{"id":"https://openalex.org/W2133677080","doi":"https://doi.org/10.1093/jac/34.6.1051","title":"Synergic inhibitory activity of amphotericin-B and \u03b3 interferon against intracellular Cryptococcus neoformans in murine macrophages","display_name":"Synergic inhibitory activity of amphotericin-B and \u03b3 interferon against intracellular Cryptococcus neoformans in murine macrophages","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2133677080","doi":"https://doi.org/10.1093/jac/34.6.1051","mag":"2133677080","pmid":"https://pubmed.ncbi.nlm.nih.gov/7730221"},"language":"en","primary_location":{"id":"doi:10.1093/jac/34.6.1051","doi":"https://doi.org/10.1093/jac/34.6.1051","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/34.6.1051","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029558296","display_name":"Jean\u2010Louis Herrmann","orcid":"https://orcid.org/0000-0003-2347-6418","observed_orcids":["https://orcid.org/0000-0003-2347-6418","https://orcid.org/0000-0001-5907-5793"]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Louis Herrmann","raw_affiliation_strings":["Laboratoire de Microbiologie, Hopital Hotel Dieu, Paris, France","Laboratoire de Microbiologie, Hopital Hotel Dieu1, Place du Parvis Notre Dame, 75004 Paris, France. Universit\u00e9 Pierre et Marie CurieParis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie, Hopital Hotel Dieu, Paris, France","institution_ids":["https://openalex.org/I4210133078"]},{"raw_affiliation_string":"Laboratoire de Microbiologie, Hopital Hotel Dieu1, Place du Parvis Notre Dame, 75004 Paris, France. Universit\u00e9 Pierre et Marie CurieParis, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110234810","display_name":"Nicolas Dubois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Dubois","raw_affiliation_strings":["Laboratoire de Microbiologie, Hopital Hotel Dieu 1, Place du Parvis Notre Dame, 75004 Paris, France . Universit\u00e9 Pierre et Marie Curie Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie, Hopital Hotel Dieu 1, Place du Parvis Notre Dame, 75004 Paris, France . Universit\u00e9 Pierre et Marie Curie Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034128562","display_name":"Martine Fourgeaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martine Fourgeaud","raw_affiliation_strings":["Laboratoire de Microbiologie, Hopital Hotel Dieu 1, Place du Parvis Notre Dame, 75004 Paris, France . Universit\u00e9 Pierre et Marie Curie Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie, Hopital Hotel Dieu 1, Place du Parvis Notre Dame, 75004 Paris, France . Universit\u00e9 Pierre et Marie Curie Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111491661","display_name":"Didier Basset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Basset","raw_affiliation_strings":["Laboratoire de Microbiologie, Hopital Hotel Dieu 1, Place du Parvis Notre Dame, 75004 Paris, France . Universit\u00e9 Pierre et Marie Curie Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie, Hopital Hotel Dieu 1, Place du Parvis Notre Dame, 75004 Paris, France . Universit\u00e9 Pierre et Marie Curie Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082022450","display_name":"Philippe Henri Lagrange","orcid":"https://orcid.org/0009-0000-2650-0036","observed_orcids":["https://orcid.org/0009-0000-2650-0036"]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe H. Lagrange","raw_affiliation_strings":["Laboratoire de Microbiologie, Hopital Hotel Dieu 1, Place du Parvis Notre Dame, 75004 Paris, France . Universit\u00e9 Pierre et Marie Curie Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Microbiologie, Hopital Hotel Dieu 1, Place du Parvis Notre Dame, 75004 Paris, France . Universit\u00e9 Pierre et Marie Curie Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":1.3712,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.81039562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"34","issue":"6","first_page":"1051","last_page":"1058"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptococcus-neoformans","display_name":"Cryptococcus neoformans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.996999979019165},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.9570000171661377},{"id":"https://openalex.org/keywords/antifungal-synergy","display_name":"antifungal synergy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.859000027179718},{"id":"https://openalex.org/keywords/j774a-1-cells","display_name":"J774A.1 cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/l-nmma","display_name":"L-NMMA","score":0.875},{"id":"https://openalex.org/keywords/hiv-associated-cryptococcosis","display_name":"HIV-associated