{"id":"https://openalex.org/W2133976385","doi":null,"title":"PET studies of the dopamine system in relation to cognitive functions","display_name":"PET studies of the dopamine system in relation to cognitive functions","publication_year":2007,"publication_date":"2007-09-21","ids":{"openalex":"https://openalex.org/W2133976385","mag":"2133976385"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26901709","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/PET_studies_of_the_dopamine_system_in_relation_to_cognitive_functions/26901709","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/39192","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005160720","display_name":"Nina Erixon-Lindroth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nina Erixon-Lindroth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005160720"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopaminergic-system","display_name":"dopaminergic system","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.9649999737739563},{"id":"https://openalex.org/keywords/11c-pe2i","display_name":"[11C]PE2I","score":0.9229999780654907},{"id":"https://openalex.org/keywords/radioligand-development","display_name":"radioligand development","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.871999979019165},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7979999780654907},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9959999918937683},{"id":"https://openalex.org/keywords/visuospatial-working-memory","display_name":"visuospatial working memory","score":0.875},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.949999988079071},{"id":"https://openalex.org/keywords/cognitive-strategies","display_name":"cognitive strategies","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.421999990940094},{"id":"https://openalex.org/keywords/attention","display_name":"attention","score":0.36500000953674316},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.640999972820282},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.5799999833106995},{"id":"https://openalex.org/keywords/ceiling-effect","display_name":"ceiling effect","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5811758637428284},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.5371001958847046},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.48097172379493713},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.423796147108078},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3812204897403717},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3358560800552368},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.32427868247032166},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.284610778093338},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.11789461970329285}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26901709","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/PET_studies_of_the_dopamine_system_in_relation_to_cognitive_functions/26901709","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/39192","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39192","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2133976385","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/39192","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/39192","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39192","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W37005","https://openalex.org/W163992591","https://openalex.org/W180263596","https://openalex.org/W192936045","https://openalex.org/W290696508","https://openalex.org/W349886740","https://openalex.org/W566809821","https://openalex.org/W612682118","https://openalex.org/W1238819995","https://openalex.org/W1506946474","https://openalex.org/W1521032026","https://openalex.org/W1539006433","https://openalex.org/W1546941611","https://openalex.org/W1563959665","https://openalex.org/W1641421106","https://openalex.org/W1819927624","https://openalex.org/W1864551508","https://openalex.org/W1911640279","https://openalex.org/W1921980981","https://openalex.org/W1925492557","https://openalex.org/W1964141250","https://openalex.org/W1964979617","https://openalex.org/W1965502156","https://openalex.org/W1969967069","https://openalex.org/W1972856556","https://openalex.org/W1973932158","https://openalex.org/W1976630512","https://openalex.org/W1976707961","https://openalex.org/W1977410909","https://openalex.org/W1977869470","https://openalex.org/W1982819749","https://openalex.org/W1983200793","https://openalex.org/W1983695475","https://openalex.org/W1983779361","https://openalex.org/W1987683081","https://openalex.org/W1990840741","https://openalex.org/W1991859664","https://openalex.org/W1992634843","https://openalex.org/W1993616139","https://openalex.org/W1994357188","https://openalex.org/W1995362640","https://openalex.org/W2001110708","https://openalex.org/W2002132239","https://openalex.org/W2003708984","https://openalex.org/W2004553