{"id":"https://openalex.org/W2134116359","doi":"https://doi.org/10.1016/j.jalz.2011.05.122","title":"IC\u2010P\u2010053: Age\u2010associated memory impairment is associated with greater rate of longitudinal brain atrophy","display_name":"IC\u2010P\u2010053: Age\u2010associated memory impairment is associated with greater rate of longitudinal brain atrophy","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2134116359","doi":"https://doi.org/10.1016/j.jalz.2011.05.122","mag":"2134116359"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2011.05.122","doi":"https://doi.org/10.1016/j.jalz.2011.05.122","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.122","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089954565","display_name":"Po\u2010Haong Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Po\u2010Haong Lu","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Grace Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Lee","raw_affiliation_strings":["UCLA Easton Center for Alzheimer's Disease Research, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Easton Center for Alzheimer's Disease Research, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100548510","display_name":"Xue Hua","orcid":"https://orcid.org/0009-0007-7625-4049","observed_orcids":["https://orcid.org/0009-0007-7625-4049"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Hua","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035692604","display_name":"Alex Leow","orcid":"https://orcid.org/0000-0002-5660-8651","observed_orcids":["https://orcid.org/0000-0002-5660-8651"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Leow","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007668185","display_name":"Stephanie J. Melchor","orcid":"https://orcid.org/0000-0003-3922-3394","observed_orcids":["https://orcid.org/0000-0003-3922-3394"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Melchor","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014949118","display_name":"Arthur W. Toga","orcid":"https://orcid.org/0000-0001-7902-3755","observed_orcids":["https://orcid.org/0000-0001-7902-3755","https://orcid.org/0000-0003-1454-8643"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Toga","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford Jack","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102977342","display_name":"Michael Walter Weiner","orcid":"https://orcid.org/0000-0002-0144-1954","observed_orcids":["https://orcid.org/0000-0002-0144-1954","https://orcid.org/0000-0002-7601-0702","https://orcid.org/0000-0002-0877-4583"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Weiner","raw_affiliation_strings":["Veterans Affairs and UCSF, San Francisco, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs and UCSF, San Francisco, California, United States","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867","observed_orcids":["https://orcid.org/0000-0002-4720-8867","https://orcid.org/0000-0003-2476-2803","https://orcid.org/0000-0002-2305-8438"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Thompson","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20806806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4S_Part_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-associated-memory-impairment","display_name":"age-associated memory impairment","score":0.9959999918937683},{"id":"https://openalex.org/keywords/brain-atrophy","display_name":"brain atrophy","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.6022751927375793},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5919545292854309},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.571155846118927},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5638212561607361},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5350154042243958},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5088944435119629},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4805793762207031},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.463284432888031},{"id":"https://openalex.org/C100660578","wikidata":"https://www.wikidata.org/wiki/Q18733","display_name":"Recall","level":2,"score":0.4108280837535858},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3574952483177185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3379138708114624},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