{"id":"https://openalex.org/W2133776100","doi":null,"title":"Prevalence of the HFE gene mutation in the liver transplanted and primary hemochromatosis patients in the Southern Iran.","display_name":"Prevalence of the HFE gene mutation in the liver transplanted and primary hemochromatosis patients in the Southern Iran.","publication_year":2010,"publication_date":"2010-02-28","ids":{"openalex":"https://openalex.org/W2133776100","mag":"2133776100"},"language":"en","primary_location":{"id":"mag:2133776100","doi":null,"is_oa":false,"landing_page_url":"https://www.sid.ir/en/VEWSSID/J_pdf/88120100119.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S185149661","display_name":"Iranian Red Crescent Medical Journal","issn_l":"2074-1804","issn":["2074-1804","2074-1812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4324113678","host_organization_name":"Kowsar Publishing Company","host_organization_lineage":["https://openalex.org/P4324113678"],"host_organization_lineage_names":["Kowsar Publishing Company"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Iranian Red Crescent Medical Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081708128","display_name":"Majid Yavarian","orcid":"https://orcid.org/0000-0002-4708-6281","observed_orcids":["https://orcid.org/0000-0002-4708-6281"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Majid Yavarian","raw_affiliation_strings":["Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, yavarian@sums.ac.ir, Fars, Iran"],"raw_orcid":"https://orcid.org/0000-0002-4708-6281","affiliations":[{"raw_affiliation_string":"Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, yavarian@sums.ac.ir, Fars, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024296414","display_name":"Mehdi Saberfiroozi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehdi Saberfiroozi","raw_affiliation_strings":["Gastroentrohepatlogy Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroentrohepatlogy Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049882423","display_name":"Davood Mehrabani","orcid":"https://orcid.org/0000-0002-5738-1719","observed_orcids":["https://orcid.org/0000-0002-5738-1719"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Davood Mehrabani","raw_affiliation_strings":["Gastroentrohepatlogy Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran"],"raw_orcid":"https://orcid.org/0000-0002-5738-1719","affiliations":[{"raw_affiliation_string":"Gastroentrohepatlogy Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007299494","display_name":"Saeed Amiri-Zadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Saeed Amiri-Zadeh","raw_affiliation_strings":["Gastroentrohepatlogy Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroentrohepatlogy Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058902392","display_name":"Mehran Karimi","orcid":"https://orcid.org/0000-0001-8555-1001","observed_orcids":["https://orcid.org/0000-0001-8555-1001"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehran Karimi","raw_affiliation_strings":["Gastroentrohepatlogy Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran"],"raw_orcid":"https://orcid.org/0000-0001-8555-1001","affiliations":[{"raw_affiliation_string":"Gastroentrohepatlogy Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Fars, Iran","institution_ids":["https://openalex.org/I194604659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I194604659"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"1","first_page":"22","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hfe-mutations","display_name":"HFE gene mutations","score":0.8840000033378601},{"id":"https://openalex.org/keywords/primary-hemochromatosis","display_name":"primary hemochromatosis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/end-stage-liver-disease","display_name":"end-stage liver disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/h63d-mutation","display_name":"H63D mutation","score":0.902999997138977},{"id":"https://openalex.org/keywords/c282y-mutation","display_name":"C282Y mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mutation-prevalence","display_name":"mutation prevalence","score":0.7260000109672546},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.7160000205039978},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.5929999947547913},{"id":"https://openalex.org/keywords/southern-iran","display_name":"southern Iran","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C3018783601","wikidata":"https://www.wikidata.org/wiki/Q3144934","display_name":"Hereditary hemochromatosis","level":3,"score":0.8758634328842163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7683998346328735},{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.7592862844467163},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.6118023991584778},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6056503057479858},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5755159854888916},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5207326412200928},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5182392597198486},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.4960497319698334},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.45798009634017944},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3916499614715576},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.33568936586380005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2595570385456085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13636404275894165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1280212700366974}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2133776100","doi":null,"is_oa":false,"landing_page_url":"https://www.sid.ir/en/VEWSSID/J_pdf/88120100119.