{"id":"https://openalex.org/W2134229222","doi":"https://doi.org/10.1083/jcb.107.1.267","title":"Regulation of agrin-induced acetylcholine receptor aggregation by Ca++ and phorbol ester.","display_name":"Regulation of agrin-induced acetylcholine receptor aggregation by Ca++ and phorbol ester.","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W2134229222","doi":"https://doi.org/10.1083/jcb.107.1.267","mag":"2134229222","pmid":"https://pubmed.ncbi.nlm.nih.gov/2839519","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115175"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.107.1.267","doi":"https://doi.org/10.1083/jcb.107.1.267","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.107.1.267","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115175","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108468322","display_name":"Bruce G. Wallace","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B G Wallace","raw_affiliation_strings":["Department of Neurobiology, Stanford University School of Medicine, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Stanford University School of Medicine, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108468322"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":1.6723,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.84963571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"107","issue":"1","first_page":"267","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agrin","display_name":"agrin","score":1.0},{"id":"https://openalex.org/keywords/acetylcholine-receptor-aggregation","display_name":"acetylcholine receptor aggregation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neuromuscular-junction-development","display_name":"neuromuscular junction formation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/postsynaptic-apparatus","display_name":"postsynaptic apparatus","score":0.7559999823570251},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.5600000023841858},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.8199999928474426},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cholinesterase","display_name":"cholinesterase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/metal-ion-inhibition","display_name":"metal ion inhibition","score":0.38199999928474426},{"id":"https://openalex.org/keywords/energy-metabolism-inhibitors","display_name":"energy metabolism inhibitors","score":0.6449999809265137},{"id":"https://openalex.org/keywords/torpedo-californica-electric-organ","display_name":"Torpedo californica electric organ","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2779024559","wikidata":"https://www.wikidata.org/wiki/Q4694120","display_name":"Agrin","level":4,"score":0.9927864074707031},{"id":"https://openalex.org/C2777240379","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular junction","level":2,"score":0.7226724624633789},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.7214638590812683},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.6616048216819763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6615102291107178},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.5502130389213562},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5444222688674927},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.43911799788475037},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43438422679901123},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4277960956096649},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4124016761779785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37959104776382446},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08574438095092773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05357778072357178}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011940","descriptor_name":"Receptor Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013324","descriptor_name":"Strontium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018171","descriptor_name":"Agrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.107.1.267","doi":"https://doi.org/10.1083/jcb.107.1.267","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.107.1.267","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1466061","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2115175","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115175","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:2839519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2839519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.6927","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.6927","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/50/46/J_Cell_Biol_1988_Jul_1_107(1)_267-278.