{"id":"https://openalex.org/W2134171193","doi":"https://doi.org/10.1200/jco.2013.49.7735","title":"Antitumor Granuloma Formation by CD4+ T Cells in a Patient With Rapidly Progressive Melanoma Experiencing Spiking Fevers, Neuropathy, and Other Immune-Related Toxicity After Treatment With Ipilimumab","display_name":"Antitumor Granuloma Formation by CD4+ T Cells in a Patient With Rapidly Progressive Melanoma Experiencing Spiking Fevers, Neuropathy, and Other Immune-Related Toxicity After Treatment With Ipilimumab","publication_year":2014,"publication_date":"2014-03-11","ids":{"openalex":"https://openalex.org/W2134171193","doi":"https://doi.org/10.1200/jco.2013.49.7735","mag":"2134171193","pmid":"https://pubmed.ncbi.nlm.nih.gov/24616309","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4881373"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.49.7735","doi":"https://doi.org/10.1200/jco.2013.49.7735","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.49.7735","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4881373","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063337705","display_name":"Jason J. Luke","orcid":"https://orcid.org/0000-0002-1182-4908","observed_orcids":["https://orcid.org/0000-0002-1182-4908"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason J. Luke","raw_affiliation_strings":["Melanoma Disease Center of Dana-Farber Cancer Institute; Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Disease Center of Dana-Farber Cancer Institute; Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080410786","display_name":"Cecilia M. Lezcano","orcid":"https://orcid.org/0000-0001-9436-9623","observed_orcids":["https://orcid.org/0000-0001-9436-9623"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia Lezcano","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084967339","display_name":"Frank Stephen Hodi","orcid":"https://orcid.org/0000-0001-6825-091X","observed_orcids":["https://orcid.org/0000-0001-6825-091X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Stephen Hodi","raw_affiliation_strings":["Melanoma Disease Center of Dana-Farber Cancer Institute; Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Disease Center of Dana-Farber Cancer Institute; Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018856906","display_name":"G\u00eborge F. Murphy","orcid":"https://orcid.org/0000-0001-9362-5146","observed_orcids":["https://orcid.org/0000-0001-9362-5146"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George F. Murphy","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0549,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.77494774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"6","first_page":"e32","last_page":"e35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9589999914169312},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/axillary-lymphadenopathy","display_name":"axillary lymphadenopathy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.7129999995231628},{"id":"https://openalex.org/keywords/neuropathy","display_name":"neuropathy","score":0.6779999732971191},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-toxicity","display_name":"immune checkpoint inhibitor toxicity","score":0.6299999952316284},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.640999972820282},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.656000018119812},{"id":"https://openalex.org/keywords/axillary-lymph-node-metastasis","display_name":"axillary lymph node metastasis","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.9246253967285156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.896454930305481},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6647224426269531},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6553722023963928},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6301049590110779},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.5929602980613708},{"id":"https://openalex.org/C2780140890","wikidata":"https://www.wikidata.org/wiki/Q1129338","display_name":"Granuloma","level":2,"score":0.43634337186813354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4081161916255951},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3917885720729828},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37068912386894226},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27683329582214355}],"mesh":[{"descriptor_ui":"D000074324","descriptor_name":"Ipilimumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1200/jco.2013.49.7735","doi":"https://doi.org/10.1200/jco.2013.49.7735","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.49.7735","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3863030","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4881373","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4881373","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4881373","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Oncol","raw_type":"Text"},{"id":"pmid:24616309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24616309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Case Reports"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3863030","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4881373","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G3016707047","display_name":"Immunology of human malignant melanoma initiating cells","funder_award_id":"R01CA158467","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4772125397","display_name":"Melanoma Stem Cells, Vasculogenesis and Neoplastic