{"id":"https://openalex.org/W2133679933","doi":"https://doi.org/10.3174/ajnr.a2691","title":"Modeling MR Imaging Enhancing-Lesion Volumes in Multiple Sclerosis: Application in Clinical Trials","display_name":"Modeling MR Imaging Enhancing-Lesion Volumes in Multiple Sclerosis: Application in Clinical Trials","publication_year":2011,"publication_date":"2011-11-03","ids":{"openalex":"https://openalex.org/W2133679933","doi":"https://doi.org/10.3174/ajnr.a2691","mag":"2133679933","pmid":"https://pubmed.ncbi.nlm.nih.gov/22051810","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7964415"},"language":"en","primary_location":{"id":"doi:10.3174/ajnr.a2691","doi":"https://doi.org/10.3174/ajnr.a2691","is_oa":true,"landing_page_url":"https://doi.org/10.3174/ajnr.a2691","pdf_url":"http://www.ajnr.org/content/ajnr/32/11/2093.full.pdf","source":{"id":"https://openalex.org/S101278519","display_name":"American Journal of Neuroradiology","issn_l":"0195-6108","issn":["0195-6108","1936-959X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316165","host_organization_name":"American Society of Neuroradiology","host_organization_lineage":["https://openalex.org/P4310316165"],"host_organization_lineage_names":["American Society of Neuroradiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Neuroradiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.ajnr.org/content/ajnr/32/11/2093.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111987707","display_name":"I.J. van den Elskamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"I.J. van den Elskamp","raw_affiliation_strings":["Department of Radiology, VU University Medical Center, Amsterdam, theNetherlands. i.vandenelskamp@vumc.nl","aFrom the Departments of Radiology (I.J.v.d.E., F.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, VU University Medical Center, Amsterdam, theNetherlands. i.vandenelskamp@vumc.nl","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"aFrom the Departments of Radiology (I.J.v.d.E., F.B.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108515688","display_name":"D.L. Knol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.L. Knol","raw_affiliation_strings":["bEpidemiology and Biostatistics (D.L.K., B.M.J.U.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bEpidemiology and Biostatistics (D.L.K., B.M.J.U.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015569020","display_name":"Bernard M.J. Uitdehaag","orcid":"https://orcid.org/0000-0002-9226-7364","observed_orcids":["https://orcid.org/0000-0002-9226-7364"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"B.M.J. Uitdehaag","raw_affiliation_strings":["bEpidemiology and Biostatistics (D.L.K., B.M.J.U.)","cNeurology (B.M.J.U.), VU University Medical Center, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bEpidemiology and Biostatistics (D.L.K., B.M.J.U.)","institution_ids":[]},{"raw_affiliation_string":"cNeurology (B.M.J.U.), VU University Medical Center, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064378373","display_name":"Frederik Barkhof","orcid":"https://orcid.org/0000-0003-3543-3706","observed_orcids":["https://orcid.org/0000-0003-3543-3706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Barkhof","raw_affiliation_strings":["aFrom the Departments of Radiology (I.J.v.d.E., F.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aFrom the Departments of Radiology (I.J.v.d.E., F.B.)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2242,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62581278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"32","issue":"11","first_page":"2093","last_page":"2097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14374","display_name":"Statistical Methods in Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/enhancing-lesions","display_name":"enhancing lesions","score":0.5730000138282776},{"id":"https://openalex.org/keywords/lesion-volume","display_name":"lesion volume","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sample-size-calculation","display_name":"sample size determination","score":0.6859999895095825},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.9620000123977661},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/clinical-trial-outcome-measures","display_name":"clinical trial outcome measures","score":0.7860000133514404},{"id":"https://openalex.org/keywords/lesion-count","display_name":"lesion