{"id":"https://openalex.org/W2134281733","doi":"https://doi.org/10.1146/annurev-immunol-032713-120222","title":"Anticytokine Autoantibody\u2013Associated Immunodeficiency","display_name":"Anticytokine Autoantibody\u2013Associated Immunodeficiency","publication_year":2014,"publication_date":"2014-02-06","ids":{"openalex":"https://openalex.org/W2134281733","doi":"https://doi.org/10.1146/annurev-immunol-032713-120222","mag":"2134281733","pmid":"https://pubmed.ncbi.nlm.nih.gov/24499273"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-immunol-032713-120222","doi":"https://doi.org/10.1146/annurev-immunol-032713-120222","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-immunol-032713-120222","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-032713-120222","source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-032713-120222","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043605887","display_name":"Sarah Browne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah K. Browne","raw_affiliation_strings":["Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043605887"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":null,"apc_paid":null,"fwci":1.3017,"has_fulltext":true,"cited_by_count":136,"citation_normalized_percentile":{"value":0.80360206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"32","issue":"1","first_page":"635","last_page":"657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-interferon-gamma-autoantibodies","display_name":"anti-interferon-gamma autoantibodies","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nontuberculous-mycobacteria","display_name":"nontuberculous mycobacteria","score":0.8790000081062317},{"id":"https://openalex.org/keywords/anti-gm-csf-autoantibodies","display_name":"anti-GM-CSF autoantibodies","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cryptococcal-meningitis","display_name":"cryptococcal meningitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/staphylococcal-skin-infections","display_name":"staphylococcal skin infections","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mucocutaneous-candidiasis","display_name":"mucocutaneous candidiasis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/apeced","display_name":"APECED","score":0.9559999704360962},{"id":"https://openalex.org/keywords/thymoma","display_name":"thymoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8572583198547363},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.723552942276001},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.5888581871986389},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.586693525314331},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.4818519353866577},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4416516125202179},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42620405554771423},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17292523384094238},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17240548133850098}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013945","descriptor_name":"Thymoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013945","descriptor_name":"Thymoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013945","descriptor_name":"Thymoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016884","descriptor_name":"Polyendocrinopathies, Autoimmune","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016884","descriptor_name":"Polyendocrinopathies, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016884","descriptor_name":"Polyendocrinopathies, Autoimmune","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev-immunol-032713-120222","doi":"https://doi.org/10.1146/annurev-immunol-032713-120222","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-immunol-032713-120222","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-032713-120222","source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},{"id":"pmid:24499273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24499273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of immunology","raw_type":"Journal