{"id":"https://openalex.org/W2133718917","doi":"https://doi.org/10.1093/infdis/jiu840","title":"HIV infection Worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine","display_name":"HIV infection Worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine","publication_year":2015,"publication_date":"2015-01-02","ids":{"openalex":"https://openalex.org/W2133718917","doi":"https://doi.org/10.1093/infdis/jiu840","mag":"2133718917","pmid":"https://pubmed.ncbi.nlm.nih.gov/25556252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836723"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiu840","doi":"https://doi.org/10.1093/infdis/jiu840","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/jiu840","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836723","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113742710","display_name":"Varghese K. George","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Varghese K. George","raw_affiliation_strings":["Department of Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024777848","display_name":"Suresh Pallikkuth","orcid":"https://orcid.org/0000-0003-4451-8859","observed_orcids":["https://orcid.org/0000-0003-4451-8859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh Pallikkuth","raw_affiliation_strings":["Department of Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052054078","display_name":"Anita Parmigiani","orcid":"https://orcid.org/0000-0002-1780-0376","observed_orcids":["https://orcid.org/0000-0002-1780-0376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anita Parmigiani","raw_affiliation_strings":["Department of Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011011893","display_name":"Maria Luisa Alcaide","orcid":"https://orcid.org/0000-0003-4648-0145","observed_orcids":["https://orcid.org/0000-0003-4648-0145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Alcaide","raw_affiliation_strings":["Division of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084232309","display_name":"Margaret A. Fischl","orcid":"https://orcid.org/0000-0001-9241-5390","observed_orcids":["https://orcid.org/0000-0001-9241-5390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margaret Fischl","raw_affiliation_strings":["AIDS Clinical Research Unit, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS Clinical Research Unit, Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025834447","display_name":"Kristopher L. Arheart","orcid":"https://orcid.org/0000-0001-7699-2278","observed_orcids":["https://orcid.org/0000-0001-7699-2278"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristopher L. Arheart","raw_affiliation_strings":["Division of Biostatistics, Epidemiology and Public Health Department, University of Miami Miller School of Medicine, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Epidemiology and Public Health Department, University of Miami Miller School of Medicine, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002278563","display_name":"Savita G. Pahwa","orcid":"https://orcid.org/0000-0002-4470-4216","observed_orcids":["https://orcid.org/0000-0002-4470-4216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Savita Pahwa","raw_affiliation_strings":["Department of Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113742710"],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":2.9673,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.92257134,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"211","issue":"12","first_page":"1959","last_page":"1968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.1979999989271164,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.7789999842643738},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.7540000081062317},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.843999981880188},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5849999785423279},{"id":"https://openalex.org/keywords/vaccine-non-responders","display_name":"vaccine non-responders","score":0.8320000171661377},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cd4-t-cell-activation","display_name":"CD4+ T cell activation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/il-21","display_name":"IL-21","score":0.9179999828338623},{"id":"https://openalex.org/keywords/h1n1-influenza","display_name":"H1N1 influenza","score":0.7889999747276306},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7649221420288086},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7258983850479126},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6448840498924255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6399087905883789},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6177507042884827},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.5713401436805725},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.5616393685340881},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.5554860830307007},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.507478654384613},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4451886713504791},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.43791553378105164},{"id":"https://openalex.org/C2779359726","wikidata":"https://www.wikidata.org/wiki/Q1195394","display_name":"Memory B cell","level":4,"score":0.42355674505233765},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4151303768157959},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.3034817576408386},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.25586551427841187},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/infdis/jiu840","doi":"https://doi.org/10.1093/infdis/jiu840","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/jiu840","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3871451","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836723","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4836723","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836723","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Infect Dis","raw_type":"Text"},{"id":"pmid:25556252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25556252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.869.4426","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.869.4426","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jid.oxfordjournals.org/content/211/12/1959.