{"id":"https://openalex.org/W2134243996","doi":"https://doi.org/10.3382/ps.0551933","title":"Antibody Response and Reduction in Bursa of Fabricius and Spleen Weights of Progeny of Chickens Fed PCBs","display_name":"Antibody Response and Reduction in Bursa of Fabricius and Spleen Weights of Progeny of Chickens Fed PCBs","publication_year":1976,"publication_date":"1976-09-01","ids":{"openalex":"https://openalex.org/W2134243996","doi":"https://doi.org/10.3382/ps.0551933","mag":"2134243996","pmid":"https://pubmed.ncbi.nlm.nih.gov/825848"},"language":"en","primary_location":{"id":"doi:10.3382/ps.0551933","doi":"https://doi.org/10.3382/ps.0551933","is_oa":true,"landing_page_url":"https://doi.org/10.3382/ps.0551933","pdf_url":null,"source":{"id":"https://openalex.org/S133896805","display_name":"Poultry Science","issn_l":"0032-5791","issn":["0032-5791","1525-3171"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poultry Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3382/ps.0551933","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042705870","display_name":"Susan J. Harris","orcid":"https://orcid.org/0000-0003-4052-8427","observed_orcids":["https://orcid.org/0000-0003-4052-8427"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan J. Harris","raw_affiliation_strings":["U.S. Department of Agriculture, Agricultural Research Service, Animal Physiology and Genetics Institute, and Nutrition Institute, Beltsville, Maryland 20705"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Department of Agriculture, Agricultural Research Service, Animal Physiology and Genetics Institute, and Nutrition Institute, Beltsville, Maryland 20705","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110177320","display_name":"Helene C. Cecil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helene C. Cecil","raw_affiliation_strings":["U.S. Department of Agriculture, Agricultural Research Service, Animal Physiology and Genetics Institute, and Nutrition Institute, Beltsville, Maryland 20705"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Department of Agriculture, Agricultural Research Service, Animal Physiology and Genetics Institute, and Nutrition Institute, Beltsville, Maryland 20705","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064215748","display_name":"Joel Bitman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Bitman","raw_affiliation_strings":["U.S. Department of Agriculture, Agricultural Research Service, Animal Physiology and Genetics Institute, and Nutrition Institute, Beltsville, Maryland 20705"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Department of Agriculture, Agricultural Research Service, Animal Physiology and Genetics Institute, and Nutrition Institute, Beltsville, Maryland 20705","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004472222","display_name":"Robert J. Lillie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Lillie","raw_affiliation_strings":["U.S. Department of Agriculture, Agricultural Research Service, Animal Physiology and Genetics Institute, and Nutrition Institute, Beltsville, Maryland 20705"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Department of Agriculture, Agricultural Research Service, Animal Physiology and Genetics Institute, and Nutrition Institute, Beltsville, Maryland 20705","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.1782,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.48823398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"55","issue":"5","first_page":"1933","last_page":"1940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.3197999894618988,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":1.0},{"id":"https://openalex.org/keywords/aroclor","display_name":"Aroclor","score":0.6729999780654907},{"id":"https://openalex.org/keywords/broiler-chickens","display_name":"broiler chickens","score":0.6430000066757202},{"id":"https://openalex.org/keywords/hatchability","display_name":"hatchability","score":0.5860000252723694},{"id":"https://openalex.org/keywords/bursa-of-fabricius","display_name":"bursa of Fabricius","score":0.9190000295639038},{"id":"https://openalex.org/keywords/spleen-weight","display_name":"spleen weight","score":0.9700000286102295},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bursectomy","display_name":"bursectomy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/white-leghorn-hens","display_name":"White Leghorn hens","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C196978929","wikidata":"https://www.wikidata.org/wiki/Q1016975","display_name":"Bursa of Fabricius","level":3,"score":0.900412917137146},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.6404744386672974},{"id":"https://openalex.org/C2777744765","wikidata":"https://www.wikidata.org/wiki/Q2734755","display_name":"Hatching","level":2,"score":0.6153454184532166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5311656594276428},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4850156009197235},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4663611650466919},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46283841133117676},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.4274749159812927},{"id":"https://openalex.org/C22830521","wikidata":"https://www.wikidata.org/wiki/Q649967","display_name":"Feed conversion