{"id":"https://openalex.org/W2134047057","doi":"https://doi.org/10.1099/mic.0.042564-0","title":"Polyamine biosynthesis and transport mechanisms are crucial for fitness and pathogenesis of Streptococcus pneumoniae","display_name":"Polyamine biosynthesis and transport mechanisms are crucial for fitness and pathogenesis of Streptococcus pneumoniae","publication_year":2010,"publication_date":"2010-10-22","ids":{"openalex":"https://openalex.org/W2134047057","doi":"https://doi.org/10.1099/mic.0.042564-0","mag":"2134047057","pmid":"https://pubmed.ncbi.nlm.nih.gov/20966092"},"language":"en","primary_location":{"id":"doi:10.1099/mic.0.042564-0","doi":"https://doi.org/10.1099/mic.0.042564-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.042564-0","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044336434","display_name":"Pratik Shah","orcid":"https://orcid.org/0000-0003-2037-5697","observed_orcids":["https://orcid.org/0000-0003-2037-5697"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratik Shah","raw_affiliation_strings":["Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060469989","display_name":"Bindu Nanduri","orcid":"https://orcid.org/0000-0002-9996-2976","observed_orcids":["https://orcid.org/0000-0002-9996-2976"]},"institutions":[{"id":"https://openalex.org/I99041443","display_name":"Mississippi State University","ror":"https://ror.org/0432jq872","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I99041443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bindu Nanduri","raw_affiliation_strings":["College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA","institution_ids":["https://openalex.org/I99041443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009027494","display_name":"Edwin Swiatlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Swiatlo","raw_affiliation_strings":["Research Service, Veteran Affairs Medical Center, 1500 East Woodrow Wilson Drive, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Service, Veteran Affairs Medical Center, 1500 East Woodrow Wilson Drive, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210144720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081352482","display_name":"Yinfa Ma","orcid":"https://orcid.org/0000-0002-9719-8345","observed_orcids":["https://orcid.org/0000-0002-9719-8345"]},"institutions":[{"id":"https://openalex.org/I20382870","display_name":"Missouri University of Science and Technology","ror":"https://ror.org/00scwqd12","country_code":"US","type":"education","lineage":["https://openalex.org/I20382870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinfa Ma","raw_affiliation_strings":["Department of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA","institution_ids":["https://openalex.org/I20382870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086928200","display_name":"Ken Pendarvis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99041443","display_name":"Mississippi State University","ror":"https://ror.org/0432jq872","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I99041443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Pendarvis","raw_affiliation_strings":["College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA","institution_ids":["https://openalex.org/I99041443"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1984,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.8766075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"157","issue":"2","first_page":"504","last_page":"515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9769999980926514},{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.8519999980926514},{"id":"https://openalex.org/keywords/polyamine-biosynthesis","display_name":"polyamine biosynthesis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/polyamine-transport","display_name":"polyamine transport","score":0.9620000123977661},{"id":"https://openalex.org/keywords/spermidine-synthase","display_name":"spermidine synthase","score":0.7879999876022339},{"id":"https://openalex.org/keywords/lysine-decarboxylase","display_name":"lysine decarboxylase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/putrescine","display_name":"putrescine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cadaverine","display_name":"cadaverine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.871999979019165},{"id":"https://openalex.org/keywords/pneumococcal-pneumonia","display_name":"pneumococcal pneumonia","score":0.7540000081062317},{"id":"https://openalex.org/keywords/invasive-pneumococcal-disease","display_name":"invasive pneumococcal disease","score":0.9039999842643738},{"id":"https://openalex.org/keywords/bacterial-fitness","display_name":"bacterial fitness","score":0.5149999856948853},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.5649999976158142},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.8701155185699463},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.7845580577850342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6678118705749512},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.6221652030944824},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6118853092193604},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5765550136566162},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49677807092666626},{"id":"https://openalex.org/C2776928777","wikidata":"https://www.wikidata.org/wiki/Q161555","display_name":"Cadaverine","level":4,"score":0.4704519808292389},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.4428720474243164},{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.44102802872657776},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.42233920097351074},{"id":"https://openalex.org/C2777107663","wikidata":"https://www.wikidata.org/wiki/Q4789579","display_name":"Arginine