count","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.8023898601531982},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.767279326915741},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5992545485496521},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5022001266479492},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.47361159324645996},{"id":"https://openalex.org/C41054675","wikidata":"https://www.wikidata.org/wiki/Q185547","display_name":"Binomial distribution","level":2,"score":0.46617937088012695},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.45584434270858765},{"id":"https://openalex.org/C173291955","wikidata":"https://www.wikidata.org/wiki/Q732332","display_name":"Weibull distribution","level":2,"score":0.4511326253414154},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.44451531767845154},{"id":"https://openalex.org/C199335787","wikidata":"https://www.wikidata.org/wiki/Q743364","display_name":"Negative binomial distribution","level":3,"score":0.42104750871658325},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.318350613117218},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.22747153043746948},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14213988184928894},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.3174/ajnr.a2691","doi":"https://doi.org/10.3174/ajnr.a2691","is_oa":true,"landing_page_url":"https://doi.org/10.3174/ajnr.a2691","pdf_url":"http://www.ajnr.org/content/ajnr/32/11/2093.full.pdf","source":{"id":"https://openalex.org/S101278519","display_name":"American Journal of Neuroradiology","issn_l":"0195-6108","issn":["0195-6108","1936-959X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316165","host_organization_name":"American Society of Neuroradiology","host_organization_lineage":["https://openalex.org/P4310316165"],"host_organization_lineage_names":["American Society of Neuroradiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Neuroradiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7964415","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7964415","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJNR Am J Neuroradiol","raw_type":"Text"},{"id":"pmid:22051810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22051810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJNR. American journal of neuroradiology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/af224a25-b141-4e9c-beb7-06a5de2128b2","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/af224a25-b141-4e9c-beb7-06a5de2128b2","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van den Elskamp, I J, Knol, D L, Uitdehaag, B M J & Barkhof, F 2011, 'Modeling MR Imaging Enhancing-Lesion Volumes in Multiple Sclerosis: Application in Clinical Trials', American Journal of Neuroradiology, vol. 32, no. 11, pp. 2093-2097. https://doi.org/10.3174/ajnr.A2691","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.971.6009","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.971.6009","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ajnr.org/content/32/11/2093.full.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1492206","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1492206/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AMERICAN JOURNAL OF NEURORADIOLOGY , 32 (11) pp. 2093-2097. (2011)","raw_type":"Article"},{"id":"pmh:oai:research.vu.nl:openaire/bc634061-2e8d-482a-a5e6-7afc809008aa","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/bc634061-2e8d-482a-a5e6-7afc809008aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"van den Elskamp, I J, Knol, D L, Uitdehaag, B M J & Barkhof, F 2011, 'Modeling MR Imaging Enhancing-Lesion Volumes in Multiple Sclerosis: Application in Clinical Trials', American Journal of Neuroradiology, vol. 32, no. 11, pp. 2093-2097. https://doi.org/10.3174/ajnr.A2691","raw_type":"article"},{"id":"pmh:vu:oai:research.vu.nl:publications/bc634061-2e8d-482a-a5e6-7afc809008aa","doi":null,"is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/bc634061-2e8d-482a-a5e6-7afc809008aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Neuroradiology, 32(11), 2093 - 2097. American Society of Neuroradiology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/930eeb53-d896-49fb-b0da-72104e8b7d6a","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/930eeb53-d896-49fb-b0da-72104e8b7d6a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Neuroradiology, 