{"id":"https://openalex.org/W2133679962","doi":"https://doi.org/10.1161/circulationaha.112.114165","title":"Forever Young","display_name":"Forever Young","publication_year":2012,"publication_date":"2012-05-31","ids":{"openalex":"https://openalex.org/W2133679962","doi":"https://doi.org/10.1161/circulationaha.112.114165","mag":"2133679962","pmid":"https://pubmed.ncbi.nlm.nih.gov/22647977","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3630473"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.112.114165","doi":"https://doi.org/10.1161/circulationaha.112.114165","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.112.114165","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.112.114165","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.112.114165","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101821421","display_name":"David S. Park","orcid":"https://orcid.org/0000-0001-5858-5353","observed_orcids":["https://orcid.org/0000-0001-5858-5353"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Park","raw_affiliation_strings":["From the Leon H. Charney Division of Cardiology (D.S.P., G.I.F.) and the Heart Rhythm Center (D.S.P.), New York University School of Medicine, New York, NY","David S. Park From the Leon H. Charney Division of Cardiology (D.S.P., G.I.F.) and the Heart Rhythm Center (D.S.P.), New York University School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Leon H. Charney Division of Cardiology (D.S.P., G.I.F.) and the Heart Rhythm Center (D.S.P.), New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"David S. Park From the Leon H. Charney Division of Cardiology (D.S.P., G.I.F.) and the Heart Rhythm Center (D.S.P.), New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056576364","display_name":"Glenn I. Fishman","orcid":"https://orcid.org/0000-0002-2366-8527","observed_orcids":["https://orcid.org/0000-0002-2366-8527"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn I. Fishman","raw_affiliation_strings":["From the Leon H. Charney Division of Cardiology (D.S.P., G.I.F.) and the Heart Rhythm Center (D.S.P.), New York University School of Medicine, New York, NY","Glenn I. Fishman From the Leon H. Charney Division of Cardiology (D.S.P., G.I.F.) and the Heart Rhythm Center (D.S.P.), New York University School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Leon H. Charney Division of Cardiology (D.S.P., G.I.F.) and the Heart Rhythm Center (D.S.P.), New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Glenn I. Fishman From the Leon H. Charney Division of Cardiology (D.S.P., G.I.F.) and the Heart Rhythm Center (D.S.P.), New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"125","issue":"25","first_page":"3055","last_page":"3056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scn5a","display_name":"SCN5A","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nav1-5","display_name":"cardiac sodium channel","score":0.9039999842643738},{"id":"https://openalex.org/keywords/long-qt-syndrome-type-3","display_name":"long QT syndrome type 3","score":0.953000009059906},{"id":"https://openalex.org/keywords/brugada-syndrome","display_name":"Brugada syndrome","score":1.0},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.777999997138977},{"id":"https://openalex.org/keywords/phenotypic-overlap","display_name":"phenotypic overlap","score":0.5619999766349792},{"id":"https://openalex.org/keywords/sodium-channel-regulation","display_name":"sodium channel regulation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/cardiac-conduction-disorders","display_name":"cardiac conduction disorders","score":0.574999988079071},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.89383864402771}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D062554","descriptor_name":"NAV1.5 Voltage-Gated Sodium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/circulationaha.112.114165","doi":"https://doi.org/10.1161/circulationaha.112.114165","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.112.114165","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.112.114165","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:22647977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22647977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Editorial"},{"id":"pmh:oai:europepmc.org:2628390","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3630473","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3630473","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3630473","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/circulationaha.112.114165","doi":"https://doi.org/10.1161/circulationaha.112.114165","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.112.114165","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.112.114165","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3757018691","display_name":"Connexin43 Regulation and Cardiovascular Function","funder_award_id":"R01HL082727","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7468175711","display_name":"Purkinje Cells and Arrhythmia Mechanisms","funder_award_id":"R01HL105983","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320308035","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133679962.pdf","grobid_xml":"https://content.openalex.org/works/W2133679962.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2018346270","https://openalex.org/W2066767635","https://openalex.org/W2074781011","https://openalex.org/W2076944129","https://openalex.org/W2093214695","https://openalex.org/W2104996733","https://openalex.org/W2106326075","https://openalex.org/W2106379660","https://openalex.org/W2114460071","https://openalex.org/W2115644752","https://openalex.org/W2133338187","https://openalex.org/W2134798732","https://openalex.org/W2148036689","https://openalex.org/W2157647701","https://openalex.org/W2165593572","https://openalex.org/W4246928383"],"related_works":["https://openalex.org/W2074781011","https://openalex.org/W2083480024","https://openalex.org/W1991492314","https://openalex.org/W2119327816","https://openalex.org/W2097590818","https://openalex.org/W2084451450","https://openalex.org/W2044000885","https://openalex.org/W2097979065","https://openalex.org/W2747107740","https://openalex.org/W1986721438"],"abstract_inverted_index":{"utations":[0],"in":[1,16,50,54,80,112],"the":[2,6,43,46,105],"\u2423":[3],"subunit":[4],"of":[5,20,45,87,101,107],"cardiac":[7,21,32],"sodium":[8,109],"channel,":[9],"encoded":[10],"by":[11],"SCN5A,":[12],"have":[13,58],"been":[14,60],"identified":[15],"a":[17,73],"broad":[18,98],"range":[19,100],"rhythm":[22],"disorders":[23],"that":[24,66],"include":[25],"long":[26,51],"QT3":[27],"(LQT3),":[28],"Brugada":[29,88],"syndrome,":[30,37],"progressive":[31],"conduction":[33],"disease,":[34],"sick":[35],"sinus":[36],"atrial":[38],"fibrillation,":[39],"and":[40,90],"dilated":[41],"cardiomyopathy.Since":[42],"identification":[44],"first":[47],"SCN5A":[48,75,102],"mutation":[49],"QT":[52],"syndrome":[53,89],"1995,":[55],"\u03fe200":[56],"mutations":[57,103],"now":[59,93],"reported.1":[61],"Initially,":[62],"it":[63],"was":[64,70],"assumed":[65],"each":[67],"arrhythmic":[68],"phenotype":[69],"attributable":[71],"to":[72],"specific":[74],"mutation;":[76],"however,":[77],"overlap":[78],"syndromes,":[79],"which":[81],"single":[82],"individuals":[83],"exhibit":[84],"clinical":[85],"features":[86],"LQT3,":[91],"are":[92],"well":[94],"characterized.":[95],"2":[96],"The":[97],"phenotypic":[99],"underscores":[104],"importance":[106],"tight":[108],"channel":[110],"regulation":[111],"maintaining":[113],"normal":[114],"rhythmicity.":[115]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