227","https://openalex.org/W2006186060","https://openalex.org/W2006715508","https://openalex.org/W2009074722","https://openalex.org/W2009077748","https://openalex.org/W2010230693","https://openalex.org/W2010755056","https://openalex.org/W2014793858","https://openalex.org/W2020404764","https://openalex.org/W2021304061","https://openalex.org/W2024249150","https://openalex.org/W2028322865","https://openalex.org/W2028619376","https://openalex.org/W2028884770","https://openalex.org/W2029313053","https://openalex.org/W2030236696","https://openalex.org/W2030605350","https://openalex.org/W2030905853","https://openalex.org/W2033720653","https://openalex.org/W2036974111","https://openalex.org/W2038054494","https://openalex.org/W2038409107","https://openalex.org/W2039884145","https://openalex.org/W2042066622","https://openalex.org/W2043941998","https://openalex.org/W2044474088","https://openalex.org/W2050894512","https://openalex.org/W2051761345","https://openalex.org/W2053293311","https://openalex.org/W2053925782","https://openalex.org/W2054230322","https://openalex.org/W2055651914","https://openalex.org/W2058329491","https://openalex.org/W2058563612","https://openalex.org/W2058795043","https://openalex.org/W2058966392","https://openalex.org/W2061471303","https://openalex.org/W2062608310","https://openalex.org/W2062990061","https://openalex.org/W2063879547","https://openalex.org/W2066735646","https://openalex.org/W2070900790","https://openalex.org/W2070924027","https://openalex.org/W2072581810","https://openalex.org/W2074482523","https://openalex.org/W2075328753","https://openalex.org/W2075362165","https://openalex.org/W2076734975","https://openalex.org/W2077108130","https://openalex.org/W2077634993","https://openalex.org/W2077767624","https://openalex.org/W2079128738","https://openalex.org/W2080895738","https://openalex.org/W2089686687","https://openalex.org/W2090156827","https://openalex.org/W2090291844","https://openalex.org/W2092462980","https://openalex.org/W2092868760","https://openalex.org/W2093795230","https://openalex.org/W2099652807","https://openalex.org/W2100017853","https://openalex.org/W2107457769","https://openalex.org/W2110771878","https://openalex.org/W2113449040","https://openalex.org/W2114177397","https://openalex.org/W2114581688","https://openalex.org/W2115045018","https://openalex.org/W2117518771","https://openalex.org/W2117594753","https://openalex.org/W2118907570","https://openalex.org/W2119410682","https://openalex.org/W2120481681","https://openalex.org/W2121878832","https://openalex.org/W2122694895","https://openalex.org/W2125253069","https://openalex.org/W2126281826","https://openalex.org/W2126488639","https://openalex.org/W2132569138","https://openalex.org/W2133510276","https://openalex.org/W2133748952","https://openalex.org/W2135018536","https://openalex.org/W2135550220","https://openalex.org/W2137145004","https://openalex.org/W2142525406","https://openalex.org/W2142801688","https://openalex.org/W2148477876","https://openalex.org/W2149885167","https://openalex.org/W2150459251","https://openalex.org/W2150672384","https://openalex.org/W2151128435","https://openalex.org/W2151132195","https://openalex.org/W2153525031","https://openalex.org/W2155125375","https://openalex.org/W2157861272","https://openalex.org/W2159006998","https://openalex.org/W2159996636","https://openalex.org/W2160891205","https://openalex.org/W2163033248","https://openalex.org/W2163033967","https://openalex.org/W2165692873","https://openalex.org/W2165698679","https://openalex.org/W2171140194","https://openalex.org/W2206687388","https://openalex.org/W2284323937","https://openalex.org/W2298845081","https://openalex.org/W2395525054","https://openalex.org/W2400308077","https://openalex.org/W2411997828","https://openalex.org/W2785913106","https://openalex.org/W2798631809","https://openalex.org/W2897111684","https://openalex.org/W2909675640","https://openalex.org/W2924822559","https://openalex.org/W2949561799","https://openalex.org/W2964138113","https://openalex.org/W2996961565","https://openalex.org/W3026424478","https://openalex.org/W3125146978"],"related_works":["https://openalex.org/W2003904223","https://openalex.org/W1509731021","https://openalex.org/W2626640","https://openalex.org/W39774712","https://openalex.org/W2151132195","https://openalex.org/W2314633410","https://openalex.org/W2018944162","https://openalex.org/W2518153831","https://openalex.org/W4247672416","https://openalex.org/W2221497706"],"abstract_inverted_index":{"The":[0,244,344,397],"human":[1,73,140,171,226,384],"brain":[2,74,141,446],"is":[3,38,52,58,266,417],"intricately":[4],"designed":[5],"to":[6,46,79,93,106,119,129,181,287,357],"execute":[7],"cognitive":[8,36,114,146,323,420,436],"functions\\nsuch":[9],"as":[10,24,325,361,404],"perception,":[11],"attention,":[12],"memory":[13,264,411],"and":[14,29,77,113,142,208,278,303,391,412,415,435],"learning.":[15],"Deficits":[16],"in":[17,71,75,89,123,145,165,169,