{"id":"https://openalex.org/W2134092288","doi":"https://doi.org/10.1186/1129-2377-14-s1-i2","title":"Analgesic drug development: time to break the mould","display_name":"Analgesic drug development: time to break the mould","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W2134092288","doi":"https://doi.org/10.1186/1129-2377-14-s1-i2","mag":"2134092288"},"language":"en","primary_location":{"id":"doi:10.1186/1129-2377-14-s1-i2","doi":"https://doi.org/10.1186/1129-2377-14-s1-i2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1129-2377-14-s1-i2","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/1129-2377-14-S1-I2","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/1129-2377-14-S1-I2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017534594","display_name":"Clifford J. Woolf","orcid":"https://orcid.org/0000-0002-6636-3897","observed_orcids":["https://orcid.org/0000-0002-6636-3897","https://orcid.org/0000-0001-9840-596X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clifford Woolf","raw_affiliation_strings":["F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, USA","F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital and Department of Neurobiology, Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"F.M. Kirby Neurobiology Center, Boston Children\u2019s Hospital and Department of Neurobiology, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017534594"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":0.207,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60979368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.13420000672340393,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/analgesic-drug-development","display_name":"analgesic drug development","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-target-selection","display_name":"drug target selection","score":0.46000000834465027},{"id":"https://openalex.org/keywords/hit-identification","display_name":"hit identification","score":0.6859999895095825},{"id":"https://openalex.org/keywords/proof-of-concept","display_name":"proof of concept","score":0.6930000185966492},{"id":"https://openalex.org/keywords/clinical-trial-failure","display_name":"clinical trial failure","score":0.6940000057220459},{"id":"https://openalex.org/keywords/disease-phenotype","display_name":"disease phenotypes","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8386878967285156},{"id":"https://openalex.org/C2991975920","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain medicine","level":3,"score":0.6620553731918335},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.6537158489227295},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6126390099525452},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5459628701210022},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5257226824760437},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5231978893280029},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.4494676887989044},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.36162450909614563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3039202094078064},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.25041839480400085},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16743820905685425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08925873041152954},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1129-2377-14-s1-i2","doi":"https://doi.org/10.1186/1129-2377-14-s1-i2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1129-2377-14-s1-i2","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/1129-2377-14-S1-I2","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2769108","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3619983","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3619983","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3619983","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Headache Pain","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/11877041","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:11877041","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1129-2377-14-s1-i2","doi":"https://doi.org/10.1186/1129-2377-14-s1-i2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1129-2377-14-s1-i2","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/1129-2377-14-S1-I2","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2134092288.pdf","grobid_xml":"https://content.openalex.org/works/W2134092288.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966551501","https://openalex.org/W2074216430","https://openalex.org/W149604944","https://openalex.org/W2924671081","https://openalex.org/W2055557036","https://openalex.org/W2009881406","https://openalex.org/W3196169613","https://openalex.org/W4413164633","https://openalex.org/W3185474353","https://openalex.org/W2000464567"],"abstract_inverted_index":{"Success":[0],"in":[1,55,60],"the":[2,15,73,78,105],"introduction":[3],"of":[4,35,80,83,86,90],"novel,":[5],"effective":[6],"and":[7,27,44,88,107,122],"safe":[8],"analgesics":[9],"has":[10],"been":[11,47],"notably":[12],"limited":[13],"over":[14],"past":[16],"ten":[17],"years":[18],"even":[19],"though":[20],"existing":[21],"treatments":[22],"have":[23,46,64],"low":[24],"responder":[25],"rates":[26],"a":[28],"high":[29],"side":[30],"effect":[31],"burden.":[32],"The":[33],"pipeline":[34],"compounds":[36],"acting":[37],"on":[38,109],"novel":[39],"targets":[40],"is":[41,69,98,102],"very":[42],"restricted":[43],"there":[45],"many":[48],"disappointments":[49],"with":[50,72],"drugs":[51],"that":[52,67,101],"appeared":[53],"promising":[54],"preclinical":[56],"studies,":[57],"failing":[58],"repeatedly":[59],"clinical":[61,92],"trials.":[62],"We":[63],"to":[65,77,127],"recognize":[66],"something":[68],"fundamentally":[70],"wrong":[71],"industry":[74],"standard":[75],"approach":[76,118],"selection":[79],"targets,":[81],"identification":[82],"hits,":[84],"validation":[85],"leads":[87],"proof":[89],"concept":[91],"studies.":[93],"A":[94],"radically":[95],"alternative":[96],"strategy":[97],"required,":[99],"one":[100],"driven":[103],"by":[104],"patient":[106],"focused":[108],"disease":[110],"phenotype.":[111],"I":[112],"will":[113],"discuss":[114],"what":[115],"such":[116],"an":[117],"may":[119,125],"look":[120],"like":[121],"how":[123],"it":[124],"contribute":[126],"new":[128],"therapeutics.":[129]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
