{"id":"https://openalex.org/W2134199765","doi":"https://doi.org/10.1111/j.1601-0825.2010.01701.x","title":"The road to ruin: the formation of disease\u2010associated oral biofilms","display_name":"The road to ruin: the formation of disease\u2010associated oral biofilms","publication_year":2010,"publication_date":"2010-07-20","ids":{"openalex":"https://openalex.org/W2134199765","doi":"https://doi.org/10.1111/j.1601-0825.2010.01701.x","mag":"2134199765","pmid":"https://pubmed.ncbi.nlm.nih.gov/20646235"},"language":"en","primary_location":{"id":"doi:10.1111/j.1601-0825.2010.01701.x","doi":"https://doi.org/10.1111/j.1601-0825.2010.01701.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1601-0825.2010.01701.x","pdf_url":null,"source":{"id":"https://openalex.org/S144270092","display_name":"Oral Diseases","issn_l":"1354-523X","issn":["1354-523X","1601-0825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Diseases","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34140327","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064605701","display_name":"Nicholas Stephen Jakubovics","orcid":"https://orcid.org/0000-0001-6667-0515","observed_orcids":["https://orcid.org/0000-0001-6667-0515"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"NS Jakubovics","raw_affiliation_strings":["Oral Biology, School of Dental Sciences, Newcastle University, UK. nick.jakubovics@ncl.ac.uk","Oral Biology, School of Dental Sciences, Newcastle University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Biology, School of Dental Sciences, Newcastle University, UK. nick.jakubovics@ncl.ac.uk","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Oral Biology, School of Dental Sciences, Newcastle University, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108573576","display_name":"Paul E. Kolenbrander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PE Kolenbrander","raw_affiliation_strings":["National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":1.2547,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.75352113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"16","issue":"8","first_page":"729","last_page":"739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12439","display_name":"Dental Research and COVID-19","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dental-plaque","display_name":"dental plaque","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bacterial-adhesion","display_name":"bacterial adhesion","score":0.7860000133514404},{"id":"https://openalex.org/keywords/salivary-pellicle","display_name":"salivary pellicle","score":0.9819999933242798},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.5680000185966492},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.6800000071525574},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microbial-signaling","display_name":"microbial signaling","score":0.43700000643730164},{"id":"https://openalex.org/keywords/oral-infectious-diseases","display_name":"oral infectious diseases","score":0.5630000233650208},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9321591258049011},{"id":"https://openalex.org/C2779914569","wikidata":"https://www.wikidata.org/wiki/Q143504","display_name":"Dental plaque","level":2,"score":0.6169831156730652},{"id":"https://openalex.org/C3020197141","wikidata":"https://www.wikidata.org/wiki/Q6621541","display_name":"Tooth surface","level":2,"score":0.6030064225196838},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5548096895217896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5102376937866211},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4989488124847412},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4892289638519287},{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.4807886481285095},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4524499177932739},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.42598623037338257},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.41360852122306824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38862505555152893},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27226200699806213},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.1961035430431366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19027340412139893},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12196037173271179},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003731","descriptor_name":"Dental Caries","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003773","descriptor_name":"Dental Plaque","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009059","descriptor_name":"Mouth Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014076","descriptor_name":"Tooth Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D044622","descriptor_name":"Dental Pellicle","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1601-0825.2010.01701.x","doi":"https://doi.org/10.1111/j.1601-0825.2010.01701.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1601-0825.2010.01701.x","pdf_url":null,"source":{"id":"https://openalex.org/S144270092","display_name":"Oral Diseases","issn_l":"1354-523X","issn":["1354-523X","1601-0825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Diseases","raw_type":"journal-article"},{"id":"pmid:20646235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20646235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral diseases","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34140327","doi":"https://doi.org/10.25405/ncl.34140327","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34140327","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34140327.v1","doi":"https://doi.org/10.25405/ncl.34140327.