{"id":"https://openalex.org/W2133701720","doi":null,"title":"Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells.","display_name":"Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells.","publication_year":2003,"publication_date":"2003-07-15","ids":{"openalex":"https://openalex.org/W2133701720","mag":"2133701720","pmid":"https://pubmed.ncbi.nlm.nih.gov/12874004"},"language":"en","primary_location":{"id":"pmid:12874004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12874004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036995841","display_name":"Takashi Shingu","orcid":"https://orcid.org/0000-0002-9829-8225","observed_orcids":["https://orcid.org/0000-0002-9829-8225"]},"institutions":[{"id":"https://openalex.org/I4405285000","display_name":"Shimane Medical University","ror":"https://ror.org/04kg5pk90","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828","https://openalex.org/I4405285000"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Shingu","raw_affiliation_strings":["Department of Biochemistry, Shimane Medical University, Izumo 693-8501, Japan. nogeka@shimane-med.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Shimane Medical University, Izumo 693-8501, Japan. nogeka@shimane-med.ac.jp","institution_ids":["https://openalex.org/I4405285000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053982233","display_name":"Kazuo Yamada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuo Yamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002690197","display_name":"Nobumasa Hara","orcid":"https://orcid.org/0000-0002-3007-8808","observed_orcids":["https://orcid.org/0000-0002-3007-8808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobumasa Hara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110047047","display_name":"Kouzo Moritake","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kouzo Moritake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044235116","display_name":"Harumi Osago","orcid":"https://orcid.org/0000-0002-4327-9297","observed_orcids":["https://orcid.org/0000-0002-4327-9297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harumi Osago","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036310564","display_name":"Masaharu Terashima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaharu Terashima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Takeshi Uemura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Uemura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108590222","display_name":"Toshiki Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiki Yamasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111842520","display_name":"Mikako Tsuchiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikako Tsuchiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9799,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.86279327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"63","issue":"14","first_page":"4044","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8289999961853027},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9070000052452087},{"id":"https://openalex.org/keywords/microtubule-inhibitors","display_name":"microtubule inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5920000076293945},{"id":"https://openalex.org/keywords/isobologram-analysis","display_name":"isobolographic analysis","score":0.5789999961853027},{"id":"https://openalex.org/keywords/median-effect-analysis","display_name":"median effect analysis","score":0.6370000243186951},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.5979999899864197},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8359800577163696},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.758558452129364},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6847492456436157},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6183756589889526},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.568859338760376},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.5596696138381958},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5593758225440979},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5512019395828247},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5310512185096741},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5274620056152344},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5020301342010498},{"id":"https://openalex.org/C2776946711","wikidata":"https://www.wikidata.org/wiki/Q418311","display_name":"Nitrosourea","level":3,"score":0.4617946147918701},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.44997841119766235},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44304850697517395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4246228337287903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32759690284729004},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2614988684654236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2443927526473999},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1616266667842865},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15106472373008728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10038721561431885},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.07697069644927979}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002330","descriptor_name":"Carmustine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002330","descriptor_name":"Carmustine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12874004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12874004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2133701720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12874004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1526781836","https://openalex.org/W1529396499","https://openalex.org/W1604468403","https://openalex.org/W1907295631","https://openalex.org/W1907545229","https://openalex.org/W1980897034","https://openalex.org/W2021286142","https://openalex.org/W2030766685","https://openalex.org/W2057331147","https://openalex.org/W2077945404","https://openalex.org/W2079571554","https://openalex.org/W2083977617","https://openalex.org/W2087245640","https://openalex.org/W2100470338","https://openalex.org/W2143739956","https://openalex.org/W2162592548","https://openalex.org/W2167974749","https://openalex.org/W2172908331","https://openalex.org/W2296043460"],"related_works":["https://openalex.org/W2169908182","https://openalex.org/W2081626155","https://openalex.org/W2083977617","https://openalex.org/W2149210554","https://openalex.org/W1980218169","https://openalex.org/W7096708199","https://openalex.org/W2037763288","https://openalex.org/W2049786372","https://openalex.org/W2007349116","https://openalex.org/W2387074970"],"abstract_inverted_index":{"Because":[0],"the":[1,23,30,35,50,88,175,179,190,194,219],"aberrantly":[2],"activated":[3],"phosphoinositide":[4],"3-kinase":[5],"(PI3K)/Akt":[6],"pathway":[7,24,221],"renders":[8],"tumor":[9],"cells":[10],"resistant":[11],"to":[12,18,97,113,237],"cytotoxic":[13],"insults,":[14],"including":[15,63],"those":[16,94],"related":[17],"anticancer":[19],"drugs,":[20],"inhibition":[21],"of":[22,32,49,91,93,135,165,178,193,218],"may":[25,227],"possibly":[26],"restore":[27],"or":[28,167],"augment":[29],"effectiveness":[31],"chemotherapy.":[33],"Using":[34],"human":[36],"malignant":[37,127,241],"glioma":[38,128],"cell":[39,129,229],"lines":[40,130],"U87,":[41],"A172,":[42],"LN18,":[43],"and":[44,57,67,78,85,105,122,155,213,232],"LN229,":[45],"we":[46,86,214],"examined":[47],"effects":[48,92],"PI3K":[51,176],"inhibitor":[52,76,177],"LY294002":[53,101,136,164,197],"on":[54],"both":[55,103],"apoptosis":[56,104],"cytotoxicity":[58,138,169,183,195],"induced":[59,118],"by":[60,110,119,163,174,196],"chemotherapeutic":[61,147,181],"agents,":[62,202],"antimicrotubule":[64,111,142,201,225],"agents":[65,112,143,226],"vincristine":[66],"paclitaxel,":[68],"an":[69,207],"alkylating":[70],"agent":[71,82],"1,3-bis(2-chloroethyl)-1-nitrosourea,":[72,120],"a":[73,79,114,152,234],"topoisomerase":[74],"II":[75],"etoposide,":[77,121],"DNA":[80],"cross-linking":[81],"cisplatin":[83,123],"(cis-diamminedichloroplatinum),":[84],"compared":[87],"LY294002-induced":[89],"enhancement":[90,162,173],"agents.":[95,148],"Ten":[96],"20":[98],"micro":[99],"M":[100],"augmented":[102],"caspase":[106,210],"3-like":[107],"activity":[108],"caused":[109],"larger":[115],"extent":[116],"than":[117,144],"in":[124,209,222],"all":[125],"four":[126],"examined.":[131],"The":[132],"same":[133],"doses":[134],"enhanced":[137],"more":[139],"efficiently":[140],"with":[141,145,200,224,240],"other":[146,180],"Quantitative":[149],"analyses":[150],"using":[151],"modified":[153],"isobologram":[154],"median":[156],"effect":[157],"plot":[158],"method":[159],"revealed":[160],"that":[161,189,216],"vincristine-":[166],"paclitaxel-induced":[168],"was":[170,184],"synergistic,":[171],"whereas":[172],"agent-induced":[182],"additive.":[185],"Our":[186],"study":[187],"indicates":[188],"synergistic":[191],"augmentation":[192],"occurs":[198],"specifically":[199],"at":[203],"least":[204],"partially":[205],"through":[206],"increase":[208],"3-dependent":[211],"apoptosis,":[212],"suggest":[215],"inhibitors":[217],"PI3K/Akt":[220],"combination":[223],"induce":[228],"death":[230],"effectively":[231],"be":[233],"potent":[235],"modality":[236],"treat":[238],"patients":[239],"gliomas.":[242]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}