{"id":"https://openalex.org/W2133965525","doi":"https://doi.org/10.4269/ajtmh.1998.59.889","title":"Lack of efficacy of mefloquine in the treatment of New World cutaneous leishmaniasis in Colombia.","display_name":"Lack of efficacy of mefloquine in the treatment of New World cutaneous leishmaniasis in Colombia.","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2133965525","doi":"https://doi.org/10.4269/ajtmh.1998.59.889","mag":"2133965525","pmid":"https://pubmed.ncbi.nlm.nih.gov/9886195"},"language":"en","primary_location":{"id":"doi:10.4269/ajtmh.1998.59.889","doi":"https://doi.org/10.4269/ajtmh.1998.59.889","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.1998.59.889","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10495/32064","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110197296","display_name":"Erik Hendrickx","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"E P Hendrickx","raw_affiliation_strings":["Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia","Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia","institution_ids":["https://openalex.org/I35961687"]},{"raw_affiliation_string":"Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111938359","display_name":"Stephanie Agudelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"S P Agudelo","raw_affiliation_strings":["Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101751917","display_name":"Diana L. Mu\u00f1oz","orcid":"https://orcid.org/0000-0001-8044-7117","observed_orcids":["https://orcid.org/0000-0001-8044-7117"]},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"D L Munoz","raw_affiliation_strings":["Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080485781","display_name":"Juan Alberto Puerta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"J A Puerta","raw_affiliation_strings":["Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia","institution_ids":["https://openalex.org/I35961687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042780289","display_name":"Iv\u00e1n Dar\u00edo V\u00e9lez","orcid":"https://orcid.org/0000-0003-2227-4662","observed_orcids":["https://orcid.org/0000-0003-2227-4662"]},"institutions":[{"id":"https://openalex.org/I35961687","display_name":"Universidad de Antioquia","ror":"https://ror.org/03bp5hc83","country_code":"CO","type":"education","lineage":["https://openalex.org/I35961687"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"I D Velez Bernal","raw_affiliation_strings":["Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programa de Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia","institution_ids":["https://openalex.org/I35961687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I35961687"],"apc_list":null,"apc_paid":null,"fwci":1.0462,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.7825114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"59","issue":"6","first_page":"889","last_page":"892"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mefloquine","display_name":"mefloquine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cutaneous-leishmaniasis","display_name":"cutaneous leishmaniasis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/leishmania-panamensis","display_name":"Leishmania panamensis","score":0.968999981880188},{"id":"https://openalex.org/keywords/antimonial-therapy","display_name":"antimonial therapy","score":0.5740000009536743},{"id":"https://openalex.org/keywords/meglumine-antimoniate","display_name":"meglumine antimoniate","score":0.9179999828338623},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/scar-formation","display_name":"scar formation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/colombia","display_name":"Colombia","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2780423678","wikidata":"https://www.wikidata.org/wiki/Q2757969","display_name":"Meglumine antimoniate","level":4,"score":0.9744714498519897},{"id":"https://openalex.org/C2778702967","wikidata":"https://www.wikidata.org/wiki/Q2590966","display_name":"Cutaneous leishmaniasis","level":3,"score":0.8299369215965271},{"id":"https://openalex.org/C2777199930","wikidata":"https://www.wikidata.org/wiki/Q736270","display_name":"Mefloquine","level":4,"score":0.8246985077857971},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7526752948760986},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.714184582233429},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6262639164924622},{"id":"https://openalex.org/C2994123057","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Cure rate","level":2,"score":0.4531349539756775},{"id":"https://openalex.org/C2777843234","wikidata":"https://www.wikidata.org/wiki/Q288875","display_name":"Meglumine","level":3,"score":0.4384700655937195},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3697279095649719},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.35538703203201294},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3478856086730957},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3406074643135071},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.22727468609809875},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15451860427856445},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.11582756042480469},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08831143379211426},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015767","descriptor_name":"Mefloquine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015767","descriptor_name":"Mefloquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016773","descriptor_name":"Leishmaniasis, Cutaneous","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4269/ajtmh.1998.59.889","doi":"https://doi.org/10.4269/ajtmh.1998.59.889","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.1998.59.889","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"journal-article"},{"id":"pmid:9886195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9886195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"Clinical Trial"},{"id":"pmh:oai:bibliotecadigital.udea.edu.co:10495/32064","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10495/32064","pdf_url":null,"source":{"id":"https://openalex.org/S4377196334","display_name":"Institutional Repository University of Antioquia (University of Antioquia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35961687","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/I35961687"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:bibliotecadigital.udea.edu.co:10495/32064","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10495/32064","pdf_url":null,"source":{"id":"https://openalex.org/S4377196334","display_name":"Institutional Repository University of Antioquia (University of Antioquia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35961687","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/I35961687"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1895017226","https://openalex.org/W1983584866","https://openalex.org/W1984069235","https://openalex.org/W1999809189","https://openalex.org/W2000769719","https://openalex.org/W2005875868","https://openalex.org/W2006054062","https://openalex.org/W2012545515","https://openalex.org/W2065362620","https://openalex.org/W2075055204","https://openalex.org/W2080606952","https://openalex.org/W2151176434","https://openalex.org/W2279417831","https://openalex.org/W2472577208"],"related_works":["https://openalex.org/W2031556756","https://openalex.org/W1978009940","https://openalex.org/W2069498867","https://openalex.org/W1985053263","https://openalex.org/W2006054062","https://openalex.org/W2085229422","https://openalex.org/W7099787901","https://openalex.org/W6901433928","https://openalex.org/W2089677688","https://openalex.org/W2104134989"],"abstract_inverted_index":{"In":[0],"a":[1,15,23,64,106],"nonblinded,":[2],"therapeutic":[3],"trial":[4],"conducted":[5],"in":[6,32,69,81,117],"Colombia,":[7],"1.25-1.5":[8],"grams":[9],"of":[10,35,47,59,120],"mefloquine":[11,111],"base":[12],"given":[13],"as":[14,20,61,115],"single":[16,107],"oral":[17],"dose":[18],"or":[19],"250":[21],"mg":[22],"day":[24],"for":[25,92],"5-6":[26],"consecutive":[27],"days":[28],"was":[29],"not":[30,113],"efficacious":[31],"the":[33,54,118],"treatment":[34,109,119],"New":[36],"World":[37],"cutaneous":[38,122],"leishmaniasis.":[39],"The":[40],"drug":[41],"had":[42],"cured":[43],"only":[44],"30.8":[45],"%":[46],"patients":[48],"with":[49,63,73,95,110],"leishmaniasis":[50,123],"skin":[51],"lesions":[52],"by":[53],"10th":[55],"week":[56],"after":[57],"start":[58],"therapy":[60],"compared":[62],"27.9%":[65],"complete":[66],"cicatrization":[67,79],"rate":[68,80],"historical":[70,82],"controls":[71,83],"treated":[72],"placebo":[74],"tablets":[75],"and":[76],"an":[77],"86.3%":[78],"who":[84],"received":[85],"meglumine":[86],"antimoniate,":[87],"20":[88,93],"mg/":[89],"kg/day":[90],"intramuscularly":[91],"days,":[94],"no":[96],"upper":[97],"limit":[98],"to":[99,126],"daily":[100],"dose.":[101],"It":[102],"is":[103,112],"concluded":[104],"that":[105],"course":[108],"indicated":[114],"monotherapy":[116],"Colombian":[121],"primarily":[124],"due":[125],"L.":[127],"panamensis.":[128]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}