ratio","level":3,"score":0.422995001077652},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23266613483428955},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14731758832931519}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002003","descriptor_name":"Brucella abortus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002060","descriptor_name":"Bursa of Fabricius","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002060","descriptor_name":"Bursa of Fabricius","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004531","descriptor_name":"Eggs","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011078","descriptor_name":"Polychlorinated Biphenyls","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011078","descriptor_name":"Polychlorinated Biphenyls","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3382/ps.0551933","doi":"https://doi.org/10.3382/ps.0551933","is_oa":true,"landing_page_url":"https://doi.org/10.3382/ps.0551933","pdf_url":null,"source":{"id":"https://openalex.org/S133896805","display_name":"Poultry Science","issn_l":"0032-5791","issn":["0032-5791","1525-3171"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poultry Science","raw_type":"journal-article"},{"id":"pmid:825848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/825848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poultry science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3382/ps.0551933","doi":"https://doi.org/10.3382/ps.0551933","is_oa":true,"landing_page_url":"https://doi.org/10.3382/ps.0551933","pdf_url":null,"source":{"id":"https://openalex.org/S133896805","display_name":"Poultry Science","issn_l":"0032-5791","issn":["0032-5791","1525-3171"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poultry Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6735000014305115,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"},{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1864211316","https://openalex.org/W1966077770","https://openalex.org/W1974103513","https://openalex.org/W1977246437","https://openalex.org/W2003353941","https://openalex.org/W2009488257","https://openalex.org/W2009893269","https://openalex.org/W2017404126","https://openalex.org/W2017505839","https://openalex.org/W2023256535","https://openalex.org/W2046655976","https://openalex.org/W2051820030","https://openalex.org/W2052903180","https://openalex.org/W2066842637","https://openalex.org/W2095069647","https://openalex.org/W2130372616","https://openalex.org/W2145407859","https://openalex.org/W2168845854","https://openalex.org/W2313393548","https://openalex.org/W2315369971","https://openalex.org/W2330033696","https://openalex.org/W4322149280"],"related_works":["https://openalex.org/W2313393548","https://openalex.org/W2046655976","https://openalex.org/W1495916082","https://openalex.org/W2023256535","https://openalex.org/W2334321266","https://openalex.org/W37207719","https://openalex.org/W1998945208","https://openalex.org/W2017404126","https://openalex.org/W1971010363","https://openalex.org/W2126188118"],"abstract_inverted_index":{"In":[0,150],"Experiment":[1,151],"1,":[2],"polychlorinated":[3,223],"biphenyls":[4,224,230,251],"(Aroclors":[5],"1016,":[6],"1232,":[7,44,77],"1242,":[8,45,78],"1248,":[9,79],"and":[10,26,39,46,55,70,80,114,137,208],"1254)":[11],"were":[12,82,91,116,146,154,168],"fed":[13,37,64,109,147,155],"ad":[14,159],"libitum":[15,160],"to":[16,93,143,241,264,268],"White":[17],"Leghorn":[18],"chickens":[19],"at":[20,97],"dietary":[21,247,270],"levels":[22],"of":[23,33,42,52,57,59,67,75,86,95,105,120,125,204,221,238,245,258],"5,":[24],"10,":[25],"20":[27,40,73,110],"p.p.m.":[28,41,66,74,111,157],"for":[29,161],"8":[30,139,162],"weeks.":[31,163],"Hatchability":[32],"eggs":[34],"from":[35,62,107],"hens":[36,63,108,145,153],"10":[38,65,156],"Aroclors":[43,68,76,112],"1248":[47,71,115,158],"was":[48,141],"reduced.":[49],"The":[50,164],"weights":[51,90,167],"the":[53,100,126,144,171,199,206,216,222,227,246,262,269],"spleen":[54],"bursa":[56,166],"Fabricius":[58],"day-old":[60],"chicks":[61],"1242":[69,113],"or":[72,191],"1254":[81],"less":[83,117,235,242],"than":[84,118,215,236,243,256],"those":[85,94],"control":[87,121,207],"chicks.":[88],"Body":[89],"similar":[92,142],"controls":[96],"hatching,":[98],"but":[99,170],"3":[101],"week":[102],"weight":[103],"gains":[104,119],"progeny":[106,165],"progeny.":[122],"After":[123],"replacement":[124],"PCB":[127,181,209],"diet":[128],"with":[129,176,178,194,231,252],"uncontaminated":[130,148],"feed,":[131],"hatchability":[132],"improved":[133],"within":[134],"2":[135],"weeks":[136,140],"by":[138],"feed.":[149],"2,":[152],"reduced,":[169],"treatment":[172,182],"did":[173],"not":[174],"interfere":[175,177],"antibody":[179,187],"production.":[180],"had":[183],"no":[184],"effect":[185],"on":[186],"production":[188],"after":[189,198],"primary":[190,200],"secondary":[192],"challenges":[193],"Brucella":[195],"abortus.":[196],"However,":[197],"challenge,":[201],"bursectomized":[202],"birds":[203],"both":[205],"groups":[210],"produced":[211],"significantly":[212],"fewer":[213],"antibodies":[214],"nonbursectomized":[217],"birds.":[218],"Differential":[219],"accumulations":[220],"occurred":[225],"in":[226,261],"effs.":[228],"Chlorinated":[229],"relative":[232],"retention":[233,253],"times":[234,254],"that":[237,257],"DDE":[239,259],"accumulated":[240,260],"one-half":[244],"concentration":[248,266],"whereas":[249],"chlorinated":[250],"greater":[255],"eff":[263],"a":[265],"equivalent":[267],"concentration.":[271]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}