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1466061","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G349478604","display_name":"Structure of the Active Zone at Nanometer Scale","funder_award_id":"R01NS014506","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W399028147","https://openalex.org/W1538351630","https://openalex.org/W1541728118","https://openalex.org/W1551997385","https://openalex.org/W1553306509","https://openalex.org/W1564811077","https://openalex.org/W1582831322","https://openalex.org/W1613388146","https://openalex.org/W1817774339","https://openalex.org/W1934058639","https://openalex.org/W1965351111","https://openalex.org/W1965983162","https://openalex.org/W1968928884","https://openalex.org/W1969183608","https://openalex.org/W1969549699","https://openalex.org/W1974749992","https://openalex.org/W1976697869","https://openalex.org/W1980301714","https://openalex.org/W1981166736","https://openalex.org/W1983176891","https://openalex.org/W1984775157","https://openalex.org/W1987057771","https://openalex.org/W1988304344","https://openalex.org/W1996828377","https://openalex.org/W1999860614","https://openalex.org/W2001692359","https://openalex.org/W2004774850","https://openalex.org/W2006298249","https://openalex.org/W2010146725","https://openalex.org/W2015287703","https://openalex.org/W2019960246","https://openalex.org/W2020066112","https://openalex.org/W2023022232","https://openalex.org/W2027207199","https://openalex.org/W2031236724","https://openalex.org/W2035359717","https://openalex.org/W2037782174","https://openalex.org/W2038340962","https://openalex.org/W2038813635","https://openalex.org/W2040092085","https://openalex.org/W2042499941","https://openalex.org/W2046143101","https://openalex.org/W2053024285","https://openalex.org/W2058802664","https://openalex.org/W2062077844","https://openalex.org/W2064641995","https://openalex.org/W2076572621","https://openalex.org/W2084936952","https://openalex.org/W2084943582","https://openalex.org/W2092929260","https://openalex.org/W2093176116","https://openalex.org/W2095372670","https://openalex.org/W2096571156","https://openalex.org/W2099703541","https://openalex.org/W2102360814","https://openalex.org/W2128054725","https://openalex.org/W2128453064","https://openalex.org/W2139650552","https://openalex.org/W2140372796","https://openalex.org/W2155080404","https://openalex.org/W2157730824","https://openalex.org/W2167366126","https://openalex.org/W2170755191","https://openalex.org/W2172124787","https://openalex.org/W2185441160","https://openalex.org/W2327689712","https://openalex.org/W2412544282","https://openalex.org/W2417105792","https://openalex.org/W2481734442"],"related_works":["https://openalex.org/W7099594353","https://openalex.org/W2065346776","https://openalex.org/W2058698951","https://openalex.org/W2056743924","https://openalex.org/W2068836997","https://openalex.org/W2108147568","https://openalex.org/W1168805970","https://openalex.org/W2016828215","https://openalex.org/W2049592263","https://openalex.org/W2130294004"],"abstract_inverted_index":{"Agrin,":[0],"a":[1,53],"protein":[2,218],"extracted":[3],"from":[4],"the":[5,12,22,26,32,39,44,66,95,99,107,135,140,146,161,167,192,245,257,260],"electric":[6],"organ":[7],"of":[8,14,31,41,46,59,78,101,110,121,131,149,169,177,194,217,224,241,259],"Torpedo":[9],"californica,":[10],"induces":[11],"formation":[13,174,240],"specializations":[15],"on":[16,43,232],"cultured":[17,233],"chick":[18,69],"myotubes":[19,70,234],"that":[20,237,247,255],"resemble":[21],"postsynaptic":[23,261],"apparatus":[24],"at":[25,139],"neuromuscular":[27,242],"junction.":[28],"The":[29,119,173,227],"aim":[30],"studies":[33],"reported":[34],"here":[35],"was":[36,63,143,158,165,209],"to":[37,65,81,114,145,253],"characterize":[38],"effects":[40,231],"agrin":[42,62,142,157,164,254],"distribution":[45],"acetylcholine":[47],"receptors":[48],"(AChRs)":[49],"and":[50,86,151,175,184,190,198,221,235],"cholinesterase":[51,152],"as":[52,106,154,156],"step":[54],"toward":[55],"determining":[56],"agrin's":[57,230],"mechanism":[58],"action.":[60],"When":[61],"added":[64,144],"medium":[67],"bathing":[68],"small":[71],"(less":[72],"than":[73],"4":[74,92],"micron":[75,117],"2)":[76],"aggregates":[77,102,125,170,180],"AChRs":[79,122,132,150],"began":[80],"appear":[82],"within":[83],"2":[84],"h":[85,98],"increased":[87,113,191],"rapidly":[88],"in":[89,134,160],"number":[90,100,168],"until":[91],"h.":[93],"Over":[94],"next":[96],"12-20":[97],"per":[103],"myotube":[104,136],"decreased":[105],"mean":[108],"size":[109],"each":[111],"aggregate":[112,195],"approximately":[115],"15":[116],"2.":[118],"accumulation":[120],"into":[123],"agrin-induced":[124,178,187],"occurred":[126],"primarily":[127],"by":[128,211,222],"lateral":[129],"migration":[130],"already":[133],"plasma":[137],"membrane":[138],"time":[141],"cultures.":[147],"Aggregates":[148],"remained":[153],"long":[155],"present":[159],"medium;":[162],"if":[163],"removed":[166],"declined":[171],"slowly.":[172],"maintenance":[176],"AChR":[179,188],"required":[181],"Ca++,":[182],"Co++":[183],"Mn++":[185],"inhibited":[186,210],"aggregation":[189,207],"rate":[193],"dispersal.":[196],"Mg++":[197],"Sr++":[199],"could":[200],"not":[201],"substitute":[202],"for":[203],"Ca++.":[204],"Agrin-induced":[205],"receptor":[206],"also":[208],"phorbol":[212],"12-myristate":[213],"13-acetate,":[214],"an":[215],"activator":[216],"kinase":[219],"C,":[220],"inhibitors":[223],"energy":[225],"metabolism.":[226],"similarities":[228],"between":[229],"events":[236],"occur":[238],"during":[239],"junctions":[243],"support":[244],"hypothesis":[246],"axon":[248],"terminals":[249],"release":[250],"molecules":[251],"similar":[252],"induce":[256],"differentiation":[258],"apparatus.":[262]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}