{"id":"https://openalex.org/W2134277408","doi":null,"title":"Aliskiren (tekturna), a novel antihypertensive approach to inhibition of the Renin-Angiotensin-aldosterone system.","display_name":"Aliskiren (tekturna), a novel antihypertensive approach to inhibition of the Renin-Angiotensin-aldosterone system.","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W2134277408","mag":"2134277408","pmid":"https://pubmed.ncbi.nlm.nih.gov/19749993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2730067"},"language":"en","primary_location":{"id":"pmid:19749993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19749993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P & T : a peer-reviewed journal for formulary management","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2730067/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042377258","display_name":"Julie Cromer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Cromer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018066668","display_name":"Simona Peker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simona Peker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2354,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62472951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"2","first_page":"92","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aliskiren","display_name":"aliskiren","score":0.9929999709129333},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.9169999957084656},{"id":"https://openalex.org/keywords/renin-inhibition","display_name":"renin inhibition","score":0.6520000100135803},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6620000004768372},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2779838083","wikidata":"https://www.wikidata.org/wiki/Q414904","display_name":"Aliskiren","level":4,"score":0.7803707122802734},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7413309216499329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6924517154693604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6768341660499573},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6329231262207031},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.6011534929275513},{"id":"https://openalex.org/C2780192228","wikidata":"https://www.wikidata.org/wiki/Q575890","display_name":"Antihypertensive drug","level":3,"score":0.5424670577049255},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5370146036148071},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.535894513130188},{"id":"https://openalex.org/C2909579140","wikidata":"https://www.wikidata.org/wiki/Q7663896","display_name":"Isolated systolic hypertension","level":3,"score":0.5250083208084106},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4228062331676483},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34392574429512024},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:19749993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19749993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P & T : a peer-reviewed journal for formulary management","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2730067","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2730067/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P T","raw_type":"Text"},{"id":"mag:2134277408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19749993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2730067","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2730067/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"P T","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1974174019","https://openalex.org/W2007772636","https://openalex.org/W2015569360","https://openalex.org/W2037521161","https://openalex.org/W2042794875","https://openalex.org/W2056976690","https://openalex.org/W2125966706","https://openalex.org/W2128921112","https://openalex.org/W2133217116","https://openalex.org/W2151295696","https://openalex.org/W2156121263","https://openalex.org/W2305118939","https://openalex.org/W2615043561","https://openalex.org/W2615684303"],"related_works":["https://openalex.org/W2182122229","https://openalex.org/W2131454364","https://openalex.org/W2439452563","https://openalex.org/W2318618496","https://openalex.org/W2075354764","https://openalex.org/W2029496628","https://openalex.org/W4298498773","https://openalex.org/W1699180303","https://openalex.org/W2359513929","https://openalex.org/W1998224752"],"abstract_inverted_index":{"Hypertension":[0,58],"is":[1,59,76],"defined":[2],"as":[3],"a":[4,15,119],"systolic":[5,86],"blood":[6],"pressure":[7],"(BP)":[8],"of":[9,18,34,53,71,81,89,121,125],"140":[10],"mm":[11,20,83,91,105,113],"Hg":[12,21,84,92,114],"or":[13,22,24,88,115],"higher,":[14,23],"diastolic":[16,94],"BP":[17,87,100],"90":[19],"the":[25,69,122],"need":[26],"to":[27,103,109],"take":[28],"an":[29],"antihypertensive":[30],"drug.1":[31],"The":[32],"prevalence":[33,55],"hypertension":[35],"in":[36,48,85,93,99,118],"America":[37],"has":[38],"reached":[39],"epidemic":[40],"proportions;":[41],"almost":[42],"72":[43],"million":[44],"adults":[45],"(nearly":[46],"one":[47],"three)":[49],"have":[50],"hypertension.2\r\n\r\nThe":[51],"implications":[52],"this":[54],"are":[56],"devastating.":[57],"strongly":[60],"associated":[61],"with":[62,78],"ischemic":[63],"heart":[64],"disease":[65],"and":[66,68],"stroke,":[67],"risk":[70,124],"mortality":[72],"from":[73],"these":[74],"conditions":[75],"doubled":[77],"every":[79],"increase":[80],"20":[82],"10":[90],"BP.":[95],"Even":[96],"small":[97],"increases":[98],"(values":[101],"up":[102],"130\u2013139/85\u201389":[104],"Hg),":[106],"when":[107],"compared":[108],"normotensive":[110],"levels":[111],"(120/80":[112],"below),":[116],"result":[117],"doubling":[120],"relative":[123],"cardiovascular":[126],"disease.1":[127]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