decarboxylase","level":4,"score":0.41137897968292236},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38426390290260315},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20820868015289307},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19647273421287537},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000143","descriptor_name":"Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011018","descriptor_name":"Pneumonia, Pneumococcal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/mic.0.042564-0","doi":"https://doi.org/10.1099/mic.0.042564-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/mic.0.042564-0","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},{"id":"pmid:20966092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20966092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology (Reading, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W111229387","https://openalex.org/W176970103","https://openalex.org/W197445827","https://openalex.org/W1496998265","https://openalex.org/W1553269682","https://openalex.org/W1558162435","https://openalex.org/W1568874761","https://openalex.org/W1976667340","https://openalex.org/W1977782657","https://openalex.org/W1987176581","https://openalex.org/W2008229139","https://openalex.org/W2015616512","https://openalex.org/W2017636699","https://openalex.org/W2017801880","https://openalex.org/W2021164435","https://openalex.org/W2025320937","https://openalex.org/W2026465178","https://openalex.org/W2028255595","https://openalex.org/W2032045884","https://openalex.org/W2034204696","https://openalex.org/W2037825029","https://openalex.org/W2038169339","https://openalex.org/W2043801100","https://openalex.org/W2050974949","https://openalex.org/W2053867514","https://openalex.org/W2056118948","https://openalex.org/W2063649343","https://openalex.org/W2071037031","https://openalex.org/W2071348210","https://openalex.org/W2072000480","https://openalex.org/W2079255865","https://openalex.org/W2089492568","https://openalex.org/W2098544115","https://openalex.org/W2105247882","https://openalex.org/W2108360478","https://openalex.org/W2108604935","https://openalex.org/W2110065044","https://openalex.org/W2112296388","https://openalex.org/W2118107917","https://openalex.org/W2118244289","https://openalex.org/W2119422239","https://openalex.org/W2126687190","https://openalex.org/W2130011291","https://openalex.org/W2131464452","https://openalex.org/W2131942193","https://openalex.org/W2132664565","https://openalex.org/W2135875089","https://openalex.org/W2136315974","https://openalex.org/W2145435157","https://openalex.org/W2146024729","https://openalex.org/W2146460181","https://openalex.org/W2149395493","https://openalex.org/W2155446791","https://openalex.org/W2156328657","https://openalex.org/W2158267918","https://openalex.org/W2160110467","https://openalex.org/W2162953780","https://openalex.org/W2164191772","https://openalex.org/W2167320966","https://openalex.org/W2167797060","https://openalex.org/W2199320714","https://openalex.org/W4231862266","https://openalex.org/W4244022288","https://openalex.org/W6644263887"],"related_works":["https://openalex.org/W2136315974","https://openalex.org/W3207317166","https://openalex.org/W3126563814","https://openalex.org/W3136972637","https://openalex.org/W7095350046","https://openalex.org/W2425724872","https://openalex.org/W2622731166","https://openalex.org/W2071037031","https://openalex.org/W2087631453","https://openalex.org/W2793018931"],"abstract_inverted_index":{"Polyamines":[0],"such":[1],"as":[2],"cadaverine,":[3],"putrescine":[4,53],"and":[5,37,50,54,56,60,67,101,126,146,158,181,212,221,231,239,246],"spermidine":[6,61,68],"are":[7,105,224],"polycationic":[8],"molecules":[9],"that":[10,79],"have":[11,40,77],"pleiotropic":[12],"effects":[13],"on":[14],"cells":[15],"via":[16],"their":[17,63,112],"interaction":[18],"with":[19,165,200],"nucleic":[20],"acids.":[21],"Streptococcus":[22],"pneumoniae":[23],"(the":[24],"pneumococcus)":[25],"is":[26,85,117],"a":[27,41],"Gram-positive":[28],"pathogen":[29],"capable":[30],"of":[31,52,111,123,155,209,233],"causing":[32],"pneumonia,":[33,159],"septicaemia,":[34],"otitis":[35],"media":[36],"meningitis.":[38],"Pneumococci":[39],"polyamine":[42,124,135,193,219],"transport":[43,51,127,141,222],"operon":[44],"(potABCD)":[45],"responsible":[46],"for":[47,244],"the":[48,120,166,179,228,234],"binding":[49],"spermidine,":[55],"can":[57],"synthesize":[58],"cadaverine":[59],"using":[62],"lysine":[64],"decarboxylase":[65],"(cad)":[66],"synthase":[69],"(speE)":[70],"enzymes.":[71],"Previous":[72],"studies":[73],"from":[74],"our":[75],"laboratory":[76],"shown":[78],"an":[80],"increase":[81],"in":[82,107,134,152,163,195,215,236],"PotD":[83],"expression":[84,208],"seen":[86],"following":[87],"exposure":[88],"to":[89,129,149,185,227],"various":[90],"stresses,":[91],"while":[92,178],"during":[93,175],"infection,":[94],"potD":[95],"inactivation":[96],"significantly":[97],"attenuates":[98],"pneumococcal":[99,130,156],"virulence,":[100],"anti-PotD":[102],"immune":[103],"responses":[104],"protective":[106],"mice.":[108],"In":[109],"spite":[110],"relative":[113],"importance,":[114],"not":[115],"much":[116],"known":[118],"about":[119],"global":[121],"contribution":[122],"biosynthesis":[125,136,220],"pathways":[128],"disease.":[131],"Mutants":[132],"deficient":[133],"(\u0394speE":[137],"or":[138,140,162],"\u0394cad)":[139],"genes":[142,183],"(\u0394potABCD)":[143],"were":[144,147],"constructed":[145],"found":[148],"be":[150,186],"attenuated":[151,174],"murine":[153],"models":[154],"colonization":[157],"either":[160],"alone":[161],"competition":[164],"wild-type":[167,201],"strain.":[168],"The":[169],"\u0394speE":[170],"mutant":[171,197,216],"was":[172],"also":[173],"invasive":[176],"disease,":[177],"potABCD":[180],"cad":[182],"seemed":[184],"dispensable.":[187],"HPLC":[188],"analyses":[189,205],"showed":[190],"reduced":[191,207],"intracellular":[192],"levels":[194],"all":[196],"strains":[198],"compared":[199],"bacteria.":[202],"High-throughput":[203],"proteomic":[204],"indicated":[206],"growth,":[210],"replication":[211],"virulence":[213],"factors":[214],"strains.":[217],"Thus,":[218],"mechanisms":[223],"intricately":[225],"linked":[226],"fitness,":[229],"survival":[230],"pathogenesis":[232],"pneumococcus":[235],"host":[237],"microenvironments,":[238],"may":[240],"represent":[241],"important":[242],"targets":[243],"prophylactic":[245],"therapeutic":[247],"interventions.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}