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34140327.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34140327","doi":"https://doi.org/10.25405/ncl.34140327","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34140327","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1492655095","https://openalex.org/W1556184331","https://openalex.org/W1730439168","https://openalex.org/W1778125126","https://openalex.org/W1845949782","https://openalex.org/W1864251586","https://openalex.org/W1883937874","https://openalex.org/W1916401377","https://openalex.org/W1950469557","https://openalex.org/W1967900692","https://openalex.org/W1970063271","https://openalex.org/W1973192271","https://openalex.org/W1976657756","https://openalex.org/W1977882228","https://openalex.org/W1978492370","https://openalex.org/W1978772641","https://openalex.org/W1979772969","https://openalex.org/W1991745053","https://openalex.org/W1993272563","https://openalex.org/W2000118500","https://openalex.org/W2005421221","https://openalex.org/W2007380246","https://openalex.org/W2017586786","https://openalex.org/W2017846450","https://openalex.org/W2022124341","https://openalex.org/W2024431465","https://openalex.org/W2025248886","https://openalex.org/W2035135773","https://openalex.org/W2035959356","https://openalex.org/W2036148129","https://openalex.org/W2037895543","https://openalex.org/W2043213635","https://openalex.org/W2045466186","https://openalex.org/W2045878113","https://openalex.org/W2048044149","https://openalex.org/W2055898472","https://openalex.org/W2062863297","https://openalex.org/W2067727329","https://openalex.org/W2077236546","https://openalex.org/W2085411273","https://openalex.org/W2090731549","https://openalex.org/W2091337262","https://openalex.org/W2095566926","https://openalex.org/W2098252888","https://openalex.org/W2104537952","https://openalex.org/W2104771379","https://openalex.org/W2108094670","https://openalex.org/W2109833361","https://openalex.org/W2119459276","https://openalex.org/W2119483434","https://openalex.org/W2119610831","https://openalex.org/W2123235711","https://openalex.org/W2125770874","https://openalex.org/W2125826054","https://openalex.org/W2128618257","https://openalex.org/W2129508575","https://openalex.org/W2130239469","https://openalex.org/W2130763979","https://openalex.org/W2131230616","https://openalex.org/W2135226445","https://openalex.org/W2137511001","https://openalex.org/W2138037404","https://openalex.org/W2138051254","https://openalex.org/W2140195816","https://openalex.org/W2143134178","https://openalex.org/W2143732865","https://openalex.org/W2144963203","https://openalex.org/W2146521357","https://openalex.org/W2147925086","https://openalex.org/W2150477308","https://openalex.org/W2153375130","https://openalex.org/W2156382695","https://openalex.org/W2157852790","https://openalex.org/W2162149255","https://openalex.org/W2164453191","https://openalex.org/W2165431499","https://openalex.org/W2168557435","https://openalex.org/W2169677384","https://openalex.org/W2169846007","https://openalex.org/W2170247585","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4242970892","https://openalex.org/W131736010","https://openalex.org/W4410891713","https://openalex.org/W2002518856","https://openalex.org/W2148803346","https://openalex.org/W4245601710","https://openalex.org/W1925150870","https://openalex.org/W4234240297","https://openalex.org/W4229679853","https://openalex.org/W2069785635"],"abstract_inverted_index":{"The":[0,23,120],"colonization":[1],"of":[2,12,15,29,52,59,74,113,122,132],"oral":[3,67,133,147],"surfaces":[4,88],"by":[5,71],"micro-organisms":[6],"occurs":[7],"in":[8,38,66,129],"a":[9,105],"characteristic":[10],"sequence":[11],"stages,":[13],"each":[14,127],"which":[16],"is":[17,69],"potentially":[18],"amenable":[19],"to":[20,31,110,118],"external":[21],"intervention.":[22],"process":[24],"begins":[25],"with":[26],"the":[27,39,50,57,60,72,111,130],"adhesion":[28],"bacteria":[30],"host":[32],"receptors":[33],"on":[34,86],"epithelial":[35],"cells":[36,85],"or":[37,141],"salivary":[40],"pellicle":[41],"covering":[42],"tooth":[43,87],"surfaces.":[44],"Interbacterial":[45],"cell-cell":[46],"binding":[47],"interactions":[48],"facilitate":[49],"attachment":[51],"new":[53,137],"species":[54],"and":[55,78,98],"increase":[56],"diversity":[58],"adherent":[61],"microbial":[62,124],"population.":[63],"Microbial":[64],"growth":[65],"biofilms":[68,134],"influenced":[70],"exchange":[73],"chemical":[75],"signals,":[76],"metabolites":[77],"toxic":[79],"products":[80],"between":[81],"neighbouring":[82],"cells.":[83],"Bacterial":[84],"(dental":[89],"plaque)":[90],"produce":[91],"extracellular":[92],"polymers":[93],"such":[94],"as":[95],"complex":[96],"carbohydrates":[97],"nucleic":[99],"acids.":[100],"These":[101],"large":[102],"molecules":[103],"form":[104],"protective":[106],"matrix":[107],"that":[108],"contributes":[109],"development":[112],"dental":[114],"caries":[115],"and,":[116],"possibly,":[117],"periodontitis.":[119],"identification":[121],"key":[123],"factors":[125],"underlying":[126],"step":[128],"formation":[131],"will":[135],"provide":[136],"opportunities":[138],"for":[139],"preventative":[140],"therapeutic":[142],"measures":[143],"aimed":[144],"at":[145],"controlling":[146],"infectious":[148],"diseases.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}