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.880.6910","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.880.6910","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jid.oxfordjournals.org/content/early/2015/02/08/infdis.jiu840.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3871451","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836723","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3283394321","display_name":"Antibody Responses in HIV and Aging","funder_award_id":"R01AI108472","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000913280","display_name":"Miami Center for AIDS Research","funder_award_id":"P30AI073961","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W18238130","https://openalex.org/W87082738","https://openalex.org/W611498512","https://openalex.org/W1504079946","https://openalex.org/W1957514873","https://openalex.org/W1981732254","https://openalex.org/W1982595765","https://openalex.org/W1991780615","https://openalex.org/W1992604744","https://openalex.org/W1998562159","https://openalex.org/W2000049562","https://openalex.org/W2005377557","https://openalex.org/W2008221016","https://openalex.org/W2016666924","https://openalex.org/W2023169697","https://openalex.org/W2023718350","https://openalex.org/W2025193872","https://openalex.org/W2045473798","https://openalex.org/W2049614028","https://openalex.org/W2062274686","https://openalex.org/W2065172977","https://openalex.org/W2065188389","https://openalex.org/W2066489069","https://openalex.org/W2076599494","https://openalex.org/W2079025244","https://openalex.org/W2084038115","https://openalex.org/W2090884804","https://openalex.org/W2093138102","https://openalex.org/W2093324837","https://openalex.org/W2096976270","https://openalex.org/W2098930053","https://openalex.org/W2114825231","https://openalex.org/W2115101818","https://openalex.org/W2127354472","https://openalex.org/W2129302556","https://openalex.org/W2134342374","https://openalex.org/W2138694347","https://openalex.org/W2150152496","https://openalex.org/W2153191296","https://openalex.org/W2155847407","https://openalex.org/W2166559731","https://openalex.org/W2168805652","https://openalex.org/W2417989506","https://openalex.org/W2734408370","https://openalex.org/W6603548264"],"related_works":["https://openalex.org/W2084038115","https://openalex.org/W2797942581","https://openalex.org/W2792343481","https://openalex.org/W2801770772","https://openalex.org/W4313356147","https://openalex.org/W7171555269","https://openalex.org/W2115101818","https://openalex.org/W2152641956","https://openalex.org/W2609678925","https://openalex.org/W3044965310"],"abstract_inverted_index":{"BACKGROUND:":[0],"Antibody":[1],"responses":[2,51,179,198],"to":[3,89,93,180,187],"seasonal":[4],"influenza":[5,57,120,181],"vaccines":[6],"are":[7],"defective":[8],"during":[9],"older":[10,40,132,161,184],"age":[11],"and":[12,32,39,49,53,64,91,101,119,125,140,147,171],"human":[13],"immunodeficiency":[14],"virus":[15],"(HIV)":[16],"infection.":[17],"The":[18],"effect":[19],"of":[20,61,84,97,108],"HIV":[21,169],"on":[22],"immune":[23,138,189],"function":[24,118,174,194],"in":[25,69,74,78,131,159,177,183,199],"aging":[26,201],"is":[27],"relatively":[28],"unknown.":[29],"METHODS:":[30],"HIV-infected":[31,75,133,202],"HIV-uninfected":[33,80],"young":[34],"women":[35,41],"(age,":[36,42],"19-54":[37],"years)":[38,44],">55":[43],"were":[45,72,87,128],"evaluated":[46],"for":[47],"B-cell":[48,117,148],"T-cell":[50,137],"before":[52],"4":[54],"weeks":[55],"after":[56,105],"vaccination.":[58,106],"RESULTS:":[59],"Frequencies":[60,107],"seroprotection":[62],"pre-vaccination":[63],"vaccine":[65,85,162,182],"responsiveness":[66],"(\u22654-fold":[67],"increase":[68],"antibody":[70,122,145,178,197],"titer)":[71],"lower":[73],"participants":[76],"than":[77],"age-matched":[79],"participants.":[81,134],"A":[82],"subgroup":[83],"nonresponders":[86],"compared":[88],"responders":[90],"found":[92],"have":[94],"reduced":[95],"frequencies":[96],"memory":[98,116],"B":[99],"cells":[100,104,113],"antigen-specific":[102],"antibody-secreting":[103],"peripheral":[109],"T-follicular":[110],"helper":[111],"(pTfh)":[112],"correlated":[114,142],"with":[115,144,168],"A(H1N1)":[121],"titers.":[123],"Serologic":[124],"immunologic":[126],"deficits":[127],"most":[129],"frequent":[130],"Underlying":[135],"CD4(+)":[136],"activation":[139,166,190],"inflammation":[141],"negatively":[143],"titers":[146],"function,":[149],"which":[150],"was":[151],"not":[152],"enhanced":[153],"by":[154],"exogenous":[155],"interleukin":[156],"21":[157],"supplementation":[158],"HIV-infected,":[160],"nonresponders.":[163],"CONCLUSIONS:":[164],"Immune":[165],"associated":[167],"infection":[170],"impaired":[172],"pTfh":[173,193],"heighten":[175],"deficiencies":[176],"individuals.":[185],"Strategies":[186],"reduce":[188],"or":[191],"augment":[192],"may":[195],"enhance":[196],"the":[200],"population.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