196,200,216,241,260,269,273,275,340,374,382,409,419,448],"cognitive\\nfunctions":[18],"accompany":[19],"major":[20],"psychiatric":[21],"disorders":[22],"such":[23],"schizophrenia,\\nattention":[25],"deficit":[26],"hyperactivity":[27],"disorder":[28],"Parkinson":[30],"s":[31],"disease.":[32],"The\\nbiological":[33],"underpinnings":[34],"of":[35,42,83,97,101,132,135,189,231,236,322,332,369,389,423,433],"functions,":[37],"however":[39],"poorly\\nunderstood.":[40],"One":[41],"the":[43,72,102,133,136,139,149,156,178,205,209,237,242,257,261,310,320,333,341,358,364,367,370,426,442],"neurotransmitters":[44],"proposed":[45],"play":[47],"a":[48,59,124,151,217,229,232,282,296,405,431,439],"central":[49],"role\\nin":[50],"cognition":[51],"dopamine":[53,157],"(DA).\\n\\nPositron":[54],"emission":[55],"tomography":[56],"(PET)":[57],"non-invasive":[60],"molecular":[61,111],"imaging\\ntechnique":[62],"by":[63],"which":[64],"biomarkers":[65,240,250],"for":[66,110,155,177,295,441],"neurotransmission":[67],"systems":[68],"can":[69],"be\\nexamined":[70],"vivo":[76],"related":[78],"higher":[80,445],"brain\\nfunctions.":[81],"Development":[82],"new":[84,152],"tests":[85],"based":[86,429],"on":[87,430],"advances":[88],"cognitive\\nscience":[90],"provides":[91],"tools":[92],"identify":[94],"basic":[95],"elements":[96],"cognition.\\n\\nThe":[98],"first":[99],"aim":[100,117],"present":[103,339,427],"thesis":[104],"was":[105,118,163,214,285,337,372,380,394],"develop":[107],"improved\\nmethodologies,":[108],"both":[109,276],"imaging":[112],"testing.":[115],"The\\nsecond":[116],"apply":[120],"these":[121,248],"methods":[122],"combined":[125],"fashion":[126],"with":[127,301,329,348],"the\\nintention":[128],"increase":[130],"understanding":[131],"organization":[134],"DA":[137,239,443],"system\\nin":[138,444],"its":[143],"role":[144,368,440],"functions.":[147],"In":[148,185,305],"first\\nstudy,":[150],"selective":[153],"radioligand":[154,191],"transporter":[158],"(DAT)":[159],"was\\ndeveloped.":[160],"[11C]PE2I":[161],"binding":[162],"characterized":[164],"four":[166],"non-human":[167],"primates\\nand":[168],"one":[170],"control":[172,291,311,362],"subject,":[173],"showing":[174],"better":[175],"selectivity":[176],"DAT\\nwhen":[179],"compared":[180],"previously":[182],"developed":[183],"radioligands.":[184],"addition,":[186,306],"the\\ndistinctive":[187],"contrast":[188],"this":[190],"demonstrated":[192,228],"sufficient":[193],"signal\\nnot":[194],"only":[195],"striatum,":[197],"but":[198],"also":[199],"substantia":[201],"nigra.\\n\\nThe":[202],"relationship":[203],"between":[204],"presynaptic":[206],"DAT":[207,371,392,401],"mainly":[210],"postsynaptic\\nDA":[211],"D2":[212],"receptor":[213],"examined":[215,373],"double-tracer":[218],"PET":[219],"study":[220],"(Study":[221],"II).":[222],"The\\nresults":[223],"from":[224,386],"17":[225],"subjects":[227],"lack":[230],"correlation,\\nsuggesting":[233],"independent":[234],"regulation":[235],"two":[238,249],"human\\nstriatum.":[243],"results":[245,345,398],"suggest":[246],"that":[247,400],"may":[251,402],"not":[252,338,351],"be\\nmutually":[253],"interchangeable":[254],"when":[255,316],"assessing":[256],"DAergic":[258],"system":[259],"healthy\\nbrain.\\n\\nVisuospatial":[262],"working":[263],"(VSWM)":[265],"commonly":[267],"impaired":[268],"patients":[270,300,347],"with\\nschizophrenia":[271],"resulting":[272],"disorganization":[274],"thoughts":[277],"behavior.\\nIn":[279],"Study":[280],"III,":[281],"standard":[283],"VSWM-test":[284],"modified":[286],"reduce":[288],"ceiling":[289],"effects\\namong":[290],"subjects,":[292],"thus":[293],"allowing":[294],"less":[297],"biased":[298],"comparison\\nbetween":[299],"schizophrenia":[302,349],"controls.":[304],"during\\nhigh":[307],"WM":[308],"load":[309],"group":[312],"showed":[313],"improved":[314],"performance":[315,379,421],"the\\nstimulus":[317],"arrangement":[318,328],"invited":[319],"use":[321,353],"strategies,":[324],"compared\\nto":[326],"an":[327],"random":[330],"location":[331],"target":[334],"stimulus.":[335],"This\\nimprovement":[336],"patient":[342],"group.":[343],"indicate\\nthat":[346],"do":[350],"make":[352],"of,":[354],"or":[355],"generate\\nstrategies":[356],"same":[359],"extent":[360],"subjects.\\n\\nIn":[363],"final":[365],"study,":[366],"relation":[375],"to\\ncognitive":[376],"aging.":[377],"Cognitive":[378],"assessed":[381],"12":[383],"subjects,\\nranging":[385],"34-81":[387],"years":[388],"age,":[390],"density":[393],"quantified":[395],"using\\nPET.":[396],"indicate":[399],"serve":[403],"biomarker":[406],"of\\nage-related":[407],"deficits":[408],"episodic":[410],"executive":[413],"function,":[414],"that\\nDAT":[416],"implicated":[418],"irrespective":[422],"age.\\n\\nIn":[424],"conclusion":[425],"thesis,":[428],"combination":[432],"molecular\\nimaging":[434],"assessment,":[437],"corroborates":[438],"functions":[447],"man.":[449]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