Article"},{"id":"mag:2189448960","doi":null,"is_oa":false,"landing_page_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-032713-120222","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1146/annurev-immunol-032713-120222","doi":"https://doi.org/10.1146/annurev-immunol-032713-120222","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-immunol-032713-120222","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-032713-120222","source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338421","display_name":"NHLBI Division of Intramural Research","ror":"https://ror.org/023ny1p48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2134281733.pdf","grobid_xml":"https://content.openalex.org/works/W2134281733.grobid-xml"},"referenced_works_count":157,"referenced_works":["https://openalex.org/W164824509","https://openalex.org/W1499340535","https://openalex.org/W1505854055","https://openalex.org/W1528158334","https://openalex.org/W1538069960","https://openalex.org/W1555469017","https://openalex.org/W1555988808","https://openalex.org/W1558936262","https://openalex.org/W1564948114","https://openalex.org/W1575239044","https://openalex.org/W1575529010","https://openalex.org/W1582154377","https://openalex.org/W1586347655","https://openalex.org/W1591908466","https://openalex.org/W1892054757","https://openalex.org/W1897894242","https://openalex.org/W1948268265","https://openalex.org/W1965206234","https://openalex.org/W1965688386","https://openalex.org/W1966966217","https://openalex.org/W1967829819","https://openalex.org/W1968737533","https://openalex.org/W1971075443","https://openalex.org/W1972502437","https://openalex.org/W1973046191","https://openalex.org/W1974501695","https://openalex.org/W1981127449","https://openalex.org/W1981431233","https://openalex.org/W1983037898","https://openalex.org/W1986426423","https://openalex.org/W1987191562","https://openalex.org/W1988540882","https://openalex.org/W1990534952","https://openalex.org/W1991113199","https://openalex.org/W1996642272","https://openalex.org/W1997128138","https://openalex.org/W1997959054","https://openalex.org/W1998814322","https://openalex.org/W2000314587","https://openalex.org/W2002540493","https://openalex.org/W2005341345","https://openalex.org/W2014009872","https://openalex.org/W2015640498","https://openalex.org/W2016677756","https://openalex.org/W2017027775","https://openalex.org/W2019275773","https://openalex.org/W2019825687","https://openalex.org/W2021293284","https://openalex.org/W2021711999","https://openalex.org/W2021810420","https://openalex.org/W2026978452","https://openalex.org/W2026993313","https://openalex.org/W2031971245","https://openalex.org/W2033824818","https://openalex.org/W2034021739","https://openalex.org/W2034453891","https://openalex.org/W2034489572","https://openalex.org/W2037258736","https://openalex.org/W2038212284","https://openalex.org/W2040739057","https://openalex.org/W2042920536","https://openalex.org/W2043774001","https://openalex.org/W2044085031","https://openalex.org/W2044325609","https://openalex.org/W2044471002","https://openalex.org/W2045278721","https://openalex.org/W2046793800","https://openalex.org/W2047392472","https://openalex.org/W2048548715","https://openalex.org/W2050842983","https://openalex.org/W2052068396","https://openalex.org/W2056532039","https://openalex.org/W2058231635","https://openalex.org/W2058947736","https://openalex.org/W2061490601","https://openalex.org/W2061689736","https://openalex.org/W2062481536","https://openalex.org/W2063499973","https://openalex.org/W2063710124","https://openalex.org/W2063733110","https://openalex.org/W2064593825","https://openalex.org/W2069983935","https://openalex.org/W2070395473","https://openalex.org/W2072010123","https://openalex.org/W2072912136","https://openalex.org/W2077939324","https://openalex.org/W2078509644","https://openalex.org/W2080385201","https://openalex.org/W2083737302","https://openalex.org/W2086332067","https://openalex.org/W2086437884","https://openalex.org/W2087172387","https://openalex.org/W2088574571","https://openalex.org/W2090902480","https://openalex.org/W2091160833","https://openalex.org/W2093440835","https://openalex.org/W2094909945","https://openalex.org/W2095141070","https://openalex.org/W2098754939","https://openalex.org/W2099498614","https://openalex.org/W2099570251","https://openalex.org/W2101524137","https://openalex.org/W2103433909","https://openalex.org/W2104822415","https://openalex.org/W2105815838","https://openalex.org/W2106273198","https://openalex.org