Progression","funder_award_id":"R01CA138231","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308347","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1556990476","https://openalex.org/W1979446115","https://openalex.org/W1981409467","https://openalex.org/W1982282657","https://openalex.org/W1982889687","https://openalex.org/W1997825389","https://openalex.org/W1998073711","https://openalex.org/W2020048983","https://openalex.org/W2020767958","https://openalex.org/W2035992494","https://openalex.org/W2038935770","https://openalex.org/W2066671159","https://openalex.org/W2071148552","https://openalex.org/W2078197336","https://openalex.org/W2091082335","https://openalex.org/W2095267413","https://openalex.org/W2097995306","https://openalex.org/W2099170730","https://openalex.org/W2109653150","https://openalex.org/W2122037714","https://openalex.org/W2140254549","https://openalex.org/W2155189639","https://openalex.org/W2243877964","https://openalex.org/W4252493435","https://openalex.org/W4302067670"],"related_works":["https://openalex.org/W1970166962","https://openalex.org/W2000289048","https://openalex.org/W2099651334","https://openalex.org/W7096586660","https://openalex.org/W2128965385","https://openalex.org/W2488328439","https://openalex.org/W2095267413","https://openalex.org/W1992104213","https://openalex.org/W7096377071","https://openalex.org/W2523659358"],"abstract_inverted_index":{"Case":[0],"ReportA":[1],"61-year-old":[2],"woman":[3],"was":[4,48,53,159,191,231,270,289,293,301,318,358],"diagnosed":[5],"in":[6,44,115,121,127,135,198,233,256,275],"1990":[7],"with":[8,71,170,266,370],"malignant":[9],"melanoma":[10,70],"arising":[11],"on":[12,272],"the":[13,26,33,51,95,109,128,181,189,207,217,220,228,234,242,247,257,279,299,316,325,332,339,354],"left":[14,37,143,215,326,355],"shoulder":[15],"and":[16,76,86,104,147,187,263,303,383,386,391,402],"underwent":[17],"wide":[18],"local":[19],"excision.No":[20],"other":[21],"details":[22],"are":[23],"available":[24],"regarding":[25],"initial":[27,337],"histology":[28],"or":[29],"work-up.In":[30],"late":[31],"2011,":[32],"patient":[34,158,190,248,269,317],"developed":[35],"a":[36,57,66,112,153,173,195,351,371],"axillary":[38,199,327,356],"mass.An":[39],"attempted":[40],"resection":[41],"took":[42],"place":[43],"early":[45],"2012.This":[46],"procedure":[47],"aborted":[49],"after":[50,241],"mass":[52,221],"deemed":[54],"unresectable":[55],"as":[56,150,152],"result":[58],"of":[59,108,118,123,175,227,238,245,259,298,307,313,341,353,365],"close":[60],"proximity":[61],"to":[62,162,193,261,331,345],"essential":[63],"neurovascular":[64],"structures.However,":[65],"biopsy":[67,79,352,360],"revealed":[68,80,111,140,361],"metastatic":[69],"immunohistochemistry":[72],"positive":[73],"for":[74,125,320,397],"Melan-A":[75],"S100.Histologically,":[77],"this":[78],"sparse,":[81],"individually":[82],"disposed":[83],"CD4":[84,103,373,382,398],"\u03e9":[85,88],"CD8":[87,376],"T":[89,368,406],"cells":[90,407],"that":[91,225,394],"were":[92,133,254,264,286,309],"scattered":[93],"throughout":[94],"tumor":[96,110,357,366],"nodule":[97],"(Figs":[98,377],"1A":[99],"through":[100,379],"1C;":[101],"H&E,":[102,381],"CD8,":[105,384],"respectively).Mutational":[106],"analysis":[107],"point":[113],"mutation":[114],"codon":[116],"61":[117],"NRAS":[119],"resulting":[120],"replacement":[122],"glutamine":[124],"arginine":[126],"product":[129],"protein.Only":[130],"wild-type":[131],"sequences":[132],"found":[134],"BRAF.A":[136],"positron-emission":[137],"tomography":[138,296],"scan":[139],"extensive":[141],"hypermetabolic":[142,154],"axillary,":[144],"infraclavicular,":[145],"supraclavicular,":[146],"cervical":[148],"lymphadenopathy":[149,328],"well":[151],"intraparotid":[155],"lymph":[156],"node.The":[157],"then":[160],"referred":[161],"our":[163],"institution,":[164],"where":[165,283],"she":[166,202],"began":[167,249],"receiving":[168],"treatment":[169],"ipilimumab":[171],"at":[172,335],"dose":[174,244],"3":[176,179,182],"mg/kg":[177],"every":[178],"weeks.In":[180],"weeks":[183],"between":[184],"doses":[185],"one":[186],"two,":[188],"noted":[192,334],"have":[194],"massive":[196],"increase":[197],"lymphadenopathy.Before":[200],"treatment,":[201],"had":[203,222,329],"palpable":[204],"disease":[205],"within":[206],"axilla,":[208],"although":[209],"it":[210],"did":[211],"not":[212],"affect":[213],"her":[214,336],"arm.By":[216],"second":[218,243],"dose,":[219],"grown":[223],"such":[224],"adduction":[226],"patient's":[229],"arm":[230],"limited":[232],"final":[235],"45":[236],"degrees":[237],"motion.Two":[239],"days":[240],"ipilimumab,":[246],"experiencing":[250],"twice-daily":[251],"relapsing":[252],"fevers.These":[253],"consistently":[255],"range":[258],"38.9\u00b0C":[260],"40\u00b0C":[262],"associated":[265],"drenching":[267],"sweats.The":[268],"evaluated":[271],"two":[273],"occasions":[274],"emergency":[276],"departments":[277],"over":[278,375],"next":[280],"7":[281],"days,":[282],"blood":[284],"cultures":[285],"negative,":[287],"CBC":[288],"unremarkable,":[290,302],"chest":[291],"x-ray":[292],"clear,":[294],"computed":[295],"(CT)":[297],"abdomen":[300],"no":[304],"localizing":[305],"signs":[306],"infection":[308],"observed.By":[310],"day":[311],"10":[312],"these":[314],"fevers,":[315],"admitted":[319],"palliative":[321],"support.On":[322],"physical":[323],"examination,":[324],"decreased":[330],"size":[333],"consultation.In":[338],"context":[340],"what":[342],"seemed":[343],"clinically":[344],"be":[346],"an":[347],"ipilimumab-induced":[348],"cytokine":[349],"storm,":[350],"obtained.This":[359],"focally":[362],"brisk":[363],"infiltration":[364],"by":[367],"cells,":[369],"marked":[372],"predominance":[374],"1D":[378,390],"1F;":[380],"respectively)":[385],"multinucleated":[387],"histiocytes":[388],"(Fig":[389,399],"1H,":[392],"arrows)":[393],"also":[395],"stained":[396],"1I,":[400],"arrow)":[401],"formed":[403],"small":[404],"microgranulomas.The":[405],"varied":[408],"from":[409]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
