{"id":"https://openalex.org/W2134245262","doi":"https://doi.org/10.1080/09553009414551571","title":"A Component of DNA Double-strand Break Repair Is Dependent on the Spatial Orientation of the Lesions within the Higher-order Structures of Chromatin","display_name":"A Component of DNA Double-strand Break Repair Is Dependent on the Spatial Orientation of the Lesions within the Higher-order Structures of Chromatin","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2134245262","doi":"https://doi.org/10.1080/09553009414551571","mag":"2134245262","pmid":"https://pubmed.ncbi.nlm.nih.gov/7983441"},"language":"en","primary_location":{"id":"doi:10.1080/09553009414551571","doi":"https://doi.org/10.1080/09553009414551571","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553009414551571","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022633208","display_name":"Peter J. Johnston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.J. Johnston","raw_affiliation_strings":["School of Biological and Medical Sciences, Bute Medical Buildings, University of St Andrews, St Andrews, Fife KY16 9TS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Medical Sciences, Bute Medical Buildings, University of St Andrews, St Andrews, Fife KY16 9TS, UK","institution_ids":["https://openalex.org/I16835326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111479338","display_name":"Peter E. Bryant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P.E. Bryant","raw_affiliation_strings":["School of Biological and Medical Sciences, Bute Medical Buildings, University of St Andrews, St Andrews, Fife KY16 9TS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Medical Sciences, Bute Medical Buildings, University of St Andrews, St Andrews, Fife KY16 9TS, UK","institution_ids":["https://openalex.org/I16835326"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16835326"],"apc_list":null,"apc_paid":null,"fwci":0.8493,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.7047287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"66","issue":"5","first_page":"531","last_page":"536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9940000176429749},{"id":"https://openalex.org/keywords/higher-order-chromatin-structure","display_name":"higher-order chromatin structure","score":0.8339999914169312},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.9330000281333923},{"id":"https://openalex.org/keywords/nuclear-matrix","display_name":"nuclear matrix","score":0.8330000042915344},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cho-k1-cells","display_name":"CHO-K1 cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/repair-kinetics","display_name":"repair kinetics","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8694506883621216},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6553674936294556},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6443547010421753},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.6078434586524963},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.517894983291626},{"id":"https://openalex.org/C105686024","wikidata":"https://www.wikidata.org/wiki/Q906755","display_name":"Nuclear matrix","level":4,"score":0.5090203285217285},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4965687394142151},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.49444055557250977},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4635889232158661},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.46320876479148865},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.43774348497390747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4335978031158447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3471715450286865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3302241563796997},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2920052409172058},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2289116084575653},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.19637775421142578},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18037211894989014},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06938967108726501},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/09553009414551571","doi":"https://doi.org/10.1080/09553009414551571","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553009414551571","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:7983441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7983441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1552353351","https://openalex.org/W1780177435","https://openalex.org/W1818252956","https://openalex.org/W1965242104","https://openalex.org/W1969894162","https://openalex.org/W1980414005","https://openalex.org/W1984019551","https://openalex.org/W2016908381","https://openalex.org/W2019963243","https://openalex.org/W2025823605","https://openalex.org/W2041517407","https://openalex.org/W2043734426","https://openalex.org/W2051475975","https://openalex.org/W2069914850","https://openalex.org/W2070134424","https://openalex.org/W2077757406","https://openalex.org/W2078477496","https://openalex.org/W2081199263","https://openalex.org/W2138576404","https://openalex.org/W2144915067","https://openalex.org/W2145381472","https://openalex.org/W2198880228","https://openalex.org/W2209286605","https://openalex.org/W2411979509","https://openalex.org/W2419306075","https://openalex.org/W4247418383","https://openalex.org/W4255244349"],"related_works":["https://openalex.org/W4302445930","https://openalex.org/W2334018569","https://openalex.org/W2318222641","https://openalex.org/W1984019551","https://openalex.org/W2734355740","https://openalex.org/W2808369892","https://openalex.org/W1998592800","https://openalex.org/W2086539901","https://openalex.org/W2603176394","https://openalex.org/W1983111965"],"abstract_inverted_index":{"By":[0,54],"the":[1,12,21,28,61,72,106,147,157,163,173],"use":[2],"of":[3,14,50,63,103,117,149,160,166,175],"a":[4,97,169],"modified":[5],"neutral":[6,34],"filter":[7,35],"elution":[8,36,49],"procedure":[9],"variations":[10],"in":[11,60,113,119,132,146,162,172],"repair":[13,116,148,174],"DNA":[15,51],"dsb":[16,94,118,123,130,136,161],"have":[17],"been":[18],"observed":[19],"between":[20],"ionizing":[22],"radiation":[23],"sensitive":[24],"mutant":[25],"xrs-5":[26],"and":[27],"parent":[29],"cell":[30],"line":[31],"CHO-K1.":[32],"Conventional":[33],"requires":[37],"harsh":[38],"lysis":[39],"conditions":[40],"to":[41,105],"remove":[42],"higher-order":[43,73,164],"chromatin":[44,78,167],"structures":[45,69,86,165],"which":[46],"interfere":[47],"with":[48,57,126,139],"containing":[52,121,134],"dsb.":[53],"lysing":[55],"cells":[56,115,143],"non-ionic":[58],"detergent":[59],"presence":[62],"2":[64],"mol":[65],"dm-3":[66],"salt,":[67],"histone-depleted":[68],"that":[70,112,156],"retain":[71],"nuclear":[74,107],"matrix":[75],"organization,":[76],"including":[77],"loops,":[79],"can":[80],"be":[81],"produced.":[82],"Elution":[83],"from":[84],"these":[85,176],"will":[87],"only":[88],"occur":[89],"if":[90],"two":[91],"or":[92],"more":[93],"lie":[95],"within":[96],"single-looped":[98],"domain":[99],"delineated":[100],"by":[101],"points":[102],"attachment":[104],"matrix.":[108],"Repair":[109],"experiments":[110],"indicate":[111],"CHO":[114],"loops":[120,133],"multiple":[122],"are":[124,137,144,168],"repaired":[125,138],"slow":[127],"kinetics":[128],"whilst":[129],"occurring":[131],"single":[135],"fast":[140],"kinetics.":[141],"Xrs-5":[142],"defective":[145],"multiply":[150],"damaged":[151],"loops.":[152],"This":[153],"work":[154],"indicates":[155],"spatial":[158],"orientation":[159],"possible":[170],"factor":[171],"lesions.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}