","https://openalex.org/W4417001615","https://openalex.org/W7163583021","https://openalex.org/W2016419970","https://openalex.org/W2099640897"],"abstract_inverted_index":{"La":[0,42],"interacci\u00f3n":[1],"entre":[2,32],"factores":[3],"gen\u00e9ticos":[4,154],"y":[5,13,37,58,115,136,181,195,210,213,222],"ambientales":[6],"explican":[7],"muchos":[8],"aspectos":[9],"de":[10,19,21,35,54,56,61,70,77,93,104,117,147,161,164,171,178,185,189,192,219,244],"la":[11,22,26,59,68,82,95,102,112,159,176,190,204,217,220],"aterosclerosis":[12],"las":[14,33,162,226],"variaciones":[15],"gen\u00e9ticas":[16,72],"constituyen":[17],"marcadores":[18],"riesgo":[20,146,237],"enfermedad":[23],"coronaria":[24],"(EC),":[25],"cual":[27],"ocupa":[28],"el":[29,75,167,229,236,249],"primer":[30],"lugar":[31],"causas":[34],"morbilidad":[36],"mortalidad":[38],"a":[39,45,80,101,145,187,207],"nivel":[40],"mundial.":[41],"predisposici\u00f3n":[43,205],"familiar":[44],"padecer":[46],"EC,":[47,172],"junto":[48],"al":[49],"avance":[50],"vertiginoso":[51],"en":[52,89,108,111,121,149,166,216,233],"t\u00e9cnicas":[53],"an\u00e1lisis":[55],"ADN":[57],"disponibilidad":[60],"secuencias":[62],"del":[63,169,241],"genoma":[64],"humano,":[65],"han":[66,138],"orientado":[67],"investigaci\u00f3n":[69,97],"alteraciones":[71,88,120,163],"relacionadas":[73,227],"con":[74,87,228],"desarrollo":[76,168],"EC.":[78],"Debido":[79],"que":[81,235,247],"EC":[83,148,221],"est\u00e1":[84,99],"directamente":[85],"relacionada":[86],"los":[90,211],"niveles":[91],"plasm\u00e1ticos":[92],"l\u00edpidos,":[94],"principal":[96],"gen\u00e9tica":[98,206],"dirigida":[100],"identificaci\u00f3n":[103,191],"mutaciones":[105,214],"o":[106],"polimorfismos":[107,212,245],"genes":[109,123,165],"involucrados":[110],"s\u00edntesis,":[113],"transporte":[114],"metabolismo":[116,230],"lipoprote\u00ednas.":[118],"Las":[119],"algunos":[122],"candidatos,":[124],"tales":[125],"como":[126,225],"R-LDL,":[127],"apo-B100,":[128],"apo-E,":[129],"LPA,":[130],"LPL,":[131],"LH,":[132],"CETP,":[133],"apoAI,":[134],"apoAII":[135],"LCAT":[137],"sido":[139],"bien":[140],"caracterizadas,":[141],"demostr\u00e1ndose":[142],"su":[143,179],"asociaci\u00f3n":[144],"diversas":[150],"poblaciones.":[151],"Los":[152],"estudios":[153],"no":[155],"solo":[156],"permiten":[157],"definir":[158,182],"contribuci\u00f3n":[160],"fenotipo":[170],"sino":[173],"tambi\u00e9n,":[174],"mejorar":[175],"comprensi\u00f3n":[177],"fisiopatolog\u00eda":[180],"nuevas":[183,193],"alternativas":[184],"tratamiento":[186],"trav\u00e9s":[188],"mol\u00e9culas":[194],"posibles":[196],"blancos":[197],"terap\u00e9uticos.":[198],"En":[199],"este":[200],"trabajo":[201],"se":[202],"analiza":[203],"desarrollar":[208],"dislipidemias":[209],"implicadas":[215],"fisiopatogenia":[218],"sus":[223],"complicaciones,":[224],"lip\u00eddico,":[231],"teniendo":[232],"cuenta":[234],"coronario":[238],"puede":[239],"depender":[240],"n\u00famero":[242],"acumulado":[243],"desfavorales":[246],"porte":[248],"individuo.":[250]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
