{"id":"https://openalex.org/W2134166459","doi":"https://doi.org/10.1016/j.bbr.2003.10.034","title":"NMDA lesions in the medial prefrontal cortex impair the ability to inhibit responses during reversal of a simple spatial discrimination","display_name":"NMDA lesions in the medial prefrontal cortex impair the ability to inhibit responses during reversal of a simple spatial discrimination","publication_year":2004,"publication_date":"2004-01-30","ids":{"openalex":"https://openalex.org/W2134166459","doi":"https://doi.org/10.1016/j.bbr.2003.10.034","mag":"2134166459","pmid":"https://pubmed.ncbi.nlm.nih.gov/15196810"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbr.2003.10.034","doi":"https://doi.org/10.1016/j.bbr.2003.10.034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2003.10.034","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080936143","display_name":"Rodrigo F. Salazar","orcid":"https://orcid.org/0000-0003-3530-666X","observed_orcids":["https://orcid.org/0000-0003-3530-666X"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4405256566","display_name":"Institute of Neuroinformatics","ror":"https://ror.org/04a7xee56","country_code":"CH","type":"facility","lineage":["https://openalex.org/I202697423","https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405256566"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rodrigo F Salazar","raw_affiliation_strings":["Institute of Neuroinformatics, University Zuerich, Winterthurerstrasse 190 Zuerich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroinformatics, University Zuerich, Winterthurerstrasse 190 Zuerich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4405256566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051704458","display_name":"Wesley O White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44206873","display_name":"Morehead State University","ror":"https://ror.org/018yta094","country_code":"US","type":"education","lineage":["https://openalex.org/I44206873"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley White","raw_affiliation_strings":["Department of Psychology, Morehead State University, 601 Ginger Hall, Morehead, KY 40351, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Morehead State University, 601 Ginger Hall, Morehead, KY 40351, USA","institution_ids":["https://openalex.org/I44206873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081409534","display_name":"Laurent P. Lacroix","orcid":"https://orcid.org/0000-0002-5715-8058","observed_orcids":["https://orcid.org/0000-0002-5715-8058"]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laurent Lacroix","raw_affiliation_strings":["Drug Dependence and Behavioral Neurochemistry, GlaxoSmithKline, PsyCEDD 4, Via A. Fleming, 37135 Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Dependence and Behavioral Neurochemistry, GlaxoSmithKline, PsyCEDD 4, Via A. Fleming, 37135 Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113578168","display_name":"Joram Feldon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joram Feldon","raw_affiliation_strings":["Institute of Toxicology, Schorenstrasse 16, Swiss Federal Institute of Technology, Schwerzenbach, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Toxicology, Schorenstrasse 16, Swiss Federal Institute of Technology, Schwerzenbach, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113607076","display_name":"Ilsun M. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44206873","display_name":"Morehead State University","ror":"https://ror.org/018yta094","country_code":"US","type":"education","lineage":["https://openalex.org/I44206873"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ilsun M White","raw_affiliation_strings":["Department of Psychology, Morehead State University, 601 Ginger Hall, Morehead, KY 40351, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Morehead State University, 601 Ginger Hall, Morehead, KY 40351, USA","institution_ids":["https://openalex.org/I44206873"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5113607076"],"corresponding_institution_ids":["https://openalex.org/I44206873"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":2.6811,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.89461223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"152","issue":"2","first_page":"413","last_page":"424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.10329999774694443,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9739999771118164},{"id":"https://openalex.org/keywords/nmda-lesions","display_name":"NMDA lesions","score":0.8709999918937683},{"id":"https://openalex.org/keywords/reversal-learning","display_name":"reversal learning","score":0.8169999718666077},{"id":"https://openalex.org/keywords/spatial-discrimination","display_name":"spatial discrimination","score":0.9290000200271606},{"id":"https://openalex.org/keywords/response-inhibition","display_name":"response inhibition","score":0.9819999933242798},{"id":"https://openalex.org/keywords/instrumental-responding","display_name":"instrumental