33211278915405273},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.31925132870674133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.286274254322052},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19745787978172302},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.12752822041511536}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2011.05.122","doi":"https://doi.org/10.1016/j.jalz.2011.05.122","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.122","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4206844168","https://openalex.org/W7099559147","https://openalex.org/W1989378889","https://openalex.org/W2072617415","https://openalex.org/W2090220821","https://openalex.org/W1991451437","https://openalex.org/W2536757673","https://openalex.org/W2079488381","https://openalex.org/W4232805074","https://openalex.org/W2005546154"],"abstract_inverted_index":{"Age-Associated":[0],"Memory":[1],"Impairment":[2],"(AAMI)":[3],"was":[4,125,168,271],"initially":[5,89],"conceptualized":[6],"to":[7,170,233,263,280],"describe":[8],"a":[9,49],"feature":[10],"of":[11,43,51,58,67,117,175,201,257,269,276,303,313],"cognitive":[12,53],"aging.":[13],"It":[14],"is":[15,21,34,47],"defined":[16],"as":[17,148,223,225],"memory":[18],"performance":[19,111],"that":[20,37,206,285],"consistent":[22],"with":[23,73,91,273,300],"age-matched":[24],"peers":[25],"but":[26,46],"significantly":[27,211],"lower":[28],"than":[29,132],"younger":[30],"adults.":[31],"However,":[32],"there":[33],"mounting":[35],"evidence":[36],"AAMI":[38,74,156,208,265,270,292],"may":[39,293,307],"not":[40,253],"be":[41,294,308],"characteristic":[42],"healthy":[44],"aging":[45],"instead":[48],"harbinger":[50],"future":[52],"decline":[54],"and":[55,62,75,95,101,127,198,219,228],"eventual":[56],"development":[57],"dementia.":[59],"We":[60],"examined":[61],"compared":[63,189],"the":[64,81,107,113,118,138,162,191,202,207,216,226,234,249,264,310],"longitudinal":[65,213],"progression":[66],"brain":[68,177,259,277],"volume":[69,260],"changes":[70],"between":[71,190],"individuals":[72,128,299],"normal":[76,92],"cognition.":[77],"151":[78],"subjects":[79,152,159,282],"from":[80],"Alzheimer's":[82,289],"Disease":[83],"Neuroimaging":[84],"Initiative":[85],"(ADNI)":[86],"who":[87,129,306],"were":[88,104,146,188,196],"diagnosed":[90],"cognition":[93],"(NC)":[94],"had":[96],"MRI":[97],"scans":[98],"at":[99],"baseline":[100],"2-year":[102],"follow-up":[103],"included":[105],"in":[106,161,215,283,288,297,309],"present":[108],"study.":[109],"Baseline":[110],"on":[112],"delayed":[114],"recall":[115],"trial":[116],"Rey":[119],"Auditory":[120],"Verbal":[121],"Learning":[122],"Test":[123],"(RAVLT)":[124],"examined,":[126],"scored":[130],"more":[131],"1":[133],"standard":[134],"deviation":[135],"(SD)":[136],"below":[137],"mean":[139],"established":[140],"for":[141,155,180,241],"young":[142],"adults":[143],"(ages":[144],"20-29)":[145],"reclassified":[147],"having":[149],"AAMI.":[150],"Ninety":[151],"met":[153],"criteria":[154],"while":[157],"61":[158],"remained":[160],"NC":[163,235,250,281],"group.":[164,266],"Tensor-based":[165],"morphometry":[166],"(TBM)":[167],"used":[169],"create":[171],"3D":[172,186],"Jacobian":[173,203],"maps":[174,187,204],"local":[176],"atrophy":[178,214,278],"rates":[179],"individual":[181],"participants;":[182],"these":[183],"spatially":[184],"detailed":[185],"two":[192],"groups.":[193],"Regional":[194],"analyses":[195],"performed":[197],"direct":[199],"comparisons":[200,243],"revealed":[205],"group":[209,236,251],"demonstrated":[210],"greater":[212,258],"right":[217,220],"frontal":[218],"temporal":[221],"lobes":[222],"well":[224],"anterior":[227],"posterior":[229],"cingulate":[230],"gyrus":[231],"relative":[232,262,279],"(p":[237],"<":[238],"0.05;":[239],"corrected":[240],"multiple":[242],"using":[244],"permutation":[245],"tests).":[246],"In":[247],"contrast,":[248],"did":[252],"show":[254],"any":[255],"area":[256],"loss":[261],"The":[267],"diagnosis":[268],"associated":[272],"increased":[274],"rate":[275],"regions":[284],"are":[286],"affected":[287],"disease":[290],"(AD).":[291],"diagnostically":[295],"useful":[296],"identifying":[298],"early":[301],"signs":[302],"underlying":[304],"pathology":[305],"prodromal":[311],"stages":[312],"AD.":[314]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}