{"id":"https://openalex.org/W2134106936","doi":null,"title":"Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor gamma and retinoid X receptor alpha in human keratinocytes.","display_name":"Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor gamma and retinoid X receptor alpha in human keratinocytes.","publication_year":2000,"publication_date":"2000-04-15","ids":{"openalex":"https://openalex.org/W2134106936","mag":"2134106936","pmid":"https://pubmed.ncbi.nlm.nih.gov/10786691"},"language":"en","primary_location":{"id":"pmid:10786691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089718146","display_name":"Mohamed Boudjelal","orcid":"https://orcid.org/0000-0003-1009-4031","observed_orcids":["https://orcid.org/0000-0003-1009-4031"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Boudjelal","raw_affiliation_strings":["Department of Dermatology, University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087143608","display_name":"Zengquan Wang","orcid":"https://orcid.org/0000-0003-2797-4895","observed_orcids":["https://orcid.org/0000-0003-2797-4895"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z Wang","raw_affiliation_strings":["Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005798011","display_name":"John J. Voorhees","orcid":"https://orcid.org/0000-0003-1856-785X","observed_orcids":["https://orcid.org/0000-0003-1856-785X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J J Voorhees","raw_affiliation_strings":["Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086349143","display_name":"Gary J. Fisher","orcid":"https://orcid.org/0000-0002-6065-6242","observed_orcids":["https://orcid.org/0000-0002-6065-6242"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G J Fisher","raw_affiliation_strings":["Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":9.0736,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.98470877,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"60","issue":"8","first_page":"2247","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.2087000012397766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.1906999945640564,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9890000224113464},{"id":"https://openalex.org/keywords/retinoic-acid-receptor-gamma","display_name":"retinoic acid receptor gamma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/retinoid-x-receptor-alpha","display_name":"retinoid X receptor alpha","score":0.9990000128746033},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/pest-motif","display_name":"PEST motif","score":0.8410000205039978},{"id":"https://openalex.org/keywords/polyubiquitination","display_name":"polyubiquitination","score":0.9139999747276306},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.8240000009536743},{"id":"https://openalex.org/keywords/photoaging","display_name":"photoaging","score":0.8209999799728394},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C68484354","wikidata":"https://www.wikidata.org/wiki/Q17516011","display_name":"Retinoid X receptor alpha","level":5,"score":0.6093611717224121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5912997126579285},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5403033494949341},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.535402774810791},{"id":"https://openalex.org/C162253465","wikidata":"https://www.wikidata.org/wiki/Q18031338","display_name":"Retinoid X receptor gamma","level":5,"score":0.4843329191207886},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.48332715034484863},{"id":"https://openalex.org/C758759","wikidata":"https://www.wikidata.org/wiki/Q18031337","display_name":"Retinoid X receptor beta","level":5,"score":0.4765244722366333},{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.4605751037597656},{"id":"https://openalex.org/C119775778","wikidata":"https://www.wikidata.org/wiki/Q18031040","display_name":"Retinoic acid receptor alpha","level":5,"score":0.439981609582901},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4395178258419037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4354686737060547},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.4022866189479828},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.3477640151977539},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32925018668174744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3217344284057617},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.2039211094379425},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.14679676294326782},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.05605432391166687},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000097768","descriptor_name":"Retinoic Acid Receptor gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10786691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.1152","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.1152","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/60/8/2247.full.pdf","raw_type":"text"},{"id":"mag:2134106936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10786691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W79321944","https://openalex.org/W566534948","https://openalex.org/W1542669094","https://openalex.org/W1551998217","https://openalex.org/W1594617739","https://openalex.org/W1653065940","https://openalex.org/W1812339273","https://openalex.org/W1927684145","https://openalex.org/W1966263533","https://openalex.org/W1972300087","https://openalex.org/W1982597283","https://openalex.org/W1995891446","https://openalex.org/W2002223631","https://openalex.org/W2008744347","https://openalex.org/W2010601153","https://openalex.org/W2011230305","https://openalex.org/W2015357935","https://openalex.org/W2018397818","https://openalex.org/W2026199417","https://openalex.org/W2044005280","https://openalex.org/W2051237142","https://openalex.org/W2053632669","https://openalex.org/W2060736209","https://openalex.org/W2067233094","https://openalex.org/W2082079445","https://openalex.org/W2105024913","https://openalex.org/W2118684251","https://openalex.org/W2178503716","https://openalex.org/W2623930462"],"related_works":["https://openalex.org/W1580003303","https://openalex.org/W2098829197","https://openalex.org/W7095679203","https://openalex.org/W2025244294","https://openalex.org/W1977030901","https://openalex.org/W1990968397","https://openalex.org/W2422887374","https://openalex.org/W1990818717","https://openalex.org/W1981397830","https://openalex.org/W2136610413"],"abstract_inverted_index":{"Repeated":[0],"exposure":[1,55,89,142],"of":[2,30,56,80,82,107,109,118,122,136,143,161,198,225,239,246,277],"human":[3,59],"skin":[4,15,18,34],"to":[5,10,61,145,184,219],"solar":[6],"UV":[7,62,88,100,147,252],"radiation":[8,148],"leads":[9],"premature":[11],"aging":[12],"(photoaging)":[13],"and":[14,46,70,73,84,126,138,167,174,190,248],"cancer.":[16],"UV-induced":[17],"damage":[19],"can":[20],"be":[21],"ameliorated":[22],"by":[23,39,206],"all-trans":[24],"retinoic":[25,31,41],"acid":[26,32,42],"treatment.":[27],"The":[28,78,120],"actions":[29],"in":[33,170,178,214],"keratinocytes":[35,60,144,157],"are":[36,204],"mediated":[37],"primarily":[38],"nuclear":[40,278],"receptor":[43,49],"gamma":[44],"(RARgamma)":[45],"retinoid":[47,279],"X":[48],"alpha":[50],"(RXRalpha).":[51],"We":[52],"found":[53,183],"that":[54,164,203,244,267],"cultured":[57],"primary":[58],"irradiation":[63,101,253],"(30":[64],"mJ/cm2)":[65],"substantially":[66],"reduced":[67,115],"(50-90%)":[68],"RARgamma":[69,83,110,137,166,173,247],"RXRalpha":[71,85,112,139,168,175,181,215,249],"mRNA":[72],"protein":[74,94],"within":[75],"8":[76],"h.":[77],"rates":[79],"disappearance":[81],"proteins":[86,140,169,202,250],"after":[87,141,251],"or":[90,111,149,155,230,236],"treatment":[91],"with":[92],"the":[93,105,130,207,211,226,258,263,275],"synthesis":[95],"inhibitor":[96,132],"cycloheximide":[97],"were":[98,176],"similar.":[99],"did":[102,216,232],"not":[103,129,217,233],"increase":[104],"rate":[106,117],"breakdown":[108,269],"but":[113,128],"rather":[114],"their":[116],"synthesis.":[119],"addition":[121],"proteasome":[123,162],"inhibitors":[124],"MG132":[125],"LLvL,":[127],"lysosomal":[131],"E64,":[133],"prevented":[134],"loss":[135,245],"either":[146],"cycloheximide.":[150],"Soluble":[151],"extracts":[152],"from":[153,255],"nonirradiated":[154],"UV-irradiated":[156],"possessed":[158],"similar":[159],"levels":[160,276],"activity":[163],"degraded":[165,205],"vitro.":[171],"Furthermore,":[172],"polyubiquitinated":[177],"intact":[179],"cells.":[180],"was":[182],"contain":[185],"two":[186],"proline,":[187],"glutamate/aspartate,":[188],"serine,":[189],"threonine":[191],"(PEST)":[192],"motifs,":[193],"which":[194],"confer":[195],"rapid":[196],"turnover":[197],"many":[199],"short-lived":[200],"regulatory":[201],"ubiquitin/proteasome":[208,259],"pathway.":[209,260],"However,":[210],"PEST":[212,227],"motifs":[213,228],"function":[218],"regulate":[220],"its":[221],"stability,":[222],"because":[223],"deletion":[224],"individually":[229],"together":[231],"alter":[234],"ubiquitination":[235],"proteasome-mediated":[237],"degradation":[238,256],"RXRalpha.":[240],"These":[241],"results":[242,254],"demonstrate":[243],"via":[257],"Taken":[261],"together,":[262],"data":[264],"here":[265],"indicate":[266],"ubiquitin/proteasome-mediated":[268],"is":[270],"an":[271],"important":[272],"mechanism":[273],"regulating":[274],"receptors.":[280]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
