{"id":"https://openalex.org/W2133870156","doi":null,"title":"Phosphatidylinositol 3-kinase inhibitor wortmannin blocks mitogenic activation of the transferrin receptor gene promoter in late G1.","display_name":"Phosphatidylinositol 3-kinase inhibitor wortmannin blocks mitogenic activation of the transferrin receptor gene promoter in late G1.","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W2133870156","mag":"2133870156","pmid":"https://pubmed.ncbi.nlm.nih.gov/9149907"},"language":"en","primary_location":{"id":"pmid:9149907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9149907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056934029","display_name":"W. Keith Miskimins","orcid":"https://orcid.org/0000-0001-9950-7351","observed_orcids":["https://orcid.org/0000-0001-9950-7351"]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W K Miskimins","raw_affiliation_strings":["University of South Dakota School of Medicine, Department of Biochemistry and Molecular Biology, Vermillion 57069, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Dakota School of Medicine, Department of Biochemistry and Molecular Biology, Vermillion 57069, USA","institution_ids":["https://openalex.org/I189957204"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F King","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F King","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084130138","display_name":"Robin Miskimins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Miskimins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2977,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.46184482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"5","first_page":"565","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.968999981880188},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":1.0},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.875},{"id":"https://openalex.org/keywords/promoter-activation","display_name":"promoter activation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mitogenic-stimulation","display_name":"mitogen stimulation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/g1-phase","display_name":"G1 phase","score":0.7749999761581421},{"id":"https://openalex.org/keywords/quiescent-fibroblasts","display_name":"quiescent fibroblasts","score":0.875},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/serum-stimulation","display_name":"serum stimulation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/vanadate","display_name":"vanadate","score":0.8270000219345093},{"id":"https://openalex.org/keywords/s6-kinase","display_name":"S6 kinase","score":0.875},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.902999997138977},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.8961191177368164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6460760831832886},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.6336950063705444},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5289034247398376},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.49304506182670593},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.49238574504852295},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.45445704460144043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44545817375183105},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.40427154302597046},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19424989819526672}],"mesh":[{"descriptor_ui":"D000077191","descriptor_name":"Wortmannin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004336","descriptor_name":"Drug Antagonism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9149907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9149907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.576.332","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.576.332","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cgd.aacrjournals.org/cgi/reprint/8/5/565.pdf","raw_type":"text"},{"id":"mag:2133870156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9149907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1578504987","https://openalex.org/W1585517331","https://openalex.org/W1969161473","https://openalex.org/W1969442037","https://openalex.org/W1974010399","https://openalex.org/W2002310626","https://openalex.org/W2002796914","https://openalex.org/W2004078164","https://openalex.org/W2004331296","https://openalex.org/W2012377043","https://openalex.org/W2014186158","https://openalex.org/W2015113703","https://openalex.org/W2036668653","https://openalex.org/W2039563328","https://openalex.org/W2043701906","https://openalex.org/W2044868069","https://openalex.org/W2048488778","https://openalex.org/W2063117678","https://openalex.org/W2079229575","https://openalex.org/W2105779783","https://openalex.org/W2108302526","https://openalex.org/W2114859236","https://openalex.org/W2131244463","https://openalex.org/W2134100982","https://openalex.org/W2148231718","https://openalex.org/W2150228169","https://openalex.org/W2160746910","https://openalex.org/W2408828038"],"related_works":["https://openalex.org/W2414156519","https://openalex.org/W2068295905","https://openalex.org/W1980403683","https://openalex.org/W2022632480","https://openalex.org/W2145782063","https://openalex.org/W1967107611","https://openalex.org/W1980383883","https://openalex.org/W1732973792","https://openalex.org/W1921314723","https://openalex.org/W1528368632"],"abstract_inverted_index":{"Expression":[0],"of":[1,28,36,41,56,66,78,88,116,152,159,168,179,191],"the":[2,34,42,67,117,126,129,153,180],"transferrin":[3,14,43,68,118,130,181],"receptor":[4,15,44,69,119,131,182],"is":[5,18,107,122,133],"necessary":[6],"for":[7,49],"cells":[8,141,192],"to":[9,39,75,101,114,137,165,174],"progress":[10],"through":[11],"S-phase.":[12],"The":[13],"gene":[16],"promoter":[17,80,132,183],"activated":[19],"as":[20],"a":[21,47,53,59,111,148],"delayed":[22],"event":[23,163],"following":[24],"growth":[25],"factor":[26],"stimulation":[27,32,87,139],"quiescent":[29,89],"fibroblasts.":[30],"Serum":[31],"in":[33,99,110,140,177],"presence":[35],"vanadate":[37],"leads":[38],"superactivation":[40],"promoter,":[45],"suggesting":[46],"role":[48],"tyrosine":[50,60],"phosphorylation.":[51],"Wortmannin,":[52],"potent":[54],"inhibitor":[55],"phosphatidylinositol":[57,94,154,169],"3-kinase,":[58],"kinase-regulated":[61],"enzyme,":[62],"blocks":[63],"mitogen-dependent":[64],"activation":[65,77,115,178],"promoter.":[70,120],"Furthermore,":[71],"wortmannin":[72],"was":[73,187],"able":[74],"block":[76],"this":[79],"when":[81],"added":[82],"several":[83],"hours":[84],"after":[85],"serum":[86],"cells.":[90],"This":[91,121],"suggests":[92],"that":[93,105,128,142],"3-kinase":[95,155,170],"may":[96],"be":[97,166,175],"required":[98],"mid":[100],"late":[102],"G1":[103],"and":[104],"it":[106],"directly":[108],"involved":[109,176],"pathway":[112],"leading":[113],"further":[123],"supported":[124],"by":[125,189],"finding":[127],"much":[134],"less":[135],"responsive":[136],"mitogenic":[138],"have":[143],"been":[144],"stably":[145],"transfected":[146],"with":[147,193],"dominant":[149],"negative":[150],"form":[151],"regulatory":[156],"subunit.":[157],"Activation":[158],"S6":[160],"kinase,":[161],"an":[162],"known":[164],"downstream":[167],"activation,":[171],"appears":[172],"not":[173],"since":[184],"no":[185],"effect":[186],"observed":[188],"treatment":[190],"rapamycin.":[194]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}