{"id":"https://openalex.org/W2134199290","doi":"https://doi.org/10.1210/jcem-56-2-352","title":"Cortisol Secretion Is Inhibited during Sleep in Normal Man*","display_name":"Cortisol Secretion Is Inhibited during Sleep in Normal Man*","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W2134199290","doi":"https://doi.org/10.1210/jcem-56-2-352","mag":"2134199290","pmid":"https://pubmed.ncbi.nlm.nih.gov/6822642"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-56-2-352","doi":"https://doi.org/10.1210/jcem-56-2-352","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-56-2-352","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111510937","display_name":"Elliot D. Weitzman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ELLIOT D. WEITZMAN","raw_affiliation_strings":["Laboratory of Human Chronophysiology, Department of Neurology, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine, Bronx, New York 10467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Chronophysiology, Department of Neurology, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine, Bronx, New York 10467","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035221153","display_name":"Janet C. Zimmerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JANET C. ZIMMERMAN","raw_affiliation_strings":["Laboratory of Human Chronophysiology, Department of Neurology, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine, Bronx, New York 10467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Chronophysiology, Department of Neurology, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine, Bronx, New York 10467","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087686970","display_name":"Charles Andrew Czeisler","orcid":"https://orcid.org/0000-0002-7408-1849","observed_orcids":["https://orcid.org/0000-0002-7408-1849"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHARLES A. CZEISLER","raw_affiliation_strings":["Laboratory of Human Chronophysiology, Department of Neurology, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine, Bronx, New York 10467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Chronophysiology, Department of Neurology, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine, Bronx, New York 10467","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036155950","display_name":"Joseph M. Ronda","orcid":"https://orcid.org/0000-0003-3878-7673","observed_orcids":["https://orcid.org/0000-0003-3878-7673"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOSEPH RONDA","raw_affiliation_strings":["Laboratory of Human Chronophysiology, Department of Neurology, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine, Bronx, New York 10467"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Chronophysiology, Department of Neurology, Montefiore Hospital and Medical Center, The Albert Einstein College of Medicine, Bronx, New York 10467","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.3063,"has_fulltext":false,"cited_by_count":268,"citation_normalized_percentile":{"value":0.92859341,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"56","issue":"2","first_page":"352","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.22450000047683716,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortisol-secretion","display_name":"cortisol secretion","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.9449999928474426},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ultradian-rhythms","display_name":"ultradian rhythms","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/180-degree-phase-shift","display_name":"180-degree phase shift","score":0.8370000123977661},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.7519999742507935},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.9890000224113464},{"id":"https://openalex.org/keywords/stage-4-sleep","display_name":"stage 4 sleep","score":0.7889999747276306},{"id":"https://openalex.org/keywords/sleep-stages","display_name":"sleep stages","score":0.3619999885559082},{"id":"https://openalex.org/keywords/shift-work","display_name":"shift work","score":0.7480000257492065},{"id":"https://openalex.org/keywords/jet-lag","display_name":"jet lag","score":0.7739999890327454},{"id":"https://openalex.org/keywords/biological-rhythms","display_name":"biological rhythms","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C136792703","wikidata":"https://www.wikidata.org/wiki/Q377893","display_name":"Ultradian rhythm","level":3,"score":0.8252436518669128},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.800883412361145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7729414701461792},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7080377340316772},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.7016549706459045},{"id":"https://openalex.org/C2777334680","wikidata":"https://www.wikidata.org/wiki/Q1607611","display_name":"Nocturnal","level":2,"score":0.5239232182502747},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.48411476612091064},{"id":"https://openalex.org/C2910364982","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep Stages","level":4,"score":0.4714169204235077},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.4412022531032562},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40701526403427124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3941419720649719},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.2500276565551758},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.22928386926651},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06126627326011658},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-56-2-352","doi":"https://doi.org/10.1210/jcem-56-2-352","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-56-2-352","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:6822642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6822642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W91649809","https://openalex.org/W103237393","https://openalex.org/W2006753879","https://openalex.org/W2008074001","https://openalex.org/W2026156430","https://openalex.org/W2035849185","https://openalex.org/W2039546583","https://openalex.org/W2043185535","https://openalex.org/W2045582164","https://openalex.org/W2054244022","https://openalex.org/W2071525837","https://openalex.org/W2132673430","https://openalex.org/W2148510598","https://openalex.org/W2167465959","https://openalex.org/W2396013880","https://openalex.org/W2415645137","https://openalex.org/W2415915148"],"related_works":["https://openalex.org/W96537532","https://openalex.org/W2012118444","https://openalex.org/W2034353806","https://openalex.org/W2068794238","https://openalex.org/W2066411740","https://openalex.org/W1983680482","https://openalex.org/W2321967345","https://openalex.org/W2026156430","https://openalex.org/W2155890529","https://openalex.org/W2016737414"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,48,140,237,250],"test":[3],"the":[4,81,100,112,121,124,166,196,211,215,241],"hypothesis":[5],"that":[6],"cortisol":[7,56,88,152,221],"secretion":[8,89,222],"is":[9],"inhibited":[10],"during":[11,96,136,165,174,181],"sleep,":[12,87],"six":[13],"healthy":[14],"young":[15],"men":[16],"(ages":[17],"18-24)":[18],"were":[19,58],"studied":[20],"in":[21,157,248],"a":[22,49,97,147],"4-day":[23],"protocol.":[24],"A":[25,183],"baseline":[26],"nocturnal":[27,51],"sleep":[28,36,39,52,76,94,142,162,170,177,205,253],"period":[29,242],"was":[30,71,77,90,102,107,119,132,163,179,186],"followed":[31],"by":[32,64],"one":[33],"night's":[34],"total":[35],"deprivation,":[37,254],"then":[38,46],"at":[40,111],"180":[41,167],"degrees":[42,168],"phase":[43,244],"shift,":[44],"and":[45,75,153,172,190,193,199,201,228,239,243,255],"return":[47],"normal":[50],"episode":[53,171],"(SP-3).":[54],"Plasma":[55],"concentrations":[57],"measured":[59,72],"every":[60,73],"20":[61],"min":[62],"(obtained":[63],"an":[65],"indwelling":[66],"venous":[67],"catheter),":[68],"rectal":[69],"temperature":[70,131],"minute,":[74],"polygraphically":[78],"defined.":[79],"During":[80],"first":[82],"4":[83,126,161,194],"h":[84,127,203],"of":[85,116,128,151,204,214,218,245],"sustained":[86],"decreased":[91,134,173],"even":[92],"when":[93,99],"occurred":[95],"time":[98,115,240],"subject":[101],"usually":[103],"awake;":[104],"conversely,":[105],"it":[106],"elevated":[108],"if":[109],"awake":[110],"usual":[113],"daily":[114],"sleeping.":[117],"This":[118],"not":[120],"case":[122],"for":[123,195,206],"last":[125],"sleep.":[129],"Body":[130],"also":[133],"but":[135],"each":[137],"entire":[138],"7-":[139],"8-h":[141],"period.":[143],"Meals":[144],"produced":[145,154],"only":[146],"small":[148],"brief":[149],"rise":[150],"no":[155],"change":[156],"body":[158],"temperature.":[159],"Stage":[160],"increased":[164,180],"inverted":[169],"SP-3,":[175],"REM":[176,189],"however":[178],"SP-3.":[182,207],"reciprocal":[184],"relationship":[185],"found":[187],"between":[188],"stages":[191],"3":[192],"second,":[197],"third,":[198],"fourth,":[200],"sixth":[202],"These":[208,231],"results":[209],"demonstrate":[210],"inhibitory":[212],"effect":[213],"behavioral":[216],"complex":[217],"sleeping":[219],"on":[220,224],"superimposed":[223],"its":[225],"endogenous":[226],"circadian":[227],"ultradian":[229],"rhythm.":[230],"neurophysiological":[232],"events":[233],"may":[234],"be":[235],"used":[236],"entrain":[238],"biological":[246],"rhythms":[247],"relation":[249],"shift":[251],"work,":[252],"transmeridian":[256],"jet":[257],"travel.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}