responding","score":0.5559999942779541},{"id":"https://openalex.org/keywords/sensorimotor-gating","display_name":"sensorimotor gating","score":0.875},{"id":"https://openalex.org/keywords/prepulse-inhibition","display_name":"prepulse inhibition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/open-field-behavior","display_name":"open field behavior","score":0.8140000104904175},{"id":"https://openalex.org/keywords/lister-hooded-rats","display_name":"Lister hooded rats","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C141421786","wikidata":"https://www.wikidata.org/wiki/Q1128897","display_name":"Prepulse inhibition","level":3,"score":0.7656500339508057},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7378888726234436},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7224270105361938},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.7092335224151611},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6808280348777771},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.5494024157524109},{"id":"https://openalex.org/C1337776","wikidata":"https://www.wikidata.org/wiki/Q1941955","display_name":"Facilitation","level":2,"score":0.5352417230606079},{"id":"https://openalex.org/C2779188335","wikidata":"https://www.wikidata.org/wiki/Q412504","display_name":"Muscimol","level":4,"score":0.4436585605144501},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4245930314064026},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.23768219351768494},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.17547181248664856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14554664492607117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1361875832080841},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.08700689673423767},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004193","descriptor_name":"Discrimination Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012193","descriptor_name":"Reversal Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013028","descriptor_name":"Space Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018690","descriptor_name":"Excitatory Amino Acid Agonists","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbr.2003.10.034","doi":"https://doi.org/10.1016/j.bbr.2003.10.034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2003.10.034","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},{"id":"pmid:15196810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15196810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural brain research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4924379136","display_name":"Prefrontal Cortex and Striatum in Rule Selection","funder_award_id":"1r15mh067606-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7389508618","display_name":null,"funder_award_id":"1 R15 MH067606-01","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1530071747","https://openalex.org/W1774425324","https://openalex.org/W1924760937","https://openalex.org/W1948130162","https://openalex.org/W1967443835","https://openalex.org/W1976707961","https://openalex.org/W1979704968","https://openalex.org/W1980025376","https://openalex.org/W1980727604","https://openalex.org/W1985857090","https://openalex.org/W1986566435","https://openalex.org/W1988283934","https://openalex.org/W1995023607","https://openalex.org/W1996244586","https://openalex.org/W1998592627","https://openalex.org/W1999333694","https://openalex.org/W2007909289","https://openalex.org/W2009797032","https://openalex.org/W2017192345","https://openalex.org/W2019908283","https://openalex.org/W2029499396","https://openalex.org/W2034155842","https://openalex.org/W2036326015","https://openalex.org/W2037707974","https://openalex.org/W2039285811","https://openalex.org/W2055420781","https://openalex.org/W2057627385","https://openalex.org/W2058675645","https://openalex.org/W2059415755","https://openalex.org/W2060095471","https://openalex.org/W2063513639","https://openalex.org/W2069222462","https://openalex.org/W2072175866","https://openalex.org/W2073714333","https://openalex.org/W2076365218","https://openalex.org/W2077222662","https://openalex.org/W2082887417","https://openalex.org/W2083273446","https://openalex.org/W2089232386","https://openalex.org/W2090332953","https://openalex.org/W2092843094","https://openalex.org/W2157671708","https://openalex.org/W2158052449","https://openalex.org/W2159648246","https://openalex.org/W2202136649","https://openalex.org/W4247603503","https://openalex.org/W4253452508"],"related_works":["https://openalex.org/W7202355586","https://openalex.org/W1980659383","https://openalex.org/W2795835241","https://openalex.org/W2158776599","https://openalex.org/W4407394568","https://openalex.org/W2006007844","https://openalex.org/W2021096516","https://openalex.org/W2049540001","https://openalex.org/W1979704968","https://openalex.org/W2092843094"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}