32(11), 2093 - 2097. American Society of Neuroradiology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3174/ajnr.a2691","doi":"https://doi.org/10.3174/ajnr.a2691","is_oa":true,"landing_page_url":"https://doi.org/10.3174/ajnr.a2691","pdf_url":"http://www.ajnr.org/content/ajnr/32/11/2093.full.pdf","source":{"id":"https://openalex.org/S101278519","display_name":"American Journal of Neuroradiology","issn_l":"0195-6108","issn":["0195-6108","1936-959X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316165","host_organization_name":"American Society of Neuroradiology","host_organization_lineage":["https://openalex.org/P4310316165"],"host_organization_lineage_names":["American Society of Neuroradiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Neuroradiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2133679933.pdf","grobid_xml":"https://content.openalex.org/works/W2133679933.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1498065827","https://openalex.org/W1966592054","https://openalex.org/W1988283995","https://openalex.org/W1992656196","https://openalex.org/W2015238396","https://openalex.org/W2016896159","https://openalex.org/W2030792741","https://openalex.org/W2038421851","https://openalex.org/W2051663530","https://openalex.org/W2053283278","https://openalex.org/W2063416972","https://openalex.org/W2091713192","https://openalex.org/W2122656834","https://openalex.org/W2126429052","https://openalex.org/W2140395003","https://openalex.org/W2141230684","https://openalex.org/W2164556363","https://openalex.org/W4366064463"],"related_works":["https://openalex.org/W2187079205","https://openalex.org/W2140395003","https://openalex.org/W7217039212","https://openalex.org/W1862695416","https://openalex.org/W2034651911","https://openalex.org/W2135686765","https://openalex.org/W4234982509","https://openalex.org/W1970885273","https://openalex.org/W2066311653","https://openalex.org/W2155815576"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,77],"PURPOSE:":[2],"Although":[3],"the":[4,10,32,42,48,68,71,87,92,107,110,138,207],"number":[5,72,93],"of":[6,14,34,47,50,60,73,89,96,109,112,118,137,171,206,247],"enhancing":[7,35,51,74,97,113,183],"lesions":[8,53,114],"is":[9,31,212],"typical":[11],"outcome":[12,29,56,130,239],"measure":[13,30,57,131,240],"choice":[15],"in":[16,19,115,149,174,180,216,221,245],"clinical":[17,230],"trials":[18],"MS,":[20],"a":[21,80,100,169,200,213],"potentially":[22],"more":[23,27],"sensitive":[24],"and":[25,44,65,94,122,140,177,209,223],"statistically":[26],"powerful":[28],"volume":[33,49,95,111,127,176],"lesions.":[36,75,98],"In":[37],"this":[38],"study,":[39],"we":[40,66],"assessed":[41],"distribution":[43,108,142,211],"statistical":[45,101,248],"power":[46],"brain":[52],"as":[54,128],"an":[55,237],"by":[58],"means":[59],"their":[61],"required":[62,166,197],"sample":[63,123,226],"size,":[64],"compared":[67,241],"results":[69],"with":[70,120,242],"MATERIAL":[76],"METHODS:":[78],"First,":[79],"literature":[81],"search":[82],"was":[83,103,143],"performed":[84],"to":[85,105,145,167,198,235],"compare":[86],"effects":[88],"treatment":[90],"on":[91],"Then,":[99],"model":[102,146],"proposed":[104],"describe":[106],"2":[116],"datasets":[117],"patients":[119,161,181,194],"RRMS,":[121],"sizes":[124],"for":[125,154,187,229],"enhancing-lesion":[126,147,155,188,219],"primary":[129],"were":[132],"calculated.":[133],"RESULTS:":[134],"A":[135],"mixture":[136,205],"binomial":[139,208],"Weibull":[141,210],"determined":[144],"volumes":[148,156,220,234],"patients.":[150],"Sample":[151],"size":[152,227],"calculations":[153,186],"showed":[157,190],"that":[158,191],"approximately":[159,192],"94":[160],"per":[162],"arm":[163],"would":[164,195],"be":[165,196,236],"detect":[168,199],"combination":[170],"20%":[172,178],"decrease":[173],"lesion":[175,233,243],"increase":[179],"without":[182],"lesions,":[184],"whereas":[185],"counts":[189,244],"129":[193],"50%":[201],"decrease.":[202],"CONCLUSIONS:":[203],"The":[204],"suitable":[214],"approach":[215],"modeling":[217],"new":[218],"MS":[222],"yielded":[224],"feasible":[225],"estimates":[228],"trials,":[231],"showing":[232],"advantageous":[238],"terms":[246],"power.":[249]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}