cryptococcosis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/combination-antifungal-therapy","display_name":"combination antifungal therapy","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.8951783180236816},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.8882783651351929},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8006988167762756},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.5960302352905273},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5823843479156494},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5429787635803223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5407874584197998},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.5232203006744385},{"id":"https://openalex.org/C2778952914","wikidata":"https://www.wikidata.org/wiki/Q309498","display_name":"Cryptococcus","level":2,"score":0.48864394426345825},{"id":"https://openalex.org/C2779413141","wikidata":"https://www.wikidata.org/wiki/Q1470140","display_name":"Cryptococcosis","level":2,"score":0.474685400724411},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.4390959143638611},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.336145281791687},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.27180778980255127},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2605955898761749},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16570740938186646},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.14598006010055542}],"mesh":[{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003455","descriptor_name":"Cryptococcus neoformans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003455","descriptor_name":"Cryptococcus neoformans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015725","descriptor_name":"Fluconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jac/34.6.1051","doi":"https://doi.org/10.1093/jac/34.6.1051","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/34.6.1051","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:7730221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7730221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323400","display_name":"Universit\u00e9 Pierre et Marie Curie","ror":"https://ror.org/02en5vm52"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170668949","https://openalex.org/W92093530","https://openalex.org/W2106767016","https://openalex.org/W1987138641","https://openalex.org/W1572407579","https://openalex.org/W1586347655","https://openalex.org/W3096472176","https://openalex.org/W2900536140","https://openalex.org/W7100569911","https://openalex.org/W1966545614"],"abstract_inverted_index":{"Cryptococcus":[0],"neoformans":[1,31,55],"is":[2],"responsible":[3],"for":[4],"pulmonary":[5],"and":[6,26,36,59,70,90,147],"meningal":[7],"infections":[8],"in":[9,41,74,114,136,174,189,193],"HIV":[10],"patients.":[11],"The":[12,78],"lack":[13],"of":[14,23,29,38,50,53,62,67,87,95,112,130,133,144,150,161,170],"effective":[15],"cellular":[16],"cooperation":[17],"caused":[18],"by":[19,142,148],"the":[20,27,39,42,60,63,123,131,151,168],"low":[21],"level":[22,146],"CD4+":[24],"cells,":[25],"resistance":[28],"C.":[30,54],"to":[32,166,185],"phagocytosis":[33],"allows":[34],"growth":[35],"persistence":[37],"yeast":[40],"host.":[43],"We":[44],"describe":[45],"here":[46],"an":[47],"in-vitro":[48],"model":[49],"intracellular":[51,64],"replication":[52],"inside":[56],"J774-A.1":[57],"macrophages,":[58,119],"determination":[61],"antifungal":[65],"activity":[66],"amphotericin":[68,88,97,134,162,195],"B":[69,89,98,135,163,196],"fluconazole":[71,113],"alone":[72,99],"or":[73,92,104,108,116],"association":[75],"with":[76,84],"IFN-gamma.":[77,96],"maximum":[79],"inhibitory":[80],"effect":[81],"was":[82,140,164],"observed":[83],"one":[85],"MIC":[86,111,160],"100":[91],"1000":[93],"IU/mL":[94],"(at":[100],"1":[101,106],"x":[102,107,110],"MIC),":[103],"either":[105],"50":[109],"normal":[115],"IFN-gamma":[117,137,186],"activated":[118],"did":[120],"not":[121],"eradicate":[122],"ingested":[124],"yeast.":[125],"A":[126],"potential":[127],"underlying":[128],"mechanism":[129],"synergy":[132],"primed":[138],"macrophages":[139,181],"investigated":[141],"measurement":[143],"nitrite":[145],"use":[149],"NO":[152],"synthase":[153],"competitive":[154],"inhibitor,":[155],"NG-monomethyl":[156],"L-arginine":[157],"(NMMA).":[158],"One":[159],"able":[165],"activate":[167],"synthesis":[169],"nitrogen":[171],"reactive":[172],"intermediates":[173],"IFN":[175],"gamma-primed":[176],"macrophages.":[177],"NMMA":[178],"treated":[179],"infected":[180],"responded":[182],"less":[183],"well":[184],"priming,":[187],"resulting":[188],"a":[190],"moderate":[191],"inhibition":[192],"subsequent":[194],"exposure.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