/W2107922239","https://openalex.org/W2108046487","https://openalex.org/W2111297722","https://openalex.org/W2112698713","https://openalex.org/W2113560700","https://openalex.org/W2115055179","https://openalex.org/W2116622733","https://openalex.org/W2123678024","https://openalex.org/W2125038143","https://openalex.org/W2125573161","https://openalex.org/W2126605488","https://openalex.org/W2132566864","https://openalex.org/W2132972741","https://openalex.org/W2133315766","https://openalex.org/W2134248888","https://openalex.org/W2136555350","https://openalex.org/W2136699613","https://openalex.org/W2136745465","https://openalex.org/W2145503413","https://openalex.org/W2151219000","https://openalex.org/W2153570621","https://openalex.org/W2154401749","https://openalex.org/W2154965207","https://openalex.org/W2160364353","https://openalex.org/W2162534589","https://openalex.org/W2162721157","https://openalex.org/W2163694362","https://openalex.org/W2164082708","https://openalex.org/W2164500783","https://openalex.org/W2165214298","https://openalex.org/W2167612169","https://openalex.org/W2280395417","https://openalex.org/W2289958400","https://openalex.org/W2317276018","https://openalex.org/W2338669471","https://openalex.org/W2395153365","https://openalex.org/W2397457433","https://openalex.org/W2407272674","https://openalex.org/W2411478150","https://openalex.org/W2416525945","https://openalex.org/W2418821394","https://openalex.org/W2462360331","https://openalex.org/W2488458071","https://openalex.org/W2989337141","https://openalex.org/W3024918698","https://openalex.org/W4231530066","https://openalex.org/W4233268456","https://openalex.org/W4234736096","https://openalex.org/W4237777218","https://openalex.org/W4250812191","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2189448960","https://openalex.org/W2021554541","https://openalex.org/W2564102184","https://openalex.org/W4205602947","https://openalex.org/W2238905589","https://openalex.org/W2098025419","https://openalex.org/W4243010863","https://openalex.org/W4206481981","https://openalex.org/W2945484649","https://openalex.org/W3025126813"],"abstract_inverted_index":{"Anticytokine":[0],"autoantibodies":[1,24,34,43,49,59,79],"are":[2],"an":[3,83],"emerging":[4],"mechanism":[5],"of":[6,66,98,117,153],"disease":[7,109],"in":[8,63],"previously":[9],"healthy":[10],"adults.":[11],"Patients":[12],"with":[13,22],"these":[14],"syndromes":[15],"demonstrate":[16],"a":[17,27,137],"unique":[18],"infectious":[19,84],"phenotype":[20,85],"associated":[21],"neutralizing":[23],"that":[25,128],"target":[26],"specific":[28,121],"cytokine.":[29],"Examples":[30],"include":[31],"anti-interferon":[32],"(IFN)-\u03b3":[33],"and":[35,44,50,54,60,92,151],"disseminated":[36],"nontuberculous":[37],"mycobacteria;":[38],"anti-granulocyte":[39,88],"macrophage":[40],"colony-stimulating":[41],"factor":[42,91],"cryptococcal":[45],"meningitis;":[46],"anti-interleukin":[47],"(IL)-6":[48],"staphylococcal":[51],"skin":[52],"infection;":[53],"anti-IL-17A,":[55],"anti-IL-17F,":[56],"or":[57,75],"anti-IL-22":[58],"mucocutaneous":[61],"candidiasis":[62],"the":[64,96,99,126,146],"setting":[65],"either":[67],"APECED":[68],"(autoimmune":[69],"polyendocrinopathy,":[70],"candidiasis,":[71],"ectodermal":[72],"dystrophy":[73],"syndrome)":[74],"thymoma.":[76],"Other":[77],"anticytokine":[78,140,154],"may":[80,113],"contribute":[81],"to":[82],"such":[86],"as":[87],"colony":[89],"stimulating":[90],"anti-IFN-\u03b1":[93],"autoantibodies,":[94],"although":[95],"strength":[97],"association":[100],"is":[101],"less":[102],"clear.":[103],"Their":[104],"identification":[105],"not":[106],"only":[107],"affects":[108],"management":[110],"but":[111],"also":[112],"uncover":[114],"key":[115],"mechanisms":[116],"host":[118],"defense":[119],"against":[120],"organisms.":[122],"Furthermore,":[123],"it":[124],"raises":[125],"possibility":[127],"currently":[129],"idiopathic":[130],"diseases":[131],"will":[132],"someday":[133],"be":[134],"explained":[135],"by":[136],"yet":[138],"unidentified":[139],"autoantibody.":[141],"This":[142],"review":[143],"focuses":[144],"on":[145],"current":[147],"understanding,":[148],"both":[149],"clinical":[150],"mechanistic,":[152],"autoantibody-associated":[155],"immunodeficiency.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}