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S185149661","display_name":"Iranian Red Crescent Medical Journal","issn_l":"2074-1804","issn":["2074-1804","2074-1812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4324113678","host_organization_name":"Kowsar Publishing Company","host_organization_lineage":["https://openalex.org/P4324113678"],"host_organization_lineage_names":["Kowsar Publishing Company"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Iranian Red Crescent Medical Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W138656917","https://openalex.org/W1964093299","https://openalex.org/W1984023087","https://openalex.org/W1990385611","https://openalex.org/W1990537388","https://openalex.org/W1999764352","https://openalex.org/W2000645323","https://openalex.org/W2027151038","https://openalex.org/W2038231266","https://openalex.org/W2039021931","https://openalex.org/W2050212047","https://openalex.org/W2050364585","https://openalex.org/W2091028002","https://openalex.org/W2091491906","https://openalex.org/W2118094114","https://openalex.org/W2128049446","https://openalex.org/W2137766764","https://openalex.org/W2141275282","https://openalex.org/W2141937988","https://openalex.org/W2156004361","https://openalex.org/W2333021017"],"related_works":["https://openalex.org/W2142430930","https://openalex.org/W2000645323","https://openalex.org/W2007764025","https://openalex.org/W2085284338","https://openalex.org/W2091491906","https://openalex.org/W2043814525","https://openalex.org/W7099051066","https://openalex.org/W2249220275","https://openalex.org/W2171606749","https://openalex.org/W2417194389"],"abstract_inverted_index":{"Background:":[0],"Primary":[1],"hemochromatosis":[2,134,184],"is":[3,11,192,205,240],"an":[4],"inherited":[5],"disorder.":[6],"Mutation":[7],"in":[8,16,77,109,156,168,202,243,262],"this":[9,62],"gene":[10,31,75,95,164],"accompanied":[12],"with":[13,28,46,101,233],"iron":[14],"overload":[15],"the":[17,37,47,68,73,78,129,178,203,211,237,244,269],"body":[18],"leading":[19,56],"to":[20,35,57,65,113,138,145,252,268],"organ":[21],"failure":[22],"that":[23,209],"primarily":[24],"affects":[25],"liver.":[26],"Individuals":[27],"homozygote":[29],"HFE":[30,44,74,94,163,199],"mutation":[32,45,165,200,239],"are":[33],"prone":[34],"developing":[36],"end":[38],"stage":[39],"liver":[40,79,82,260,271],"disease.":[41],"Concomitance":[42],"heterozygote":[43],"other":[48],"hepatic":[49,54],"risk":[50],"factors":[51],"may":[52,266],"accelerate":[53],"damage,":[55],"cirrhosis.":[58],"The":[59,187,198],"aim":[60],"of":[61,72,106,116,159,177,190,210,257],"study":[63],"was":[64,166],"find":[66],"out":[67],"spectrum":[69],"and":[70,132,151,173,183,265],"frequency":[71,189],"mutations":[76,96],"transplantation":[80,272],"(end-stage":[81],"disease":[83,261],"[ESLD])":[84],"candidate":[85],"groups.":[86],"Methods:":[87],"Totally,":[88],"170":[89],"individuals":[90],"were":[91,126,154],"studied":[92],"for":[93,141,259],"including":[97],"87":[98],"ESLD":[99,179,204],"patients":[100,135,264],"various":[102],"etiologies":[103],"from":[104],"Division":[105],"Liver":[107],"Transplant":[108],"Nemazee":[110],"Hospital":[111],"affiliated":[112],"Shiraz":[114],"University":[115],"Medical":[117],"Sciences.":[118],"Seventy":[119],"four":[120],"randomly":[121],"selected":[122],"healthy":[123],"blood":[124],"donors":[125],"evaluated":[127],"as":[128],"control":[130,181,212],"group,":[131,180],"9":[133],"who":[136],"referred":[137],"our":[139,234],"lab":[140],"genetic":[142],"analysis":[143],"due":[144,251],"their":[146],"high":[147],"serum":[148],"ferritin":[149],"levels":[150],"clinical":[152],"diagnosis":[153],"surveyed":[155],"a":[157,253],"period":[158],"one":[160],"year.":[161],"Results:":[162],"found":[167],"57":[169],"(~33%),":[170],"14":[171],"(~9%),":[172],"15":[174],"(~83%)":[175],"chromatids":[176],"sample,":[182],"patients,":[185],"respectively.":[186],"allele":[188],"H63D":[191,201,258],"about":[193],"0.085":[194],"among":[195],"these":[196,263],"people.":[197],"significantly":[206],"higher":[207],"than":[208],"group":[213],"(W/H63D:":[214],"odds":[215,224],"ratio":[216,225],"5.70,":[217],"95%":[218,227],"CI=":[219,228],"2.6":[220],"\u2013":[221],"12.55;":[222],"H63D/H63D:":[223],"6.39,":[226],"0.77-53.1).":[229],"Conclusion:":[230],"In":[231],"compliance":[232],"previous":[235],"report,":[236],"C282Y":[238],"very":[241],"uncommon":[242],"southern":[245],"population.":[246],"This":[247],"prevalence":[248],"could":[249],"be":[250],"significant":[254],"aggravating":[255],"effect":[256],"contribute":[267],"poor":[270],"outcome.":[273]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}